CA2739460C - Cd86 antagonist multi-target binding proteins - Google Patents

Cd86 antagonist multi-target binding proteins Download PDF

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Publication number
CA2739460C
CA2739460C CA2739460A CA2739460A CA2739460C CA 2739460 C CA2739460 C CA 2739460C CA 2739460 A CA2739460 A CA 2739460A CA 2739460 A CA2739460 A CA 2739460A CA 2739460 C CA2739460 C CA 2739460C
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Canada
Prior art keywords
seq
fusion protein
domain
binding domain
binding
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Expired - Fee Related
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CA2739460A
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English (en)
French (fr)
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CA2739460A1 (en
Inventor
Peter Armstrong Thompson
Peter Robert Baum
Philip Tan
John W. Blankenship
Sateesh Kumar Natarajan
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Aptevo Research and Development LLC
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Aptevo Research and Development LLC
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Priority to CA3038442A priority Critical patent/CA3038442A1/en
Publication of CA2739460A1 publication Critical patent/CA2739460A1/en
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    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
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    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C07—ORGANIC CHEMISTRY
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/244—Interleukins [IL]
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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    • C07K16/2833—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against MHC-molecules, e.g. HLA-molecules
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/2875—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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CA2739460A 2008-10-02 2009-10-02 Cd86 antagonist multi-target binding proteins Expired - Fee Related CA2739460C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA3038442A CA3038442A1 (en) 2008-10-02 2009-10-02 Cd86 antagonist multi-target binding proteins

Applications Claiming Priority (19)

Application Number Priority Date Filing Date Title
US10229708P 2008-10-02 2008-10-02
US10233608P 2008-10-02 2008-10-02
US10230708P 2008-10-02 2008-10-02
US10231508P 2008-10-02 2008-10-02
US10233108P 2008-10-02 2008-10-02
US10232708P 2008-10-02 2008-10-02
US10228808P 2008-10-02 2008-10-02
US10231908P 2008-10-02 2008-10-02
US10233408P 2008-10-02 2008-10-02
US61/102,307 2008-10-02
US61/102,331 2008-10-02
US61/102,297 2008-10-02
US61/102,288 2008-10-02
US61/102,315 2008-10-02
US61/102,334 2008-10-02
US61/102,327 2008-10-02
US61/102,319 2008-10-02
US61/102,336 2008-10-02
PCT/US2009/059446 WO2010040105A2 (en) 2008-10-02 2009-10-02 Cd86 antagonist multi-target binding proteins

Related Child Applications (1)

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CA3038442A Division CA3038442A1 (en) 2008-10-02 2009-10-02 Cd86 antagonist multi-target binding proteins

Publications (2)

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CA2739460A1 CA2739460A1 (en) 2010-04-08
CA2739460C true CA2739460C (en) 2019-05-21

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CA3038442A Abandoned CA3038442A1 (en) 2008-10-02 2009-10-02 Cd86 antagonist multi-target binding proteins
CA2739460A Expired - Fee Related CA2739460C (en) 2008-10-02 2009-10-02 Cd86 antagonist multi-target binding proteins

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Application Number Title Priority Date Filing Date
CA3038442A Abandoned CA3038442A1 (en) 2008-10-02 2009-10-02 Cd86 antagonist multi-target binding proteins

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US (2) US9493564B2 (ru)
EP (2) EP2344540B1 (ru)
JP (4) JP5840494B2 (ru)
KR (5) KR20160120812A (ru)
CN (2) CN107056951A (ru)
AU (4) AU2009298131B2 (ru)
BR (1) BRPI0920749A8 (ru)
CA (2) CA3038442A1 (ru)
CY (1) CY1119874T1 (ru)
DK (1) DK2344540T3 (ru)
EA (1) EA024877B1 (ru)
ES (1) ES2657220T3 (ru)
HK (1) HK1251000A1 (ru)
HR (1) HRP20180045T1 (ru)
LT (1) LT2344540T (ru)
MX (1) MX338825B (ru)
NO (1) NO2344540T3 (ru)
NZ (1) NZ592420A (ru)
PL (1) PL2344540T3 (ru)
PT (1) PT2344540T (ru)
SI (1) SI2344540T1 (ru)
WO (1) WO2010040105A2 (ru)
ZA (1) ZA201102637B (ru)

Families Citing this family (67)

* Cited by examiner, † Cited by third party
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