JP4927751B2 - マイクロニードルアレイのコーティング方法 - Google Patents

マイクロニードルアレイのコーティング方法 Download PDF

Info

Publication number
JP4927751B2
JP4927751B2 JP2007543281A JP2007543281A JP4927751B2 JP 4927751 B2 JP4927751 B2 JP 4927751B2 JP 2007543281 A JP2007543281 A JP 2007543281A JP 2007543281 A JP2007543281 A JP 2007543281A JP 4927751 B2 JP4927751 B2 JP 4927751B2
Authority
JP
Japan
Prior art keywords
array
coating
microneedle
fluid
masking
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2007543281A
Other languages
English (en)
Japanese (ja)
Other versions
JP2008520370A (ja
JP2008520370A5 (enExample
Inventor
アール． ジョンソン，ピーター
アール． エメリー，マーラ
ティー． ウォルター，ジェイムズ
イー． レーダー−デベンス，ジェニファー
シー． デュアン，ダニエル
エム． デイビッド，モーゼス
チョイ，ヒェ−オク
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
3M Innovative Properties Co
Original Assignee
3M Innovative Properties Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 3M Innovative Properties Co filed Critical 3M Innovative Properties Co
Publication of JP2008520370A publication Critical patent/JP2008520370A/ja
Publication of JP2008520370A5 publication Critical patent/JP2008520370A5/ja
Application granted granted Critical
Publication of JP4927751B2 publication Critical patent/JP4927751B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0046—Solid microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0053—Methods for producing microneedles

Landscapes

  • Health & Medical Sciences (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Anesthesiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Medical Informatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Application Of Or Painting With Fluid Materials (AREA)
JP2007543281A 2004-11-18 2005-11-18 マイクロニードルアレイのコーティング方法 Expired - Fee Related JP4927751B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US62920904P 2004-11-18 2004-11-18
US60/629,209 2004-11-18
PCT/US2005/041858 WO2006055799A1 (en) 2004-11-18 2005-11-18 Masking method for coating a microneedle array

Publications (3)

Publication Number Publication Date
JP2008520370A JP2008520370A (ja) 2008-06-19
JP2008520370A5 JP2008520370A5 (enExample) 2009-01-15
JP4927751B2 true JP4927751B2 (ja) 2012-05-09

Family

ID=36013286

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2007543281A Expired - Fee Related JP4927751B2 (ja) 2004-11-18 2005-11-18 マイクロニードルアレイのコーティング方法

Country Status (9)

Country Link
US (1) US7846488B2 (enExample)
EP (1) EP1827564B1 (enExample)
JP (1) JP4927751B2 (enExample)
KR (1) KR101224257B1 (enExample)
CN (1) CN101102809B (enExample)
AU (1) AU2005306426B2 (enExample)
CA (1) CA2588080C (enExample)
IL (1) IL183205A0 (enExample)
WO (1) WO2006055799A1 (enExample)

