CA2656622C - Hydroxylated and methoxylated cyclopenta [d] pyrimidines as akt protein kinase inhibitors - Google Patents

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Publication number

CA2656622C

CA2656622C CA2656622A CA2656622A CA2656622C CA 2656622 C CA2656622 C CA 2656622C CA 2656622 A CA2656622 A CA 2656622A CA 2656622 A CA2656622 A CA 2656622A CA 2656622 C CA2656622 C CA 2656622C

Authority

CA

Canada

Prior art keywords

dihydro

cyclopenta

methyl

hydroxy

pyrimidin

Prior art date

2006-07-06

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

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• 108091008611 Protein Kinase B Proteins 0.000 title claims abstract description 61
• 229940045988 antineoplastic drug protein kinase inhibitors Drugs 0.000 title abstract description 4
• 239000003909 protein kinase inhibitor Substances 0.000 title abstract description 4
• LTFBFZBWUKWXID-UHFFFAOYSA-N 1h-cyclopenta[d]pyrimidine Chemical class N1=CNC2=CC=CC2=C1 LTFBFZBWUKWXID-UHFFFAOYSA-N 0.000 title 1
• 150000001875 compounds Chemical class 0.000 claims abstract description 314
• -1 resolved enantiomers Chemical class 0.000 claims abstract description 227
• 238000000034 method Methods 0.000 claims abstract description 81
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• 102100033810 RAC-alpha serine/threonine-protein kinase Human genes 0.000 claims abstract description 43
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• HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims abstract description 18
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• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 61
• IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 59
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• 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims description 27
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• VWFHPQXIADBYRU-JRGCBEDISA-N (2r)-2-(4-chlorophenyl)-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-3-thiomorpholin-4-ylpropan-1-one Chemical compound C([C@H](C(=O)N1CCN(CC1)C=1N=CN=C2[C@H](O)C[C@H](C=12)C)C=1C=CC(Cl)=CC=1)N1CCSCC1 VWFHPQXIADBYRU-JRGCBEDISA-N 0.000 claims 1
• OOOZFSVNJMFYIK-VXZFSVQYSA-N (2r)-2-(4-chlorophenyl)-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-4-(2-hydroxypropylamino)butan-1-one Chemical compound C1([C@H](C(=O)N2CCN(CC2)C=2C=3[C@H](C)C[C@@H](O)C=3N=CN=2)CCNCC(O)C)=CC=C(Cl)C=C1 OOOZFSVNJMFYIK-VXZFSVQYSA-N 0.000 claims 1
• VUUMEPNCTXLZSL-SXSPYAJSSA-N (2r)-2-(4-chlorophenyl)-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-4-(oxan-4-ylamino)butan-1-one Chemical compound C([C@@H](C(=O)N1CCN(CC1)C=1N=CN=C2[C@H](O)C[C@H](C=12)C)C=1C=CC(Cl)=CC=1)CNC1CCOCC1 VUUMEPNCTXLZSL-SXSPYAJSSA-N 0.000 claims 1
• MOJSLARYQDHGHK-STZQEDGTSA-N (2r)-2-(4-chlorophenyl)-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-4-[2-methoxyethyl(methyl)amino]butan-1-one Chemical compound C1([C@H](C(=O)N2CCN(CC2)C=2C=3[C@H](C)C[C@@H](O)C=3N=CN=2)CCN(C)CCOC)=CC=C(Cl)C=C1 MOJSLARYQDHGHK-STZQEDGTSA-N 0.000 claims 1
• DLMLJPXUDAUIRE-RVPRBQHHSA-N (2r)-2-(4-chlorophenyl)-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-4-[[2-hydroxy-1-(oxan-4-yl)ethyl]amino]butan-1-one Chemical compound C([C@@H](C(=O)N1CCN(CC1)C=1N=CN=C2[C@H](O)C[C@H](C=12)C)C=1C=CC(Cl)=CC=1)CNC(CO)C1CCOCC1 DLMLJPXUDAUIRE-RVPRBQHHSA-N 0.000 claims 1
• QGUOXJAMLQVZTF-UIAACRFSSA-N (2r)-2-(4-chlorophenyl)-3-(3-hydroxyazetidin-1-yl)-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]propan-1-one Chemical compound C([C@H](C(=O)N1CCN(CC1)C=1N=CN=C2[C@H](O)C[C@H](C=12)C)C=1C=CC(Cl)=CC=1)N1CC(O)C1 QGUOXJAMLQVZTF-UIAACRFSSA-N 0.000 claims 1
• DMFQEDIRMMWZOK-VOQZNFBZSA-N (2r)-2-(4-chlorophenyl)-3-(4-fluoropiperidin-1-yl)-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]propan-1-one Chemical compound C([C@H](C(=O)N1CCN(CC1)C=1N=CN=C2[C@H](O)C[C@H](C=12)C)C=1C=CC(Cl)=CC=1)N1CCC(F)CC1 DMFQEDIRMMWZOK-VOQZNFBZSA-N 0.000 claims 1
• VEXSHJGNGILRJI-ILCQWTCRSA-N (2r)-2-(4-chlorophenyl)-3-[(2s,6r)-2,6-dimethylmorpholin-4-yl]-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]propan-1-one Chemical compound C([C@H](C(=O)N1CCN(CC1)C=1N=CN=C2[C@H](O)C[C@H](C=12)C)C=1C=CC(Cl)=CC=1)N1C[C@H](C)O[C@H](C)C1 VEXSHJGNGILRJI-ILCQWTCRSA-N 0.000 claims 1
• UKUKRSMZCFAQGY-HGSOSGBHSA-N (2r)-2-(4-chlorophenyl)-3-[(3s)-3-(dimethylamino)pyrrolidin-1-yl]-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]propan-1-one Chemical compound C([C@H](C(=O)N1CCN(CC1)C=1N=CN=C2[C@H](O)C[C@H](C=12)C)C=1C=CC(Cl)=CC=1)N1CC[C@H](N(C)C)C1 UKUKRSMZCFAQGY-HGSOSGBHSA-N 0.000 claims 1
• JOADGYMGMILDPB-WTIAFYNJSA-N (2r)-2-(4-chlorophenyl)-3-[4-(2-hydroxyethyl)piperazin-1-yl]-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]propan-1-one Chemical compound C([C@H](C(=O)N1CCN(CC1)C=1N=CN=C2[C@H](O)C[C@H](C=12)C)C=1C=CC(Cl)=CC=1)N1CCN(CCO)CC1 JOADGYMGMILDPB-WTIAFYNJSA-N 0.000 claims 1
• LHESKSDGVWTWIF-VEXUSMLFSA-N (2r)-2-(4-chlorophenyl)-3-[4-(dimethylamino)piperidin-1-yl]-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]propan-1-one Chemical compound C([C@H](C(=O)N1CCN(CC1)C=1N=CN=C2[C@H](O)C[C@H](C=12)C)C=1C=CC(Cl)=CC=1)N1CCC(N(C)C)CC1 LHESKSDGVWTWIF-VEXUSMLFSA-N 0.000 claims 1
• GOLLEMCTBRDVMY-CTUHWIOQSA-N (2r)-2-(4-chlorophenyl)-4-(cyclohexylamino)-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]butan-1-one Chemical compound C([C@@H](C(=O)N1CCN(CC1)C=1N=CN=C2[C@H](O)C[C@H](C=12)C)C=1C=CC(Cl)=CC=1)CNC1CCCCC1 GOLLEMCTBRDVMY-CTUHWIOQSA-N 0.000 claims 1
• AGKRBOABBMQFSL-SZVBFZGTSA-N (2r)-2-(5-bromopyridin-2-yl)-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-3-(propan-2-ylamino)propan-1-one Chemical compound C1([C@H](C(=O)N2CCN(CC2)C=2C=3[C@H](C)C[C@@H](O)C=3N=CN=2)CNC(C)C)=CC=C(Br)C=N1 AGKRBOABBMQFSL-SZVBFZGTSA-N 0.000 claims 1
• KBAMXFJMRDMARS-DQMJNTIXSA-N (2r)-2-[(1-acetylpiperidin-4-yl)amino]-3-(4-chlorophenyl)-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]propan-1-one Chemical compound C([C@H](C(=O)N1CCN(CC1)C=1N=CN=C2[C@H](O)C[C@H](C=12)C)NC1CCN(CC1)C(C)=O)C1=CC=C(Cl)C=C1 KBAMXFJMRDMARS-DQMJNTIXSA-N 0.000 claims 1
• AZINUGHITMTEKR-LKUPVBHCSA-N (2r)-2-[3-fluoro-4-(trifluoromethoxy)phenyl]-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-3-(4-hydroxypiperidin-1-yl)propan-1-one Chemical compound C([C@H](C(=O)N1CCN(CC1)C=1N=CN=C2[C@H](O)C[C@H](C=12)C)C=1C=C(F)C(OC(F)(F)F)=CC=1)N1CCC(O)CC1 AZINUGHITMTEKR-LKUPVBHCSA-N 0.000 claims 1
• OJQBGEUQOPGUJO-SLYNCCJLSA-N (2r)-2-[3-fluoro-4-(trifluoromethoxy)phenyl]-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-3-(4-methylpiperazin-1-yl)propan-1-one Chemical compound C([C@H](C(=O)N1CCN(CC1)C=1N=CN=C2[C@H](O)C[C@H](C=12)C)C=1C=C(F)C(OC(F)(F)F)=CC=1)N1CCN(C)CC1 OJQBGEUQOPGUJO-SLYNCCJLSA-N 0.000 claims 1
• GROLACOOUFTTBG-IMFGXOCKSA-N (2r)-2-[3-fluoro-4-(trifluoromethoxy)phenyl]-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-3-morpholin-4-ylpropan-1-one Chemical compound C([C@H](C(=O)N1CCN(CC1)C=1N=CN=C2[C@H](O)C[C@H](C=12)C)C=1C=C(F)C(OC(F)(F)F)=CC=1)N1CCOCC1 GROLACOOUFTTBG-IMFGXOCKSA-N 0.000 claims 1
• JCNGTRXRBGDTTA-GTCCEBARSA-N (2r)-2-[3-fluoro-4-(trifluoromethyl)phenyl]-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-3-(4-hydroxypiperidin-1-yl)propan-1-one Chemical compound C([C@H](C(=O)N1CCN(CC1)C=1N=CN=C2[C@H](O)C[C@H](C=12)C)C=1C=C(F)C(=CC=1)C(F)(F)F)N1CCC(O)CC1 JCNGTRXRBGDTTA-GTCCEBARSA-N 0.000 claims 1
• XBLQKLOXSQXHJY-ZWCUEREDSA-N (2r)-2-[3-fluoro-4-(trifluoromethyl)phenyl]-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-3-(4-methylpiperazin-1-yl)propan-1-one Chemical compound C([C@H](C(=O)N1CCN(CC1)C=1N=CN=C2[C@H](O)C[C@H](C=12)C)C=1C=C(F)C(=CC=1)C(F)(F)F)N1CCN(C)CC1 XBLQKLOXSQXHJY-ZWCUEREDSA-N 0.000 claims 1
