CA2558351A1 - Method for producing shaped bodies made from crosslinked gelatine - Google Patents
Method for producing shaped bodies made from crosslinked gelatine Download PDFInfo
- Publication number
- CA2558351A1 CA2558351A1 CA002558351A CA2558351A CA2558351A1 CA 2558351 A1 CA2558351 A1 CA 2558351A1 CA 002558351 A CA002558351 A CA 002558351A CA 2558351 A CA2558351 A CA 2558351A CA 2558351 A1 CA2558351 A1 CA 2558351A1
- Authority
- CA
- Canada
- Prior art keywords
- accordance
- shaped body
- sheet material
- gelatin
- crosslinking
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 229920000159 gelatin Polymers 0.000 title claims abstract description 120
- 235000019322 gelatine Nutrition 0.000 title claims abstract description 120
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 21
- 239000001828 Gelatine Substances 0.000 title abstract 7
- 238000004132 cross linking Methods 0.000 claims abstract description 55
- 238000000034 method Methods 0.000 claims abstract description 38
- 239000007943 implant Substances 0.000 claims abstract description 23
- 108010010803 Gelatin Proteins 0.000 claims description 113
- 239000008273 gelatin Substances 0.000 claims description 113
- 235000011852 gelatine desserts Nutrition 0.000 claims description 113
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 claims description 92
- 239000000463 material Substances 0.000 claims description 83
- 210000004027 cell Anatomy 0.000 claims description 74
- 239000000243 solution Substances 0.000 claims description 38
- 238000010438 heat treatment Methods 0.000 claims description 32
- 239000003431 cross linking reagent Substances 0.000 claims description 26
- PEDCQBHIVMGVHV-UHFFFAOYSA-N glycerol group Chemical group OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 22
- 239000011148 porous material Substances 0.000 claims description 17
- 230000009471 action Effects 0.000 claims description 13
- 230000004962 physiological condition Effects 0.000 claims description 13
- 235000011187 glycerol Nutrition 0.000 claims description 11
- 210000002950 fibroblast Anatomy 0.000 claims description 9
- 208000027418 Wounds and injury Diseases 0.000 claims description 8
- 210000005036 nerve Anatomy 0.000 claims description 8
- 210000000845 cartilage Anatomy 0.000 claims description 7
- 210000001612 chondrocyte Anatomy 0.000 claims description 7
- 210000004962 mammalian cell Anatomy 0.000 claims description 6
- 206010052428 Wound Diseases 0.000 claims description 5
- 239000000853 adhesive Substances 0.000 claims description 5
- 230000001070 adhesive effect Effects 0.000 claims description 5
- 230000006378 damage Effects 0.000 claims description 5
- 239000007792 gaseous phase Substances 0.000 claims description 5
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 4
- 210000002421 cell wall Anatomy 0.000 claims description 4
- -1 dialdehydes Chemical class 0.000 claims description 4
- 238000000338 in vitro Methods 0.000 claims description 4
- 241001465754 Metazoa Species 0.000 claims description 3
- 239000007864 aqueous solution Substances 0.000 claims description 3
- 230000000740 bleeding effect Effects 0.000 claims description 3
- 208000014674 injury Diseases 0.000 claims description 3
- 238000005304 joining Methods 0.000 claims description 3
- 150000001299 aldehydes Chemical class 0.000 claims description 2
- 125000000217 alkyl group Chemical group 0.000 claims description 2
- 150000001718 carbodiimides Chemical class 0.000 claims description 2
- 125000005442 diisocyanate group Chemical group 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims description 2
- 239000012948 isocyanate Substances 0.000 claims description 2
- 150000002513 isocyanates Chemical class 0.000 claims description 2
- 238000003825 pressing Methods 0.000 claims description 2
- 238000000354 decomposition reaction Methods 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 239000000758 substrate Substances 0.000 abstract 1
- 210000001519 tissue Anatomy 0.000 description 19
- 230000015556 catabolic process Effects 0.000 description 13
- 238000006731 degradation reaction Methods 0.000 description 13