Families Citing this family (113)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0402131D0 (en) 2004-01-30 2004-03-03 Isis Innovation Delivery method
WO2006138719A2 (en) 2005-06-17 2006-12-28 Georgia Tech Research Corporation Coated microstructures and method of manufacture thereof
CA2614927A1 (en) * 2005-07-25 2007-02-01 Nanotechnology Victoria Pty Ltd Microarray device
EP1948139A4 (en) 2005-11-18 2012-04-04 3M Innovative Properties Co COATING COMPOSITIONS, COATINGS DERIVED THEREFROM, AND MICRO-NETWORKS COMPRISING SUCH COATINGS
EP1957145A4 (en) 2005-11-30 2011-03-23 3M Innovative Properties Co MICRONADEL ASSEMBLIES AND APPLICATION METHOD
WO2007116959A1 (ja) * 2006-04-07 2007-10-18 Hisamitsu Pharmaceutical Co., Inc. マイクロニードルデバイスおよびマイクロニードル付き経皮薬物投与装置
US8574315B2 (en) * 2006-05-09 2013-11-05 The University Of Akron Electrospun structures and methods for forming and using same
US20080138581A1 (en) * 2006-07-17 2008-06-12 Rajmohan Bhandari Masking high-aspect aspect ratio structures
US7951300B2 (en) * 2006-07-17 2011-05-31 University Of Utah Research Foundation Water-scale needle array
US8865288B2 (en) * 2006-07-17 2014-10-21 University Of Utah Research Foundation Micro-needle arrays having non-planar tips and methods of manufacture thereof
WO2008033199A1 (en) * 2006-09-12 2008-03-20 Boston Scientific Limited Liquid masking for selective coating of a stent
US9114238B2 (en) 2007-04-16 2015-08-25 Corium International, Inc. Solvent-cast microprotrusion arrays containing active ingredient
JP5298011B2 (ja) 2007-05-15 2013-09-25 久光製薬株式会社 マイクロニードルのコーティング方法
US20090017210A1 (en) * 2007-07-09 2009-01-15 Andrianov Alexander K Methods and systems for coating a microneedle with a dosage of a biologically active compound
EP2178585B1 (en) * 2007-08-14 2021-04-07 Fred Hutchinson Cancer Research Center Needle array assembly and method for delivering therapeutic agents
EP2213284B1 (en) * 2007-11-21 2017-11-15 BioSerenTach Co., Ltd. Preparation for application to body surface and preparation holding sheet for application to body surface
WO2009079712A1 (en) * 2007-12-24 2009-07-02 The University Of Queensland Coating method
CN102007066B (zh) 2008-02-07 2013-06-26 昆士兰大学 贴片制造
US20090301994A1 (en) * 2008-05-12 2009-12-10 Rajmohan Bhandari Methods for Wafer Scale Processing of Needle Array Devices
CA2760680A1 (en) 2008-05-23 2009-11-26 The University Of Queensland Analyte detection by microneedle patch with analyte selective reagents
WO2009149197A2 (en) 2008-06-03 2009-12-10 University Of Utah Research Foundation High aspect ratio microelectrode arrays enabled to have customizable lengths and methods of making the same
JP5902390B2 (ja) * 2008-12-26 2016-04-13 久光製薬株式会社 マイクロニードルデバイス
CN102300601A (zh) * 2009-01-30 2011-12-28 久光制药株式会社 微针装置
CA2759850C (en) * 2009-04-24 2019-10-22 Corium International, Inc. Methods for manufacturing microprojection arrays
US8834423B2 (en) 2009-10-23 2014-09-16 University of Pittsburgh—of the Commonwealth System of Higher Education Dissolvable microneedle arrays for transdermal delivery to human skin
US9259219B2 (en) 2009-11-09 2016-02-16 Ethicon, Llc Surgical needle coatings and methods
US9221075B2 (en) * 2009-11-09 2015-12-29 Ethicon, Inc. Surgical needle coatings and methods
US9332982B2 (en) * 2009-11-09 2016-05-10 Ethicon, Llc Surgical needle coatings and methods
US20110144591A1 (en) * 2009-12-11 2011-06-16 Ross Russell F Transdermal Delivery Device
US8956685B2 (en) * 2010-02-24 2015-02-17 Monosol Rx, Llc Use of dams to improve yield in film processing
CA2796965C (en) 2010-04-28 2019-04-16 Kimberly-Clark Worldwide, Inc. Method for increasing permeability of an epithelial barrier
RU2585138C2 (ru) * 2010-04-28 2016-05-27 Кимберли-Кларк Ворлдвайд, Инк. Медицинские устройства для доставки кирнк
PT2563450T (pt) * 2010-04-28 2017-08-28 Kimberly Clark Co Dispositivo para entrega de medicação para a artrite reumatóide
US10245421B2 (en) 2010-04-28 2019-04-02 Sorrento Therapeutics, Inc. Nanopatterned medical device with enhanced cellular interaction
US9687641B2 (en) 2010-05-04 2017-06-27 Corium International, Inc. Method and device for transdermal delivery of parathyroid hormone using a microprojection array