• MHAHVLOPCSKGNI-NHCICSSKSA-N (2r)-2-[3-fluoro-4-(trifluoromethyl)phenyl]-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-3-(4-propan-2-ylpiperazin-1-yl)propan-1-one Chemical compound C1CN(C(C)C)CCN1C[C@@H](C=1C=C(F)C(=CC=1)C(F)(F)F)C(=O)N1CCN(C=2C=3[C@H](C)C[C@@H](O)C=3N=CN=2)CC1 MHAHVLOPCSKGNI-NHCICSSKSA-N 0.000 claims 1
• IJWCTXNBWAOIQW-ZTFGCOKTSA-N (2r)-2-amino-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-3-(4-methoxyphenyl)propan-1-one Chemical compound C1=CC(OC)=CC=C1C[C@@H](N)C(=O)N1CCN(C=2C=3[C@H](C)C[C@@H](O)C=3N=CN=2)CC1 IJWCTXNBWAOIQW-ZTFGCOKTSA-N 0.000 claims 1
• NZWOHIMDSZEHGF-KBRIMQKVSA-N (2r)-2-amino-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-3-[4-(trifluoromethyl)phenyl]propan-1-one Chemical compound C([C@@H](N)C(=O)N1CCN(CC1)C=1N=CN=C2[C@H](O)C[C@H](C=12)C)C1=CC=C(C(F)(F)F)C=C1 NZWOHIMDSZEHGF-KBRIMQKVSA-N 0.000 claims 1
• IAJISHPPISWUQW-UGDMHMSLSA-N (2r)-2-amino-3-(4-chloro-3-fluorophenyl)-1-[(3s)-4-[(5r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]-3-methylpiperazin-1-yl]propan-1-one Chemical compound C([C@@H](N)C(=O)N1CCN([C@H](C1)C)C=1N=CN=C2C(O)C[C@H](C=12)C)C1=CC=C(Cl)C(F)=C1 IAJISHPPISWUQW-UGDMHMSLSA-N 0.000 claims 1
• CSPDGZFTWANITO-SZCVLSFYSA-N (2r)-2-amino-3-(4-chloro-3-fluorophenyl)-1-[(3s)-4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]-3-methylpiperazin-1-yl]propan-1-one;dihydrochloride Chemical compound Cl.Cl.C([C@@H](N)C(=O)N1CCN([C@H](C1)C)C=1N=CN=C2[C@H](O)C[C@H](C=12)C)C1=CC=C(Cl)C(F)=C1 CSPDGZFTWANITO-SZCVLSFYSA-N 0.000 claims 1
• HBFAICUEFLTRKR-BOKOPVRGSA-N (2r)-2-amino-3-(4-chloro-3-fluorophenyl)-1-[(3s)-4-[(5r,7r)-7-methoxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]-3-methylpiperazin-1-yl]propan-1-one;dihydrochloride Chemical compound Cl.Cl.C([C@@H](N)C(=O)N1CCN([C@H](C1)C)C1=NC=NC2=C1[C@H](C)C[C@H]2OC)C1=CC=C(Cl)C(F)=C1 HBFAICUEFLTRKR-BOKOPVRGSA-N 0.000 claims 1
• JWTBZMPUBOQQQY-JBBXEZCESA-N (2r)-2-amino-3-(4-chloro-3-fluorophenyl)-1-[(3s)-4-[(7r)-7-hydroxy-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]-3-methylpiperazin-1-yl]propan-1-one Chemical compound C([C@@H](N)C(=O)N1C[C@@H](N(CC1)C=1C=2CC[C@@H](O)C=2N=CN=1)C)C1=CC=C(Cl)C(F)=C1 JWTBZMPUBOQQQY-JBBXEZCESA-N 0.000 claims 1
• JWTBZMPUBOQQQY-RZAIGCCYSA-N (2r)-2-amino-3-(4-chloro-3-fluorophenyl)-1-[(3s)-4-[(7s)-7-hydroxy-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]-3-methylpiperazin-1-yl]propan-1-one Chemical compound C([C@@H](N)C(=O)N1C[C@@H](N(CC1)C=1C=2CC[C@H](O)C=2N=CN=1)C)C1=CC=C(Cl)C(F)=C1 JWTBZMPUBOQQQY-RZAIGCCYSA-N 0.000 claims 1
• YMZHIOJTIJMPLR-DCRQNVTHSA-N (2r)-2-amino-3-(4-chlorophenyl)-1-[(3s)-4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]-3-methylpiperazin-1-yl]propan-1-one;dihydrochloride Chemical compound Cl.Cl.C([C@@H](N)C(=O)N1CCN([C@H](C1)C)C=1N=CN=C2[C@H](O)C[C@H](C=12)C)C1=CC=C(Cl)C=C1 YMZHIOJTIJMPLR-DCRQNVTHSA-N 0.000 claims 1
• UHLAXFHHMRDMIK-VHSSKADRSA-N (2r)-2-amino-3-(4-chlorophenyl)-1-[(3s)-4-[(7s)-7-hydroxy-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]-3-methylpiperazin-1-yl]propan-1-one Chemical compound C([C@@H](N)C(=O)N1C[C@@H](N(CC1)C=1C=2CC[C@H](O)C=2N=CN=1)C)C1=CC=C(Cl)C=C1 UHLAXFHHMRDMIK-VHSSKADRSA-N 0.000 claims 1
• GXQHQVGUCDFJSU-TZHYSIJRSA-N (2r)-2-amino-3-(4-chlorophenyl)-1-[4-(7-hydroxy-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl)piperazin-1-yl]propan-1-one Chemical compound C([C@@H](N)C(=O)N1CCN(CC1)C=1C=2CCC(O)C=2N=CN=1)C1=CC=C(Cl)C=C1 GXQHQVGUCDFJSU-TZHYSIJRSA-N 0.000 claims 1
• HONZACGKBSSZKP-XYPHTWIQSA-N (2r)-2-amino-3-(4-chlorophenyl)-1-[4-[(5r,7s)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]propan-1-one Chemical compound C([C@@H](N)C(=O)N1CCN(CC1)C=1N=CN=C2[C@@H](O)C[C@H](C=12)C)C1=CC=C(Cl)C=C1 HONZACGKBSSZKP-XYPHTWIQSA-N 0.000 claims 1
• WXBZEODTEQDLCC-UIAACRFSSA-N (2r)-3-(3-aminoazetidin-1-yl)-2-(4-chlorophenyl)-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]propan-1-one Chemical compound C([C@H](C(=O)N1CCN(CC1)C=1N=CN=C2[C@H](O)C[C@H](C=12)C)C=1C=CC(Cl)=CC=1)N1CC(N)C1 WXBZEODTEQDLCC-UIAACRFSSA-N 0.000 claims 1
• NLJZHCYNUJUZLQ-YFXJRYMSSA-N (2r)-3-(4-acetylpiperazin-1-yl)-2-(4-chlorophenyl)-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]propan-1-one Chemical compound C([C@H](C(=O)N1CCN(CC1)C=1N=CN=C2[C@H](O)C[C@H](C=12)C)C=1C=CC(Cl)=CC=1)N1CCN(C(C)=O)CC1 NLJZHCYNUJUZLQ-YFXJRYMSSA-N 0.000 claims 1
• GFXVLXGVPHKNGB-PIPMEXSNSA-N (2r)-3-(4-acetylpiperazin-1-yl)-2-[3-fluoro-4-(trifluoromethoxy)phenyl]-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]propan-1-one Chemical compound C([C@H](C(=O)N1CCN(CC1)C=1N=CN=C2[C@H](O)C[C@H](C=12)C)C=1C=C(F)C(OC(F)(F)F)=CC=1)N1CCN(C(C)=O)CC1 GFXVLXGVPHKNGB-PIPMEXSNSA-N 0.000 claims 1
• XQHJGSRNSFPVKJ-VOQZNFBZSA-N (2r)-3-(4-aminopiperidin-1-yl)-2-(4-chlorophenyl)-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]propan-1-one Chemical compound C([C@H](C(=O)N1CCN(CC1)C=1N=CN=C2[C@H](O)C[C@H](C=12)C)C=1C=CC(Cl)=CC=1)N1CCC(N)CC1 XQHJGSRNSFPVKJ-VOQZNFBZSA-N 0.000 claims 1
• MBLVTQGQFDXNGG-HRQSHJORSA-N (2r)-3-(4-chlorophenyl)-1-[(3s)-4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]-3-methylpiperazin-1-yl]-2-(propan-2-ylamino)propan-1-one Chemical compound C([C@@H](NC(C)C)C(=O)N1C[C@H](C)N(CC1)C=1C=2[C@H](C)C[C@@H](O)C=2N=CN=1)C1=CC=C(Cl)C=C1 MBLVTQGQFDXNGG-HRQSHJORSA-N 0.000 claims 1
• CMVNYMUISARIQV-UEVCKROQSA-N (2r)-3-(4-chlorophenyl)-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-2-(2-morpholin-4-ylethylamino)propan-1-one Chemical compound C([C@H](C(=O)N1CCN(CC1)C=1N=CN=C2[C@H](O)C[C@H](C=12)C)NCCN1CCOCC1)C1=CC=C(Cl)C=C1 CMVNYMUISARIQV-UEVCKROQSA-N 0.000 claims 1
• DINHPIWJRMNIKJ-ATZDWAIDSA-N (2r)-3-(4-chlorophenyl)-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-2-(3,3,3-trifluoropropylamino)propan-1-one Chemical compound C([C@H](C(=O)N1CCN(CC1)C=1N=CN=C2[C@H](O)C[C@H](C=12)C)NCCC(F)(F)F)C1=CC=C(Cl)C=C1 DINHPIWJRMNIKJ-ATZDWAIDSA-N 0.000 claims 1
• BBDMVOVPMWICSB-ZTFGCOKTSA-N (2r)-3-(4-chlorophenyl)-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-2-(methylamino)propan-1-one Chemical compound C([C@@H](NC)C(=O)N1CCN(CC1)C=1C=2[C@H](C)C[C@@H](O)C=2N=CN=1)C1=CC=C(Cl)C=C1 BBDMVOVPMWICSB-ZTFGCOKTSA-N 0.000 claims 1
• JROJOLJOOUSKRZ-ZPMCFJSWSA-N (2r)-3-(4-chlorophenyl)-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-2-(oxan-4-ylamino)propan-1-one Chemical compound C([C@H](C(=O)N1CCN(CC1)C=1N=CN=C2[C@H](O)C[C@H](C=12)C)NC1CCOCC1)C1=CC=C(Cl)C=C1 JROJOLJOOUSKRZ-ZPMCFJSWSA-N 0.000 claims 1
• NVCHJODXYHLZON-SXSPYAJSSA-N (2r)-3-(4-chlorophenyl)-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-2-(oxan-4-ylmethylamino)propan-1-one Chemical compound C([C@H](C(=O)N1CCN(CC1)C=1N=CN=C2[C@H](O)C[C@H](C=12)C)NCC1CCOCC1)C1=CC=C(Cl)C=C1 NVCHJODXYHLZON-SXSPYAJSSA-N 0.000 claims 1
• LJNQSLASMVEVEG-ZPMCFJSWSA-N (2r)-3-(4-chlorophenyl)-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-2-(piperidin-4-ylamino)propan-1-one Chemical compound C([C@H](C(=O)N1CCN(CC1)C=1N=CN=C2[C@H](O)C[C@H](C=12)C)NC1CCNCC1)C1=CC=C(Cl)C=C1 LJNQSLASMVEVEG-ZPMCFJSWSA-N 0.000 claims 1
• RBSAFTREFIOLQE-NSISKUIASA-N (2r)-3-(4-chlorophenyl)-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-2-(propan-2-ylamino)propan-1-one Chemical compound C([C@@H](NC(C)C)C(=O)N1CCN(CC1)C=1C=2[C@H](C)C[C@@H](O)C=2N=CN=1)C1=CC=C(Cl)C=C1 RBSAFTREFIOLQE-NSISKUIASA-N 0.000 claims 1
• LINZZWXKVYZWQW-DUXKGJEZSA-N (2r)-3-(4-chlorophenyl)-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-2-[methyl(propan-2-yl)amino]propan-1-one Chemical compound C([C@@H](N(C)C(C)C)C(=O)N1CCN(CC1)C=1C=2[C@H](C)C[C@@H](O)C=2N=CN=1)C1=CC=C(Cl)C=C1 LINZZWXKVYZWQW-DUXKGJEZSA-N 0.000 claims 1
