CA2588080C - Masking method for coating a microneedle array - Google Patents
Masking method for coating a microneedle array Download PDFInfo
- Publication number
- CA2588080C CA2588080C CA2588080A CA2588080A CA2588080C CA 2588080 C CA2588080 C CA 2588080C CA 2588080 A CA2588080 A CA 2588080A CA 2588080 A CA2588080 A CA 2588080A CA 2588080 C CA2588080 C CA 2588080C
- Authority
- CA
- Canada
- Prior art keywords
- coating
- array
- fluid
- masking layer
- microneedle array
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0046—Solid microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0053—Methods for producing microneedles
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- Health & Medical Sciences (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Hematology (AREA)
- Anesthesiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Medical Informatics (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Media Introduction/Drainage Providing Device (AREA)
- Application Of Or Painting With Fluid Materials (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US62920904P | 2004-11-18 | 2004-11-18 | |
| US60/629,209 | 2004-11-18 | ||
| PCT/US2005/041858 WO2006055799A1 (en) | 2004-11-18 | 2005-11-18 | Masking method for coating a microneedle array |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2588080A1 CA2588080A1 (en) | 2006-05-26 |
| CA2588080C true CA2588080C (en) | 2013-01-08 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2588080A Expired - Fee Related CA2588080C (en) | 2004-11-18 | 2005-11-18 | Masking method for coating a microneedle array |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US7846488B2 (enExample) |
| EP (1) | EP1827564B1 (enExample) |
| JP (1) | JP4927751B2 (enExample) |
| KR (1) | KR101224257B1 (enExample) |
| CN (1) | CN101102809B (enExample) |
| AU (1) | AU2005306426B2 (enExample) |
| CA (1) | CA2588080C (enExample) |
| IL (1) | IL183205A0 (enExample) |
| WO (1) | WO2006055799A1 (enExample) |
Families Citing this family (113)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0402131D0 (en) | 2004-01-30 | 2004-03-03 | Isis Innovation | Delivery method |
| WO2006138719A2 (en) | 2005-06-17 | 2006-12-28 | Georgia Tech Research Corporation | Coated microstructures and method of manufacture thereof |
| CA2614927A1 (en) * | 2005-07-25 | 2007-02-01 | Nanotechnology Victoria Pty Ltd | Microarray device |
| WO2007061781A1 (en) | 2005-11-18 | 2007-05-31 | 3M Innovative Properties Company | Coatable compositions, coatings derived therefrom and microarrays having such coatings |
| US8554317B2 (en) | 2005-11-30 | 2013-10-08 | 3M Innovative Properties Company | Microneedle arrays and methods of use thereof |
| EP2005990B1 (en) * | 2006-04-07 | 2013-08-28 | Hisamitsu Pharmaceutical Co., Inc. | Microneedle device and transdermal administration device provided with microneedles |
| US8574315B2 (en) * | 2006-05-09 | 2013-11-05 | The University Of Akron | Electrospun structures and methods for forming and using same |
| US8865288B2 (en) | 2006-07-17 | 2014-10-21 | University Of Utah Research Foundation | Micro-needle arrays having non-planar tips and methods of manufacture thereof |
| US7951300B2 (en) * | 2006-07-17 | 2011-05-31 | University Of Utah Research Foundation | Water-scale needle array |
| US20080138581A1 (en) * | 2006-07-17 | 2008-06-12 | Rajmohan Bhandari | Masking high-aspect aspect ratio structures |
| WO2008033199A1 (en) * | 2006-09-12 | 2008-03-20 | Boston Scientific Limited | Liquid masking for selective coating of a stent |
| WO2008130587A2 (en) | 2007-04-16 | 2008-10-30 | Corium International, Inc. | Solvent-cast microneedle arrays containing active |
