WO2005111121A3 - Verfahren zur herstellung von formkörpern auf basis von vernetzter gelatine - Google Patents

Verfahren zur herstellung von formkörpern auf basis von vernetzter gelatine Download PDF

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Publication number
WO2005111121A3
WO2005111121A3 PCT/EP2005/005174 EP2005005174W WO2005111121A3 WO 2005111121 A3 WO2005111121 A3 WO 2005111121A3 EP 2005005174 W EP2005005174 W EP 2005005174W WO 2005111121 A3 WO2005111121 A3 WO 2005111121A3
Authority
WO
WIPO (PCT)
Prior art keywords
gelatine
bodies made
shaped bodies
producing shaped
crosslinked
Prior art date
Application number
PCT/EP2005/005174
Other languages
English (en)
French (fr)
Other versions
WO2005111121A2 (de
Inventor
Michael Ahlers
Original Assignee
Gelita Ag
Michael Ahlers
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gelita Ag, Michael Ahlers filed Critical Gelita Ag
Priority to EP05745724A priority Critical patent/EP1747247A2/de
Priority to JP2007512103A priority patent/JP2007537314A/ja
Priority to CA002558351A priority patent/CA2558351A1/en
Priority to AU2005243474A priority patent/AU2005243474A1/en
Priority to EA200602031A priority patent/EA200602031A1/ru
Priority to BRPI0510782-2A priority patent/BRPI0510782A/pt
Publication of WO2005111121A2 publication Critical patent/WO2005111121A2/de
Publication of WO2005111121A3 publication Critical patent/WO2005111121A3/de
Priority to US11/555,295 priority patent/US20070077274A1/en
Priority to NO20065652A priority patent/NO20065652L/no

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08H—DERIVATIVES OF NATURAL MACROMOLECULAR COMPOUNDS
    • C08H1/00—Macromolecular products derived from proteins
    • C08H1/06—Macromolecular products derived from proteins derived from horn, hoofs, hair, skin or leather
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/222—Gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A61L27/3817—Cartilage-forming cells, e.g. pre-chondrocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3839—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by the site of application in the body
    • A61L27/3843—Connective tissue
    • A61L27/3852—Cartilage, e.g. meniscus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/58—Materials at least partially resorbable by the body
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J3/00—Processes of treating or compounding macromolecular substances
    • C08J3/24—Crosslinking, e.g. vulcanising, of macromolecules
    • C08J3/244—Stepwise homogeneous crosslinking of one polymer with one crosslinking system, e.g. partial curing
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J9/00—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof
    • C08J9/30—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof by mixing gases into liquid compositions or plastisols, e.g. frothing with air
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J9/00—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof
    • C08J9/36—After-treatment
    • C08J9/38—Destruction of cell membranes
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L89/00—Compositions of proteins; Compositions of derivatives thereof
    • C08L89/04—Products derived from waste materials, e.g. horn, hoof or hair
    • C08L89/06—Products derived from waste materials, e.g. horn, hoof or hair derived from leather or skin, e.g. gelatin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0068—General culture methods using substrates
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2201/00—Foams characterised by the foaming process
    • C08J2201/02—Foams characterised by the foaming process characterised by mechanical pre- or post-treatments
    • C08J2201/024—Preparation or use of a blowing agent concentrate, i.e. masterbatch in a foamable composition
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2207/00—Foams characterised by their intended use
    • C08J2207/10—Medical applications, e.g. biocompatible scaffolds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2389/00—Characterised by the use of proteins; Derivatives thereof
    • C08J2389/04—Products derived from waste materials, e.g. horn, hoof or hair
    • C08J2389/06—Products derived from waste materials, e.g. horn, hoof or hair derived from leather or skin
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K5/00—Use of organic ingredients
    • C08K5/0008—Organic ingredients according to more than one of the "one dot" groups of C08K5/01 - C08K5/59
    • C08K5/0016—Plasticisers
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K5/00—Use of organic ingredients
    • C08K5/0008—Organic ingredients according to more than one of the "one dot" groups of C08K5/01 - C08K5/59
    • C08K5/0025—Crosslinking or vulcanising agents; including accelerators
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K5/00—Use of organic ingredients
    • C08K5/04—Oxygen-containing compounds
    • C08K5/05—Alcohols; Metal alcoholates
    • C08K5/053—Polyhydroxylic alcohols
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/50—Proteins
    • C12N2533/54—Collagen; Gelatin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Cell Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Dermatology (AREA)
  • Veterinary Medicine (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Zoology (AREA)
  • Polymers & Plastics (AREA)
  • Botany (AREA)
  • Materials Engineering (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Urology & Nephrology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Vascular Medicine (AREA)
  • Rheumatology (AREA)
  • Materials For Medical Uses (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
  • Medicinal Preparation (AREA)
  • Manufacture Of Porous Articles, And Recovery And Treatment Of Waste Products (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Prostheses (AREA)
  • Manufacture Of Macromolecular Shaped Articles (AREA)
  • Laminated Bodies (AREA)

