TWI347935B - Isomerisation of pharmaceutical intermediates - Google Patents

Isomerisation of pharmaceutical intermediates

Info

Publication number
TWI347935B
TWI347935B TW095118618A TW95118618A TWI347935B TW I347935 B TWI347935 B TW I347935B TW 095118618 A TW095118618 A TW 095118618A TW 95118618 A TW95118618 A TW 95118618A TW I347935 B TWI347935 B TW I347935B
Authority
TW
Taiwan
Prior art keywords
isomerisation
pharmaceutical intermediates
intermediates
pharmaceutical
Prior art date
Application number
TW095118618A
Other languages
English (en)
Other versions
TW200736208A (en
Inventor
Michael Peter Folkmann
Erik Torngaard Hansen
Original Assignee
Leo Pharma As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Leo Pharma As filed Critical Leo Pharma As
Publication of TW200736208A publication Critical patent/TW200736208A/zh
Application granted granted Critical
Publication of TWI347935B publication Critical patent/TWI347935B/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B37/00—Reactions without formation or introduction of functional groups containing hetero atoms, involving either the formation of a carbon-to-carbon bond between two carbon atoms not directly linked already or the disconnection of two directly linked carbon atoms
    • C07B37/08—Isomerisation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C07F7/1872—Preparation; Treatments not provided for in C07F7/20
    • C07F7/1892—Preparation; Treatments not provided for in C07F7/20 by reactions not provided for in C07F7/1876 - C07F7/1888
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Nutrition Science (AREA)
  • Dermatology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Medicinal Preparation (AREA)
TW095118618A 2006-03-17 2006-05-25 Isomerisation of pharmaceutical intermediates TWI347935B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US78307606P 2006-03-17 2006-03-17
PCT/DK2006/000244 WO2007082533A1 (en) 2006-03-17 2006-05-08 Isomerisation of pharmaceutical intermediates

Publications (2)

Publication Number Publication Date
TW200736208A TW200736208A (en) 2007-10-01
TWI347935B true TWI347935B (en) 2011-09-01

Family

ID=37566638

Family Applications (1)

Application Number Title Priority Date Filing Date
TW095118618A TWI347935B (en) 2006-03-17 2006-05-25 Isomerisation of pharmaceutical intermediates

Country Status (14)

Country Link
US (1) US20070215455A1 (zh)
EP (1) EP1844010B1 (zh)
JP (2) JP5204088B2 (zh)
CN (1) CN101400649B (zh)
BR (1) BRPI0621471A2 (zh)
CA (1) CA2646856C (zh)
DE (1) DE06722936T8 (zh)
ES (1) ES2406735T3 (zh)
HK (1) HK1125623A1 (zh)
IL (1) IL186074A (zh)
MX (1) MX2008011557A (zh)
RU (1) RU2412165C2 (zh)
TW (1) TWI347935B (zh)
WO (1) WO2007082533A1 (zh)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8263580B2 (en) 1998-09-11 2012-09-11 Stiefel Research Australia Pty Ltd Vitamin formulation
AU2006253913B2 (en) 2005-06-01 2010-09-16 Mayne Pharma Llc Vitamin formulation
ES2272198B1 (es) * 2006-12-28 2008-06-01 Laboratorios Viñas S.A. Procedimiento para la obtencion de hidrato de calcipotriol.
CN101607932B (zh) * 2009-07-23 2012-05-09 青岛正大海尔制药有限公司 一种光化学反应制备骨化三醇的方法及其装置
EP2613632A1 (en) * 2010-09-10 2013-07-17 Genzyme Corporation Continuous photolytic process for the preparation of vitamin d related substances
EP2751113B1 (en) 2011-08-29 2017-07-05 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Method and device for the synthesis of artemisinin
ES2411834B1 (es) * 2011-12-30 2014-03-18 Laboratorios Viñas S.A. Proceso industrial para obtener intermedios aptos para la síntesis de análogos de Vitamina D
WO2014140642A1 (en) 2013-03-15 2014-09-18 Veryan Medical Limited Stent apparatus and treatment methods
CN103694156B (zh) * 2014-01-07 2015-09-02 成都医路康医学技术服务有限公司 一种银屑病治疗药物钙泊三醇的制备方法
CN105753758B (zh) * 2014-12-17 2017-11-03 上虞京新药业有限公司 卡泊三醇的制备方法
WO2016100892A1 (en) * 2014-12-18 2016-06-23 Nucelis Llc Methods for improved production of vitamins d2 and d3
CN106908524B (zh) * 2015-12-23 2021-05-04 重庆华邦胜凯制药有限公司 卡泊三醇中间体l及其潜在基因毒性杂质的分离与测定方法
CN107033017B (zh) * 2017-04-25 2018-11-13 四川大学 一种快速制备高纯度羟基-γ-山椒素的方法
EP3888784A1 (en) * 2020-03-31 2021-10-06 Signify Holding B.V. Improved continuous flow reactor for photochemical processes with concave-faced sides
DE102021132074A1 (de) * 2021-12-06 2023-06-07 EKATO Rühr- und Mischtechnik GmbH Reaktorvorrichtung und Verfahren zur Durchführung photochemischer Reaktionen mit einer Reaktorvorrichtung
DE102021132073A1 (de) * 2021-12-06 2023-06-07 EKATO Rühr- und Mischtechnik GmbH Photoreaktorvorrichtung und Verfahren zum Betrieb einer Photoreaktorvorrichtung