| JP5298011B2 (ja) | 2007-05-15 | 2013-09-25 | 久光製薬株式会社 | マイクロニードルのコーティング方法 |
| US20090017210A1 (en) * | 2007-07-09 | 2009-01-15 | Andrianov Alexander K | Methods and systems for coating a microneedle with a dosage of a biologically active compound |
| SG183726A1 (en) * | 2007-08-14 | 2012-09-27 | Hutchinson Fred Cancer Res | Needle array assembly and method for delivering therapeutic agents |
| CN101868229A (zh) * | 2007-11-21 | 2010-10-20 | 株式会社培旺精廉宅 | 体表适用制剂和体表适用制剂保持片 |
| CA2745339C (en) * | 2007-12-24 | 2016-06-28 | The University Of Queensland | Coating method |
| US8883015B2 (en) | 2008-02-07 | 2014-11-11 | The University Of Queensland | Patch production |
| US20090301994A1 (en) * | 2008-05-12 | 2009-12-10 | Rajmohan Bhandari | Methods for Wafer Scale Processing of Needle Array Devices |
| WO2009140735A1 (en) | 2008-05-23 | 2009-11-26 | The University Of Queensland | Analyte detection by microneedle patch with analyte selective reagents. |
| US8886279B2 (en) | 2008-06-03 | 2014-11-11 | University Of Utah Research Foundation | High aspect ratio microelectrode arrays enabled to have customizable lengths and methods of making the same |
| JP5902390B2 (ja) * | 2008-12-26 | 2016-04-13 | 久光製薬株式会社 | マイクロニードルデバイス |
| WO2010087300A1 (ja) * | 2009-01-30 | 2010-08-05 | 久光製薬株式会社 | マイクロニードルデバイス |
| US20110006458A1 (en) * | 2009-04-24 | 2011-01-13 | Corium International, Inc. | Methods for manufacturing microprojection arrays |
| US8834423B2 (en) | 2009-10-23 | 2014-09-16 | University of Pittsburgh—of the Commonwealth System of Higher Education | Dissolvable microneedle arrays for transdermal delivery to human skin |
| US9221075B2 (en) * | 2009-11-09 | 2015-12-29 | Ethicon, Inc. | Surgical needle coatings and methods |
| US9332982B2 (en) * | 2009-11-09 | 2016-05-10 | Ethicon, Llc | Surgical needle coatings and methods |
| US9259219B2 (en) | 2009-11-09 | 2016-02-16 | Ethicon, Llc | Surgical needle coatings and methods |
| US20110144591A1 (en) * | 2009-12-11 | 2011-06-16 | Ross Russell F | Transdermal Delivery Device |
| US8956685B2 (en) * | 2010-02-24 | 2015-02-17 | Monosol Rx, Llc | Use of dams to improve yield in film processing |
| JP5860033B2 (ja) * | 2010-04-28 | 2016-02-16 | キンバリー クラーク ワールドワイド インコーポレイテッド | ｓｉＲＮＡ送達用の医療デバイス |
| WO2011135533A2 (en) * | 2010-04-28 | 2011-11-03 | Kimberly-Clark Worldwide, Inc. | Nanopatterned medical device with enhanced cellular interaction |
| MX345837B (es) * | 2010-04-28 | 2017-02-16 | Kimberly-Clark Worldwide Incorporated | Dispositivo para la entrega de un medicamento para la artritis reumatoide. |
| US9586044B2 (en) | 2010-04-28 | 2017-03-07 | Kimberly-Clark Worldwide, Inc. | Method for increasing the permeability of an epithelial barrier |
| EP2566501B1 (en) | 2010-05-04 | 2019-03-13 | Corium International, Inc. | Method and device for transdermal delivery of parathyroid hormone using a microprojection array |
| WO2012006677A1 (en) | 2010-07-14 | 2012-01-19 | The University Of Queensland | Patch applying apparatus |
| US8696637B2 (en) | 2011-02-28 | 2014-04-15 | Kimberly-Clark Worldwide | Transdermal patch containing microneedles |
| US8636696B2 (en) | 2011-06-10 | 2014-01-28 | Kimberly-Clark Worldwide, Inc. | Transdermal device containing microneedles |
| KR101314091B1 (ko) * | 2011-07-26 | 2013-10-04 | 연세대학교 산학협력단 | 치료 부위내 경피 유전자 전달을 위한 일렉트로 마이크로니들 집적체 및 이의 제조방법 |
| NL2007382C2 (en) * | 2011-09-09 | 2013-03-12 | Univ Leiden | Method to coat an active agent to a surface. |
| EP2765927B1 (en) | 2011-10-12 | 2021-02-24 | Vaxxas Pty Limited | Delivery device |
| CN104039382B (zh) | 2011-10-27 | 2018-01-12 | 金伯利-克拉克环球有限公司 | 高粘度生物活性剂的经皮递送 |