- 239000008098 formaldehyde solution Substances 0.000 description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 11
- 230000007547 defect Effects 0.000 description 9
- 239000000203 mixture Substances 0.000 description 8
- 239000012876 carrier material Substances 0.000 description 7
- 230000008901 benefit Effects 0.000 description 6
- 230000008929 regeneration Effects 0.000 description 6
- 238000011069 regeneration method Methods 0.000 description 6
- 239000000523 sample Substances 0.000 description 6
- 108091005804 Peptidases Proteins 0.000 description 5
- 239000004365 Protease Substances 0.000 description 5
- 238000005187 foaming Methods 0.000 description 5
- 239000002609 medium Substances 0.000 description 5
- 239000013074 reference sample Substances 0.000 description 5
- 238000005406 washing Methods 0.000 description 5
- 102000008186 Collagen Human genes 0.000 description 4
- 108010035532 Collagen Proteins 0.000 description 4
- 229920001436 collagen Polymers 0.000 description 4
- 238000007872 degassing Methods 0.000 description 4
- 238000010586 diagram Methods 0.000 description 4
- 239000001963 growth medium Substances 0.000 description 4
- 101100352919 Caenorhabditis elegans ppm-2 gene Proteins 0.000 description 3
- 102000057297 Pepsin A Human genes 0.000 description 3
- 108090000284 Pepsin A Proteins 0.000 description 3
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 description 3
- 230000001413 cellular effect Effects 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 238000009826 distribution Methods 0.000 description 3
- 238000001035 drying Methods 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 230000012010 growth Effects 0.000 description 3
- 230000007774 longterm Effects 0.000 description 3
- 229940111202 pepsin Drugs 0.000 description 3
- 230000035484 reaction time Effects 0.000 description 3
- 238000005096 rolling process Methods 0.000 description 3
- 239000006144 Dulbecco’s modified Eagle's medium Substances 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 description 2
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 description 2
- 102000035195 Peptidases Human genes 0.000 description 2
- 239000004698 Polyethylene Substances 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 210000000988 bone and bone Anatomy 0.000 description 2
- 230000010261 cell growth Effects 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 210000002744 extracellular matrix Anatomy 0.000 description 2
- 239000006260 foam Substances 0.000 description 2
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 description 2
- 230000036571 hydration Effects 0.000 description 2
- 238000006703 hydration reaction Methods 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 238000000465 moulding Methods 0.000 description 2
- 210000002569 neuron Anatomy 0.000 description 2
- 235000015097 nutrients Nutrition 0.000 description 2
- 239000007858 starting material Substances 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 1
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 description 1
- 229920000936 Agarose Polymers 0.000 description 1
- 229920001661 Chitosan Polymers 0.000 description 1
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 description 1
- 229940072056 alginate Drugs 0.000 description 1
- 235000010443 alginic acid Nutrition 0.000 description 1
- 229920000615 alginic acid Polymers 0.000 description 1
- 150000001413 amino acids Chemical group 0.000 description 1
- 230000003698 anagen phase Effects 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 210000004102 animal cell Anatomy 0.000 description 1
- 239000012298 atmosphere Substances 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 238000005266 casting Methods 0.000 description 1
- 239000006285 cell suspension Substances 0.000 description 1
- 238000010382 chemical cross-linking Methods 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000001125 extrusion Methods 0.000 description 1
- 210000003953 foreskin Anatomy 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 210000005260 human cell Anatomy 0.000 description 1
- 229920002674 hyaluronan Polymers 0.000 description 1