Abstract

Um ein Verfahren zur Herstellung von Formkörpern auf Basis von vernetzter Gelatine zur Verfügung zu stellen, welche als Trägermaterial für Gewebeim­plantate eingesetzt werden können und eine individuell einstellbare Abbauzeit aufweisen, wird vorgeschlagen, dass dieses Verfahren folgende Schritte um­fasst: a) Herstellen einer wässrigen Gelatinelösung; b) partielles Vernetzen der gelösten Gelatine; c) Herstellen eines Formkörpers ausgehend von der Gelatinelösung mit der partiell vernetzten Gelatine; und d) Vernetzen der im Formkörper enthaltenen Gelatine.
PCT/EP2005/005174 2004-05-12 2005-05-12 Verfahren zur herstellung von formkörpern auf basis von vernetzter gelatine WO2005111121A2 (de)

Priority Applications (8)

Application Number Priority Date Filing Date Title
EP05745724A EP1747247A2 (de) 2004-05-12 2005-05-12 Verfahren zur herstellung von formkörpern auf basis von vernetzter gelatine
JP2007512103A JP2007537314A (ja) 2004-05-12 2005-05-12 架橋したゼラチンを基にした造形体の製造法
CA002558351A CA2558351A1 (en) 2004-05-12 2005-05-12 Method for producing shaped bodies made from crosslinked gelatine
AU2005243474A AU2005243474A1 (en) 2004-05-12 2005-05-12 Method for producing shaped bodies made from crosslinked gelatine
EA200602031A EA200602031A1 (ru) 2004-05-12 2005-05-12 Способ изготовления формованных изделий на основе сшитого желатина
BRPI0510782-2A BRPI0510782A (pt) 2004-05-12 2005-05-12 processo para a produção de artigos moldados à base de gelatinas reticuladas
US11/555,295 US20070077274A1 (en) 2004-05-12 2006-11-01 Method for producing shaped bodies based on crosslinked gelatine
NO20065652A NO20065652L (no) 2004-05-12 2006-12-07 Fremgangsmate for fremstilling av formede gjenstander pa basis av tverrbundet gelatin

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102004024635.1 2004-05-12
DE102004024635A DE102004024635A1 (de) 2004-05-12 2004-05-12 Verfahren zur Herstellung von Formkörpern auf Basis von vernetzter Gelatine

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US11/555,295 Continuation-In-Part US20070077274A1 (en) 2004-05-12 2006-11-01 Method for producing shaped bodies based on crosslinked gelatine

Publications (2)

Publication Number Publication Date
WO2005111121A2 WO2005111121A2 (de) 2005-11-24
WO2005111121A3 true WO2005111121A3 (de) 2006-03-02

Family

ID=35058421

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2005/005174 WO2005111121A2 (de) 2004-05-12 2005-05-12 Verfahren zur herstellung von formkörpern auf basis von vernetzter gelatine

Country Status (13)

Country Link
US (1) US20070077274A1 (de)
EP (1) EP1747247A2 (de)
JP (1) JP2007537314A (de)
AU (1) AU2005243474A1 (de)
BR (1) BRPI0510782A (de)
CA (1) CA2558351A1 (de)
CR (1) CR8427A (de)
DE (1) DE102004024635A1 (de)
EA (1) EA200602031A1 (de)
EC (1) ECSP066989A (de)
NO (1) NO20065652L (de)
WO (1) WO2005111121A2 (de)
ZA (1) ZA200609115B (de)