| US20170246439A9 (en) | 2011-10-27 | 2017-08-31 | Kimberly-Clark Worldwide, Inc. | Increased Bioavailability of Transdermally Delivered Agents |
| KR20140079429A (ko) | 2011-10-27 | 2014-06-26 | 킴벌리-클라크 월드와이드, 인크. | 생체활성 제제를 전달하기 위한 이식형 기구 |
| SG10201508662SA (en) | 2011-10-28 | 2015-11-27 | Presage Biosciences Inc | Methods for drug delivery |
| GB201120000D0 (en) | 2011-11-20 | 2012-01-04 | Glaxosmithkline Biolog Sa | Vaccine |
| GB201119999D0 (en) | 2011-11-20 | 2012-01-04 | Glaxosmithkline Biolog Sa | Vaccine |
| CN102553066B (zh) * | 2011-12-28 | 2013-07-17 | 上海交通大学 | 基于多孔微针结构的经皮给药系统 |
| BR112014026570B1 (pt) | 2012-04-25 | 2021-06-29 | Medrx Co., Ltd | Microagulha, arranjo de microagulha e dispositivo de microagulha |
| WO2013166162A1 (en) | 2012-05-01 | 2013-11-07 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Tip-loaded microneedle arrays for transdermal insertion |
| US20140200509A1 (en) * | 2012-06-29 | 2014-07-17 | Issac David Cohen | Dissolvable Microneedles Comprising One Or More Encapsulated Cosmetic Ingredients |
| EP2866608A4 (en) * | 2012-06-29 | 2016-07-06 | Elc Man Llc | MICRO NEEDLES COMPRISING ONE OR MORE COSMETIC INGREDIENTS |
| WO2014024026A1 (en) | 2012-08-06 | 2014-02-13 | Glaxosmithkline Biologicals S.A. | Method for eliciting in infants an immune response against rsv and b. pertussis |
| US20140037680A1 (en) | 2012-08-06 | 2014-02-06 | Glaxosmithkline Biologicals, S.A. | Novel method |
| JP5472771B1 (ja) | 2012-09-28 | 2014-04-16 | コスメディ製薬株式会社 | 段差に薬物を保持したマイクロニードル |
| MX375307B (es) | 2012-12-21 | 2025-03-06 | Corium Inc | Microarreglo para la entrega de agente terapeutico y metodos de uso. |
| EP2968887B1 (en) | 2013-03-12 | 2022-05-04 | Corium, Inc. | Microprojection applicators |
| EP2968116A1 (en) | 2013-03-15 | 2016-01-20 | Corium International, Inc. | Microarray with polymer-free microstructures, methods of making, and methods of use |
| AU2014237357B2 (en) | 2013-03-15 | 2019-11-28 | Corium Pharma Solutions, Inc. | Multiple impact microprojection applicators and methods of use |
| MX380204B (es) | 2013-03-15 | 2025-03-12 | Corium Inc | Micrordenamiento para suministro de agente terapeútico y métodos de uso. |
| US9750533B2 (en) * | 2013-04-12 | 2017-09-05 | L'oreal | Exfoliating head for a personal care appliance |
| WO2014196522A1 (ja) * | 2013-06-03 | 2014-12-11 | 凸版印刷株式会社 | 針状体の製造方法及び製造装置 |
| CN108785847B (zh) * | 2013-06-13 | 2020-10-20 | 微德米克斯公司 | 金属微针 |
| EP3030260A1 (en) | 2013-08-05 | 2016-06-15 | GlaxoSmithKline Biologicals S.A. | Combination immunogenic compositions |
| WO2015093452A1 (ja) | 2013-12-16 | 2015-06-25 | 武田薬品工業株式会社 | マイクロニードル |
| PL3122426T3 (pl) | 2014-03-28 | 2023-05-15 | Duke University | Leczenie raka sutka z zastosowaniem selektywnych modulatorów receptora estrogenowego |
| EP3127552B1 (en) * | 2014-04-04 | 2019-01-23 | FUJIFILM Corporation | Inactivated whole virion vaccine-containing microneedle array preparation and method for administering the same |
| CA2951430A1 (en) | 2014-06-13 | 2015-12-17 | Glaxosmithkline Biologicals Sa | Immunogenic combinations |
| US10624843B2 (en) | 2014-09-04 | 2020-04-21 | Corium, Inc. | Microstructure array, methods of making, and methods of use |
| KR101626053B1 (ko) * | 2014-09-19 | 2016-06-01 | 연세대학교 산학협력단 | 원터치 유체 채취용 디바이스 |
| WO2016123665A1 (en) | 2015-02-02 | 2016-08-11 | Vaxxas Pty Limited | Microprojection array applicator and method |
| WO2016149673A1 (en) | 2015-03-18 | 2016-09-22 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Bioactive components conjugated to substrates of microneedle arrays |
| MA41818A (fr) * | 2015-03-27 | 2018-01-30 | Leo Pharma As | Timbre à micro-aiguilles pour administration d'un principe actif à la peau |