- 229960003160 hyaluronic acid Drugs 0.000 description 1
- 230000002163 immunogen Effects 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 238000002513 implantation Methods 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 230000005923 long-lasting effect Effects 0.000 description 1
- WSFSSNUMVMOOMR-NJFSPNSNSA-N methanone Chemical compound O=[14CH2] WSFSSNUMVMOOMR-NJFSPNSNSA-N 0.000 description 1
- 238000000386 microscopy Methods 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 230000017854 proteolysis Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 238000004626 scanning electron microscopy Methods 0.000 description 1
- 230000036962 time dependent Effects 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08H—DERIVATIVES OF NATURAL MACROMOLECULAR COMPOUNDS
- C08H1/00—Macromolecular products derived from proteins
- C08H1/06—Macromolecular products derived from proteins derived from horn, hoofs, hair, skin or leather
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/222—Gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
- A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
- A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
- A61L27/3817—Cartilage-forming cells, e.g. pre-chondrocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
- A61L27/3839—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by the site of application in the body
- A61L27/3843—Connective tissue
- A61L27/3852—Cartilage, e.g. meniscus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/58—Materials at least partially resorbable by the body
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J3/00—Processes of treating or compounding macromolecular substances
- C08J3/24—Crosslinking, e.g. vulcanising, of macromolecules
- C08J3/244—Stepwise homogeneous crosslinking of one polymer with one crosslinking system, e.g. partial curing
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J9/00—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof
- C08J9/30—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof by mixing gases into liquid compositions or plastisols, e.g. frothing with air
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J9/00—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof
- C08J9/36—After-treatment
- C08J9/38—Destruction of cell membranes
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L89/00—Compositions of proteins; Compositions of derivatives thereof
- C08L89/04—Products derived from waste materials, e.g. horn, hoof or hair
- C08L89/06—Products derived from waste materials, e.g. horn, hoof or hair derived from leather or skin, e.g. gelatin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0068—General culture methods using substrates
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2201/00—Foams characterised by the foaming process
- C08J2201/02—Foams characterised by the foaming process characterised by mechanical pre- or post-treatments
- C08J2201/024—Preparation or use of a blowing agent concentrate, i.e. masterbatch in a foamable composition
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2207/00—Foams characterised by their intended use
- C08J2207/10—Medical applications, e.g. biocompatible scaffolds
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2389/00—Characterised by the use of proteins; Derivatives thereof
- C08J2389/04—Products derived from waste materials, e.g. horn, hoof or hair
- C08J2389/06—Products derived from waste materials, e.g. horn, hoof or hair derived from leather or skin
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K5/00—Use of organic ingredients
- C08K5/0008—Organic ingredients according to more than one of the "one dot" groups of C08K5/01 - C08K5/59
- C08K5/0016—Plasticisers
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K5/00—Use of organic ingredients
- C08K5/0008—Organic ingredients according to more than one of the "one dot" groups of C08K5/01 - C08K5/59
- C08K5/0025—Crosslinking or vulcanising agents; including accelerators
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K5/00—Use of organic ingredients
- C08K5/04—Oxygen-containing compounds
