CA2558615C - Azabicyclo-octane inhibitors of iap - Google Patents

Azabicyclo-octane inhibitors of iap Download PDF

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Publication number
CA2558615C
CA2558615C CA2558615A CA2558615A CA2558615C CA 2558615 C CA2558615 C CA 2558615C CA 2558615 A CA2558615 A CA 2558615A CA 2558615 A CA2558615 A CA 2558615A CA 2558615 C CA2558615 C CA 2558615C
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CA
Canada
Prior art keywords
compound
alkyl
group
methyl
aryl
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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CA2558615A
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English (en)
French (fr)
Other versions
CA2558615A1 (en
Inventor
Frederick Cohen
Wayne Fairbrother
John Flygare
Vickie Hsiao-Wei Tsui
Stephen Franz Keteltas
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Genentech Inc
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Genentech Inc
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Publication of CA2558615A1 publication Critical patent/CA2558615A1/en
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Publication of CA2558615C publication Critical patent/CA2558615C/en
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Expired - Fee Related legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4747—Apoptosis related proteins

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
CA2558615A 2004-03-23 2005-03-22 Azabicyclo-octane inhibitors of iap Expired - Fee Related CA2558615C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US55575504P 2004-03-23 2004-03-23
US60/555,755 2004-03-23
PCT/US2005/009328 WO2005094818A1 (en) 2004-03-23 2005-03-22 Azabicyclo-octane inhibitors of iap

Publications (2)

Publication Number Publication Date
CA2558615A1 CA2558615A1 (en) 2005-10-13
CA2558615C true CA2558615C (en) 2013-10-29

Family

ID=35063498

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2558615A Expired - Fee Related CA2558615C (en) 2004-03-23 2005-03-22 Azabicyclo-octane inhibitors of iap

Country Status (6)

Country Link
US (2) US7345081B2 (https=)
EP (1) EP1740173A4 (https=)
JP (1) JP5122275B2 (https=)
AU (1) AU2005228950B2 (https=)
CA (1) CA2558615C (https=)
WO (1) WO2005094818A1 (https=)

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Publication number Publication date
WO2005094818A1 (en) 2005-10-13
AU2005228950B2 (en) 2012-02-02
JP5122275B2 (ja) 2013-01-16
EP1740173A4 (en) 2009-05-27
US20050261203A1 (en) 2005-11-24
EP1740173A1 (en) 2007-01-10
US7345081B2 (en) 2008-03-18
CA2558615A1 (en) 2005-10-13
AU2005228950A1 (en) 2005-10-13
US20080146808A1 (en) 2008-06-19
JP2007530553A (ja) 2007-11-01

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