| EP3280964B1 (en) | 2015-04-09 | 2019-02-13 | Boston Scientific Scimed Inc. | Method for drying coated medical devices |
| WO2016176665A1 (en) | 2015-04-29 | 2016-11-03 | Radius Health, Inc. | Methods of treating cancer |
| WO2017004067A1 (en) | 2015-06-29 | 2017-01-05 | Corium International, Inc. | Microarray for delivery of therapeutic agent, methods of use, and methods of making |
| CN105126243B (zh) * | 2015-09-06 | 2018-08-07 | 台州薇凯生物科技有限公司 | 微针注射弹及其制备方法和微针注射设备 |
| US11103259B2 (en) | 2015-09-18 | 2021-08-31 | Vaxxas Pty Limited | Microprojection arrays with microprojections having large surface area profiles |
| AU2016333148B2 (en) | 2015-09-28 | 2021-10-14 | Vaxxas Pty Limited | Microprojection arrays with enhanced skin penetrating properties and methods thereof |
| ES2909043T3 (es) * | 2015-10-09 | 2022-05-05 | Kindeva Drug Delivery Lp | Composiciones de zinc para sistemas de microagujas recubiertos |
| WO2017066768A1 (en) | 2015-10-16 | 2017-04-20 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Mullti-component biio-active drug delivery and controlled release to the skin by microneedle array devices |
| UA122353C2 (uk) * | 2015-12-28 | 2020-10-26 | Ендодерма Ко., Лтд. | Мікроструктура для трансдермальної абсорбції та спосіб її виробництва |
| KR101785930B1 (ko) * | 2015-12-30 | 2017-10-16 | 주식회사 쿼드메디슨 | 수분 환경에서 변형 및 변성 억제를 위한 마이크로 니들 및 그 제작 방법 |
| WO2017120322A1 (en) | 2016-01-05 | 2017-07-13 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Skin microenvironment targeted delivery for promoting immune and other responses |
| JP7034425B2 (ja) | 2016-04-15 | 2022-03-14 | エーディーエムバイオサイエンス インコーポレイテッド | 核酸フィルムの製造方法及び核酸フィルムを用いた薬物注入装置 |
| KR102510967B1 (ko) | 2016-12-07 | 2023-03-16 | 노오쓰웨스턴 유니버시티 | 마이크로제조 프로세스를 위한 액체 마스크 |
| US20190344062A1 (en) | 2016-12-28 | 2019-11-14 | Cosmed Pharmaceutical Co., Ltd. | Microneedle array coated with drug |
| EP4374925A3 (en) | 2017-01-05 | 2025-01-15 | Radius Pharmaceuticals, Inc. | Polymorphic forms of rad1901-2hcl |
| EP3586905B1 (en) * | 2017-02-24 | 2023-07-26 | Hisamitsu Pharmaceutical Co., Inc. | Method for producing microneedle device |
| WO2018155431A1 (ja) | 2017-02-24 | 2018-08-30 | 久光製薬株式会社 | マイクロニードルデバイス |
| CN110709250B (zh) | 2017-03-31 | 2022-10-11 | 瓦克萨斯私人有限公司 | 用于涂覆表面的设备和方法 |
| EP3639010B1 (en) | 2017-06-13 | 2025-08-06 | Vaxxas Pty Limited | Quality control of substrate coatings |
| EP3661587B1 (en) | 2017-08-04 | 2024-10-23 | Vaxxas Pty Limited | Compact high mechanical energy storage and low trigger force actuator for the delivery of microprojection array patches (map) |
| US11197666B2 (en) | 2017-09-15 | 2021-12-14 | Cilag Gmbh International | Surgical coated needles |
| KR102001305B1 (ko) * | 2017-09-29 | 2019-07-17 | 부산대학교 산학협력단 | 마이크로니들을 포함하는 패치 |
| KR102139335B1 (ko) | 2017-11-24 | 2020-07-29 | 주식회사 엘지생활건강 | 니들 팁에 코팅부를 보유하는 마이크로니들을 제조하는 방법 및 장치 |
| CN112423844B (zh) | 2018-07-04 | 2024-08-13 | 雷迪厄斯制药公司 | Rad1901-2hcl的多晶型形式 |
| CN108939283B (zh) * | 2018-07-16 | 2021-04-23 | 清华大学深圳研究生院 | 一种人体安全可降解的微针阵列及其制造方法和模具 |
| US20210346662A1 (en) | 2018-10-23 | 2021-11-11 | Kindeva Drug Delivery L.P. | Tamper evident transdermal patch |
| CN113272232B (zh) | 2019-01-07 | 2022-10-04 | 金德瓦药物控释有限公司 | 用于微阵列的包装 |
| CN119390714A (zh) | 2019-02-12 | 2025-02-07 | 雷迪厄斯制药公司 | 方法和化合物 |
| CN113874065A (zh) | 2019-05-16 | 2021-12-31 | 联邦高等教育系统匹兹堡大学 | 用于皮肤和非皮肤药物递送的具有底切特征的微针阵列 |
| US11964121B2 (en) | 2021-10-13 | 2024-04-23 | Satio, Inc. | Mono dose dermal patch for pharmaceutical delivery |
| US12178979B2 (en) | 2021-10-13 | 2024-12-31 | Satio, Inc. | Dermal patch for delivering a pharmaceutical |