- C08K5/05—Alcohols; Metal alcoholates
- C08K5/053—Polyhydroxylic alcohols
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/50—Proteins
- C12N2533/54—Collagen; Gelatin
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Dermatology (AREA)
- Cell Biology (AREA)
- Transplantation (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Zoology (AREA)
- Polymers & Plastics (AREA)
- Botany (AREA)
- Materials Engineering (AREA)
- Urology & Nephrology (AREA)
- Biochemistry (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Vascular Medicine (AREA)
- Rheumatology (AREA)
- Microbiology (AREA)
- Materials For Medical Uses (AREA)
- Medicinal Preparation (AREA)
- Processes Of Treating Macromolecular Substances (AREA)
- Laminated Bodies (AREA)
- Prostheses (AREA)
- Manufacture Of Macromolecular Shaped Articles (AREA)
- Manufacture Of Porous Articles, And Recovery And Treatment Of Waste Products (AREA)
- Compositions Of Macromolecular Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102004024635A DE102004024635A1 (de) | 2004-05-12 | 2004-05-12 | Verfahren zur Herstellung von Formkörpern auf Basis von vernetzter Gelatine |
| DE102004024635.1 | 2004-05-12 | ||
| PCT/EP2005/005174 WO2005111121A2 (de) | 2004-05-12 | 2005-05-12 | Verfahren zur herstellung von formkörpern auf basis von vernetzter gelatine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2558351A1 true CA2558351A1 (en) | 2005-11-24 |
Family
ID=35058421
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002558351A Abandoned CA2558351A1 (en) | 2004-05-12 | 2005-05-12 | Method for producing shaped bodies made from crosslinked gelatine |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20070077274A1 (https=) |
| EP (1) | EP1747247A2 (https=) |
| JP (1) | JP2007537314A (https=) |
| AU (1) | AU2005243474A1 (https=) |
| BR (1) | BRPI0510782A (https=) |
| CA (1) | CA2558351A1 (https=) |
| CR (1) | CR8427A (https=) |
| DE (1) | DE102004024635A1 (https=) |
| EA (1) | EA200602031A1 (https=) |
| EC (1) | ECSP066989A (https=) |
| NO (1) | NO20065652L (https=) |
| WO (1) | WO2005111121A2 (https=) |
| ZA (1) | ZA200609115B (https=) |
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| US8741969B2 (en) * | 2005-08-05 | 2014-06-03 | Gunze Limited | Anti-adhesion membrane |
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| DE102005054941A1 (de) | 2005-11-17 | 2007-05-31 | Gelita Ag | Nervenleitschiene |
| DE102005054940A1 (de) * | 2005-11-17 | 2007-05-24 | Gelita Ag | Verbundmaterial, insbesondere für die medizinische Anwendung , und Verfahren zu dessen Herstellung |
| DE102005054938A1 (de) * | 2005-11-17 | 2007-05-24 | Gelita Ag | Formkörper auf Basis eines vernetzten, Gelatine enthaltenden Materials, Verfahren zu deren Herstellung sowie deren Verwendung |
| DE102005054937A1 (de) * | 2005-11-17 | 2007-05-24 | Gelita Ag | Angiogenese förderndes Substrat |
| US8351679B2 (en) * | 2006-05-23 | 2013-01-08 | Kirin Techno-System Company, Limited | Exclusion of recognized parts from inspection of a cylindrical object |
| DE102006033167A1 (de) * | 2006-07-10 | 2008-01-24 | Gelita Ag | Verwendung von Gelatine und einem Vernetzungsmittel zur Herstellung eines vernetzenden medizinischen Klebers |
| DE102006033168A1 (de) | 2006-07-10 | 2008-01-17 | Gelita Ag | Verwendung von Gelatine und einem Vernetzungsmittel zur Herstellung einer vernetzenden therapeutischen Zusammensetzung |
| GB2444323B (en) * | 2006-11-30 | 2011-04-06 | Ethicon Inc | Protein sheet material |
| JPWO2008072379A1 (ja) * | 2006-12-13 | 2010-03-25 | 富士フイルム株式会社 | 修飾された生体高分子の製造方法及び生体高分子の架橋方法 |
| DE102007024256A1 (de) * | 2007-05-16 | 2008-11-20 | Gelita Ag | Gefäßstent |
| DE102007024239A1 (de) * | 2007-05-16 | 2008-11-20 | Gelita Ag | Angiogenese förderndes Substrat |
| DE102007051059B4 (de) | 2007-10-18 | 2014-04-03 | NMI Naturwissenschaftliches und Medizinisches Institut an der Universität Tübingen | Bioverbundmaterial für die kontrollierte Freisetzung von Wirkstoffen |
| WO2009069727A1 (ja) * | 2007-11-28 | 2009-06-04 | Fujifilm Corporation | 生体高分子およびポリペプチドの化学修飾方法 |