• FCCXMYCNLAFOHM-ATZDWAIDSA-N (2r)-3-(4-chlorophenyl)-2-(dimethylamino)-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]propan-1-one Chemical compound C([C@H](C(=O)N1CCN(CC1)C=1N=CN=C2[C@H](O)C[C@H](C=12)C)N(C)C)C1=CC=C(Cl)C=C1 FCCXMYCNLAFOHM-ATZDWAIDSA-N 0.000 claims 1
• YEZZZABOMAUCOL-KAGYGMCKSA-N (2r)-3-(4-ethylpiperazin-1-yl)-2-[3-fluoro-4-(trifluoromethoxy)phenyl]-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]propan-1-one Chemical compound C1CN(CC)CCN1C[C@@H](C=1C=C(F)C(OC(F)(F)F)=CC=1)C(=O)N1CCN(C=2C=3[C@H](C)C[C@@H](O)C=3N=CN=2)CC1 YEZZZABOMAUCOL-KAGYGMCKSA-N 0.000 claims 1
• UWIOHODNDKXYAP-LSTHTHJFSA-N (2r)-3-(azetidin-1-yl)-2-(4-chlorophenyl)-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]propan-1-one Chemical compound C([C@H](C(=O)N1CCN(CC1)C=1N=CN=C2[C@H](O)C[C@H](C=12)C)C=1C=CC(Cl)=CC=1)N1CCC1 UWIOHODNDKXYAP-LSTHTHJFSA-N 0.000 claims 1
• YNINYIBWEWBOAK-RZXSNQJFSA-N (2r)-3-[(3r)-3-aminopyrrolidin-1-yl]-2-(4-chlorophenyl)-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]propan-1-one Chemical compound C([C@H](C(=O)N1CCN(CC1)C=1N=CN=C2[C@H](O)C[C@H](C=12)C)C=1C=CC(Cl)=CC=1)N1CC[C@@H](N)C1 YNINYIBWEWBOAK-RZXSNQJFSA-N 0.000 claims 1
• MPEGYZNMDGUYKR-ZPMCFJSWSA-N (2s)-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-3-(oxan-4-ylamino)-2-[4-(trifluoromethoxy)phenyl]propan-1-one Chemical compound C([C@@H](C(=O)N1CCN(CC1)C=1N=CN=C2[C@H](O)C[C@H](C=12)C)C=1C=CC(OC(F)(F)F)=CC=1)NC1CCOCC1 MPEGYZNMDGUYKR-ZPMCFJSWSA-N 0.000 claims 1
• PSFGVYMXTXICGR-ZPMCFJSWSA-N (2s)-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-3-(oxan-4-ylamino)-2-[4-(trifluoromethyl)phenyl]propan-1-one Chemical compound C([C@@H](C(=O)N1CCN(CC1)C=1N=CN=C2[C@H](O)C[C@H](C=12)C)C=1C=CC(=CC=1)C(F)(F)F)NC1CCOCC1 PSFGVYMXTXICGR-ZPMCFJSWSA-N 0.000 claims 1
• XPLGOANHGFSMIB-NSISKUIASA-N (2s)-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-3-(propan-2-ylamino)-2-[4-(trifluoromethoxy)phenyl]propan-1-one Chemical compound C1([C@H](C(=O)N2CCN(CC2)C=2C=3[C@H](C)C[C@@H](O)C=3N=CN=2)CNC(C)C)=CC=C(OC(F)(F)F)C=C1 XPLGOANHGFSMIB-NSISKUIASA-N 0.000 claims 1
• PSFGVYMXTXICGR-YHYVQYDKSA-N (2s)-1-[4-[(5r,7s)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-3-(oxan-4-ylamino)-2-[4-(trifluoromethyl)phenyl]propan-1-one Chemical compound C([C@@H](C(=O)N1CCN(CC1)C=1N=CN=C2[C@@H](O)C[C@H](C=12)C)C=1C=CC(=CC=1)C(F)(F)F)NC1CCOCC1 PSFGVYMXTXICGR-YHYVQYDKSA-N 0.000 claims 1
• XZXONNVBRUSPCF-ZILOHOTNSA-N (2s)-2-(3,4-dichlorophenyl)-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-3-(4-propan-2-ylpiperazin-1-yl)propan-1-one Chemical compound C1CN(C(C)C)CCN1C[C@H](C=1C=C(Cl)C(Cl)=CC=1)C(=O)N1CCN(C=2C=3[C@H](C)C[C@@H](O)C=3N=CN=2)CC1 XZXONNVBRUSPCF-ZILOHOTNSA-N 0.000 claims 1
• QSBNMLHJMWKHPC-ZWDAVXSWSA-N (2s)-2-(3,4-dichlorophenyl)-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-3-(oxan-4-ylamino)propan-1-one Chemical compound C([C@@H](C(=O)N1CCN(CC1)C=1N=CN=C2[C@H](O)C[C@H](C=12)C)C=1C=C(Cl)C(Cl)=CC=1)NC1CCOCC1 QSBNMLHJMWKHPC-ZWDAVXSWSA-N 0.000 claims 1
• YKMVGXLMROPPDA-CDHQVMDDSA-N (2s)-2-(3,5-difluorophenyl)-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-3-(propan-2-ylamino)propan-1-one Chemical compound C1([C@H](C(=O)N2CCN(CC2)C=2C=3[C@H](C)C[C@@H](O)C=3N=CN=2)CNC(C)C)=CC(F)=CC(F)=C1 YKMVGXLMROPPDA-CDHQVMDDSA-N 0.000 claims 1
• PWOQUDDUGDELMH-YVWKXTFCSA-N (2s)-2-(3-bromo-4-methoxyphenyl)-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-3-(propan-2-ylamino)propan-1-one Chemical compound C1=C(Br)C(OC)=CC=C1[C@@H](CNC(C)C)C(=O)N1CCN(C=2C=3[C@H](C)C[C@@H](O)C=3N=CN=2)CC1 PWOQUDDUGDELMH-YVWKXTFCSA-N 0.000 claims 1
• SWWHWGUJQDFXIK-CDHQVMDDSA-N (2s)-2-(3-chloro-5-fluorophenyl)-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-3-(propan-2-ylamino)propan-1-one Chemical compound C1([C@H](C(=O)N2CCN(CC2)C=2C=3[C@H](C)C[C@@H](O)C=3N=CN=2)CNC(C)C)=CC(F)=CC(Cl)=C1 SWWHWGUJQDFXIK-CDHQVMDDSA-N 0.000 claims 1
• MUXRDILUGIICGM-YVWKXTFCSA-N (2s)-2-(3-fluoro-4-methoxyphenyl)-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-3-(propan-2-ylamino)propan-1-one Chemical compound C1=C(F)C(OC)=CC=C1[C@@H](CNC(C)C)C(=O)N1CCN(C=2C=3[C@H](C)C[C@@H](O)C=3N=CN=2)CC1 MUXRDILUGIICGM-YVWKXTFCSA-N 0.000 claims 1
• DFIROWVISDLYGD-BSLALVQMSA-N (2s)-2-(4-bromo-2-fluorophenyl)-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-3-(oxan-4-ylamino)propan-1-one Chemical compound C([C@@H](C(=O)N1CCN(CC1)C=1N=CN=C2[C@H](O)C[C@H](C=12)C)C=1C(=CC(Br)=CC=1)F)NC1CCOCC1 DFIROWVISDLYGD-BSLALVQMSA-N 0.000 claims 1
• BZFDVHZRSWYZDK-XFQXTVEOSA-N (2s)-2-(4-bromo-2-fluorophenyl)-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-3-(propan-2-ylamino)propan-1-one Chemical compound C1([C@H](C(=O)N2CCN(CC2)C=2C=3[C@H](C)C[C@@H](O)C=3N=CN=2)CNC(C)C)=CC=C(Br)C=C1F BZFDVHZRSWYZDK-XFQXTVEOSA-N 0.000 claims 1
• BZFDVHZRSWYZDK-ZTNFWEORSA-N (2s)-2-(4-bromo-2-fluorophenyl)-1-[4-[(5r,7s)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-3-(propan-2-ylamino)propan-1-one Chemical compound C1([C@H](C(=O)N2CCN(CC2)C=2C=3[C@H](C)C[C@H](O)C=3N=CN=2)CNC(C)C)=CC=C(Br)C=C1F BZFDVHZRSWYZDK-ZTNFWEORSA-N 0.000 claims 1
• FTWBLDCYUPIIAY-VMRPVKRXSA-N (2s)-2-(4-bromo-2-fluorophenyl)-3-(cyclopropylmethylamino)-1-[4-[(5r,7s)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]propan-1-one Chemical compound C([C@@H](C(=O)N1CCN(CC1)C=1N=CN=C2[C@@H](O)C[C@H](C=12)C)C=1C(=CC(Br)=CC=1)F)NCC1CC1 FTWBLDCYUPIIAY-VMRPVKRXSA-N 0.000 claims 1
• OCQNQFLNELAMDZ-PERKRYKHSA-N (2s)-2-(4-bromo-3-fluorophenyl)-1-[4-[(5r,7s)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-3-(oxan-4-ylamino)propan-1-one Chemical compound C([C@@H](C(=O)N1CCN(CC1)C=1N=CN=C2[C@@H](O)C[C@H](C=12)C)C=1C=C(F)C(Br)=CC=1)NC1CCOCC1 OCQNQFLNELAMDZ-PERKRYKHSA-N 0.000 claims 1
• HFGKNCISXBYAHW-FPDPHYFHSA-N (2s)-2-(4-bromo-3-fluorophenyl)-3-(cyclopropylmethylamino)-1-[4-[(5r,7s)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]propan-1-one Chemical compound C([C@@H](C(=O)N1CCN(CC1)C=1N=CN=C2[C@@H](O)C[C@H](C=12)C)C=1C=C(F)C(Br)=CC=1)NCC1CC1 HFGKNCISXBYAHW-FPDPHYFHSA-N 0.000 claims 1
• FOQONSLSQMXHLK-AGILITTLSA-N (2s)-2-(4-bromophenyl)-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-3-(4-propan-2-ylpiperazin-1-yl)propan-1-one Chemical compound C1CN(C(C)C)CCN1C[C@H](C=1C=CC(Br)=CC=1)C(=O)N1CCN(C=2C=3[C@H](C)C[C@@H](O)C=3N=CN=2)CC1 FOQONSLSQMXHLK-AGILITTLSA-N 0.000 claims 1
• GGGQLFZGNGYUKR-NSISKUIASA-N (2s)-2-(4-bromophenyl)-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-3-(propan-2-ylamino)propan-1-one Chemical compound C1([C@H](C(=O)N2CCN(CC2)C=2C=3[C@H](C)C[C@@H](O)C=3N=CN=2)CNC(C)C)=CC=C(Br)C=C1 GGGQLFZGNGYUKR-NSISKUIASA-N 0.000 claims 1
• PUPXZZLGFLTHDO-DUXKGJEZSA-N (2s)-2-(4-bromophenyl)-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-3-[methyl(propan-2-yl)amino]propan-1-one Chemical compound C1([C@H](C(=O)N2CCN(CC2)C=2C=3[C@H](C)C[C@@H](O)C=3N=CN=2)CN(C)C(C)C)=CC=C(Br)C=C1 PUPXZZLGFLTHDO-DUXKGJEZSA-N 0.000 claims 1
• SNDIBRJFLLYGDF-YHYVQYDKSA-N (2s)-2-(4-bromophenyl)-1-[4-[(5r,7s)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-3-(oxan-4-ylamino)propan-1-one Chemical compound C([C@@H](C(=O)N1CCN(CC1)C=1N=CN=C2[C@@H](O)C[C@H](C=12)C)C=1C=CC(Br)=CC=1)NC1CCOCC1 SNDIBRJFLLYGDF-YHYVQYDKSA-N 0.000 claims 1
• PUPXZZLGFLTHDO-UIFIKXQLSA-N (2s)-2-(4-bromophenyl)-1-[4-[(5r,7s)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-3-[methyl(propan-2-yl)amino]propan-1-one Chemical compound C1([C@H](C(=O)N2CCN(CC2)C=2C=3[C@H](C)C[C@H](O)C=3N=CN=2)CN(C)C(C)C)=CC=C(Br)C=C1 PUPXZZLGFLTHDO-UIFIKXQLSA-N 0.000 claims 1
• WPELGIJMNKTPIX-MAODMQOUSA-N (2s)-2-(4-bromophenyl)-3-(cyclopropylmethylamino)-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]propan-1-one Chemical compound C([C@@H](C(=O)N1CCN(CC1)C=1N=CN=C2[C@H](O)C[C@H](C=12)C)C=1C=CC(Br)=CC=1)NCC1CC1 WPELGIJMNKTPIX-MAODMQOUSA-N 0.000 claims 1