WO2012006677A1 (en) 2010-07-14 2012-01-19 The University Of Queensland Patch applying apparatus
US8696637B2 (en) 2011-02-28 2014-04-15 Kimberly-Clark Worldwide Transdermal patch containing microneedles
US8636696B2 (en) 2011-06-10 2014-01-28 Kimberly-Clark Worldwide, Inc. Transdermal device containing microneedles
KR101314091B1 (ko) * 2011-07-26 2013-10-04 연세대학교 산학협력단 치료 부위내 경피 유전자 전달을 위한 일렉트로 마이크로니들 집적체 및 이의 제조방법
NL2007382C2 (en) * 2011-09-09 2013-03-12 Univ Leiden Method to coat an active agent to a surface.
EP2765927B1 (en) 2011-10-12 2021-02-24 Vaxxas Pty Limited Delivery device
EP3542851B1 (en) 2011-10-27 2021-12-15 Sorrento Therapeutics, Inc. Implantable devices for delivery of bioactive agents
US20170246439A9 (en) 2011-10-27 2017-08-31 Kimberly-Clark Worldwide, Inc. Increased Bioavailability of Transdermally Delivered Agents
CN104039382B (zh) 2011-10-27 2018-01-12 金伯利-克拉克环球有限公司 高粘度生物活性剂的经皮递送
AU2012328457A1 (en) 2011-10-28 2014-04-24 Presage Biosciences, Inc. Methods for drug delivery
GB201120000D0 (en) 2011-11-20 2012-01-04 Glaxosmithkline Biolog Sa Vaccine
GB201119999D0 (en) 2011-11-20 2012-01-04 Glaxosmithkline Biolog Sa Vaccine
CN102553066B (zh) * 2011-12-28 2013-07-17 上海交通大学 基于多孔微针结构的经皮给药系统
CN104321105B (zh) 2012-04-25 2016-11-23 株式会社梅德雷克斯 微针和微针阵列
HK1209658A1 (en) 2012-05-01 2016-04-08 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Tip-loaded microneedle arrays for transdermal insertion
EP2866608A4 (en) * 2012-06-29 2016-07-06 Elc Man Llc MICRO NEEDLES COMPRISING ONE OR MORE COSMETIC INGREDIENTS
JP2015521910A (ja) * 2012-06-29 2015-08-03 イーエルシー マネージメント エルエルシー １つ以上の封入された化粧品成分を含む可溶性マイクロニードル
US20140037680A1 (en) 2012-08-06 2014-02-06 Glaxosmithkline Biologicals, S.A. Novel method
JP2015525794A (ja) 2012-08-06 2015-09-07 グラクソスミスクライン バイオロジカルズ ソシエテ アノニム 乳児においてｒｓｖ及び百日咳菌に対する免疫応答を惹起するための方法
JP5472771B1 (ja) 2012-09-28 2014-04-16 コスメディ製薬株式会社 段差に薬物を保持したマイクロニードル
JP6865524B2 (ja) 2012-12-21 2021-04-28 コリウム， インコーポレイテッド 治療剤を送達するためのマイクロアレイおよび使用方法
JP6487899B2 (ja) 2013-03-12 2019-03-20 コリウム インターナショナル， インコーポレイテッド 微小突起アプリケータ
EP2968118B1 (en) 2013-03-15 2022-02-09 Corium, Inc. Microarray for delivery of therapeutic agent and methods of use
WO2014150285A2 (en) 2013-03-15 2014-09-25 Corium International, Inc. Multiple impact microprojection applicators and methods of use
AU2014237279B2 (en) 2013-03-15 2018-11-22 Corium Pharma Solutions, Inc. Microarray with polymer-free microstructures, methods of making, and methods of use
US9750533B2 (en) * 2013-04-12 2017-09-05 L'oreal Exfoliating head for a personal care appliance
WO2014196522A1 (ja) * 2013-06-03 2014-12-11 凸版印刷株式会社 針状体の製造方法及び製造装置
KR20160019944A (ko) * 2013-06-13 2016-02-22 마이크로데믹스 인코퍼레이티드 금속 마이크로니들
CA2919773A1 (en) 2013-08-05 2015-02-12 Glaxosmithkline Biologicals S.A. Combination immunogenic compositions
US20160310412A1 (en) 2013-12-16 2016-10-27 Takeda Pharmaceutical Company Limited Microneedle
PT3122426T (pt) 2014-03-28 2023-02-28 Univ Duke Tratamento de cancro da mama utilizando moduladores seletivos do recetor de estrogénio
EP3127552B1 (en) 2014-04-04 2019-01-23 FUJIFILM Corporation Inactivated whole virion vaccine-containing microneedle array preparation and method for administering the same
CN106659777A (zh) 2014-06-13 2017-05-10 葛兰素史密丝克莱恩生物有限公司 免疫原性组合产品
EP3188714A1 (en) 2014-09-04 2017-07-12 Corium International, Inc. Microstructure array, methods of making, and methods of use
KR101626053B1 (ko) * 2014-09-19 2016-06-01 연세대학교 산학협력단 원터치 유체 채취용 디바이스
EP4218892A1 (en) 2015-02-02 2023-08-02 Vaxxas Pty Limited Microprojection array applicator
WO2016149673A1 (en) 2015-03-18 2016-09-22 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Bioactive components conjugated to substrates of microneedle arrays
MA41818A (fr) * 2015-03-27 2018-01-30 Leo Pharma As Timbre à micro-aiguilles pour administration d'un principe actif à la peau
WO2016164749A1 (en) 2015-04-09 2016-10-13 Boston Scientific Scimed, Inc. Coated medical devices and methods for drying coated medical devices
EP3288383A4 (en) 2015-04-29 2019-01-23 Radius Pharmaceuticals, Inc. METHOD FOR THE TREATMENT OF CANCER
