CA2486157C - Opioid and opioid-like compounds and uses thereof - Google Patents
Opioid and opioid-like compounds and uses thereof Download PDFInfo
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- CA2486157C CA2486157C CA2486157A CA2486157A CA2486157C CA 2486157 C CA2486157 C CA 2486157C CA 2486157 A CA2486157 A CA 2486157A CA 2486157 A CA2486157 A CA 2486157A CA 2486157 C CA2486157 C CA 2486157C
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- Prior art keywords
- methoxy
- morphinan
- compound
- alkyl
- ring
- Prior art date
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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Landscapes
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- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
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| US7923454B2 (en) * | 2002-05-17 | 2011-04-12 | Jenken Biosciences, Inc. | Opioid and opioid-like compounds and uses thereof |
| US20040204862A1 (en) * | 2003-04-11 | 2004-10-14 | Wainer Irving W. | Computer-based model for identification and characterization for non-competitive inhibitors of nicotinic acetylcholine receptors and related ligand-gated ion channel receptors |
| AU2005244852B2 (en) * | 2004-05-12 | 2011-09-22 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Methods related to the treatment of neurodegenerative and inflammatory conditions |
| WO2005110412A1 (en) * | 2004-05-14 | 2005-11-24 | Green Cross Corp. | Neuroprotective properties of dextrorotatory morphinans |
| SA07280459B1 (ar) * | 2006-08-25 | 2011-07-20 | بيورديو فارما إل. بي. | أشكال جرعة صيدلانية للتناول عن طريق الفم مقاومة للعبث تشتمل على مسكن شبه أفيوني |
| DK2792662T3 (da) | 2007-05-01 | 2016-07-25 | Concert Pharmaceuticals Inc | Morphinanforbindelser |
| JP5451611B2 (ja) | 2007-07-26 | 2014-03-26 | ヴァイティー ファーマシューティカルズ，インコーポレイテッド | １１β−ヒドロキシステロイドデヒドロゲナーゼ１のサイクリックインヒビター |
| AR069207A1 (es) | 2007-11-07 | 2010-01-06 | Vitae Pharmaceuticals Inc | Ureas ciclicas como inhibidores de la 11 beta - hidroxi-esteroide deshidrogenasa 1 |
| US8859580B2 (en) | 2007-11-16 | 2014-10-14 | Boehringer Ingelheim International Gmbh | Aryl- and heteroarylcarbonyl derivatives of benzomorphanes and related scaffolds, medicaments containing such compounds and their use |
| MX2010005680A (es) * | 2007-11-23 | 2010-12-21 | Protect Pharmaceutical Corp | Composiciones de tapentadol. |
| CA2708303A1 (en) | 2007-12-11 | 2009-06-18 | Vitae Pharmaceuticals, Inc. | Cyclic urea inhibitors of 11.beta.-hydroxysteroid dehydrogenase 1 |
| TW200934490A (en) | 2008-01-07 | 2009-08-16 | Vitae Pharmaceuticals Inc | Lactam inhibitors of 11 &abgr;-hydroxysteroid dehydrogenase 1 |
| WO2009094169A1 (en) | 2008-01-24 | 2009-07-30 | Vitae Pharmaceuticals, Inc. | Cyclic carbazate and semicarbazide inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
| US8598160B2 (en) | 2008-02-15 | 2013-12-03 | Vitae Pharmaceuticals, Inc. | Cycloalkyl lactame derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 |
| TW201004945A (en) | 2008-05-01 | 2010-02-01 | Vitae Pharmaceuticals Inc | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
| EP2291370B1 (en) | 2008-05-01 | 2013-11-27 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
| KR20110002492A (ko) | 2008-05-01 | 2011-01-07 | 비타이 파마슈티컬즈, 인코포레이티드 | 11베타-하이드록시스테로이드 탈수소효소 1의 고리형 억제제 |
| US8765780B2 (en) | 2008-05-13 | 2014-07-01 | Boehringer Ingelheim International Gmbh | Alicyclic carboxylic acid derivatives of benzomorphans and related scaffolds, medicaments containing such compounds and their use |
| US8846668B2 (en) | 2008-07-25 | 2014-09-30 | Vitae Pharmaceuticals, Inc. | Inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
| WO2010011314A1 (en) | 2008-07-25 | 2010-01-28 | Boehringer Ingelheim International Gmbh | Cyclic inhibitors of 11 beta-hydroxysteroid dehydrogenase 1 |
| JP5730769B2 (ja) | 2008-09-19 | 2015-06-10 | コンサート ファーマシューティカルズ インコーポレイテッド | モルヒナン化合物 |
| JP5679997B2 (ja) | 2009-02-04 | 2015-03-04 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | １１β−ヒドロキシステロイドデヒドロゲナーゼ１の環状阻害剤 |