| US12048543B2 (en) | 2021-11-08 | 2024-07-30 | Satio, Inc. | Dermal patch for collecting a physiological sample with removable vial |
| US12029562B2 (en) | 2021-04-14 | 2024-07-09 | Satio, Inc. | Dermal patch system |
| US12053284B2 (en) | 2021-11-08 | 2024-08-06 | Satio, Inc. | Dermal patch for collecting a physiological sample |
| US12023156B2 (en) | 2021-10-13 | 2024-07-02 | Satio, Inc. | Dermal patch for collecting a physiological sample |
| US11877848B2 (en) | 2021-11-08 | 2024-01-23 | Satio, Inc. | Dermal patch for collecting a physiological sample |
| US12214346B2 (en) | 2021-10-13 | 2025-02-04 | Satio, Inc. | Dermal patch with a diagnostic test strip |
| US20220331572A1 (en) * | 2021-04-19 | 2022-10-20 | Tohoku University | Microneedle, microneedle array, and production method of microneedle |
| JP2023043192A (ja) | 2021-09-15 | 2023-03-28 | コスメディ製薬株式会社 | 薬剤を塗布したマイクロニードルアレイ |
| CN114950904B (zh) * | 2022-03-27 | 2023-08-29 | 灏曦(天津)生物技术有限公司 | 一种制作银纳米粒子包覆注射用硅基微针头的方法 |
Family Cites Families (94)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| USRE25637E (en) | 1964-09-08 | Means for vaccinating | ||
| US2619962A (en) | 1948-02-19 | 1952-12-02 | Res Foundation | Vaccination appliance |
| US3072122A (en) | 1959-01-15 | 1963-01-08 | Rosenthal Sol Roy | Package for transcutaneous injection |
| US3136314A (en) | 1960-08-01 | 1964-06-09 | Kravitz Harvey | Vaccinating devices |
| US3221740A (en) | 1962-08-31 | 1965-12-07 | Rosenthal Sol Roy | Injection device |
| US3466131A (en) | 1967-09-07 | 1969-09-09 | Becton Dickinson Co | Dispensing applicator package |
| US3675766A (en) | 1970-02-04 | 1972-07-11 | Sol Roy Rosenthal | Multiple puncture injector device |
| US3688764A (en) | 1970-08-20 | 1972-09-05 | Bard Hamilton Co Inc | Intracutaneous injection system |
| US3964482A (en) | 1971-05-17 | 1976-06-22 | Alza Corporation | Drug delivery device |
| US3678150A (en) | 1971-07-27 | 1972-07-18 | American Cyanamid Co | Process for improving the stability of ppd, qt and histoplasmin on tine applicators |
| US4473083A (en) | 1981-12-14 | 1984-09-25 | Maganias Nicholas H | Device and method for allergy testing |
| US4474751A (en) | 1983-05-16 | 1984-10-02 | Merck & Co., Inc. | Ophthalmic drug delivery system utilizing thermosetting gels |
| US4921475A (en) | 1983-08-18 | 1990-05-01 | Drug Delivery Systems Inc. | Transdermal drug patch with microtubes |
| US5192535A (en) | 1988-02-08 | 1993-03-09 | Insite Vision Incorporated | Ophthalmic suspensions |
| EP0429842B1 (en) | 1989-10-27 | 1996-08-28 | Korea Research Institute Of Chemical Technology | Device for the transdermal administration of protein or peptide drug |
| US5279544A (en) | 1990-12-13 | 1994-01-18 | Sil Medics Ltd. | Transdermal or interdermal drug delivery devices |
| US5402798A (en) | 1991-07-18 | 1995-04-04 | Swierczek; Remi | Disposable skin perforator and blood testing device |
| US5340572A (en) | 1993-02-08 | 1994-08-23 | Insite Vision Incorporated | Alkaline ophthalmic suspensions |
| US5440446A (en) | 1993-10-04 | 1995-08-08 | Catalina Coatings, Inc. | Acrylate coating material |
| CA2149943C (en) | 1994-05-23 | 1999-07-13 | Kwang Kyun Jang | Skin perforating device for transdermal medication |
| WO1996010630A1 (en) | 1994-09-30 | 1996-04-11 | Rutgers, The State University | Direct introduction of foreign materials into cells |
| AU5869796A (en) | 1995-05-22 | 1996-12-11 | Ned A. Godshall | Micromechanical patch for enhancing the delivery of compound s through the skin |
| WO1996037155A1 (en) | 1995-05-22 | 1996-11-28 | Silicon Microdevices, Inc. | Micromechanical device and method for enhancing delivery of compounds through the skin |