WO2017004067A1 (en) 2015-06-29 2017-01-05 Corium International, Inc. Microarray for delivery of therapeutic agent, methods of use, and methods of making
CN105126243B (zh) * 2015-09-06 2018-08-07 台州薇凯生物科技有限公司 微针注射弹及其制备方法和微针注射设备
US11103259B2 (en) 2015-09-18 2021-08-31 Vaxxas Pty Limited Microprojection arrays with microprojections having large surface area profiles
AU2016333148B2 (en) 2015-09-28 2021-10-14 Vaxxas Pty Limited Microprojection arrays with enhanced skin penetrating properties and methods thereof
US10695289B2 (en) * 2015-10-09 2020-06-30 3M Innovative Properties Company Zinc compositions for coated microneedle arrays
WO2017066768A1 (en) 2015-10-16 2017-04-20 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Mullti-component biio-active drug delivery and controlled release to the skin by microneedle array devices
WO2017116076A1 (ko) * 2015-12-28 2017-07-06 주식회사 엔도더마 경피 흡수용 마이크로구조체 및 이의 제조방법
KR101785930B1 (ko) * 2015-12-30 2017-10-16 주식회사 쿼드메디슨 수분 환경에서 변형 및 변성 억제를 위한 마이크로 니들 및 그 제작 방법
US11744889B2 (en) 2016-01-05 2023-09-05 University of Pittsburgh—of the Commonwealth System of Higher Education Skin microenvironment targeted delivery for promoting immune and other responses
WO2017179956A2 (ko) 2016-04-15 2017-10-19 한국기계연구원 핵산필름의 제조방법과 핵산필름을 이용한 약물주입장치
EP3552027B1 (en) 2016-12-07 2023-05-03 Northwestern University Liquid masks for microfabrication processes
CN110035792A (zh) 2016-12-28 2019-07-19 考司美德制药株式会社 涂布含药成分的微针制剂
ES2981967T3 (es) 2017-01-05 2024-10-14 Radius Pharmaceuticals Inc Formas polimórficas de RAD1901-2HCl
EP3586905B1 (en) * 2017-02-24 2023-07-26 Hisamitsu Pharmaceutical Co., Inc. Method for producing microneedle device
US11464956B2 (en) 2017-02-24 2022-10-11 Hisamitsu Pharmaceutical Co., Inc. Microneedle device
CN115923337A (zh) 2017-03-31 2023-04-07 瓦克萨斯私人有限公司 用于涂覆表面的设备和方法
WO2018227246A1 (en) 2017-06-13 2018-12-20 Vaxxas Pty Limited Quality control of substrate coatings
US11464957B2 (en) 2017-08-04 2022-10-11 Vaxxas Pty Limited Compact high mechanical energy storage and low trigger force actuator for the delivery of microprojection array patches (MAP)
US11197666B2 (en) 2017-09-15 2021-12-14 Cilag Gmbh International Surgical coated needles
KR102001305B1 (ko) * 2017-09-29 2019-07-17 부산대학교 산학협력단 마이크로니들을 포함하는 패치
KR102139335B1 (ko) * 2017-11-24 2020-07-29 주식회사 엘지생활건강 니들 팁에 코팅부를 보유하는 마이크로니들을 제조하는 방법 및 장치
JP7473486B2 (ja) 2018-07-04 2024-04-23 ラジウス ファーマシューティカルズ，インコーポレイテッド Ｒａｄ１９０１－２ｈｃｌの多形形態
CN108939283B (zh) * 2018-07-16 2021-04-23 清华大学深圳研究生院 一种人体安全可降解的微针阵列及其制造方法和模具
EP3870262A1 (en) 2018-10-23 2021-09-01 Kindeva Drug Delivery L.P. Tamper evident transdermal patch
US11577900B2 (en) 2019-01-07 2023-02-14 Kindeva Drug Delivery L.P. Packaging for microarrays
JOP20210218A1 (ar) 2019-02-12 2023-01-30 Radius Pharmaceuticals Inc عمليات ومركبات
WO2020232394A1 (en) 2019-05-16 2020-11-19 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Microneedle arrays with undercut features for cutaneous and non-cutaneous drug delivery
US11877848B2 (en) 2021-11-08 2024-01-23 Satio, Inc. Dermal patch for collecting a physiological sample
US12053284B2 (en) 2021-11-08 2024-08-06 Satio, Inc. Dermal patch for collecting a physiological sample
US12178979B2 (en) 2021-10-13 2024-12-31 Satio, Inc. Dermal patch for delivering a pharmaceutical
US12214346B2 (en) 2021-10-13 2025-02-04 Satio, Inc. Dermal patch with a diagnostic test strip
US12023156B2 (en) 2021-10-13 2024-07-02 Satio, Inc. Dermal patch for collecting a physiological sample
US12048543B2 (en) 2021-11-08 2024-07-30 Satio, Inc. Dermal patch for collecting a physiological sample with removable vial
US11452474B1 (en) 2021-04-14 2022-09-27 Satio, Inc. Dual lever dermal patch system
US11964121B2 (en) 2021-10-13 2024-04-23 Satio, Inc. Mono dose dermal patch for pharmaceutical delivery
US20220331572A1 (en) * 2021-04-19 2022-10-20 Tohoku University Microneedle, microneedle array, and production method of microneedle
KR20240054293A (ko) 2021-09-15 2024-04-25 코스메드 파마소티컬 씨오 쩜 엘티디 약제를 도포한 마이크로니들 어레이
CN114950904B (zh) * 2022-03-27 2023-08-29 灏曦(天津)生物技术有限公司 一种制作银纳米粒子包覆注射用硅基微针头的方法

