CA2646856C - Isomerisation of pharmaceutical intermediates - Google Patents

Isomerisation of pharmaceutical intermediates Download PDF

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Publication number
CA2646856C
CA2646856C CA2646856A CA2646856A CA2646856C CA 2646856 C CA2646856 C CA 2646856C CA 2646856 A CA2646856 A CA 2646856A CA 2646856 A CA2646856 A CA 2646856A CA 2646856 C CA2646856 C CA 2646856C
Authority
CA
Canada
Prior art keywords
photoreactor
flow
light source
solution
vitamin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2646856A
Other languages
English (en)
French (fr)
Other versions
CA2646856A1 (en
Inventor
Michael Peter Folkmann
Erik Tomgaard Hansen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Leo Pharma AS
Original Assignee
Leo Pharma AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Leo Pharma AS filed Critical Leo Pharma AS
Publication of CA2646856A1 publication Critical patent/CA2646856A1/en
Application granted granted Critical
Publication of CA2646856C publication Critical patent/CA2646856C/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B37/00—Reactions without formation or introduction of functional groups containing hetero atoms, involving either the formation of a carbon-to-carbon bond between two carbon atoms not directly linked already or the disconnection of two directly linked carbon atoms
    • C07B37/08—Isomerisation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C07F7/1872—Preparation; Treatments not provided for in C07F7/20
    • C07F7/1892—Preparation; Treatments not provided for in C07F7/20 by reactions not provided for in C07F7/1876 - C07F7/1888
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Nutrition Science (AREA)
  • Dermatology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Medicinal Preparation (AREA)
CA2646856A 2006-03-17 2006-05-08 Isomerisation of pharmaceutical intermediates Expired - Fee Related CA2646856C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US78307606P 2006-03-17 2006-03-17
US60/783,076 2006-03-17
PCT/DK2006/000244 WO2007082533A1 (en) 2006-03-17 2006-05-08 Isomerisation of pharmaceutical intermediates

Publications (2)

Publication Number Publication Date
CA2646856A1 CA2646856A1 (en) 2007-07-26
CA2646856C true CA2646856C (en) 2013-05-07

Family

ID=37566638

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2646856A Expired - Fee Related CA2646856C (en) 2006-03-17 2006-05-08 Isomerisation of pharmaceutical intermediates

Country Status (14)

Country Link
US (1) US20070215455A1 (zh)
EP (1) EP1844010B1 (zh)
JP (2) JP5204088B2 (zh)
CN (1) CN101400649B (zh)
BR (1) BRPI0621471A2 (zh)
CA (1) CA2646856C (zh)
DE (1) DE06722936T8 (zh)
ES (1) ES2406735T3 (zh)
HK (1) HK1125623A1 (zh)
IL (1) IL186074A (zh)
MX (1) MX2008011557A (zh)
RU (1) RU2412165C2 (zh)
TW (1) TWI347935B (zh)
WO (1) WO2007082533A1 (zh)

Families Citing this family (16)

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Publication number Priority date Publication date Assignee Title
US8263580B2 (en) 1998-09-11 2012-09-11 Stiefel Research Australia Pty Ltd Vitamin formulation
ES2407407T3 (es) 2005-06-01 2013-06-12 Glaxosmithkline Intellectual Property Development Limited Formulación de vitamina
ES2272198B1 (es) * 2006-12-28 2008-06-01 Laboratorios Viñas S.A. Procedimiento para la obtencion de hidrato de calcipotriol.
CN101607932B (zh) * 2009-07-23 2012-05-09 青岛正大海尔制药有限公司 一种光化学反应制备骨化三醇的方法及其装置
WO2012033703A1 (en) * 2010-09-10 2012-03-15 Genzyme Corporation Continuous photolytic process for the preparation of vitamin d related substances
AP3831A (en) * 2011-08-29 2016-09-30 Max Planck Gesellschaft Method and device for the synthesis of artemisinin
ES2411834B1 (es) * 2011-12-30 2014-03-18 Laboratorios Viñas S.A. Proceso industrial para obtener intermedios aptos para la síntesis de análogos de Vitamina D
BR112015021831A2 (pt) 2013-03-15 2017-07-18 Veryan Medical Ltd aparelho de stent e métodos de tratamento
CN103694156B (zh) * 2014-01-07 2015-09-02 成都医路康医学技术服务有限公司 一种银屑病治疗药物钙泊三醇的制备方法
CN105753758B (zh) * 2014-12-17 2017-11-03 上虞京新药业有限公司 卡泊三醇的制备方法
WO2016100892A1 (en) * 2014-12-18 2016-06-23 Nucelis Llc Methods for improved production of vitamins d2 and d3
CN106908524B (zh) * 2015-12-23 2021-05-04 重庆华邦胜凯制药有限公司 卡泊三醇中间体l及其潜在基因毒性杂质的分离与测定方法
CN107033017B (zh) * 2017-04-25 2018-11-13 四川大学 一种快速制备高纯度羟基-γ-山椒素的方法
EP3888784A1 (en) * 2020-03-31 2021-10-06 Signify Holding B.V. Improved continuous flow reactor for photochemical processes with concave-faced sides
DE102021132073A1 (de) * 2021-12-06 2023-06-07 EKATO Rühr- und Mischtechnik GmbH Photoreaktorvorrichtung und Verfahren zum Betrieb einer Photoreaktorvorrichtung
DE102021132074A1 (de) * 2021-12-06 2023-06-07 EKATO Rühr- und Mischtechnik GmbH Reaktorvorrichtung und Verfahren zur Durchführung photochemischer Reaktionen mit einer Reaktorvorrichtung

