WO2005111121A3 - Verfahren zur herstellung von formkörpern auf basis von vernetzter gelatine - Google Patents

Verfahren zur herstellung von formkörpern auf basis von vernetzter gelatine Download PDF

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Publication number
WO2005111121A3
WO2005111121A3 PCT/EP2005/005174 EP2005005174W WO2005111121A3 WO 2005111121 A3 WO2005111121 A3 WO 2005111121A3 EP 2005005174 W EP2005005174 W EP 2005005174W WO 2005111121 A3 WO2005111121 A3 WO 2005111121A3
Authority
WO
WIPO (PCT)
Prior art keywords
gelatine
bodies made
shaped bodies
producing shaped
crosslinked
Prior art date
Application number
PCT/EP2005/005174
Other languages
English (en)
French (fr)
Other versions
WO2005111121A2 (de
Inventor
Michael Ahlers
Original Assignee
Gelita Ag
Michael Ahlers
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gelita Ag, Michael Ahlers filed Critical Gelita Ag
Priority to EP05745724A priority Critical patent/EP1747247A2/de
Priority to AU2005243474A priority patent/AU2005243474A1/en
Priority to JP2007512103A priority patent/JP2007537314A/ja
Priority to EA200602031A priority patent/EA200602031A1/ru
Priority to CA002558351A priority patent/CA2558351A1/en
Priority to BRPI0510782-2A priority patent/BRPI0510782A/pt
Publication of WO2005111121A2 publication Critical patent/WO2005111121A2/de
Publication of WO2005111121A3 publication Critical patent/WO2005111121A3/de
Priority to US11/555,295 priority patent/US20070077274A1/en
Priority to NO20065652A priority patent/NO20065652L/no

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    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08HDERIVATIVES OF NATURAL MACROMOLECULAR COMPOUNDS
    • C08H1/00Macromolecular products derived from proteins
    • C08H1/06Macromolecular products derived from proteins derived from horn, hoofs, hair, skin or leather
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14Macromolecular materials
    • A61L27/22Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/222Gelatin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A61L27/3817Cartilage-forming cells, e.g. pre-chondrocytes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3839Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by the site of application in the body
    • A61L27/3843Connective tissue
    • A61L27/3852Cartilage, e.g. meniscus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/58Materials at least partially resorbable by the body
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08JWORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J3/00Processes of treating or compounding macromolecular substances
    • C08J3/24Crosslinking, e.g. vulcanising, of macromolecules
    • C08J3/244Stepwise homogeneous crosslinking of one polymer with one crosslinking system, e.g. partial curing
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08JWORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J9/00Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof
    • C08J9/30Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof by mixing gases into liquid compositions or plastisols, e.g. frothing with air
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08JWORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J9/00Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof
    • C08J9/36After-treatment
    • C08J9/38Destruction of cell membranes
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08LCOMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L89/00Compositions of proteins; Compositions of derivatives thereof
    • C08L89/04Products derived from waste materials, e.g. horn, hoof or hair
    • C08L89/06Products derived from waste materials, e.g. horn, hoof or hair derived from leather or skin, e.g. gelatin
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0068General culture methods using substrates
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08JWORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2201/00Foams characterised by the foaming process
    • C08J2201/02Foams characterised by the foaming process characterised by mechanical pre- or post-treatments
    • C08J2201/024Preparation or use of a blowing agent concentrate, i.e. masterbatch in a foamable composition
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08JWORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2207/00Foams characterised by their intended use
    • C08J2207/10Medical applications, e.g. biocompatible scaffolds
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08JWORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2389/00Characterised by the use of proteins; Derivatives thereof
    • C08J2389/04Products derived from waste materials, e.g. horn, hoof or hair
    • C08J2389/06Products derived from waste materials, e.g. horn, hoof or hair derived from leather or skin
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08KUse of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K5/00Use of organic ingredients
    • C08K5/0008Organic ingredients according to more than one of the "one dot" groups of C08K5/01 - C08K5/59
    • C08K5/0016Plasticisers
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08KUse of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K5/00Use of organic ingredients
    • C08K5/0008Organic ingredients according to more than one of the "one dot" groups of C08K5/01 - C08K5/59
    • C08K5/0025Crosslinking or vulcanising agents; including accelerators
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08KUse of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K5/00Use of organic ingredients
    • C08K5/04Oxygen-containing compounds
    • C08K5/05Alcohols; Metal alcoholates
    • C08K5/053Polyhydroxylic alcohols
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00Supports or coatings for cell culture, characterised by material
    • C12N2533/50Proteins
    • C12N2533/54Collagen; Gelatin

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Dermatology (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Transplantation (AREA)
  • Polymers & Plastics (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Epidemiology (AREA)
  • Materials Engineering (AREA)
  • Botany (AREA)
  • Urology & Nephrology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Vascular Medicine (AREA)
  • Microbiology (AREA)
  • Rheumatology (AREA)
  • General Engineering & Computer Science (AREA)
  • Materials For Medical Uses (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
  • Medicinal Preparation (AREA)
  • Prostheses (AREA)
  • Manufacture Of Macromolecular Shaped Articles (AREA)
  • Manufacture Of Porous Articles, And Recovery And Treatment Of Waste Products (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Laminated Bodies (AREA)

Abstract

Um ein Verfahren zur Herstellung von Formkörpern auf Basis von vernetzter Gelatine zur Verfügung zu stellen, welche als Trägermaterial für Gewebeim­plantate eingesetzt werden können und eine individuell einstellbare Abbauzeit aufweisen, wird vorgeschlagen, dass dieses Verfahren folgende Schritte um­fasst: a) Herstellen einer wässrigen Gelatinelösung; b) partielles Vernetzen der gelösten Gelatine; c) Herstellen eines Formkörpers ausgehend von der Gelatinelösung mit der partiell vernetzten Gelatine; und d) Vernetzen der im Formkörper enthaltenen Gelatine.
PCT/EP2005/005174 2004-05-12 2005-05-12 Verfahren zur herstellung von formkörpern auf basis von vernetzter gelatine WO2005111121A2 (de)