Family Cites Families (94)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE25637E (en) 1964-09-08 Means for vaccinating
US2619962A (en) 1948-02-19 1952-12-02 Res Foundation Vaccination appliance
US3072122A (en) 1959-01-15 1963-01-08 Rosenthal Sol Roy Package for transcutaneous injection
US3136314A (en) 1960-08-01 1964-06-09 Kravitz Harvey Vaccinating devices
US3221740A (en) 1962-08-31 1965-12-07 Rosenthal Sol Roy Injection device
US3466131A (en) 1967-09-07 1969-09-09 Becton Dickinson Co Dispensing applicator package
US3675766A (en) 1970-02-04 1972-07-11 Sol Roy Rosenthal Multiple puncture injector device
US3688764A (en) 1970-08-20 1972-09-05 Bard Hamilton Co Inc Intracutaneous injection system
US3964482A (en) 1971-05-17 1976-06-22 Alza Corporation Drug delivery device
US3678150A (en) 1971-07-27 1972-07-18 American Cyanamid Co Process for improving the stability of ppd, qt and histoplasmin on tine applicators
US4473083A (en) 1981-12-14 1984-09-25 Maganias Nicholas H Device and method for allergy testing
US4474751A (en) 1983-05-16 1984-10-02 Merck & Co., Inc. Ophthalmic drug delivery system utilizing thermosetting gels
US4921475A (en) 1983-08-18 1990-05-01 Drug Delivery Systems Inc. Transdermal drug patch with microtubes
US5192535A (en) 1988-02-08 1993-03-09 Insite Vision Incorporated Ophthalmic suspensions
EP0429842B1 (en) 1989-10-27 1996-08-28 Korea Research Institute Of Chemical Technology Device for the transdermal administration of protein or peptide drug
US5279544A (en) 1990-12-13 1994-01-18 Sil Medics Ltd. Transdermal or interdermal drug delivery devices
US5402798A (en) 1991-07-18 1995-04-04 Swierczek; Remi Disposable skin perforator and blood testing device
US5340572A (en) 1993-02-08 1994-08-23 Insite Vision Incorporated Alkaline ophthalmic suspensions
US5440446A (en) 1993-10-04 1995-08-08 Catalina Coatings, Inc. Acrylate coating material
FR2720003B1 (fr) 1994-05-23 1998-06-26 Samsung Electro Mech Dispositif servant à inciser la peau pour une médication transcutanée.
EP0782614A1 (en) 1994-09-30 1997-07-09 Rutgers, The State University Of New Jersey Direct introduction of foreign materials into cells
AU5869796A (en) 1995-05-22 1996-12-11 Ned A. Godshall Micromechanical patch for enhancing the delivery of compound s through the skin
WO1996037155A1 (en) 1995-05-22 1996-11-28 Silicon Microdevices, Inc. Micromechanical device and method for enhancing delivery of compounds through the skin
DE19525607A1 (de) 1995-07-14 1997-01-16 Boehringer Ingelheim Kg Transcorneales Arzneimittelfreigabesystem
DE69719761T2 (de) 1996-06-18 2003-12-18 Alza Corp., Palo Alto Vorrichtung zur verbesserung der transdermalen verabreichung von medikamenten oder der abnahme von körperflüssigkeiten
ATE231015T1 (de) 1996-09-17 2003-02-15 Deka Products Lp System zur medikamentenabgabe durch transport
US6797276B1 (en) 1996-11-14 2004-09-28 The United States Of America As Represented By The Secretary Of The Army Use of penetration enhancers and barrier disruption agents to enhance the transcutaneous immune response
US6171276B1 (en) 1997-08-06 2001-01-09 Pharmacia & Upjohn Ab Automated delivery device and method for its operation
DE69839969D1 (de) 1997-12-11 2008-10-16 Alza Corp Vorrichtung zur verbesserung des transdermalen flusses von medikamenten
DE69806963T2 (de) 1997-12-11 2002-11-21 Alza Corp., Mountain View Vorrichtung zur erhöhung des transdermalen wirkstoffeflusses
US6091975A (en) 1998-04-01 2000-07-18 Alza Corporation Minimally invasive detecting device
CA2229522A1 (en) 1998-04-15 1999-10-15 Thomas Randall Inkpen Needle aid
US6503231B1 (en) * 1998-06-10 2003-01-07 Georgia Tech Research Corporation Microneedle device for transport of molecules across tissue