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3554887A (en) 1966-03-16 1971-01-12 Du Pont Photochemical apparatus and process
US4087342A (en) 1976-12-22 1978-05-02 Monsanto Company Method of simultaneously carrying out plurality of photochemical reactions
DE2735550A1 (de) 1977-08-06 1979-02-08 Guenther O Prof Dr Schenck Mehrkammer-photoreaktor
DE2904242A1 (de) 1979-02-05 1980-08-14 Guenther O Prof Dr Schenck Verfahren und vorrichtung zur reinigung, insbesondere zur entkeimung und desinfektion
US4456512A (en) 1982-03-10 1984-06-26 The Dow Chemical Company Photochemical reactor and method
US4454835A (en) 1982-09-13 1984-06-19 The United States Of America As Represented By The Secretary Of The Navy Internal photolysis reactor
AU603340B2 (en) 1985-08-02 1990-11-15 Leo Pharmaceutical Products Ltd. A/S (Lovens Kemiske Fabrik Produktionsaktieselskab) Novel vitamin d analogues
DE3625006A1 (de) 1985-10-26 1987-04-30 Basf Ag Photoreaktor fuer photochemische synthesen
US5012106A (en) 1988-12-23 1991-04-30 Gte Products Corporation Axi-symmetrical flow reactor for 196 Hg photochemical enrichment
US5126111A (en) 1990-12-05 1992-06-30 Nutech Energy Systems Inc. Fluid purification
US5763426A (en) * 1993-01-15 1998-06-09 Leo Pharmaceutical Products Ltd. Crystalline form of a vitamin D analogue
US5696380A (en) * 1995-05-09 1997-12-09 Labatt Brewing Company Limited Flow-through photo-chemical reactor
HU230045B1 (hu) 1999-04-23 2015-06-29 Leo Pharmaceutical Products Ltd. A/S (Lovens Kemiske Fabrik Produktionsaktieselskab) Bőrgyógyászati alkalmazásra szolgáló nem vizes gyógyszerkészítmény
JP3820070B2 (ja) * 1999-12-13 2006-09-13 帝人株式会社 プレビタミンｄ類合成用反応装置
WO2002006218A2 (en) 2000-07-18 2002-01-24 Bone Care International, Inc. STABILIZED 1α-HYDROXY VITAMIN D
HU230005B1 (en) 2000-10-27 2015-04-28 Leo Pharma As Topical composition containing at least one vitamin d or one vitamin d analogue and at least one corticosteroid
DE10236717B4 (de) 2001-08-07 2006-04-20 Gudernatsch, Willi, Dr.-Ing. Vorrichtung zur Durchführung von photoreaktiven Prozessen bei einem Fluid
CA2489593C (en) 2002-06-13 2009-09-29 Teva Pharmaceutical Industries Ltd Epimerization of analogs of vitamin d
EP1556345B1 (en) * 2002-10-23 2010-12-15 Leo Pharma A/S Vitamin d analogues, compositions comprising said analogues and their use
US7351869B2 (en) 2002-11-18 2008-04-01 Teva Pharmaceutical Industries Ltd Crystallization method for purification of calcipotriene
BRPI0507318A (pt) 2004-03-18 2007-06-26 Leo Pharma As métodos para reduzir um composto, para a produção de calcipotriol ou monoidrato de calcipotriol, e de um composto, e de reação da mistura de compostos, composto, e, uso de um composto
UA94568C2 (ru) 2004-04-02 2011-05-25 Лео Фарма А/С Способ получения промежуточных соединений, которые применяют для синтеза аналогов витамина d

Also Published As

Publication number Publication date
BRPI0621471A2 (pt) 2012-09-11
IL186074A (en) 2011-11-30
JP2013056898A (ja) 2013-03-28
DE06722936T8 (de) 2008-06-05
HK1125623A1 (en) 2009-08-14
RU2008141150A (ru) 2010-04-27
TW200736208A (en) 2007-10-01
CN101400649B (zh) 2012-07-04
MX2008011557A (es) 2008-12-09
CA2646856A1 (en) 2007-07-26
ES2406735T3 (es) 2013-06-07
DE06722936T1 (de) 2008-02-07
CN101400649A (zh) 2009-04-01
JP5204088B2 (ja) 2013-06-05
EP1844010B1 (en) 2013-02-13
RU2412165C2 (ru) 2011-02-20
US20070215455A1 (en) 2007-09-20
JP2009530317A (ja) 2009-08-27
TWI347935B (en) 2011-09-01
EP1844010A1 (en) 2007-10-17
WO2007082533A1 (en) 2007-07-26

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Effective date: 20150508