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JP4917775B2 (ja) * 2005-08-05 2012-04-18 グンゼ株式会社 癒着防止膜の製造方法
DE102005054940A1 (de) * 2005-11-17 2007-05-24 Gelita Ag Verbundmaterial, insbesondere für die medizinische Anwendung , und Verfahren zu dessen Herstellung
DE102005054943A1 (de) * 2005-11-17 2007-05-24 Gelita Ag Verfahren zur Herstellung eines Hohlprofils auf Basis eines vernetzten, Gelatine enthaltenden Materials sowie Implantate in Form von Hohlprofilen
DE102005054938A1 (de) * 2005-11-17 2007-05-24 Gelita Ag Formkörper auf Basis eines vernetzten, Gelatine enthaltenden Materials, Verfahren zu deren Herstellung sowie deren Verwendung
DE102005054937A1 (de) * 2005-11-17 2007-05-24 Gelita Ag Angiogenese förderndes Substrat
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DE102006033167A1 (de) 2006-07-10 2008-01-24 Gelita Ag Verwendung von Gelatine und einem Vernetzungsmittel zur Herstellung eines vernetzenden medizinischen Klebers
DE102006033168A1 (de) 2006-07-10 2008-01-17 Gelita Ag Verwendung von Gelatine und einem Vernetzungsmittel zur Herstellung einer vernetzenden therapeutischen Zusammensetzung
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JP5450612B2 (ja) * 2008-06-18 2014-03-26 ライフボンド リミテッド 改良された架橋組成物
DE102008054245A1 (de) * 2008-10-24 2010-04-29 Aesculap Ag Fixierungselement zum Fixieren von Gewebe und/oder Implantaten
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JP5483274B2 (ja) * 2009-08-07 2014-05-07 利江 土屋 軟骨用移植材
EP2515957B1 (de) 2009-12-22 2015-07-29 Lifebond Ltd Modifizierung von enzymatischen vernetzern zur steuerung der eigenschaften vernetzter matrizen
DE102011004239A1 (de) 2011-02-16 2012-08-16 Gelita Ag Verwendung eines medizinischen Implantats als Adhäsionsbarriere
JP6130903B2 (ja) * 2013-02-27 2017-05-17 富士フイルム株式会社 細胞移植用細胞構造体、生体親和性高分子ブロック及びそれらの製造方法
WO2014172572A1 (en) 2013-04-18 2014-10-23 Board Of Regents, The University Of Texas System Antimicrobial wraps for medical implants
JP6355959B2 (ja) * 2014-04-24 2018-07-11 国立大学法人京都工芸繊維大学 機能性架橋構造体及びその製造方法並びに医療材料
JP6434438B2 (ja) * 2016-03-31 2018-12-05 富士フイルム株式会社 ゼラチン成形体の製造方法
DE102016110089B4 (de) 2016-06-01 2020-02-06 Christine Konert Kapsel aus vernetzter Gelatine für die portionsweise Zubereitung eines Getränks und deren Verwendung
JP7041346B2 (ja) * 2018-02-28 2022-03-24 澁谷工業株式会社 ゼラチン支持体を用いた細胞培養方法
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JP7303511B2 (ja) * 2019-02-18 2023-07-05 青葉化成株式会社 医療材料およびその製造方法
DE102020116722B4 (de) 2020-06-25 2023-12-14 Christian Klinger Mehrkomponentensystem zum Herstellen eines Materials, Material und Verfahren zum Herstellen eines solchen Materials
CN114099766B (zh) * 2020-09-01 2022-12-06 中科硅骨(东莞)医疗器械有限公司 改性明胶止血材料及其制备方法
CN112898591B (zh) * 2021-02-19 2022-06-21 杭州楠大环保科技有限公司 一种复合微生物制剂用载体及其制备方法

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EP1747247A2 (de) 2007-01-31
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DE102004024635A1 (de) 2005-12-08
CA2558351A1 (en) 2005-11-24
JP2007537314A (ja) 2007-12-20
EA200602031A1 (ru) 2007-08-31
CR8427A (es) 2006-11-23
AU2005243474A1 (en) 2005-11-24
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BRPI0510782A (pt) 2007-11-20
WO2005111121A2 (de) 2005-11-24
US20070077274A1 (en) 2007-04-05

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