WO1999064580A1 (en) 1998-06-10 1999-12-16 Georgia Tech Research Corporation Microneedle devices and methods of manufacture and use thereof
JP2000025224A (ja) * 1998-07-08 2000-01-25 Brother Ind Ltd 液体吐出装置及び液体吐出装置製造方法
CA2341446C (en) 1998-08-31 2008-10-07 Johnson & Johnson Consumer Companies, Inc. Electrotransport device comprising blades
WO2000044438A1 (en) 1999-01-28 2000-08-03 Cyto Pulse Sciences, Inc. Delivery of macromolecules into cells
US6713291B2 (en) 1999-01-28 2004-03-30 Alan D. King Electrodes coated with treating agent and uses thereof
TW480759B (en) * 1999-03-18 2002-03-21 Seiko Epson Corp Electronic machine, charged electronic machine and control method of electronic machine
US6611707B1 (en) 1999-06-04 2003-08-26 Georgia Tech Research Corporation Microneedle drug delivery device
US6743211B1 (en) 1999-11-23 2004-06-01 Georgia Tech Research Corporation Devices and methods for enhanced microneedle penetration of biological barriers
US20040039342A1 (en) 2000-06-08 2004-02-26 Jonathan Eppstein Transdermal integrated actuator device, methods of making and using same
US6312612B1 (en) 1999-06-09 2001-11-06 The Procter & Gamble Company Apparatus and method for manufacturing an intracutaneous microneedle array
US6379324B1 (en) 1999-06-09 2002-04-30 The Procter & Gamble Company Intracutaneous microneedle array apparatus
US6256533B1 (en) 1999-06-09 2001-07-03 The Procter & Gamble Company Apparatus and method for using an intracutaneous microneedle array
GB9919737D0 (en) 1999-08-21 1999-10-20 Printable Field Emitters Limit Field emitters and devices
US6623457B1 (en) 1999-09-22 2003-09-23 Becton, Dickinson And Company Method and apparatus for the transdermal administration of a substance
US20020095134A1 (en) 1999-10-14 2002-07-18 Pettis Ronald J. Method for altering drug pharmacokinetics based on medical delivery platform
CN1390148A (zh) 1999-11-15 2003-01-08 维尔克鲁工业公司 皮肤附着件
US6881538B1 (en) 2000-03-05 2005-04-19 3M Innovative Properties Company Array comprising diamond-like glass film
US6595947B1 (en) 2000-05-22 2003-07-22 Becton, Dickinson And Company Topical delivery of vaccines
AU2001265056A1 (en) * 2000-05-26 2001-12-11 The Procter And Gamble Company Microneedle apparatus used for marking skin and for dispensing semi-permanent subcutaneous makeup
US7473244B2 (en) 2000-06-02 2009-01-06 The University Of Utah Research Foundation Active needle devices with integrated functionality
US6537242B1 (en) 2000-06-06 2003-03-25 Becton, Dickinson And Company Method and apparatus for enhancing penetration of a member for the intradermal sampling or administration of a substance
US6589202B1 (en) 2000-06-29 2003-07-08 Becton Dickinson And Company Method and apparatus for transdermally sampling or administering a substance to a patient
US6440096B1 (en) 2000-07-14 2002-08-27 Becton, Dickinson And Co. Microdevice and method of manufacturing a microdevice
US6656147B1 (en) 2000-07-17 2003-12-02 Becton, Dickinson And Company Method and delivery device for the transdermal administration of a substance
GB0017999D0 (en) * 2000-07-21 2000-09-13 Smithkline Beecham Biolog Novel device
US6749575B2 (en) 2001-08-20 2004-06-15 Alza Corporation Method for transdermal nucleic acid sampling
NZ524646A (en) 2000-09-08 2004-10-29 Alza Corp Methods for inhibiting decrease in transdermal drug flux by inhibition of pathway closure
EP1341442B1 (en) 2000-10-13 2005-06-29 Alza Corporation Microblade array impact applicator
US6855131B2 (en) 2000-10-13 2005-02-15 Alza Corporation Microprotrusion member retainer for impact applicator
US7131987B2 (en) 2000-10-16 2006-11-07 Corium International, Inc. Microstructures and method for treating and conditioning skin which cause less irritation during exfoliation