Priority Applications (8)

Application Number Priority Date Filing Date Title
EP05745724A EP1747247A2 (de) 2004-05-12 2005-05-12 Verfahren zur herstellung von formkörpern auf basis von vernetzter gelatine
AU2005243474A AU2005243474A1 (en) 2004-05-12 2005-05-12 Method for producing shaped bodies made from crosslinked gelatine
JP2007512103A JP2007537314A (ja) 2004-05-12 2005-05-12 架橋したゼラチンを基にした造形体の製造法
EA200602031A EA200602031A1 (ru) 2004-05-12 2005-05-12 Способ изготовления формованных изделий на основе сшитого желатина
CA002558351A CA2558351A1 (en) 2004-05-12 2005-05-12 Method for producing shaped bodies made from crosslinked gelatine
BRPI0510782-2A BRPI0510782A (pt) 2004-05-12 2005-05-12 processo para a produção de artigos moldados à base de gelatinas reticuladas
US11/555,295 US20070077274A1 (en) 2004-05-12 2006-11-01 Method for producing shaped bodies based on crosslinked gelatine
NO20065652A NO20065652L (no) 2004-05-12 2006-12-07 Fremgangsmate for fremstilling av formede gjenstander pa basis av tverrbundet gelatin

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102004024635.1 2004-05-12
DE102004024635A DE102004024635A1 (de) 2004-05-12 2004-05-12 Verfahren zur Herstellung von Formkörpern auf Basis von vernetzter Gelatine

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US11/555,295 Continuation-In-Part US20070077274A1 (en) 2004-05-12 2006-11-01 Method for producing shaped bodies based on crosslinked gelatine

Publications (2)

Publication Number Publication Date
WO2005111121A2 WO2005111121A2 (de) 2005-11-24
WO2005111121A3 true WO2005111121A3 (de) 2006-03-02

Family

ID=35058421

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2005/005174 WO2005111121A2 (de) 2004-05-12 2005-05-12 Verfahren zur herstellung von formkörpern auf basis von vernetzter gelatine

Country Status (13)

Country Link
US (1) US20070077274A1 (de)
EP (1) EP1747247A2 (de)
JP (1) JP2007537314A (de)
AU (1) AU2005243474A1 (de)
BR (1) BRPI0510782A (de)
CA (1) CA2558351A1 (de)
CR (1) CR8427A (de)
DE (1) DE102004024635A1 (de)
EA (1) EA200602031A1 (de)
EC (1) ECSP066989A (de)
NO (1) NO20065652L (de)
WO (1) WO2005111121A2 (de)
ZA (1) ZA200609115B (de)

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DE102005054940A1 (de) * 2005-11-17 2007-05-24 Gelita Ag Verbundmaterial, insbesondere für die medizinische Anwendung , und Verfahren zu dessen Herstellung
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JP5497449B2 (ja) * 2007-11-28 2014-05-21 富士フイルム株式会社 生体高分子およびポリペプチドの化学修飾方法
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CN104031393B (zh) * 2008-06-18 2017-08-01 生命连结有限公司 改进的交联组合物
DE102008054245A1 (de) * 2008-10-24 2010-04-29 Aesculap Ag Fixierungselement zum Fixieren von Gewebe und/oder Implantaten
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JP5483274B2 (ja) * 2009-08-07 2014-05-07 利江 土屋 軟骨用移植材
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DE102011004239A1 (de) 2011-02-16 2012-08-16 Gelita Ag Verwendung eines medizinischen Implantats als Adhäsionsbarriere
EP2962703B1 (de) * 2013-02-27 2020-08-19 FUJIFILM Corporation Zellkonstrukt für zelltransplantation, biokompatibler polymerblock und verfahren zur herstellung davon
US9849217B2 (en) 2013-04-18 2017-12-26 Board Of Regents, The University Of Texas System Antimicrobial wraps for medical implants
JP6355959B2 (ja) * 2014-04-24 2018-07-11 国立大学法人京都工芸繊維大学 機能性架橋構造体及びその製造方法並びに医療材料
JP6434438B2 (ja) * 2016-03-31 2018-12-05 富士フイルム株式会社 ゼラチン成形体の製造方法
DE102016110089B4 (de) 2016-06-01 2020-02-06 Christine Konert Kapsel aus vernetzter Gelatine für die portionsweise Zubereitung eines Getränks und deren Verwendung
JP7041346B2 (ja) * 2018-02-28 2022-03-24 澁谷工業株式会社 ゼラチン支持体を用いた細胞培養方法
US11998654B2 (en) 2018-07-12 2024-06-04 Bard Shannon Limited Securing implants and medical devices
JP7303511B2 (ja) * 2019-02-18 2023-07-05 青葉化成株式会社 医療材料およびその製造方法
DE102020116722B4 (de) 2020-06-25 2023-12-14 Christian Klinger Mehrkomponentensystem zum Herstellen eines Materials, Material und Verfahren zum Herstellen eines solchen Materials
CN114099766B (zh) * 2020-09-01 2022-12-06 中科硅骨(东莞)医疗器械有限公司 改性明胶止血材料及其制备方法
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US20070077274A1 (en) 2007-04-05
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WO2005111121A2 (de) 2005-11-24
DE102004024635A1 (de) 2005-12-08
EP1747247A2 (de) 2007-01-31
AU2005243474A1 (en) 2005-11-24
CA2558351A1 (en) 2005-11-24
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ECSP066989A (es) 2006-12-29
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