| UA109255C2 (ru) | 2009-04-30 | 2015-08-10 | Берінгер Інгельхайм Інтернешнл Гмбх | Циклические ингибиторы 11бета-гидроксистероиддегидрогеназы 1 |
| WO2011011123A1 (en) | 2009-06-11 | 2011-01-27 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 based on the 1,3 -oxazinan- 2 -one structure |
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| BR112012028153A2 (pt) | 2010-05-03 | 2018-08-07 | Tsh Biopharm Corporation Ltd | composição farmacêutica e método para o tratamento de hipertensão |
| EP2582698B1 (en) | 2010-06-16 | 2016-09-14 | Vitae Pharmaceuticals, Inc. | Substituted 5-,6- and 7-membered heterocycles, medicaments containing such compounds, and their use |
| WO2011161128A1 (en) | 2010-06-25 | 2011-12-29 | Boehringer Ingelheim International Gmbh | Azaspirohexanones as inhibitors of 11-beta-hsd1 for the treatment of metabolic disorders |
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| TWI537258B (zh) | 2010-11-05 | 2016-06-11 | 百靈佳殷格翰國際股份有限公司 | 六氫茚并吡啶及八氫苯并喹啉之芳基－及雜環芳基羰基衍生物 |
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| CN103254131A (zh) * | 2013-04-23 | 2013-08-21 | 苏州谷力生物科技有限公司 | 一种右美沙芬原料药的精制工艺 |
| GB201308440D0 (en) * | 2013-05-10 | 2013-06-19 | Dalgleish Angus | Therapeutic |
| JP6248711B2 (ja) | 2014-03-06 | 2017-12-20 | 株式会社デンソー | 回転電機の固定子 |
| US9757372B2 (en) * | 2015-03-25 | 2017-09-12 | Taiwanj Pharmaceuticals Co., Ltd. | Toll-like receptor 4 antagonists and use in autoimmune liver diseases |
| CN109069503A (zh) | 2016-04-22 | 2018-12-21 | 景凯生物科技股份有限公司 | 纳美芬(nalmefene)、纳曲酮(naltrexone)或其衍生物在治疗(非)酒精性脂肪肝炎(nash)或非酒精性脂肪性肝病(nafld)的应用 |
| CN110290792A (zh) * | 2017-01-05 | 2019-09-27 | 景凯生物科技股份有限公司 | 吗啡喃衍生物和其用于治疗自体免疫、发炎或感染相关的障碍的组合物 |
| CN107157998A (zh) * | 2017-05-26 | 2017-09-15 | 张灏 | 右美沙芬的新用途 |
| EP3927709A4 (en) * | 2019-02-19 | 2022-11-02 | Robert J. Barsotti | ORGAN PRESERVATION SOLUTIONS AND PROCESSES |
| CN119977886B (zh) * | 2025-02-13 | 2025-08-22 | 安徽益普克医药科技发展有限公司 | 一种葡萄糖酸喷他佐辛苯甲酸酯及其制备方法与用途 |
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| US3275638A (en) | 1966-09-27 | Chjcoo- | ||
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2003
- 2003-05-16 WO PCT/US2003/015461 patent/WO2003097608A2/en not_active Ceased
- 2003-05-16 CA CA2486157A patent/CA2486157C/en not_active Expired - Fee Related
- 2003-05-16 EP EP15186541.7A patent/EP2987788A1/en not_active Withdrawn
- 2003-05-16 MX MXPA04011327A patent/MXPA04011327A/es not_active Application Discontinuation
- 2003-05-16 CN CN038112396A patent/CN1653050B/zh not_active Expired - Lifetime
- 2003-05-16 AU AU2003234621A patent/AU2003234621A1/en not_active Abandoned
- 2003-05-16 EP EP03728964.2A patent/EP1506174B1/en not_active Expired - Lifetime
- 2003-05-16 CN CN201310094981.6A patent/CN103405431B/zh not_active Expired - Lifetime
- 2003-05-16 JP JP2004505341A patent/JP5438250B2/ja not_active Expired - Fee Related
- 2003-11-17 TW TWOPIOIDANA patent/TWI275591B/zh not_active IP Right Cessation
-
2010
- 2010-08-24 AU AU2010212517A patent/AU2010212517A1/en not_active Abandoned
-
2013
- 2013-11-01 JP JP2013228118A patent/JP6165592B2/ja not_active Expired - Fee Related
-
2015
- 2015-04-24 JP JP2015089558A patent/JP6193298B2/ja not_active Expired - Lifetime
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2016
- 2016-07-18 HK HK16108452.6A patent/HK1220452A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HK1192711A1 (zh) | 2014-08-29 |
| EP1506174A2 (en) | 2005-02-16 |
| CN103405431A (zh) | 2013-11-27 |
| EP1506174B1 (en) | 2015-09-30 |
| TW200427690A (en) | 2004-12-16 |
| JP2005530798A (ja) | 2005-10-13 |
| WO2003097608A2 (en) | 2003-11-27 |
| EP2987788A1 (en) | 2016-02-24 |
| TWI275591B (en) | 2007-03-11 |
| JP6165592B2 (ja) | 2017-07-19 |
| CN103405431B (zh) | 2016-04-13 |
| WO2003097608A3 (en) | 2004-03-18 |
| JP2015155449A (ja) | 2015-08-27 |
| JP2014043452A (ja) | 2014-03-13 |
| MXPA04011327A (es) | 2005-08-15 |
| HK1220452A1 (en) | 2017-06-09 |
| JP6193298B2 (ja) | 2017-09-06 |
| AU2003234621A1 (en) | 2003-12-02 |
| CN1653050B (zh) | 2013-04-24 |
| CN1653050A (zh) | 2005-08-10 |
| CA2486157A1 (en) | 2003-11-27 |
| AU2010212517A1 (en) | 2010-09-16 |
| JP5438250B2 (ja) | 2014-03-12 |
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