• HSOGRIPRDLRNDR-NSISKUIASA-N (2s)-2-(4-bromophenyl)-3-(tert-butylamino)-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]propan-1-one Chemical compound C1([C@@H](CNC(C)(C)C)C(=O)N2CCN(CC2)C=2N=CN=C3[C@H](O)C[C@H](C=23)C)=CC=C(Br)C=C1 HSOGRIPRDLRNDR-NSISKUIASA-N 0.000 claims 1
• ZTYJPNKNJIXMLC-BSLALVQMSA-N (2s)-2-(4-chloro-2-fluorophenyl)-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-3-(oxan-4-ylamino)propan-1-one Chemical compound C([C@@H](C(=O)N1CCN(CC1)C=1N=CN=C2[C@H](O)C[C@H](C=12)C)C=1C(=CC(Cl)=CC=1)F)NC1CCOCC1 ZTYJPNKNJIXMLC-BSLALVQMSA-N 0.000 claims 1
• NCSAHEXYKZKHST-XFQXTVEOSA-N (2s)-2-(4-chloro-2-fluorophenyl)-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-3-(propan-2-ylamino)propan-1-one Chemical compound C1([C@H](C(=O)N2CCN(CC2)C=2C=3[C@H](C)C[C@@H](O)C=3N=CN=2)CNC(C)C)=CC=C(Cl)C=C1F NCSAHEXYKZKHST-XFQXTVEOSA-N 0.000 claims 1
• ZTYJPNKNJIXMLC-CNDZOEFASA-N (2s)-2-(4-chloro-2-fluorophenyl)-1-[4-[(5r,7s)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-3-(oxan-4-ylamino)propan-1-one Chemical compound C([C@@H](C(=O)N1CCN(CC1)C=1N=CN=C2[C@@H](O)C[C@H](C=12)C)C=1C(=CC(Cl)=CC=1)F)NC1CCOCC1 ZTYJPNKNJIXMLC-CNDZOEFASA-N 0.000 claims 1
• SVXUNOUHNODYLE-QFIXIFRTSA-N (2s)-2-(4-chloro-2-fluorophenyl)-3-(cyclopropylmethylamino)-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]propan-1-one Chemical compound C([C@@H](C(=O)N1CCN(CC1)C=1N=CN=C2[C@H](O)C[C@H](C=12)C)C=1C(=CC(Cl)=CC=1)F)NCC1CC1 SVXUNOUHNODYLE-QFIXIFRTSA-N 0.000 claims 1
• OPDRTPMRSPYJNO-ZWDAVXSWSA-N (2s)-2-(4-chloro-3-fluorophenyl)-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-3-(4-hydroxypiperidin-1-yl)propan-1-one Chemical compound C([C@@H](C(=O)N1CCN(CC1)C=1N=CN=C2[C@H](O)C[C@H](C=12)C)C=1C=C(F)C(Cl)=CC=1)N1CCC(O)CC1 OPDRTPMRSPYJNO-ZWDAVXSWSA-N 0.000 claims 1
• ASIBYZZEGYJDKR-SFGWALBWSA-N (2s)-2-(4-chloro-3-fluorophenyl)-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-3-(4-methylpiperazin-1-yl)propan-1-one Chemical compound C([C@@H](C(=O)N1CCN(CC1)C=1N=CN=C2[C@H](O)C[C@H](C=12)C)C=1C=C(F)C(Cl)=CC=1)N1CCN(C)CC1 ASIBYZZEGYJDKR-SFGWALBWSA-N 0.000 claims 1
• FOWCVNVPZAWPIC-ZILOHOTNSA-N (2s)-2-(4-chloro-3-fluorophenyl)-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-3-(4-propan-2-ylpiperazin-1-yl)propan-1-one Chemical compound C1CN(C(C)C)CCN1C[C@H](C=1C=C(F)C(Cl)=CC=1)C(=O)N1CCN(C=2C=3[C@H](C)C[C@@H](O)C=3N=CN=2)CC1 FOWCVNVPZAWPIC-ZILOHOTNSA-N 0.000 claims 1
• PSNRYUGYGZTZSY-ZWDAVXSWSA-N (2s)-2-(4-chloro-3-fluorophenyl)-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-3-(oxan-4-ylamino)propan-1-one Chemical compound C([C@@H](C(=O)N1CCN(CC1)C=1N=CN=C2[C@H](O)C[C@H](C=12)C)C=1C=C(F)C(Cl)=CC=1)NC1CCOCC1 PSNRYUGYGZTZSY-ZWDAVXSWSA-N 0.000 claims 1
• ACYVWONXYYNPDK-WRWLIDTKSA-N (2s)-2-(4-chloro-3-fluorophenyl)-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-3-(propan-2-ylamino)propan-1-one Chemical compound C1([C@H](C(=O)N2CCN(CC2)C=2C=3[C@H](C)C[C@@H](O)C=3N=CN=2)CNC(C)C)=CC=C(Cl)C(F)=C1 ACYVWONXYYNPDK-WRWLIDTKSA-N 0.000 claims 1
• PSNRYUGYGZTZSY-PERKRYKHSA-N (2s)-2-(4-chloro-3-fluorophenyl)-1-[4-[(5r,7s)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-3-(oxan-4-ylamino)propan-1-one Chemical compound C([C@@H](C(=O)N1CCN(CC1)C=1N=CN=C2[C@@H](O)C[C@H](C=12)C)C=1C=C(F)C(Cl)=CC=1)NC1CCOCC1 PSNRYUGYGZTZSY-PERKRYKHSA-N 0.000 claims 1
• ACYVWONXYYNPDK-MDYRTPRTSA-N (2s)-2-(4-chloro-3-fluorophenyl)-1-[4-[(5r,7s)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-3-(propan-2-ylamino)propan-1-one Chemical compound C1([C@H](C(=O)N2CCN(CC2)C=2C=3[C@H](C)C[C@H](O)C=3N=CN=2)CNC(C)C)=CC=C(Cl)C(F)=C1 ACYVWONXYYNPDK-MDYRTPRTSA-N 0.000 claims 1
• YCWGOSQFOZHSQF-ZWDAVXSWSA-N (2s)-2-(4-chloro-3-fluorophenyl)-3-(cyclopentylamino)-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]propan-1-one Chemical compound C([C@@H](C(=O)N1CCN(CC1)C=1N=CN=C2[C@H](O)C[C@H](C=12)C)C=1C=C(F)C(Cl)=CC=1)NC1CCCC1 YCWGOSQFOZHSQF-ZWDAVXSWSA-N 0.000 claims 1
• CHZXOMCJYQFHSX-HCLVMJGWSA-N (2s)-2-(4-chloro-3-fluorophenyl)-3-(cyclopentylmethylamino)-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]propan-1-one Chemical compound C([C@@H](C(=O)N1CCN(CC1)C=1N=CN=C2[C@H](O)C[C@H](C=12)C)C=1C=C(F)C(Cl)=CC=1)NCC1CCCC1 CHZXOMCJYQFHSX-HCLVMJGWSA-N 0.000 claims 1
• DCUUIEBXVIUTHO-FPDPHYFHSA-N (2s)-2-(4-chloro-3-fluorophenyl)-3-(cyclopropylmethylamino)-1-[4-[(5r,7s)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]propan-1-one Chemical compound C([C@@H](C(=O)N1CCN(CC1)C=1N=CN=C2[C@@H](O)C[C@H](C=12)C)C=1C=C(F)C(Cl)=CC=1)NCC1CC1 DCUUIEBXVIUTHO-FPDPHYFHSA-N 0.000 claims 1
• DACYNDHEVFUCHW-STZQEDGTSA-N (2s)-2-(4-chlorophenyl)-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-3-(1,4-oxazepan-4-yl)propan-1-one Chemical compound C([C@@H](C(=O)N1CCN(CC1)C=1N=CN=C2[C@H](O)C[C@H](C=12)C)C=1C=CC(Cl)=CC=1)N1CCCOCC1 DACYNDHEVFUCHW-STZQEDGTSA-N 0.000 claims 1
• FSRSVUZZWCRRDS-NSISKUIASA-N (2s)-2-(4-chlorophenyl)-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-3-(2-methoxyethylamino)propan-1-one Chemical compound C1([C@H](C(=O)N2CCN(CC2)C=2C=3[C@H](C)C[C@@H](O)C=3N=CN=2)CNCCOC)=CC=C(Cl)C=C1 FSRSVUZZWCRRDS-NSISKUIASA-N 0.000 claims 1
• MVKDZJLQKKHGGJ-ZPMCFJSWSA-N (2s)-2-(4-chlorophenyl)-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-3-(4-hydroxypiperidin-1-yl)propan-1-one Chemical compound C([C@@H](C(=O)N1CCN(CC1)C=1N=CN=C2[C@H](O)C[C@H](C=12)C)C=1C=CC(Cl)=CC=1)N1CCC(O)CC1 MVKDZJLQKKHGGJ-ZPMCFJSWSA-N 0.000 claims 1
• NHOOVUOOHFQRHO-SXSPYAJSSA-N (2s)-2-(4-chlorophenyl)-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-3-(4-methoxypiperidin-1-yl)propan-1-one Chemical compound C1CC(OC)CCN1C[C@H](C=1C=CC(Cl)=CC=1)C(=O)N1CCN(C=2C=3[C@H](C)C[C@@H](O)C=3N=CN=2)CC1 NHOOVUOOHFQRHO-SXSPYAJSSA-N 0.000 claims 1
• OBYJRNHAFUOFQQ-STZQEDGTSA-N (2s)-2-(4-chlorophenyl)-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-3-(4-methylpiperazin-1-yl)propan-1-one Chemical compound C([C@@H](C(=O)N1CCN(CC1)C=1N=CN=C2[C@H](O)C[C@H](C=12)C)C=1C=CC(Cl)=CC=1)N1CCN(C)CC1 OBYJRNHAFUOFQQ-STZQEDGTSA-N 0.000 claims 1
• JKUFKXQNEFTSBQ-AGILITTLSA-N (2s)-2-(4-chlorophenyl)-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-3-(4-propan-2-ylpiperazin-1-yl)propan-1-one Chemical compound C1CN(C(C)C)CCN1C[C@H](C=1C=CC(Cl)=CC=1)C(=O)N1CCN(C=2C=3[C@H](C)C[C@@H](O)C=3N=CN=2)CC1 JKUFKXQNEFTSBQ-AGILITTLSA-N 0.000 claims 1
• ZITXULFFYAZXGE-ZPMCFJSWSA-N (2s)-2-(4-chlorophenyl)-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-3-(piperidin-4-ylamino)propan-1-one Chemical compound C([C@@H](C(=O)N1CCN(CC1)C=1N=CN=C2[C@H](O)C[C@H](C=12)C)C=1C=CC(Cl)=CC=1)NC1CCNCC1 ZITXULFFYAZXGE-ZPMCFJSWSA-N 0.000 claims 1
• YNWZHSXNABPOFD-STZQEDGTSA-N (2s)-2-(4-chlorophenyl)-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-3-[(4-methyloxan-4-yl)amino]propan-1-one Chemical compound C([C@@H](C(=O)N1CCN(CC1)C=1N=CN=C2[C@H](O)C[C@H](C=12)C)C=1C=CC(Cl)=CC=1)NC1(C)CCOCC1 YNWZHSXNABPOFD-STZQEDGTSA-N 0.000 claims 1
• ZAPKSMBFGRLTBZ-QYRPDUKASA-N (2s)-2-(4-chlorophenyl)-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-3-[[(3r)-oxolan-3-yl]amino]propan-1-one Chemical compound C([C@@H](C(=O)N1CCN(CC1)C=1N=CN=C2[C@H](O)C[C@H](C=12)C)C=1C=CC(Cl)=CC=1)N[C@@H]1CCOC1 ZAPKSMBFGRLTBZ-QYRPDUKASA-N 0.000 claims 1
• MGQHBEKIVYECCS-DUXKGJEZSA-N (2s)-2-(4-chlorophenyl)-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-3-[methyl(propan-2-yl)amino]propan-1-one Chemical compound C1([C@H](C(=O)N2CCN(CC2)C=2C=3[C@H](C)C[C@@H](O)C=3N=CN=2)CN(C)C(C)C)=CC=C(Cl)C=C1 MGQHBEKIVYECCS-DUXKGJEZSA-N 0.000 claims 1
• QIURAHCFIXKZFL-DUXKGJEZSA-N (2s)-2-(4-chlorophenyl)-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-3-morpholin-4-ylpropan-1-one Chemical compound C([C@@H](C(=O)N1CCN(CC1)C=1N=CN=C2[C@H](O)C[C@H](C=12)C)C=1C=CC(Cl)=CC=1)N1CCOCC1 QIURAHCFIXKZFL-DUXKGJEZSA-N 0.000 claims 1
