WO2008058236A3 - Methods for preparing cinacalcet hydrochloride - Google Patents

Methods for preparing cinacalcet hydrochloride Download PDF

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Publication number
WO2008058236A3
WO2008058236A3 PCT/US2007/084079 US2007084079W WO2008058236A3 WO 2008058236 A3 WO2008058236 A3 WO 2008058236A3 US 2007084079 W US2007084079 W US 2007084079W WO 2008058236 A3 WO2008058236 A3 WO 2008058236A3
Authority
WO
WIPO (PCT)
Prior art keywords
cinacalcet
hydrochloride
methods
solution
cinacalcet hydrochloride
Prior art date
Application number
PCT/US2007/084079
Other languages
French (fr)
Other versions
WO2008058236A2 (en
Inventor
Pratap Reddy Padi
Surya Prabhakar Akundi
Sashi Kanth Suthrapu
Naveen Kumar Kolla
Vijaya Kumar Kotagiri
Uday Kumar Neelam
Sudhakar Reddy Baddam
Nagaraju Manne
Surya Narayana Devarakonda
Ram Thaimattam
Balaji Raghupati
Satish Kumar Vasamsetti
Original Assignee
Reddy S Labortories Ltd Dr
Reddys Lab Inc Dr
Pratap Reddy Padi
Surya Prabhakar Akundi
Sashi Kanth Suthrapu
Naveen Kumar Kolla
Vijaya Kumar Kotagiri
Uday Kumar Neelam
Sudhakar Reddy Baddam
Nagaraju Manne
Surya Narayana Devarakonda
Ram Thaimattam
Balaji Raghupati
Satish Kumar Vasamsetti
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Reddy S Labortories Ltd Dr, Reddys Lab Inc Dr, Pratap Reddy Padi, Surya Prabhakar Akundi, Sashi Kanth Suthrapu, Naveen Kumar Kolla, Vijaya Kumar Kotagiri, Uday Kumar Neelam, Sudhakar Reddy Baddam, Nagaraju Manne, Surya Narayana Devarakonda, Ram Thaimattam, Balaji Raghupati, Satish Kumar Vasamsetti filed Critical Reddy S Labortories Ltd Dr
Publication of WO2008058236A2 publication Critical patent/WO2008058236A2/en
Publication of WO2008058236A3 publication Critical patent/WO2008058236A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/82—Purification; Separation; Stabilisation; Use of additives
    • C07C209/84—Purification
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Emergency Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

There is provided a process for making cinacalcet hydrochloride, said process including a) providing a solution of free base of cinacalcet in a solvent that is an alcohol or alkyl acetate; b) treating said solution with an amount of hydrochloric acid sufficient to convert said free base to said hydrochloride salt; c) adding an anti-solvent to said treated solution in the amount sufficient to precipitate said hydrochloride salt in the form of a solid; and d) isolating said precipitated solid thereby obtaining said cinacalcet hydrochloride. Other aspects, embodiments and variant related to cinacalcet are also provided.
PCT/US2007/084079 2006-11-08 2007-11-08 Methods for preparing cinacalcet hydrochloride WO2008058236A2 (en)

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
IN2061/CHE/2006 2006-11-08
IN2061CH2006 2006-11-08
US88524207P 2007-01-17 2007-01-17
US60/885,242 2007-01-17
US89021307P 2007-02-16 2007-02-16
US60/890,213 2007-02-16
IN524CH2007 2007-03-14
IN524/CHE/2007 2007-03-14
US96906207P 2007-08-30 2007-08-30
US60/969,062 2007-08-30

Publications (2)

Publication Number Publication Date
WO2008058236A2 WO2008058236A2 (en) 2008-05-15
WO2008058236A3 true WO2008058236A3 (en) 2008-08-28

Family

ID=39365373

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/084079 WO2008058236A2 (en) 2006-11-08 2007-11-08 Methods for preparing cinacalcet hydrochloride

Country Status (1)

Country Link
WO (1) WO2008058236A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111704551B (en) * 2020-08-20 2020-11-20 天津汉一医药科技有限公司 Preparation method of cinacalcet hydrochloride

