CA2468133C - Formulation of amino acids and riboflavin useful to reduce toxic effects of cytotoxic chemotherapy - Google Patents

Formulation of amino acids and riboflavin useful to reduce toxic effects of cytotoxic chemotherapy Download PDF

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Publication number
CA2468133C
CA2468133C CA2468133A CA2468133A CA2468133C CA 2468133 C CA2468133 C CA 2468133C CA 2468133 A CA2468133 A CA 2468133A CA 2468133 A CA2468133 A CA 2468133A CA 2468133 C CA2468133 C CA 2468133C
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CA
Canada
Prior art keywords
cancer
amino acids
concentration
riboflavin
injection
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2468133A
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English (en)
French (fr)
Other versions
CA2468133A1 (en
Inventor
Stanislaw R. Burzynski
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Individual
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Individual
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Filing date
Publication date
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Publication of CA2468133A1 publication Critical patent/CA2468133A1/en
Application granted granted Critical
Publication of CA2468133C publication Critical patent/CA2468133C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/195Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/195Carboxylic acids, e.g. valproic acid having an amino group
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/525Isoalloxazines, e.g. riboflavins, vitamin B2
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00General protective or antinoxious agents
    • A61P39/02Antidotes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Surgery (AREA)
  • Oncology (AREA)
  • Toxicology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CA2468133A 2001-11-27 2002-11-21 Formulation of amino acids and riboflavin useful to reduce toxic effects of cytotoxic chemotherapy Expired - Fee Related CA2468133C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/995,010 2001-11-27
US09/995,010 US20030105104A1 (en) 2001-11-27 2001-11-27 Formulation of amino acids and riboflavin useful to reduce toxic effects of cytotoxic chemotherapy
PCT/US2002/037354 WO2003045372A1 (en) 2001-11-27 2002-11-21 Formulation of amino acids and riboflavin useful to reduce toxic effects of cytotoxic chemotherapy

Publications (2)

Publication Number Publication Date
CA2468133A1 CA2468133A1 (en) 2003-06-05
CA2468133C true CA2468133C (en) 2011-02-22

Family

ID=25541300

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2468133A Expired - Fee Related CA2468133C (en) 2001-11-27 2002-11-21 Formulation of amino acids and riboflavin useful to reduce toxic effects of cytotoxic chemotherapy

Country Status (21)

Country Link
US (2) US20030105104A1 (es)
EP (1) EP1450781B1 (es)
JP (1) JP4614660B2 (es)
KR (1) KR100953483B1 (es)
CN (1) CN100358527C (es)
AT (1) ATE330595T1 (es)
BR (1) BR0214430A (es)
CA (1) CA2468133C (es)
DE (1) DE60212693T2 (es)
EA (1) EA009516B1 (es)
HU (1) HU230986B1 (es)
IL (2) IL162141A0 (es)
MX (1) MXPA04004994A (es)
NO (1) NO332858B1 (es)
NZ (1) NZ532833A (es)
PL (1) PL353656A1 (es)
RO (1) RO121173B1 (es)
SI (1) SI21542A (es)
UA (1) UA78977C2 (es)
WO (1) WO2003045372A1 (es)
ZA (1) ZA200404115B (es)