• SEOVPDGEKCGNRW-DUXKGJEZSA-N (2s)-2-(4-chlorophenyl)-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-3-piperazin-1-ylpropan-1-one Chemical compound C([C@@H](C(=O)N1CCN(CC1)C=1N=CN=C2[C@H](O)C[C@H](C=12)C)C=1C=CC(Cl)=CC=1)N1CCNCC1 SEOVPDGEKCGNRW-DUXKGJEZSA-N 0.000 claims 1
• VWFHPQXIADBYRU-DUXKGJEZSA-N (2s)-2-(4-chlorophenyl)-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-3-thiomorpholin-4-ylpropan-1-one Chemical compound C([C@@H](C(=O)N1CCN(CC1)C=1N=CN=C2[C@H](O)C[C@H](C=12)C)C=1C=CC(Cl)=CC=1)N1CCSCC1 VWFHPQXIADBYRU-DUXKGJEZSA-N 0.000 claims 1
• UVHCRURXEOGIOT-YHYVQYDKSA-N (2s)-2-(4-chlorophenyl)-1-[4-[(5r,7s)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-3-(oxan-4-ylamino)propan-1-one Chemical compound C([C@@H](C(=O)N1CCN(CC1)C=1N=CN=C2[C@@H](O)C[C@H](C=12)C)C=1C=CC(Cl)=CC=1)NC1CCOCC1 UVHCRURXEOGIOT-YHYVQYDKSA-N 0.000 claims 1
• GRZXWCHAXNAUHY-AHRSYUTCSA-N (2s)-2-(4-chlorophenyl)-1-[4-[(5r,7s)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-3-(propan-2-ylamino)propan-1-one Chemical compound C1([C@H](C(=O)N2CCN(CC2)C=2C=3[C@H](C)C[C@H](O)C=3N=CN=2)CNC(C)C)=CC=C(Cl)C=C1 GRZXWCHAXNAUHY-AHRSYUTCSA-N 0.000 claims 1
• GPXSIDKEQZLUST-YSZBQJHXSA-N (2s)-2-(4-chlorophenyl)-1-[4-[(5r,7s)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-3-[methyl(oxan-4-yl)amino]propan-1-one Chemical compound C([C@@H](C(=O)N1CCN(CC1)C=1N=CN=C2[C@@H](O)C[C@H](C=12)C)C=1C=CC(Cl)=CC=1)N(C)C1CCOCC1 GPXSIDKEQZLUST-YSZBQJHXSA-N 0.000 claims 1
• FBKMTIFHOJFMDP-ATZDWAIDSA-N (2s)-2-(4-chlorophenyl)-3-(2-fluoroethylamino)-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]propan-1-one Chemical compound C1([C@@H](CNCCF)C(=O)N2CCN(CC2)C=2N=CN=C3[C@H](O)C[C@H](C=23)C)=CC=C(Cl)C=C1 FBKMTIFHOJFMDP-ATZDWAIDSA-N 0.000 claims 1
• XGQBOEHKQAUZEB-UEVCKROQSA-N (2s)-2-(4-chlorophenyl)-3-(4-ethylpiperazin-1-yl)-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]propan-1-one Chemical compound C1CN(CC)CCN1C[C@H](C=1C=CC(Cl)=CC=1)C(=O)N1CCN(C=2C=3[C@H](C)C[C@@H](O)C=3N=CN=2)CC1 XGQBOEHKQAUZEB-UEVCKROQSA-N 0.000 claims 1
• SBBKNPLQAOQYBE-SXSPYAJSSA-N (2s)-2-(4-chlorophenyl)-3-(cyclohexylamino)-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]propan-1-one Chemical compound C([C@@H](C(=O)N1CCN(CC1)C=1N=CN=C2[C@H](O)C[C@H](C=12)C)C=1C=CC(Cl)=CC=1)NC1CCCCC1 SBBKNPLQAOQYBE-SXSPYAJSSA-N 0.000 claims 1
• SBBKNPLQAOQYBE-YSZBQJHXSA-N (2s)-2-(4-chlorophenyl)-3-(cyclohexylamino)-1-[4-[(5r,7s)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]propan-1-one Chemical compound C([C@@H](C(=O)N1CCN(CC1)C=1N=CN=C2[C@@H](O)C[C@H](C=12)C)C=1C=CC(Cl)=CC=1)NC1CCCCC1 SBBKNPLQAOQYBE-YSZBQJHXSA-N 0.000 claims 1
• KMKLBXPCPBKGKR-CDHQVMDDSA-N (2s)-2-(4-chlorophenyl)-3-(cyclopropylamino)-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]propan-1-one Chemical compound C([C@@H](C(=O)N1CCN(CC1)C=1N=CN=C2[C@H](O)C[C@H](C=12)C)C=1C=CC(Cl)=CC=1)NC1CC1 KMKLBXPCPBKGKR-CDHQVMDDSA-N 0.000 claims 1
• DJKIPNZIOLJURK-MAODMQOUSA-N (2s)-2-(4-chlorophenyl)-3-(cyclopropylmethylamino)-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]propan-1-one Chemical compound C([C@@H](C(=O)N1CCN(CC1)C=1N=CN=C2[C@H](O)C[C@H](C=12)C)C=1C=CC(Cl)=CC=1)NCC1CC1 DJKIPNZIOLJURK-MAODMQOUSA-N 0.000 claims 1
• DJKIPNZIOLJURK-HBGVWJBISA-N (2s)-2-(4-chlorophenyl)-3-(cyclopropylmethylamino)-1-[4-[(5r,7s)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]propan-1-one Chemical compound C([C@@H](C(=O)N1CCN(CC1)C=1N=CN=C2[C@@H](O)C[C@H](C=12)C)C=1C=CC(Cl)=CC=1)NCC1CC1 DJKIPNZIOLJURK-HBGVWJBISA-N 0.000 claims 1
• VEXSHJGNGILRJI-GWWNCLRWSA-N (2s)-2-(4-chlorophenyl)-3-[(2s,6r)-2,6-dimethylmorpholin-4-yl]-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]propan-1-one Chemical compound C([C@@H](C(=O)N1CCN(CC1)C=1N=CN=C2[C@H](O)C[C@H](C=12)C)C=1C=CC(Cl)=CC=1)N1C[C@H](C)O[C@H](C)C1 VEXSHJGNGILRJI-GWWNCLRWSA-N 0.000 claims 1
• AWFVEFPXVJEZNV-STZQEDGTSA-N (2s)-2-(4-chlorophenyl)-3-[2-hydroxyethyl(propan-2-yl)amino]-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]propan-1-one Chemical compound C1([C@H](C(=O)N2CCN(CC2)C=2C=3[C@H](C)C[C@@H](O)C=3N=CN=2)CN(CCO)C(C)C)=CC=C(Cl)C=C1 AWFVEFPXVJEZNV-STZQEDGTSA-N 0.000 claims 1
• JOADGYMGMILDPB-UEVCKROQSA-N (2s)-2-(4-chlorophenyl)-3-[4-(2-hydroxyethyl)piperazin-1-yl]-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]propan-1-one Chemical compound C([C@@H](C(=O)N1CCN(CC1)C=1N=CN=C2[C@H](O)C[C@H](C=12)C)C=1C=CC(Cl)=CC=1)N1CCN(CCO)CC1 JOADGYMGMILDPB-UEVCKROQSA-N 0.000 claims 1
• DMBALZNNOMUZOB-CTUHWIOQSA-N (2s)-2-(4-chlorophenyl)-3-[ethyl(oxan-4-yl)amino]-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]propan-1-one Chemical compound C1([C@H](C(=O)N2CCN(CC2)C=2C=3[C@H](C)C[C@@H](O)C=3N=CN=2)CN(CC)C2CCOCC2)=CC=C(Cl)C=C1 DMBALZNNOMUZOB-CTUHWIOQSA-N 0.000 claims 1
• AGKRBOABBMQFSL-HHXXYDBFSA-N (2s)-2-(5-bromopyridin-2-yl)-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-3-(propan-2-ylamino)propan-1-one Chemical compound C1([C@@H](C(=O)N2CCN(CC2)C=2C=3[C@H](C)C[C@@H](O)C=3N=CN=2)CNC(C)C)=CC=C(Br)C=N1 AGKRBOABBMQFSL-HHXXYDBFSA-N 0.000 claims 1
• CBPFHOOOOIINAJ-KBAYOESNSA-N (2s)-2-(5-bromothiophen-2-yl)-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-3-(oxan-4-ylamino)propan-1-one Chemical compound C([C@@H](C(=O)N1CCN(CC1)C=1N=CN=C2[C@H](O)C[C@H](C=12)C)C=1SC(Br)=CC=1)NC1CCOCC1 CBPFHOOOOIINAJ-KBAYOESNSA-N 0.000 claims 1
• NYYIKRNWSFCJDK-BZUAXINKSA-N (2s)-2-(5-bromothiophen-2-yl)-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-3-(propan-2-ylamino)propan-1-one Chemical compound C1([C@H](C(=O)N2CCN(CC2)C=2C=3[C@H](C)C[C@@H](O)C=3N=CN=2)CNC(C)C)=CC=C(Br)S1 NYYIKRNWSFCJDK-BZUAXINKSA-N 0.000 claims 1
• CBPFHOOOOIINAJ-NXHRZFHOSA-N (2s)-2-(5-bromothiophen-2-yl)-1-[4-[(5r,7s)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-3-(oxan-4-ylamino)propan-1-one Chemical compound C([C@@H](C(=O)N1CCN(CC1)C=1N=CN=C2[C@@H](O)C[C@H](C=12)C)C=1SC(Br)=CC=1)NC1CCOCC1 CBPFHOOOOIINAJ-NXHRZFHOSA-N 0.000 claims 1
• NYYIKRNWSFCJDK-OAGGEKHMSA-N (2s)-2-(5-bromothiophen-2-yl)-1-[4-[(5r,7s)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-3-(propan-2-ylamino)propan-1-one Chemical compound C1([C@H](C(=O)N2CCN(CC2)C=2C=3[C@H](C)C[C@H](O)C=3N=CN=2)CNC(C)C)=CC=C(Br)S1 NYYIKRNWSFCJDK-OAGGEKHMSA-N 0.000 claims 1
• CQZBIBHQPCYHOO-DJIMGWMZSA-N (2s)-2-(5-bromothiophen-2-yl)-3-(cyclopropylmethylamino)-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]propan-1-one Chemical compound C([C@@H](C(=O)N1CCN(CC1)C=1N=CN=C2[C@H](O)C[C@H](C=12)C)C=1SC(Br)=CC=1)NCC1CC1 CQZBIBHQPCYHOO-DJIMGWMZSA-N 0.000 claims 1
• GJGDNLJWWOESDA-KBAYOESNSA-N (2s)-2-(5-chlorothiophen-2-yl)-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-3-(oxan-4-ylamino)propan-1-one Chemical compound C([C@@H](C(=O)N1CCN(CC1)C=1N=CN=C2[C@H](O)C[C@H](C=12)C)C=1SC(Cl)=CC=1)NC1CCOCC1 GJGDNLJWWOESDA-KBAYOESNSA-N 0.000 claims 1
• BBXCLVDVJJVPOU-BZUAXINKSA-N (2s)-2-(5-chlorothiophen-2-yl)-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-3-(propan-2-ylamino)propan-1-one Chemical compound C1([C@H](C(=O)N2CCN(CC2)C=2C=3[C@H](C)C[C@@H](O)C=3N=CN=2)CNC(C)C)=CC=C(Cl)S1 BBXCLVDVJJVPOU-BZUAXINKSA-N 0.000 claims 1
• GJGDNLJWWOESDA-NXHRZFHOSA-N (2s)-2-(5-chlorothiophen-2-yl)-1-[4-[(5r,7s)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-3-(oxan-4-ylamino)propan-1-one Chemical compound C([C@@H](C(=O)N1CCN(CC1)C=1N=CN=C2[C@@H](O)C[C@H](C=12)C)C=1SC(Cl)=CC=1)NC1CCOCC1 GJGDNLJWWOESDA-NXHRZFHOSA-N 0.000 claims 1
• BBXCLVDVJJVPOU-OAGGEKHMSA-N (2s)-2-(5-chlorothiophen-2-yl)-1-[4-[(5r,7s)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-3-(propan-2-ylamino)propan-1-one Chemical compound C1([C@H](C(=O)N2CCN(CC2)C=2C=3[C@H](C)C[C@H](O)C=3N=CN=2)CNC(C)C)=CC=C(Cl)S1 BBXCLVDVJJVPOU-OAGGEKHMSA-N 0.000 claims 1