BR0114909A (pt) 2000-10-26 2004-02-03 Alza Corp Dispositivos de distribuição de drogas transdérmicas possuindo microprotuberâncias revestidas
ES2705729T3 (es) 2000-11-30 2019-03-26 Valeritas Inc Sistemas de suministro y medición de fluidos
WO2002064193A2 (en) 2000-12-14 2002-08-22 Georgia Tech Research Corporation Microneedle devices and production thereof
US6855372B2 (en) * 2001-03-16 2005-02-15 Alza Corporation Method and apparatus for coating skin piercing microprojections
ES2333849T3 (es) * 2001-04-20 2010-03-02 Alza Corporation Disposicion de microsalientes que presenta un revestimiento que contiene un agente beneficioso.
US20020193729A1 (en) 2001-04-20 2002-12-19 Cormier Michel J.N. Microprojection array immunization patch and method
US6591124B2 (en) 2001-05-11 2003-07-08 The Procter & Gamble Company Portable interstitial fluid monitoring system
CA2451816A1 (en) 2001-06-29 2003-01-09 Becton, Dickinson And Company Intradermal delivery of vaccines and gene therapeutic agents via microcannula
US6881203B2 (en) 2001-09-05 2005-04-19 3M Innovative Properties Company Microneedle arrays and methods of manufacturing the same
US6689100B2 (en) 2001-10-05 2004-02-10 Becton, Dickinson And Company Microdevice and method of delivering or withdrawing a substance through the skin of an animal
US7429258B2 (en) 2001-10-26 2008-09-30 Massachusetts Institute Of Technology Microneedle transport device
US6908453B2 (en) 2002-01-15 2005-06-21 3M Innovative Properties Company Microneedle devices and methods of manufacture
US6780171B2 (en) 2002-04-02 2004-08-24 Becton, Dickinson And Company Intradermal delivery device
US7115108B2 (en) 2002-04-02 2006-10-03 Becton, Dickinson And Company Method and device for intradermally delivering a substance
WO2003092785A1 (en) 2002-04-30 2003-11-13 Morteza Shirkhanzadeh Arrays of microneedles comprising porous calcium phosphate coating and bioactive agents
MXPA05000597A (es) 2002-07-19 2005-04-28 3M Innovative Properties Co Dispositivos de microaguja y aparatos de administracion por microaguja.
WO2004032990A2 (en) 2002-07-22 2004-04-22 Becton, Dickinson And Company Patch-like infusion device
CA2497128C (en) 2002-08-29 2011-10-18 Becton, Dickinson And Company Microprotrusion arrays and methods for using same to deliver substances into tissue
EP1590034B1 (en) 2002-10-07 2014-05-14 Biovalve Technologies, Inc. Microneedle array patch
CA2530954A1 (en) 2003-07-02 2005-01-13 Alza Corporation Microprojection array immunization patch and method
CA2534823A1 (en) 2003-08-04 2005-02-24 Alza Corporation Method and device for enhancing transdermal agent flux
BRPI0413538B8 (pt) 2003-08-12 2021-06-22 Becton Dickison And Company dispositivo para fornecer um medicamento para o corpo de um paciente por injeção
US8353861B2 (en) 2003-09-18 2013-01-15 Texmac, Inc. Applicator for applying functional substances into human skin
CN1897898A (zh) 2003-10-24 2007-01-17 阿尔扎公司 用于增强透皮药物传递的预处理方法和系统
AU2004285481A1 (en) 2003-10-24 2005-05-12 Alza Corporation Apparatus and method for enhancing transdermal drug delivery
AU2004287059A1 (en) 2003-10-28 2005-05-19 Alza Corporation Delivery of polymer conjugates of therapeutic peptides and proteins via coated microporjections
JP2007518468A (ja) 2003-11-21 2007-07-12 アルザ・コーポレーシヨン 超音波支援経皮ワクチン送達方法およびシステム
MXPA06006041A (es) 2003-11-28 2007-01-31 Acrux Dds Pty Ltd Metodo y sistema para administracion transdermica rapida.
ZA200604661B (en) 2003-12-18 2008-05-28 Novo Nordisk As Nozzle device with skin stretching means
AU2004311977A1 (en) 2003-12-29 2005-07-21 3M Innovative Properties Company Medical devices and kits including same
US20070191761A1 (en) 2004-02-23 2007-08-16 3M Innovative Properties Company Method of molding for microneedle arrays