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2170805B1 (en) * 2007-06-21 2016-03-16 Amgen Inc. Methods of synthesizing cinacalcet and salts thereof
WO2009039241A2 (en) * 2007-09-18 2009-03-26 Medichem, S.A. Improved process for preparing cinacalcet hydrochloride
EP2376424A1 (en) 2008-12-08 2011-10-19 Actavis Group PTC EHF Highly pure cinacalcet or a pharmaceutically acceptable salt thereof
CA2754209A1 (en) 2009-03-05 2010-09-10 Cipla Limited Process for the preparation of cinacalcet and salts thereof, and intermediates for use in the process
FR2995307A1 (en) 2012-09-07 2014-03-14 Prod Chim Auxiliaires Et De Synthese PROCESS FOR THE PREPARATION OF CINACALCET AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS
CN102885792A (en) * 2012-10-12 2013-01-23 华润赛科药业有限责任公司 Oral solid rapid release preparation of cinacalcet hydrochloride
CN103044267A (en) * 2012-12-06 2013-04-17 华润赛科药业有限责任公司 Preparation method of high-purity cinacalcet hydrochloride
CN103739500B (en) * 2012-12-27 2016-03-23 国药一心制药有限公司 A kind of synthesis of cinacalcet hydrochloride and process for purification
CN103193655B (en) * 2013-04-15 2015-06-24 山东新华制药股份有限公司 Method for preparing cinacalcet hydrochloride crystal form I
CN104045568A (en) * 2014-06-18 2014-09-17 中山奕安泰医药科技有限公司 Novel process for synthesizing (R)-1-(naphthalene-1-yl) ethylamine
CN104478736B (en) * 2014-12-16 2016-07-13 成都启泰医药技术有限公司 A kind of preparation method of cinacalcet hydrochloride
CN104592051B (en) * 2014-12-26 2016-07-06 扬子江药业集团四川海蓉药业有限公司 The method preparing N-[1-(R)-(1-naphthyl) ethyl]-3-[3-(trifluoromethyl) phenyl]-1-propionic acid amide.
CN106810452B (en) * 2017-01-13 2018-12-28 华北水利水电大学 A kind of preparation method of cinacalcet hydrochloride
US20210030671A1 (en) * 2018-03-30 2021-02-04 Ftf Pharma Private Limited Liquid dosage forms of cinacalcet or salt thereof
CN112374999A (en) * 2020-11-26 2021-02-19 福安药业集团重庆礼邦药物开发有限公司 Preparation method of impurity compound for defluorination of cinacalcet hydrochloride

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4172017A (en) * 1977-10-27 1979-10-23 Abraham Bernard M Process for producing chlorine from ammonium chloride
US5229108A (en) * 1990-11-20 1993-07-20 Solomon Montague C Pharmaceutical dosage forms
US5250157A (en) * 1993-02-22 1993-10-05 Lloyd Berg Separation of toluene from methyl isobutyl ketone by azeotropic distillation
US6211244B1 (en) * 1994-10-21 2001-04-03 Nps Pharmaceuticals, Inc. Calcium receptor-active compounds
US6699892B2 (en) * 2002-06-04 2004-03-02 Yung Shin Pharmaceutical Industrial Co., Ltd. Pharmaceutically acceptable salt of amlodipine and method of preparing the same
WO2006125026A2 (en) * 2005-05-16 2006-11-23 Teva Pharmaceutical Industries, Ltd. Process for preparing cinacalcet hydrochloride
US20070054963A1 (en) * 2005-05-23 2007-03-08 Revital Lifshitz-Liron Amorphous cinacalcet hydrochloride and preparation thereof
US20070099998A1 (en) * 2005-05-23 2007-05-03 Revital Lifshitz-Liron Processes for preparing cinacalcet hydrochloride crystal form I

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4172017A (en) * 1977-10-27 1979-10-23 Abraham Bernard M Process for producing chlorine from ammonium chloride
US5229108A (en) * 1990-11-20 1993-07-20 Solomon Montague C Pharmaceutical dosage forms
US5250157A (en) * 1993-02-22 1993-10-05 Lloyd Berg Separation of toluene from methyl isobutyl ketone by azeotropic distillation
US6211244B1 (en) * 1994-10-21 2001-04-03 Nps Pharmaceuticals, Inc. Calcium receptor-active compounds
US6699892B2 (en) * 2002-06-04 2004-03-02 Yung Shin Pharmaceutical Industrial Co., Ltd. Pharmaceutically acceptable salt of amlodipine and method of preparing the same
WO2006125026A2 (en) * 2005-05-16 2006-11-23 Teva Pharmaceutical Industries, Ltd. Process for preparing cinacalcet hydrochloride
US20070054963A1 (en) * 2005-05-23 2007-03-08 Revital Lifshitz-Liron Amorphous cinacalcet hydrochloride and preparation thereof
US20070099998A1 (en) * 2005-05-23 2007-05-03 Revital Lifshitz-Liron Processes for preparing cinacalcet hydrochloride crystal form I

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111704551B (en) * 2020-08-20 2020-11-20 天津汉一医药科技有限公司 Preparation method of cinacalcet hydrochloride

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Publication number Publication date
WO2008058236A2 (en) 2008-05-15

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