| DE19525607A1 (de) | 1995-07-14 | 1997-01-16 | Boehringer Ingelheim Kg | Transcorneales Arzneimittelfreigabesystem |
| ATE234129T1 (de) | 1996-06-18 | 2003-03-15 | Alza Corp | Vorrichtung zur verbesserung der transdermalen verabreichung von medikamenten oder der abnahme von körperflüssigkeiten |
| ATE231015T1 (de) | 1996-09-17 | 2003-02-15 | Deka Products Lp | System zur medikamentenabgabe durch transport |
| US6797276B1 (en) | 1996-11-14 | 2004-09-28 | The United States Of America As Represented By The Secretary Of The Army | Use of penetration enhancers and barrier disruption agents to enhance the transcutaneous immune response |
| US6171276B1 (en) | 1997-08-06 | 2001-01-09 | Pharmacia & Upjohn Ab | Automated delivery device and method for its operation |
| DE69839969D1 (de) | 1997-12-11 | 2008-10-16 | Alza Corp | Vorrichtung zur verbesserung des transdermalen flusses von medikamenten |
| WO1999029364A1 (en) | 1997-12-11 | 1999-06-17 | Alza Corporation | Device for enhancing transdermal agent flux |
| US6091975A (en) | 1998-04-01 | 2000-07-18 | Alza Corporation | Minimally invasive detecting device |
| CA2229522A1 (en) | 1998-04-15 | 1999-10-15 | Thomas Randall Inkpen | Needle aid |
| JP2002517300A (ja) | 1998-06-10 | 2002-06-18 | ジョージア テック リサーチ コーポレイション | 微小針デバイスおよび製造方法ならびにそれらの使用 |
| US6503231B1 (en) | 1998-06-10 | 2003-01-07 | Georgia Tech Research Corporation | Microneedle device for transport of molecules across tissue |
| JP2000025224A (ja) * | 1998-07-08 | 2000-01-25 | Brother Ind Ltd | 液体吐出装置及び液体吐出装置製造方法 |
| WO2000012173A1 (en) | 1998-08-31 | 2000-03-09 | Johnson & Johnson Consumer Companies, Inc. | Electrotransport device comprising blades |
| EP1163024B1 (en) * | 1999-01-28 | 2003-12-17 | Cyto Pulse Sciences, Inc. | Delivery of macromolecules into cells |
| US6713291B2 (en) | 1999-01-28 | 2004-03-30 | Alan D. King | Electrodes coated with treating agent and uses thereof |
| TW480759B (en) * | 1999-03-18 | 2002-03-21 | Seiko Epson Corp | Electronic machine, charged electronic machine and control method of electronic machine |
| US6743211B1 (en) | 1999-11-23 | 2004-06-01 | Georgia Tech Research Corporation | Devices and methods for enhanced microneedle penetration of biological barriers |
| US6611707B1 (en) | 1999-06-04 | 2003-08-26 | Georgia Tech Research Corporation | Microneedle drug delivery device |
| US6256533B1 (en) | 1999-06-09 | 2001-07-03 | The Procter & Gamble Company | Apparatus and method for using an intracutaneous microneedle array |
| US6312612B1 (en) | 1999-06-09 | 2001-11-06 | The Procter & Gamble Company | Apparatus and method for manufacturing an intracutaneous microneedle array |
| US6379324B1 (en) | 1999-06-09 | 2002-04-30 | The Procter & Gamble Company | Intracutaneous microneedle array apparatus |
| GB9919737D0 (en) | 1999-08-21 | 1999-10-20 | Printable Field Emitters Limit | Field emitters and devices |
| US6623457B1 (en) | 1999-09-22 | 2003-09-23 | Becton, Dickinson And Company | Method and apparatus for the transdermal administration of a substance |
| US20020095134A1 (en) | 1999-10-14 | 2002-07-18 | Pettis Ronald J. | Method for altering drug pharmacokinetics based on medical delivery platform |
| WO2001036037A2 (en) | 1999-11-15 | 2001-05-25 | Velcro Industries B.V. | Skin attachment member |
| US6881538B1 (en) | 2000-03-05 | 2005-04-19 | 3M Innovative Properties Company | Array comprising diamond-like glass film |
| US6595947B1 (en) | 2000-05-22 | 2003-07-22 | Becton, Dickinson And Company | Topical delivery of vaccines |
| AU2001265056A1 (en) * | 2000-05-26 | 2001-12-11 | The Procter And Gamble Company | Microneedle apparatus used for marking skin and for dispensing semi-permanent subcutaneous makeup |