Also Published As

Publication number Publication date
CN101102809B (zh) 2010-05-26
AU2005306426B2 (en) 2011-04-28
EP1827564A1 (en) 2007-09-05
EP1827564B1 (en) 2015-07-29
JP2008520370A (ja) 2008-06-19
CA2588080C (en) 2013-01-08
KR20070086221A (ko) 2007-08-27
KR101224257B1 (ko) 2013-01-18
WO2006055799A1 (en) 2006-05-26
IL183205A0 (en) 2007-08-19
US7846488B2 (en) 2010-12-07
CN101102809A (zh) 2008-01-09
CA2588080A1 (en) 2006-05-26
AU2005306426A1 (en) 2006-05-26
US20080102192A1 (en) 2008-05-01

Similar Documents

Publication Publication Date Title
JP4927751B2 (ja) マイクロニードルアレイのコーティング方法
US8057842B2 (en) Method of contact coating a microneedle array
JP5015787B2 (ja) マイクロニードルアレイの接触コーティング法
WO2007061964A1 (en) Methods for coating microneedles
US7963935B2 (en) Microprojection array having a beneficial agent containing coating
US20080262416A1 (en) Microneedle Arrays and Methods of Preparing Same
KR20170105105A (ko) 마이크로니들 백신 패치를 위한 명반-함유 코팅 제형
EP1951357A1 (en) Microneedle arrays and methods of preparing same
AU2002303441B2 (en) Microprojection array having a beneficial agent containing coating
NZ538043A (en) Composition having a beneficial agent for forming a solid coating on microprojections array
AU2002303441A1 (en) Microprojection array having a beneficial agent containing coating

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20081117

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20081117

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20110215

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20110513

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20110520

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20110627

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20120110

A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20120209

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20150217

Year of fee payment: 3

R150 Certificate of patent or registration of utility model

Ref document number: 4927751

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

LAPS Cancellation because of no payment of annual fees