• HYAZYJQOAUYZSW-OIISXLGYSA-N (2s)-2-(5-chlorothiophen-2-yl)-3-(cyclopropylmethylamino)-1-[4-[(5r,7s)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]propan-1-one Chemical compound C([C@@H](C(=O)N1CCN(CC1)C=1N=CN=C2[C@@H](O)C[C@H](C=12)C)C=1SC(Cl)=CC=1)NCC1CC1 HYAZYJQOAUYZSW-OIISXLGYSA-N 0.000 claims 1
• NOLUQBGMNDMEJW-XFQXTVEOSA-N (2s)-2-[2-fluoro-4-(trifluoromethyl)phenyl]-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-3-(propan-2-ylamino)propan-1-one Chemical compound C1([C@H](C(=O)N2CCN(CC2)C=2C=3[C@H](C)C[C@@H](O)C=3N=CN=2)CNC(C)C)=CC=C(C(F)(F)F)C=C1F NOLUQBGMNDMEJW-XFQXTVEOSA-N 0.000 claims 1
• XWVOYCYKVHDZAO-OZOXKJRCSA-N (2s)-2-[2-fluoro-4-(trifluoromethyl)phenyl]-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-3-[methyl(propan-2-yl)amino]propan-1-one Chemical compound C1([C@H](C(=O)N2CCN(CC2)C=2C=3[C@H](C)C[C@@H](O)C=3N=CN=2)CN(C)C(C)C)=CC=C(C(F)(F)F)C=C1F XWVOYCYKVHDZAO-OZOXKJRCSA-N 0.000 claims 1
• WSPKBGFHRZMYJR-YSGRDPCXSA-N (2s)-2-[3,5-bis(trifluoromethyl)phenyl]-1-[4-[(5r,7s)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-3-(propan-2-ylamino)propan-1-one Chemical compound C1([C@H](C(=O)N2CCN(CC2)C=2C=3[C@H](C)C[C@H](O)C=3N=CN=2)CNC(C)C)=CC(C(F)(F)F)=CC(C(F)(F)F)=C1 WSPKBGFHRZMYJR-YSGRDPCXSA-N 0.000 claims 1
• OJQBGEUQOPGUJO-YFVAEKQCSA-N (2s)-2-[3-fluoro-4-(trifluoromethoxy)phenyl]-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-3-(4-methylpiperazin-1-yl)propan-1-one Chemical compound C([C@@H](C(=O)N1CCN(CC1)C=1N=CN=C2[C@H](O)C[C@H](C=12)C)C=1C=C(F)C(OC(F)(F)F)=CC=1)N1CCN(C)CC1 OJQBGEUQOPGUJO-YFVAEKQCSA-N 0.000 claims 1
• FXGIVVSTMFKXTD-KJXAQDMKSA-N (2s)-2-[3-fluoro-4-(trifluoromethoxy)phenyl]-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-3-(4-propan-2-ylpiperazin-1-yl)propan-1-one Chemical compound C1CN(C(C)C)CCN1C[C@H](C=1C=C(F)C(OC(F)(F)F)=CC=1)C(=O)N1CCN(C=2C=3[C@H](C)C[C@@H](O)C=3N=CN=2)CC1 FXGIVVSTMFKXTD-KJXAQDMKSA-N 0.000 claims 1
• ZZPRCGSANDNMBX-OZOXKJRCSA-N (2s)-2-[3-fluoro-4-(trifluoromethoxy)phenyl]-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-3-(oxan-4-ylamino)propan-1-one Chemical compound C([C@@H](C(=O)N1CCN(CC1)C=1N=CN=C2[C@H](O)C[C@H](C=12)C)C=1C=C(F)C(OC(F)(F)F)=CC=1)NC1CCOCC1 ZZPRCGSANDNMBX-OZOXKJRCSA-N 0.000 claims 1
• BHIAOYWMILQADT-SZVBFZGTSA-N (2s)-2-[3-fluoro-4-(trifluoromethoxy)phenyl]-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-3-(propan-2-ylamino)propan-1-one Chemical compound C1([C@H](C(=O)N2CCN(CC2)C=2C=3[C@H](C)C[C@@H](O)C=3N=CN=2)CNC(C)C)=CC=C(OC(F)(F)F)C(F)=C1 BHIAOYWMILQADT-SZVBFZGTSA-N 0.000 claims 1
• GROLACOOUFTTBG-YVWKXTFCSA-N (2s)-2-[3-fluoro-4-(trifluoromethoxy)phenyl]-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-3-morpholin-4-ylpropan-1-one Chemical compound C([C@@H](C(=O)N1CCN(CC1)C=1N=CN=C2[C@H](O)C[C@H](C=12)C)C=1C=C(F)C(OC(F)(F)F)=CC=1)N1CCOCC1 GROLACOOUFTTBG-YVWKXTFCSA-N 0.000 claims 1
• ZZPRCGSANDNMBX-BSIFCXSSSA-N (2s)-2-[3-fluoro-4-(trifluoromethoxy)phenyl]-1-[4-[(5r,7s)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-3-(oxan-4-ylamino)propan-1-one Chemical compound C([C@@H](C(=O)N1CCN(CC1)C=1N=CN=C2[C@@H](O)C[C@H](C=12)C)C=1C=C(F)C(OC(F)(F)F)=CC=1)NC1CCOCC1 ZZPRCGSANDNMBX-BSIFCXSSSA-N 0.000 claims 1
• JCNGTRXRBGDTTA-ZWDAVXSWSA-N (2s)-2-[3-fluoro-4-(trifluoromethyl)phenyl]-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-3-(4-hydroxypiperidin-1-yl)propan-1-one Chemical compound C([C@@H](C(=O)N1CCN(CC1)C=1N=CN=C2[C@H](O)C[C@H](C=12)C)C=1C=C(F)C(=CC=1)C(F)(F)F)N1CCC(O)CC1 JCNGTRXRBGDTTA-ZWDAVXSWSA-N 0.000 claims 1
• XBLQKLOXSQXHJY-SFGWALBWSA-N (2s)-2-[3-fluoro-4-(trifluoromethyl)phenyl]-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-3-(4-methylpiperazin-1-yl)propan-1-one Chemical compound C([C@@H](C(=O)N1CCN(CC1)C=1N=CN=C2[C@H](O)C[C@H](C=12)C)C=1C=C(F)C(=CC=1)C(F)(F)F)N1CCN(C)CC1 XBLQKLOXSQXHJY-SFGWALBWSA-N 0.000 claims 1
• MHAHVLOPCSKGNI-ZILOHOTNSA-N (2s)-2-[3-fluoro-4-(trifluoromethyl)phenyl]-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-3-(4-propan-2-ylpiperazin-1-yl)propan-1-one Chemical compound C1CN(C(C)C)CCN1C[C@H](C=1C=C(F)C(=CC=1)C(F)(F)F)C(=O)N1CCN(C=2C=3[C@H](C)C[C@@H](O)C=3N=CN=2)CC1 MHAHVLOPCSKGNI-ZILOHOTNSA-N 0.000 claims 1
• XMGQFGHGCVFDFK-PERKRYKHSA-N (2s)-2-[3-fluoro-4-(trifluoromethyl)phenyl]-1-[4-[(5r,7s)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-3-(oxan-4-ylamino)propan-1-one Chemical compound C([C@@H](C(=O)N1CCN(CC1)C=1N=CN=C2[C@@H](O)C[C@H](C=12)C)C=1C=C(F)C(=CC=1)C(F)(F)F)NC1CCOCC1 XMGQFGHGCVFDFK-PERKRYKHSA-N 0.000 claims 1
• HPLLXKZTFYMEBR-MDYRTPRTSA-N (2s)-2-[3-fluoro-4-(trifluoromethyl)phenyl]-1-[4-[(5r,7s)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-3-(propan-2-ylamino)propan-1-one Chemical compound C1([C@H](C(=O)N2CCN(CC2)C=2C=3[C@H](C)C[C@H](O)C=3N=CN=2)CNC(C)C)=CC=C(C(F)(F)F)C(F)=C1 HPLLXKZTFYMEBR-MDYRTPRTSA-N 0.000 claims 1
• XCUWQXDXHIKEQH-SZVBFZGTSA-N (2s)-2-[4-chloro-3-(trifluoromethoxy)phenyl]-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-3-(propan-2-ylamino)propan-1-one Chemical compound C1([C@H](C(=O)N2CCN(CC2)C=2C=3[C@H](C)C[C@@H](O)C=3N=CN=2)CNC(C)C)=CC=C(Cl)C(OC(F)(F)F)=C1 XCUWQXDXHIKEQH-SZVBFZGTSA-N 0.000 claims 1
• PXNRLWPGIVMVJJ-SZVBFZGTSA-N (2s)-2-[4-fluoro-3-(trifluoromethoxy)phenyl]-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-3-(propan-2-ylamino)propan-1-one Chemical compound C1([C@H](C(=O)N2CCN(CC2)C=2C=3[C@H](C)C[C@@H](O)C=3N=CN=2)CNC(C)C)=CC=C(F)C(OC(F)(F)F)=C1 PXNRLWPGIVMVJJ-SZVBFZGTSA-N 0.000 claims 1
• KYSJQIIDJYBJQD-WRWLIDTKSA-N (2s)-2-[4-fluoro-3-(trifluoromethyl)phenyl]-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-3-(propan-2-ylamino)propan-1-one Chemical compound C1([C@H](C(=O)N2CCN(CC2)C=2C=3[C@H](C)C[C@@H](O)C=3N=CN=2)CNC(C)C)=CC=C(F)C(C(F)(F)F)=C1 KYSJQIIDJYBJQD-WRWLIDTKSA-N 0.000 claims 1
• WXBZEODTEQDLCC-CDHQVMDDSA-N (2s)-3-(3-aminoazetidin-1-yl)-2-(4-chlorophenyl)-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]propan-1-one Chemical compound C([C@@H](C(=O)N1CCN(CC1)C=1N=CN=C2[C@H](O)C[C@H](C=12)C)C=1C=CC(Cl)=CC=1)N1CC(N)C1 WXBZEODTEQDLCC-CDHQVMDDSA-N 0.000 claims 1
• NLJZHCYNUJUZLQ-SXSPYAJSSA-N (2s)-3-(4-acetylpiperazin-1-yl)-2-(4-chlorophenyl)-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]propan-1-one Chemical compound C([C@@H](C(=O)N1CCN(CC1)C=1N=CN=C2[C@H](O)C[C@H](C=12)C)C=1C=CC(Cl)=CC=1)N1CCN(C(C)=O)CC1 NLJZHCYNUJUZLQ-SXSPYAJSSA-N 0.000 claims 1
• GFXVLXGVPHKNGB-NQSCKRDGSA-N (2s)-3-(4-acetylpiperazin-1-yl)-2-[3-fluoro-4-(trifluoromethoxy)phenyl]-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]propan-1-one Chemical compound C([C@@H](C(=O)N1CCN(CC1)C=1N=CN=C2[C@H](O)C[C@H](C=12)C)C=1C=C(F)C(OC(F)(F)F)=CC=1)N1CCN(C(C)=O)CC1 GFXVLXGVPHKNGB-NQSCKRDGSA-N 0.000 claims 1
• XQHJGSRNSFPVKJ-ZPMCFJSWSA-N (2s)-3-(4-aminopiperidin-1-yl)-2-(4-chlorophenyl)-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]propan-1-one Chemical compound C([C@@H](C(=O)N1CCN(CC1)C=1N=CN=C2[C@H](O)C[C@H](C=12)C)C=1C=CC(Cl)=CC=1)N1CCC(N)CC1 XQHJGSRNSFPVKJ-ZPMCFJSWSA-N 0.000 claims 1
• YEZZZABOMAUCOL-SYYKKAFVSA-N (2s)-3-(4-ethylpiperazin-1-yl)-2-[3-fluoro-4-(trifluoromethoxy)phenyl]-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]propan-1-one Chemical compound C1CN(CC)CCN1C[C@H](C=1C=C(F)C(OC(F)(F)F)=CC=1)C(=O)N1CCN(C=2C=3[C@H](C)C[C@@H](O)C=3N=CN=2)CC1 YEZZZABOMAUCOL-SYYKKAFVSA-N 0.000 claims 1
• UWIOHODNDKXYAP-NSISKUIASA-N (2s)-3-(azetidin-1-yl)-2-(4-chlorophenyl)-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]propan-1-one Chemical compound C([C@@H](C(=O)N1CCN(CC1)C=1N=CN=C2[C@H](O)C[C@H](C=12)C)C=1C=CC(Cl)=CC=1)N1CCC1 UWIOHODNDKXYAP-NSISKUIASA-N 0.000 claims 1