| US7473244B2 (en) | 2000-06-02 | 2009-01-06 | The University Of Utah Research Foundation | Active needle devices with integrated functionality |
| US6537242B1 (en) | 2000-06-06 | 2003-03-25 | Becton, Dickinson And Company | Method and apparatus for enhancing penetration of a member for the intradermal sampling or administration of a substance |
| US6589202B1 (en) | 2000-06-29 | 2003-07-08 | Becton Dickinson And Company | Method and apparatus for transdermally sampling or administering a substance to a patient |
| US6440096B1 (en) | 2000-07-14 | 2002-08-27 | Becton, Dickinson And Co. | Microdevice and method of manufacturing a microdevice |
| US6656147B1 (en) | 2000-07-17 | 2003-12-02 | Becton, Dickinson And Company | Method and delivery device for the transdermal administration of a substance |
| GB0017999D0 (en) * | 2000-07-21 | 2000-09-13 | Smithkline Beecham Biolog | Novel device |
| US6749575B2 (en) | 2001-08-20 | 2004-06-15 | Alza Corporation | Method for transdermal nucleic acid sampling |
| ES2290166T3 (es) | 2000-09-08 | 2008-02-16 | Alza Corporation | Dispositivo transdermico. |
| ATE416692T1 (de) | 2000-10-13 | 2008-12-15 | Alza Corp | Mikronadelelementhalter für schlagapplikator |
| MXPA03003301A (es) | 2000-10-13 | 2004-12-13 | Johnson & Johnson | Aplicador de un conjunto de microsalientes mediante impacto. |
| US7131987B2 (en) | 2000-10-16 | 2006-11-07 | Corium International, Inc. | Microstructures and method for treating and conditioning skin which cause less irritation during exfoliation |
| RU2282468C2 (ru) | 2000-10-26 | 2006-08-27 | Алза Корпорейшн | Устройство для трансдермальной доставки лекарственных средств, имеющее микровыступы с покрытием |
| WO2002055128A2 (en) | 2000-11-30 | 2002-07-18 | Biovalve Technologies Inc | Fluid delivery and measurement systems and methods |
| EP1345646A2 (en) | 2000-12-14 | 2003-09-24 | Georgia Tech Research Corporation | Microneedle devices and production thereof |
| WO2002074173A1 (en) * | 2001-03-16 | 2002-09-26 | Alza Corporation | Method and apparatus for coating skin piercing microprojections |
| US20020193729A1 (en) | 2001-04-20 | 2002-12-19 | Cormier Michel J.N. | Microprojection array immunization patch and method |
| CA2444883A1 (en) | 2001-04-20 | 2002-10-31 | Alza Corporation | Microprojection array having a beneficial agent containing coating |
| US6591124B2 (en) | 2001-05-11 | 2003-07-08 | The Procter & Gamble Company | Portable interstitial fluid monitoring system |
| WO2003002069A2 (en) | 2001-06-29 | 2003-01-09 | Becton, Dickinson And Company | Intradermal delivery of vaccines and gene therapeutic agents via microcannula |
| US6881203B2 (en) | 2001-09-05 | 2005-04-19 | 3M Innovative Properties Company | Microneedle arrays and methods of manufacturing the same |
| US6689100B2 (en) | 2001-10-05 | 2004-02-10 | Becton, Dickinson And Company | Microdevice and method of delivering or withdrawing a substance through the skin of an animal |
| US7429258B2 (en) | 2001-10-26 | 2008-09-30 | Massachusetts Institute Of Technology | Microneedle transport device |
| US6908453B2 (en) | 2002-01-15 | 2005-06-21 | 3M Innovative Properties Company | Microneedle devices and methods of manufacture |
| AU2003225735A1 (en) | 2002-03-11 | 2003-09-29 | Altea Therapeutics Corporation | Transdermal drug delivery patch system, method of making same and method of using same |
| US6780171B2 (en) | 2002-04-02 | 2004-08-24 | Becton, Dickinson And Company | Intradermal delivery device |
| US7115108B2 (en) | 2002-04-02 | 2006-10-03 | Becton, Dickinson And Company | Method and device for intradermally delivering a substance |