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3554887A (en) 1966-03-16 1971-01-12 Du Pont Photochemical apparatus and process
US4087342A (en) 1976-12-22 1978-05-02 Monsanto Company Method of simultaneously carrying out plurality of photochemical reactions
DE2735550A1 (de) 1977-08-06 1979-02-08 Guenther O Prof Dr Schenck Mehrkammer-photoreaktor
DE2904242A1 (de) 1979-02-05 1980-08-14 Guenther O Prof Dr Schenck Verfahren und vorrichtung zur reinigung, insbesondere zur entkeimung und desinfektion
US4456512A (en) 1982-03-10 1984-06-26 The Dow Chemical Company Photochemical reactor and method
US4454835A (en) 1982-09-13 1984-06-19 The United States Of America As Represented By The Secretary Of The Navy Internal photolysis reactor
US4866048A (en) 1985-08-02 1989-09-12 Leo Pharmaceutical Products Ltd. Novel vitamin D analogues
DE3625006A1 (de) 1985-10-26 1987-04-30 Basf Ag Photoreaktor fuer photochemische synthesen
US5012106A (en) 1988-12-23 1991-04-30 Gte Products Corporation Axi-symmetrical flow reactor for 196 Hg photochemical enrichment
US5126111A (en) 1990-12-05 1992-06-30 Nutech Energy Systems Inc. Fluid purification
USRE39706E1 (en) 1993-01-15 2007-06-26 Leo Pharma A/S Crystalline form of a vitamin D analogue
US5696380A (en) 1995-05-09 1997-12-09 Labatt Brewing Company Limited Flow-through photo-chemical reactor
RS52182B (sr) 1999-04-23 2012-10-31 Leo Pharmaceutical Products Ltd. A/S (Løvens Kemiske Fabrik Produktionsaktieselskab) Farmaceutski preparat
JP3820070B2 (ja) * 1999-12-13 2006-09-13 帝人株式会社 プレビタミンｄ類合成用反応装置
IL153378A0 (en) 2000-07-18 2003-07-06 Bone Care Internat Inc STABILIZED 1alpha-HYDROXY VITAMIN D
AU9163701A (en) 2000-10-27 2002-05-06 Leo Pharma As Topical composition containing at least one vitamin D or one vitamin D analogue and at least one corticosteroid
DE10236717B4 (de) 2001-08-07 2006-04-20 Gudernatsch, Willi, Dr.-Ing. Vorrichtung zur Durchführung von photoreaktiven Prozessen bei einem Fluid
CA2489593C (en) 2002-06-13 2009-09-29 Teva Pharmaceutical Industries Ltd Epimerization of analogs of vitamin d
KR20050055784A (ko) * 2002-10-23 2005-06-13 레오 파마 에이/에스 비타민 디 유사체, 이 유사체를 포함하는 조성물 및 이들의용도
US7351869B2 (en) 2002-11-18 2008-04-01 Teva Pharmaceutical Industries Ltd Crystallization method for purification of calcipotriene
KR100859277B1 (ko) 2004-03-18 2008-09-19 레오 파마 에이/에스 비타민 ｄ 유사체의 입체선택적 합성
WO2005095336A2 (en) 2004-04-02 2005-10-13 Leo Pharma A/S Novel method for the preparation of intermediates useful for the synthesis of vitamin d analogues

Also Published As

Publication number Publication date
RU2412165C2 (ru) 2011-02-20
RU2008141150A (ru) 2010-04-27
DE06722936T8 (de) 2008-06-05
CA2646856C (en) 2013-05-07
CN101400649A (zh) 2009-04-01
WO2007082533A1 (en) 2007-07-26
MX2008011557A (es) 2008-12-09
EP1844010B1 (en) 2013-02-13
JP2013056898A (ja) 2013-03-28
EP1844010A1 (en) 2007-10-17
ES2406735T3 (es) 2013-06-07
BRPI0621471A2 (pt) 2012-09-11
US20070215455A1 (en) 2007-09-20
HK1125623A1 (en) 2009-08-14
JP2009530317A (ja) 2009-08-27
CN101400649B (zh) 2012-07-04
CA2646856A1 (en) 2007-07-26
IL186074A (en) 2011-11-30
TW200736208A (en) 2007-10-01
DE06722936T1 (de) 2008-02-07
JP5204088B2 (ja) 2013-06-05

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Legal Events

Date Code Title Description
MM4A Annulment or lapse of patent due to non-payment of fees