| DE102008020197A1 (de) | 2008-04-15 | 2009-10-22 | Gelita Ag | Schnell benetzbares, Hydrokolloid enthaltendes Material, Verfahren zu dessen Herstellung sowie dessen Verwendung |
| EP2487206A3 (en) * | 2008-06-18 | 2012-11-28 | Lifebond Ltd | Cross-linkable gelatin-based compositions |
| DE102008054245A1 (de) * | 2008-10-24 | 2010-04-29 | Aesculap Ag | Fixierungselement zum Fixieren von Gewebe und/oder Implantaten |
| DE102009018640A1 (de) * | 2009-04-17 | 2010-10-21 | Tetec Tissue Engineering Technologies Ag | Implantat und therapeutische Zusammensetzung zur Behandlung von Schäden und/oder Erkrankungen im Bereich des menschlichen und/oder tierischen Stütz- und Bewegungsapparates |
| JP5483274B2 (ja) * | 2009-08-07 | 2014-05-07 | 利江 土屋 | 軟骨用移植材 |
| WO2011077388A1 (en) | 2009-12-22 | 2011-06-30 | Lifebond Ltd | Modification of enzymatic crosslinkers for controlling properties of crosslinked matrices |
| DE102011004239A1 (de) | 2011-02-16 | 2012-08-16 | Gelita Ag | Verwendung eines medizinischen Implantats als Adhäsionsbarriere |
| CN107033383B (zh) * | 2013-02-27 | 2020-07-24 | 富士胶片株式会社 | 制造生物亲和性高分子的多孔体的方法 |
| US9849217B2 (en) | 2013-04-18 | 2017-12-26 | Board Of Regents, The University Of Texas System | Antimicrobial wraps for medical implants |
| JP6355959B2 (ja) * | 2014-04-24 | 2018-07-11 | 国立大学法人京都工芸繊維大学 | 機能性架橋構造体及びその製造方法並びに医療材料 |
| JP6434438B2 (ja) * | 2016-03-31 | 2018-12-05 | 富士フイルム株式会社 | ゼラチン成形体の製造方法 |
| DE102016110089B4 (de) | 2016-06-01 | 2020-02-06 | Christine Konert | Kapsel aus vernetzter Gelatine für die portionsweise Zubereitung eines Getränks und deren Verwendung |
| JP7041346B2 (ja) * | 2018-02-28 | 2022-03-24 | 澁谷工業株式会社 | ゼラチン支持体を用いた細胞培養方法 |
| US11998654B2 (en) | 2018-07-12 | 2024-06-04 | Bard Shannon Limited | Securing implants and medical devices |
| JP7303511B2 (ja) * | 2019-02-18 | 2023-07-05 | 青葉化成株式会社 | 医療材料およびその製造方法 |
| DE102020116722B4 (de) | 2020-06-25 | 2023-12-14 | Christian Klinger | Mehrkomponentensystem zum Herstellen eines Materials, Material und Verfahren zum Herstellen eines solchen Materials |
| CN114099766B (zh) * | 2020-09-01 | 2022-12-06 | 中科硅骨(东莞)医疗器械有限公司 | 改性明胶止血材料及其制备方法 |
| CN112898591B (zh) * | 2021-02-19 | 2022-06-21 | 杭州楠大环保科技有限公司 | 一种复合微生物制剂用载体及其制备方法 |
| US12440599B2 (en) | 2022-05-06 | 2025-10-14 | Pramand LLC | Water activated hydrogel-based medical patches, and methods of making and using such patches |
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| JP4295482B2 (ja) * | 2002-08-08 | 2009-07-15 | グンゼ株式会社 | 癒着防止材 |
-
2004
- 2004-05-12 DE DE102004024635A patent/DE102004024635A1/de not_active Withdrawn
-
2005
- 2005-05-12 AU AU2005243474A patent/AU2005243474A1/en not_active Abandoned
- 2005-05-12 WO PCT/EP2005/005174 patent/WO2005111121A2/de not_active Ceased
- 2005-05-12 CA CA002558351A patent/CA2558351A1/en not_active Abandoned
- 2005-05-12 BR BRPI0510782-2A patent/BRPI0510782A/pt not_active IP Right Cessation
- 2005-05-12 EA EA200602031A patent/EA200602031A1/ru unknown
- 2005-05-12 JP JP2007512103A patent/JP2007537314A/ja active Pending
- 2005-05-12 EP EP05745724A patent/EP1747247A2/de not_active Withdrawn
-
2006
- 2006-06-01 CR CR8427A patent/CR8427A/es not_active Application Discontinuation
- 2006-11-01 US US11/555,295 patent/US20070077274A1/en not_active Abandoned
- 2006-11-01 ZA ZA200609115A patent/ZA200609115B/en unknown
- 2006-11-10 EC EC2006006989A patent/ECSP066989A/es unknown
- 2006-12-07 NO NO20065652A patent/NO20065652L/no not_active Application Discontinuation
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8741969B2 (en) * | 2005-08-05 | 2014-06-03 | Gunze Limited | Anti-adhesion membrane |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2005111121A2 (de) | 2005-11-24 |
| AU2005243474A1 (en) | 2005-11-24 |
| ZA200609115B (en) | 2008-06-25 |
| BRPI0510782A (pt) | 2007-11-20 |
| JP2007537314A (ja) | 2007-12-20 |
| ECSP066989A (es) | 2006-12-29 |
| US20070077274A1 (en) | 2007-04-05 |
| NO20065652L (no) | 2006-12-07 |
| EP1747247A2 (de) | 2007-01-31 |
| DE102004024635A1 (de) | 2005-12-08 |
| WO2005111121A3 (de) | 2006-03-02 |
| EA200602031A1 (ru) | 2007-08-31 |
| CR8427A (es) | 2006-11-23 |
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