| WO2003092785A1 (en) | 2002-04-30 | 2003-11-13 | Morteza Shirkhanzadeh | Arrays of microneedles comprising porous calcium phosphate coating and bioactive agents |
| MXPA05000597A (es) | 2002-07-19 | 2005-04-28 | 3M Innovative Properties Co | Dispositivos de microaguja y aparatos de administracion por microaguja. |
| ES2720098T3 (es) | 2002-07-22 | 2019-07-17 | Becton Dickinson Co | Dispositivo de infusión similar a un parche |
| EP3075410B1 (en) | 2002-08-29 | 2017-10-25 | Becton, Dickinson and Company | Microprotrusion arrays and methods for using same to deliver substances into tissue |
| WO2004033021A1 (en) | 2002-10-07 | 2004-04-22 | Biovalve Technologies, Inc. | Microneedle array patch |
| JP2007521092A (ja) | 2003-07-02 | 2007-08-02 | アルザ・コーポレーシヨン | 小突起アレイの免疫化パッチおよび方法 |
| BRPI0413360A (pt) | 2003-08-04 | 2006-10-10 | Alza Corp | método e dispositivo para aumentar o fluxo de agentes transdérmicos |
| BRPI0413539B8 (pt) | 2003-08-12 | 2021-06-22 | Becton Dickinson Co | dispositivo para distribuir medicamento para o corpo de um paciente por injeção |
| US8353861B2 (en) | 2003-09-18 | 2013-01-15 | Texmac, Inc. | Applicator for applying functional substances into human skin |
| AU2004285484A1 (en) | 2003-10-24 | 2005-05-12 | Alza Corporation | Pretreatment method and system for enhancing transdermal drug delivery |
| US20050089554A1 (en) | 2003-10-24 | 2005-04-28 | Cormier Michel J. | Apparatus and method for enhancing transdermal drug delivery |
| BRPI0415967A (pt) | 2003-10-28 | 2007-01-23 | Alza Corp | aplicação de conjugados de polìmero de peptìdeos e proteìnas terapêuticos através de microprojeções revestidas |
| KR20070011252A (ko) | 2003-11-21 | 2007-01-24 | 알자 코포레이션 | 초음파 보조 경피 백신전달방법 및 시스템 |
| CA2547382A1 (en) | 2003-11-28 | 2005-06-09 | Acrux Dds Pty Ltd. | Method and system for rapid transdermal administration |
| WO2005058393A2 (en) | 2003-12-18 | 2005-06-30 | Novo Nordisk A/S | Nozzle device with skin stretching means |
| EP1706171A1 (en) | 2003-12-29 | 2006-10-04 | 3M Innovative Properties Company | Medical devices and kits including same |
| JP2007523771A (ja) | 2004-02-23 | 2007-08-23 | スリーエム イノベイティブ プロパティズ カンパニー | マイクロニードルアレイの成形方法 |
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2005
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- 2005-11-18 US US11/718,737 patent/US7846488B2/en active Active
- 2005-11-18 KR KR1020077013490A patent/KR101224257B1/ko not_active Expired - Fee Related
- 2005-11-18 WO PCT/US2005/041858 patent/WO2006055799A1/en not_active Ceased
- 2005-11-18 EP EP05824900.4A patent/EP1827564B1/en not_active Expired - Lifetime
- 2005-11-18 CA CA2588080A patent/CA2588080C/en not_active Expired - Fee Related
- 2005-11-18 JP JP2007543281A patent/JP4927751B2/ja not_active Expired - Fee Related
- 2005-11-18 AU AU2005306426A patent/AU2005306426B2/en not_active Ceased
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2007
- 2007-05-15 IL IL183205A patent/IL183205A0/en not_active IP Right Cessation
Also Published As
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|---|---|
| AU2005306426A1 (en) | 2006-05-26 |
| EP1827564B1 (en) | 2015-07-29 |
| WO2006055799A1 (en) | 2006-05-26 |
| CN101102809B (zh) | 2010-05-26 |
| KR20070086221A (ko) | 2007-08-27 |
| US7846488B2 (en) | 2010-12-07 |
| CN101102809A (zh) | 2008-01-09 |
| US20080102192A1 (en) | 2008-05-01 |
| KR101224257B1 (ko) | 2013-01-18 |
| EP1827564A1 (en) | 2007-09-05 |
| AU2005306426B2 (en) | 2011-04-28 |
| JP4927751B2 (ja) | 2012-05-09 |
| JP2008520370A (ja) | 2008-06-19 |
| IL183205A0 (en) | 2007-08-19 |
| CA2588080A1 (en) | 2006-05-26 |
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