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US20070248693A1 (en) * 2003-08-02 2007-10-25 Elizabeth Mazzio Nutraceutical composition and method of use for treatment / prevention of cancer
US20060035981A1 (en) * 2003-08-02 2006-02-16 Mazzio Elizabeth A Inhibition of anaerobic glucose metabolism and corresponding composition as a natural non-toxic approach to cancer treatment
PT2153870E (pt) * 2004-11-26 2014-03-12 Ucl Business Plc Composições compreendendo ornitina e fenilacetato ou fenilbutirato para tratamento de encefalopatia hepática
CN101288013B (zh) * 2005-09-19 2010-12-08 Cdm光学有限公司 基于任务的成像系统
WO2007119378A1 (ja) 2006-03-15 2007-10-25 Suntory Limited リボフラビンとセサミン類とを含有する組成物
WO2008050836A1 (fr) * 2006-10-25 2008-05-02 Ajinomoto Co., Inc. Agent destiné à l'amélioration des effets secondaires d'un agent chimiothérapeutique
JPWO2008105384A1 (ja) * 2007-02-26 2010-06-03 協和発酵バイオ株式会社 シトルリン含有錠剤
EP3342409A1 (en) 2007-03-15 2018-07-04 Suntory Holdings Limited Anti-fatigue agent
WO2010011927A1 (en) 2008-07-25 2010-01-28 Noventis, Inc. Compositions and methods for the prevention and treatment of cardiovascular diseases
JP5882735B2 (ja) 2008-09-19 2016-03-09 ネステク ソシエテ アノニム 抗癌治療の間の骨髄麻痺又は好中球減少を阻止又は緩和するための栄養支援
AU2014200578B2 (en) * 2008-09-19 2016-08-11 Société des Produits Nestlé S.A. Nutritional support to prevent or moderate bone marrow paralysis or neutropenia during anti-cancer treatment
EA023051B1 (ru) 2009-04-03 2016-04-29 Осера Терапьютикс, Инк. Кристаллические формы фенилацетата l-орнитина и их применение
EP2799067B1 (en) 2009-06-08 2019-04-03 UCL Business PLC Treatment of brain inflammation using L-Ornithine Phenylacetate
US8449512B2 (en) 2010-04-09 2013-05-28 Davinci Biomedical Research Products Inc. Stoma stabilitating device and method
EP2397458A1 (en) * 2010-06-21 2011-12-21 Lunamed AG Organic salts and co-crystals of phenylbutyric acid
AU2011280985C1 (en) 2010-07-22 2016-04-21 Reven Pharmaceuticals, Inc. Methods of treating or ameliorating diseases and enhancing performance comprising the use of a magnetic dipole stabilized solution
EP4406557A2 (en) * 2010-09-24 2024-07-31 University of Florida Research Foundation, Inc. Materials and methods for improving gastrointestinal function
BR112013008054B1 (pt) 2010-10-06 2019-04-09 Ocera Therapeutics, Inc. Composição e processo para produção de sal de acetato de fenil l-ornitina
TWI489981B (zh) * 2010-12-10 2015-07-01 柏萊迪健康科學有限責任公司 使用茉莉酸治療膀胱功能障礙
EP2676664B1 (en) * 2011-02-17 2017-06-21 EA Pharma Co., Ltd. Potentiator of antitumor activity of chemotherapeutic agent
RU2644635C2 (ru) * 2011-07-07 2018-02-13 Рисёрч Кансер Инститьют Оф Америка Системы, способы и составы для лечения рака
ES2708756T3 (es) 2013-03-11 2019-04-11 Univ Florida Materiales y métodos para mejorar la función pulmonar y para la prevención y/o el tratamiento de complicaciones pulmonares inducidas por radiación
BR112016009931B1 (pt) * 2013-11-08 2021-02-02 Legacy Healthcare Ltd composição para uso para a inibição da progressão de tumor e redução do tamanho de tumor e para o tratamento de comorbidades do câncer
JP6598425B2 (ja) * 2014-02-27 2019-10-30 花王株式会社 疲労の評価方法
BR112017010761B1 (pt) 2014-11-24 2022-10-18 Ucl Business Plc Tratamento de doenças associadas à ativação de célula estrelada hepática com o uso de terapias de redução de amônia
CA2995823A1 (en) 2015-08-18 2017-02-23 Ocera Therapeutics, Inc. Treatment and prevention of muscle loss using l-ornithine in combination with at least one of phenylacetate and phenylbutyrate
US11219611B2 (en) 2015-11-13 2022-01-11 Ocera Therapeutics, Inc. Formulations of L-ornithine phenylacetate
CN105495582A (zh) * 2015-12-11 2016-04-20 北京康比特体育科技股份有限公司 一款抗疲劳、促恢复的保健食品氨基酸组合物
JP7126520B2 (ja) 2017-05-11 2022-08-26 オセラ セラピューティクス, インコーポレイテッド L-オルニチンフェニルアセテートを製造する方法

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CA2143420C (en) * 1992-12-23 1999-01-19 Phyllis J. B. Acosta Medical foods for the nutritional support of infant/toddler metabolic diseases
US5571783A (en) * 1993-03-09 1996-11-05 Clintec Nutrition Company Composition and method for treating patients with hepatic disease
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Also Published As

Publication number Publication date
HU230986B1 (hu) 2019-08-28
KR20040065565A (ko) 2004-07-22
IL162141A (en) 2009-05-04
IL162141A0 (en) 2005-11-20
KR100953483B1 (ko) 2010-04-16
DE60212693T2 (de) 2007-07-05
MXPA04004994A (es) 2005-04-08
CN1596109A (zh) 2005-03-16
US20030105104A1 (en) 2003-06-05
NO332858B1 (no) 2013-01-21
WO2003045372A1 (en) 2003-06-05
ATE330595T1 (de) 2006-07-15
PL353656A1 (en) 2003-06-02
CA2468133A1 (en) 2003-06-05
US20050182064A1 (en) 2005-08-18
CN100358527C (zh) 2008-01-02
HUP0402240A3 (en) 2012-09-28
BR0214430A (pt) 2004-11-03
US7427619B2 (en) 2008-09-23
HUP0402240A2 (hu) 2005-02-28
JP2005518361A (ja) 2005-06-23
JP4614660B2 (ja) 2011-01-19
EP1450781B1 (en) 2006-06-21
UA78977C2 (en) 2007-05-10
RO121173B1 (ro) 2007-01-30
EP1450781A1 (en) 2004-09-01
EA009516B1 (ru) 2008-02-28
DE60212693D1 (de) 2006-08-03
SI21542A (sl) 2005-02-28
NO20042364L (no) 2004-06-07
AU2002352843A1 (en) 2003-06-10
EA200400737A1 (ru) 2004-12-30
ZA200404115B (en) 2005-11-30
NZ532833A (en) 2006-12-22

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