• RRSHYJAMIPDULM-MAODMQOUSA-N (2s)-3-(cyclopropylmethylamino)-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-2-[4-(trifluoromethyl)phenyl]propan-1-one Chemical compound C([C@@H](C(=O)N1CCN(CC1)C=1N=CN=C2[C@H](O)C[C@H](C=12)C)C=1C=CC(=CC=1)C(F)(F)F)NCC1CC1 RRSHYJAMIPDULM-MAODMQOUSA-N 0.000 claims 1
• RRSHYJAMIPDULM-HBGVWJBISA-N (2s)-3-(cyclopropylmethylamino)-1-[4-[(5r,7s)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-2-[4-(trifluoromethyl)phenyl]propan-1-one Chemical compound C([C@@H](C(=O)N1CCN(CC1)C=1N=CN=C2[C@@H](O)C[C@H](C=12)C)C=1C=CC(=CC=1)C(F)(F)F)NCC1CC1 RRSHYJAMIPDULM-HBGVWJBISA-N 0.000 claims 1
• AGYMBUBADOIQQM-FQELHTAISA-N (2s)-3-(cyclopropylmethylamino)-2-(3,4-dichlorophenyl)-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]propan-1-one Chemical compound C([C@@H](C(=O)N1CCN(CC1)C=1N=CN=C2[C@H](O)C[C@H](C=12)C)C=1C=C(Cl)C(Cl)=CC=1)NCC1CC1 AGYMBUBADOIQQM-FQELHTAISA-N 0.000 claims 1
• XGFQLCBCUUZIGA-QFIXIFRTSA-N (2s)-3-(cyclopropylmethylamino)-2-[2-fluoro-4-(trifluoromethyl)phenyl]-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]propan-1-one Chemical compound C([C@@H](C(=O)N1CCN(CC1)C=1N=CN=C2[C@H](O)C[C@H](C=12)C)C=1C(=CC(=CC=1)C(F)(F)F)F)NCC1CC1 XGFQLCBCUUZIGA-QFIXIFRTSA-N 0.000 claims 1
• ZLQWIDSPRZYJTH-XFQXTVEOSA-N (2s)-3-(cyclopropylmethylamino)-2-[3-fluoro-4-(trifluoromethoxy)phenyl]-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]propan-1-one Chemical compound C([C@@H](C(=O)N1CCN(CC1)C=1N=CN=C2[C@H](O)C[C@H](C=12)C)C=1C=C(F)C(OC(F)(F)F)=CC=1)NCC1CC1 ZLQWIDSPRZYJTH-XFQXTVEOSA-N 0.000 claims 1
• ZLQWIDSPRZYJTH-ZTNFWEORSA-N (2s)-3-(cyclopropylmethylamino)-2-[3-fluoro-4-(trifluoromethoxy)phenyl]-1-[4-[(5r,7s)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]propan-1-one Chemical compound C([C@@H](C(=O)N1CCN(CC1)C=1N=CN=C2[C@@H](O)C[C@H](C=12)C)C=1C=C(F)C(OC(F)(F)F)=CC=1)NCC1CC1 ZLQWIDSPRZYJTH-ZTNFWEORSA-N 0.000 claims 1
• NRRILVLCPJUGCY-FQELHTAISA-N (2s)-3-(cyclopropylmethylamino)-2-[3-fluoro-4-(trifluoromethyl)phenyl]-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]propan-1-one Chemical compound C([C@@H](C(=O)N1CCN(CC1)C=1N=CN=C2[C@H](O)C[C@H](C=12)C)C=1C=C(F)C(=CC=1)C(F)(F)F)NCC1CC1 NRRILVLCPJUGCY-FQELHTAISA-N 0.000 claims 1
• YNINYIBWEWBOAK-QYRPDUKASA-N (2s)-3-[(3r)-3-aminopyrrolidin-1-yl]-2-(4-chlorophenyl)-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]propan-1-one Chemical compound C([C@@H](C(=O)N1CCN(CC1)C=1N=CN=C2[C@H](O)C[C@H](C=12)C)C=1C=CC(Cl)=CC=1)N1CC[C@@H](N)C1 YNINYIBWEWBOAK-QYRPDUKASA-N 0.000 claims 1
• WYOQJYFZPBGFBZ-ULLYJBBUSA-N (2s)-3-[[(3r)-1-acetylpyrrolidin-3-yl]amino]-2-(4-chlorophenyl)-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]propan-1-one Chemical compound C([C@@H](C(=O)N1CCN(CC1)C=1N=CN=C2[C@H](O)C[C@H](C=12)C)C=1C=CC(Cl)=CC=1)N[C@@H]1CCN(C(C)=O)C1 WYOQJYFZPBGFBZ-ULLYJBBUSA-N 0.000 claims 1
• WYOQJYFZPBGFBZ-FJTGNWTPSA-N (2s)-3-[[(3s)-1-acetylpyrrolidin-3-yl]amino]-2-(4-chlorophenyl)-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]propan-1-one Chemical compound C([C@@H](C(=O)N1CCN(CC1)C=1N=CN=C2[C@H](O)C[C@H](C=12)C)C=1C=CC(Cl)=CC=1)N[C@H]1CCN(C(C)=O)C1 WYOQJYFZPBGFBZ-FJTGNWTPSA-N 0.000 claims 1
• MOFXCWWIQFLBCN-SUYBPPKGSA-N (2s)-3-amino-2-(3,4-dichlorophenyl)-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]propan-1-one Chemical compound C1([C@@H](CN)C(=O)N2CCN(CC2)C=2N=CN=C3[C@H](O)C[C@H](C=23)C)=CC=C(Cl)C(Cl)=C1 MOFXCWWIQFLBCN-SUYBPPKGSA-N 0.000 claims 1
• SWPJXSPCNDYNLD-SRCQZFHVSA-N (2s)-3-amino-2-(4-bromo-2-fluorophenyl)-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]propan-1-one Chemical compound C1([C@@H](CN)C(=O)N2CCN(CC2)C=2N=CN=C3[C@H](O)C[C@H](C=23)C)=CC=C(Br)C=C1F SWPJXSPCNDYNLD-SRCQZFHVSA-N 0.000 claims 1
• AEFICNJWUCHBJA-KBRIMQKVSA-N (2s)-3-amino-2-(4-bromophenyl)-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]propan-1-one Chemical compound C1([C@@H](CN)C(=O)N2CCN(CC2)C=2N=CN=C3[C@H](O)C[C@H](C=23)C)=CC=C(Br)C=C1 AEFICNJWUCHBJA-KBRIMQKVSA-N 0.000 claims 1
• AEFICNJWUCHBJA-XYPHTWIQSA-N (2s)-3-amino-2-(4-bromophenyl)-1-[4-[(5r,7s)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]propan-1-one Chemical compound C1([C@@H](CN)C(=O)N2CCN(CC2)C=2N=CN=C3[C@@H](O)C[C@H](C=23)C)=CC=C(Br)C=C1 AEFICNJWUCHBJA-XYPHTWIQSA-N 0.000 claims 1
• JGWUIBTXPBNBSH-SRCQZFHVSA-N (2s)-3-amino-2-(4-chloro-2-fluorophenyl)-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]propan-1-one Chemical compound C1([C@@H](CN)C(=O)N2CCN(CC2)C=2N=CN=C3[C@H](O)C[C@H](C=23)C)=CC=C(Cl)C=C1F JGWUIBTXPBNBSH-SRCQZFHVSA-N 0.000 claims 1
• NNQPXSMNFRMNIP-MRRJBJDNSA-N (2s)-3-amino-2-(4-chloro-3-fluorophenyl)-1-[4-[(5r,7s)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]propan-1-one Chemical compound C1([C@@H](CN)C(=O)N2CCN(CC2)C=2N=CN=C3[C@@H](O)C[C@H](C=23)C)=CC=C(Cl)C(F)=C1 NNQPXSMNFRMNIP-MRRJBJDNSA-N 0.000 claims 1
• FKWGZLUCQAOQDJ-KBRIMQKVSA-N (2s)-3-amino-2-(4-chlorophenyl)-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]propan-1-one Chemical group C1([C@@H](CN)C(=O)N2CCN(CC2)C=2N=CN=C3[C@H](O)C[C@H](C=23)C)=CC=C(Cl)C=C1 FKWGZLUCQAOQDJ-KBRIMQKVSA-N 0.000 claims 1
• JUPJLFOYULADQR-AXGUDRQCSA-N (2s)-3-amino-2-(4-chlorophenyl)-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]propan-1-one;dihydrochloride Chemical compound Cl.Cl.C1([C@@H](CN)C(=O)N2CCN(CC2)C=2N=CN=C3[C@H](O)C[C@H](C=23)C)=CC=C(Cl)C=C1 JUPJLFOYULADQR-AXGUDRQCSA-N 0.000 claims 1
• PNDUMSLYGKAIQS-UBCDJDFNSA-N 1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-2-(4-methoxyphenyl)-3-(propan-2-ylamino)propan-1-one Chemical compound C1=CC(OC)=CC=C1C(CNC(C)C)C(=O)N1CCN(C=2C=3[C@H](C)C[C@@H](O)C=3N=CN=2)CC1 PNDUMSLYGKAIQS-UBCDJDFNSA-N 0.000 claims 1
• LVPRCMPBTJUMIH-MCGPBEARSA-N 1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-2-(4-methoxyphenyl)-3-pyrrolidin-1-ylpropan-1-one Chemical compound C1=CC(OC)=CC=C1C(C(=O)N1CCN(CC1)C=1C=2[C@H](C)C[C@@H](O)C=2N=CN=1)CN1CCCC1 LVPRCMPBTJUMIH-MCGPBEARSA-N 0.000 claims 1
• AWRCEDBMMSBSMN-TXZDUHFLSA-N 1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-2-(4-methylphenyl)-3-(propan-2-ylamino)propan-1-one Chemical compound C1CN(C=2C=3[C@H](C)C[C@@H](O)C=3N=CN=2)CCN1C(=O)C(CNC(C)C)C1=CC=C(C)C=C1 AWRCEDBMMSBSMN-TXZDUHFLSA-N 0.000 claims 1
• PKHGVGANARDXNX-ZNCRQWOUSA-N 1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-3-(propan-2-ylamino)-2-[4-(trifluoromethyl)phenyl]propan-1-one Chemical compound C1CN(C=2C=3[C@H](C)C[C@@H](O)C=3N=CN=2)CCN1C(=O)C(CNC(C)C)C1=CC=C(C(F)(F)F)C=C1 PKHGVGANARDXNX-ZNCRQWOUSA-N 0.000 claims 1
• OBRHAGHCWYTVEO-FBOUHOSPSA-N 2-(2,4-dichlorophenyl)-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-3-(propan-2-ylamino)propan-1-one Chemical compound C1CN(C=2C=3[C@H](C)C[C@@H](O)C=3N=CN=2)CCN1C(=O)C(CNC(C)C)C1=CC=C(Cl)C=C1Cl OBRHAGHCWYTVEO-FBOUHOSPSA-N 0.000 claims 1
• OHQZJVLRYNXMAM-QMBUQHDCSA-N 2-(3,4-difluorophenyl)-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-3-(propan-2-ylamino)propan-1-one Chemical compound C1CN(C=2C=3[C@H](C)C[C@@H](O)C=3N=CN=2)CCN1C(=O)C(CNC(C)C)C1=CC=C(F)C(F)=C1 OHQZJVLRYNXMAM-QMBUQHDCSA-N 0.000 claims 1
• GGGQLFZGNGYUKR-ZNCRQWOUSA-N 2-(4-bromophenyl)-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-3-(propan-2-ylamino)propan-1-one Chemical compound C1CN(C=2C=3[C@H](C)C[C@@H](O)C=3N=CN=2)CCN1C(=O)C(CNC(C)C)C1=CC=C(Br)C=C1 GGGQLFZGNGYUKR-ZNCRQWOUSA-N 0.000 claims 1
• ACYVWONXYYNPDK-QMBUQHDCSA-N 2-(4-chloro-3-fluorophenyl)-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-3-(propan-2-ylamino)propan-1-one Chemical compound C1CN(C=2C=3[C@H](C)C[C@@H](O)C=3N=CN=2)CCN1C(=O)C(CNC(C)C)C1=CC=C(Cl)C(F)=C1 ACYVWONXYYNPDK-QMBUQHDCSA-N 0.000 claims 1
• VGXYSAUNUXEMBW-RBEDQOGGSA-N 2-(4-chlorophenyl)-1-[(3s)-4-[(7r)-7-hydroxy-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]-3-methylpiperazin-1-yl]-3-(propan-2-ylamino)propan-1-one Chemical compound C([C@H](C)N(CC1)C=2C=3CC[C@@H](O)C=3N=CN=2)N1C(=O)C(CNC(C)C)C1=CC=C(Cl)C=C1 VGXYSAUNUXEMBW-RBEDQOGGSA-N 0.000 claims 1
• KLMLPMIANLRMGB-UHFFFAOYSA-N 2-(4-chlorophenyl)-1-[4-(7-hydroxy-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl)piperazin-1-yl]-3-(propan-2-ylamino)propan-1-one;dihydrochloride Chemical compound Cl.Cl.C1CN(C=2C=3CCC(O)C=3N=CN=2)CCN1C(=O)C(CNC(C)C)C1=CC=C(Cl)C=C1 KLMLPMIANLRMGB-UHFFFAOYSA-N 0.000 claims 1
• ZKISLFNRXKZEDK-UHFFFAOYSA-N 2-(4-chlorophenyl)-1-[4-(7-methoxy-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl)piperazin-1-yl]-3-(propan-2-ylamino)propan-1-one Chemical compound COC1CCC2=C1N=CN=C2N(CC1)CCN1C(=O)C(CNC(C)C)C1=CC=C(Cl)C=C1 ZKISLFNRXKZEDK-UHFFFAOYSA-N 0.000 claims 1
• RERSEUJKWZVXCS-FHKHCFAMSA-N 2-(4-chlorophenyl)-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-3-(2,2,2-trifluoroethylamino)propan-1-one Chemical compound C1([C@H](O)C[C@H](C=21)C)=NC=NC=2N(CC1)CCN1C(=O)C(CNCC(F)(F)F)C1=CC=C(Cl)C=C1 RERSEUJKWZVXCS-FHKHCFAMSA-N 0.000 claims 1
• BDKRQVSZTNVSIM-PMYDAVCKSA-N 2-(4-chlorophenyl)-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-3-(3-methoxyazetidin-1-yl)propan-1-one Chemical compound C1C(OC)CN1CC(C=1C=CC(Cl)=CC=1)C(=O)N1CCN(C=2C=3[C@H](C)C[C@@H](O)C=3N=CN=2)CC1 BDKRQVSZTNVSIM-PMYDAVCKSA-N 0.000 claims 1
• FXEKZXBFVHSSBX-PNWAUMQTSA-N 2-(4-chlorophenyl)-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-3-(pentan-3-ylamino)propan-1-one Chemical compound C1CN(C=2C=3[C@H](C)C[C@@H](O)C=3N=CN=2)CCN1C(=O)C(CNC(CC)CC)C1=CC=C(Cl)C=C1 FXEKZXBFVHSSBX-PNWAUMQTSA-N 0.000 claims 1
• SRKVNRNRVFDUTG-QZQHDSGQSA-N 2-(4-chlorophenyl)-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-3-(propan-2-ylamino)propan-1-one;dihydrochloride Chemical compound Cl.Cl.C1CN(C=2C=3[C@H](C)C[C@@H](O)C=3N=CN=2)CCN1C(=O)C(CNC(C)C)C1=CC=C(Cl)C=C1 SRKVNRNRVFDUTG-QZQHDSGQSA-N 0.000 claims 1
• AJGZWNJCCUOQRT-OWNAHGCSSA-N 2-(4-chlorophenyl)-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-3-[[(1s,2r)-1-hydroxy-1-phenylpropan-2-yl]amino]propan-1-one Chemical compound N([C@H](C)[C@@H](O)C=1C=CC=CC=1)CC(C(=O)N1CCN(CC1)C=1C=2[C@H](C)C[C@@H](O)C=2N=CN=1)C1=CC=C(Cl)C=C1 AJGZWNJCCUOQRT-OWNAHGCSSA-N 0.000 claims 1
• QADMBESFLIDLLJ-UBCDJDFNSA-N 2-(4-chlorophenyl)-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-3-pyrrolidin-1-ylpropan-1-one Chemical compound C1([C@H](O)C[C@H](C=21)C)=NC=NC=2N(CC1)CCN1C(=O)C(C=1C=CC(Cl)=CC=1)CN1CCCC1 QADMBESFLIDLLJ-UBCDJDFNSA-N 0.000 claims 1
• DAOZAACMPCICAF-CDCMMKFZSA-N 2-(4-chlorophenyl)-2-hydroxy-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-3-(propan-2-ylamino)propan-1-one Chemical compound C1CN(C=2C=3[C@H](C)C[C@@H](O)C=3N=CN=2)CCN1C(=O)C(O)(CNC(C)C)C1=CC=C(Cl)C=C1 DAOZAACMPCICAF-CDCMMKFZSA-N 0.000 claims 1
• MDVCJJCABHQSMG-UBCDJDFNSA-N 2-(4-chlorophenyl)-3-(2,2-dimethylpropylamino)-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]propan-1-one Chemical compound C1([C@H](O)C[C@H](C=21)C)=NC=NC=2N(CC1)CCN1C(=O)C(CNCC(C)(C)C)C1=CC=C(Cl)C=C1 MDVCJJCABHQSMG-UBCDJDFNSA-N 0.000 claims 1
• QGUOXJAMLQVZTF-CSKFVBRQSA-N 2-(4-chlorophenyl)-3-(3-hydroxyazetidin-1-yl)-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]propan-1-one Chemical compound C1([C@H](O)C[C@H](C=21)C)=NC=NC=2N(CC1)CCN1C(=O)C(C=1C=CC(Cl)=CC=1)CN1CC(O)C1 QGUOXJAMLQVZTF-CSKFVBRQSA-N 0.000 claims 1
• DJKIPNZIOLJURK-PMYDAVCKSA-N 2-(4-chlorophenyl)-3-(cyclopropylmethylamino)-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]propan-1-one Chemical compound C1([C@H](O)C[C@H](C=21)C)=NC=NC=2N(CC1)CCN1C(=O)C(C=1C=CC(Cl)=CC=1)CNCC1CC1 DJKIPNZIOLJURK-PMYDAVCKSA-N 0.000 claims 1
• HFYXROOFKKTXQH-WXRLAONRSA-N 2-(4-chlorophenyl)-3-[(3s,4r)-4-(dimethylamino)-3-fluoropiperidin-1-yl]-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]propan-1-one Chemical compound C1([C@H](O)C[C@H](C=21)C)=NC=NC=2N(CC1)CCN1C(=O)C(C=1C=CC(Cl)=CC=1)CN1CC[C@@H](N(C)C)[C@@H](F)C1 HFYXROOFKKTXQH-WXRLAONRSA-N 0.000 claims 1
• RGOKOXJZWWCPIM-FHKHCFAMSA-N 2-(4-fluorophenyl)-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-3-(methylamino)propan-1-one Chemical compound C1CN(C=2C=3[C@H](C)C[C@@H](O)C=3N=CN=2)CCN1C(=O)C(CNC)C1=CC=C(F)C=C1 RGOKOXJZWWCPIM-FHKHCFAMSA-N 0.000 claims 1
• CTPBUWWGXHPLEI-ZNCRQWOUSA-N 2-(4-fluorophenyl)-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-3-(propan-2-ylamino)propan-1-one Chemical compound C1CN(C=2C=3[C@H](C)C[C@@H](O)C=3N=CN=2)CCN1C(=O)C(CNC(C)C)C1=CC=C(F)C=C1 CTPBUWWGXHPLEI-ZNCRQWOUSA-N 0.000 claims 1
• KQOXBQAEGCSAOJ-NSISKUIASA-N 2-[[(2r)-3-(4-chlorophenyl)-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-1-oxopropan-2-yl]amino]-n,n-dimethylacetamide Chemical compound C([C@H](C(=O)N1CCN(CC1)C=1N=CN=C2[C@H](O)C[C@H](C=12)C)NCC(=O)N(C)C)C1=CC=C(Cl)C=C1 KQOXBQAEGCSAOJ-NSISKUIASA-N 0.000 claims 1
• FDFKUGQSHZVMCH-DUXKGJEZSA-N 2-[[(2r)-3-(4-chlorophenyl)-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-1-oxopropan-2-yl]amino]-n-propan-2-ylacetamide Chemical compound C([C@@H](NCC(=O)NC(C)C)C(=O)N1CCN(CC1)C=1C=2[C@H](C)C[C@@H](O)C=2N=CN=1)C1=CC=C(Cl)C=C1 FDFKUGQSHZVMCH-DUXKGJEZSA-N 0.000 claims 1
• CZJLOZDWFXMMCO-NSISKUIASA-N 2-[[(2s)-2-(4-chlorophenyl)-3-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-3-oxopropyl]amino]-n,n-dimethylacetamide Chemical compound C1([C@@H](CNCC(=O)N(C)C)C(=O)N2CCN(CC2)C=2N=CN=C3[C@H](O)C[C@H](C=23)C)=CC=C(Cl)C=C1 CZJLOZDWFXMMCO-NSISKUIASA-N 0.000 claims 1
• ZAYNZTULRFSKGZ-ATZDWAIDSA-N 2-[[(2s)-2-(4-chlorophenyl)-3-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-3-oxopropyl]amino]-n-methylacetamide Chemical compound C1([C@H](C(=O)N2CCN(CC2)C=2C=3[C@H](C)C[C@@H](O)C=3N=CN=2)CNCC(=O)NC)=CC=C(Cl)C=C1 ZAYNZTULRFSKGZ-ATZDWAIDSA-N 0.000 claims 1
• FOKQYCVHFKIYFJ-ZTFGCOKTSA-N 2-[[(2s)-2-(4-chlorophenyl)-3-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-3-oxopropyl]amino]acetamide Chemical compound C1([C@@H](CNCC(N)=O)C(=O)N2CCN(CC2)C=2N=CN=C3[C@H](O)C[C@H](C=23)C)=CC=C(Cl)C=C1 FOKQYCVHFKIYFJ-ZTFGCOKTSA-N 0.000 claims 1
• NXYKZOIBJRGZGO-DUXKGJEZSA-N 2-[[(3r)-3-(4-bromophenyl)-4-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-4-oxobutyl]amino]-n,n-dimethylacetamide Chemical compound C1([C@@H](CCNCC(=O)N(C)C)C(=O)N2CCN(CC2)C=2N=CN=C3[C@H](O)C[C@H](C=23)C)=CC=C(Br)C=C1 NXYKZOIBJRGZGO-DUXKGJEZSA-N 0.000 claims 1
• DANURWGZZJGXHV-ATZDWAIDSA-N 2-[[(3r)-3-(4-bromophenyl)-4-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-4-oxobutyl]amino]acetamide Chemical compound C1([C@@H](CCNCC(N)=O)C(=O)N2CCN(CC2)C=2N=CN=C3[C@H](O)C[C@H](C=23)C)=CC=C(Br)C=C1 DANURWGZZJGXHV-ATZDWAIDSA-N 0.000 claims 1
• UWIOHODNDKXYAP-ZNCRQWOUSA-N 3-(azetidin-1-yl)-2-(4-chlorophenyl)-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]propan-1-one Chemical compound C1([C@H](O)C[C@H](C=21)C)=NC=NC=2N(CC1)CCN1C(=O)C(C=1C=CC(Cl)=CC=1)CN1CCC1 UWIOHODNDKXYAP-ZNCRQWOUSA-N 0.000 claims 1
• MIKBHJCIKFJPTM-QYHYLKRQSA-N 3-(ethylamino)-2-(4-fluorophenyl)-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]propan-1-one Chemical compound C1CN(C=2C=3[C@H](C)C[C@@H](O)C=3N=CN=2)CCN1C(=O)C(CNCC)C1=CC=C(F)C=C1 MIKBHJCIKFJPTM-QYHYLKRQSA-N 0.000 claims 1
• WIFOOIZELIVWBL-ZNCRQWOUSA-N 3-(tert-butylamino)-2-(4-chlorophenyl)-1-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]propan-1-one Chemical compound C1([C@H](O)C[C@H](C=21)C)=NC=NC=2N(CC1)CCN1C(=O)C(CNC(C)(C)C)C1=CC=C(Cl)C=C1 WIFOOIZELIVWBL-ZNCRQWOUSA-N 0.000 claims 1
• VCZYNIODTLLAFV-ATZDWAIDSA-N 3-[[(2s)-2-(4-chlorophenyl)-3-[4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-3-oxopropyl]amino]propanamide Chemical compound C1([C@@H](CNCCC(N)=O)C(=O)N2CCN(CC2)C=2N=CN=C3[C@H](O)C[C@H](C=23)C)=CC=C(Cl)C=C1 VCZYNIODTLLAFV-ATZDWAIDSA-N 0.000 claims 1
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