CA2354845C - Expression system for factor viii - Google Patents

Expression system for factor viii Download PDF

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Publication number
CA2354845C
CA2354845C CA002354845A CA2354845A CA2354845C CA 2354845 C CA2354845 C CA 2354845C CA 002354845 A CA002354845 A CA 002354845A CA 2354845 A CA2354845 A CA 2354845A CA 2354845 C CA2354845 C CA 2354845C
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CA
Canada
Prior art keywords
leu
ser
val
glu
thr
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA002354845A
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English (en)
French (fr)
Other versions
CA2354845A1 (en
Inventor
Myung-Sam Cho
Sham Yuen Chan
William Kelsey
Helena Yee
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Bayer Corp
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Bayer Corp
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Publication of CA2354845A1 publication Critical patent/CA2354845A1/en
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Publication of CA2354845C publication Critical patent/CA2354845C/en
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Expired - Lifetime legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/028—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a herpesvirus

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Biotechnology (AREA)
  • Public Health (AREA)
  • Wood Science & Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Compounds Of Unknown Constitution (AREA)
CA002354845A 1998-12-10 1999-12-08 Expression system for factor viii Expired - Lifetime CA2354845C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/209,916 US6358703B1 (en) 1998-12-10 1998-12-10 Expression system for factor VIII
US09/209,916 1998-12-10
PCT/US1999/029169 WO2000034505A1 (en) 1998-12-10 1999-12-08 Expression system for factor viii

Publications (2)

Publication Number Publication Date
CA2354845A1 CA2354845A1 (en) 2000-06-15
CA2354845C true CA2354845C (en) 2008-08-12

Family

ID=22780858

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002354845A Expired - Lifetime CA2354845C (en) 1998-12-10 1999-12-08 Expression system for factor viii

Country Status (26)

Country Link
US (10) US6358703B1 (enExample)
EP (1) EP1137797B1 (enExample)
JP (1) JP4240818B2 (enExample)
KR (1) KR100616028B1 (enExample)
AT (1) ATE412765T1 (enExample)
AU (1) AU761801B2 (enExample)
BG (1) BG65431B1 (enExample)
BR (1) BRPI9916069B8 (enExample)
CA (1) CA2354845C (enExample)
CZ (1) CZ302330B6 (enExample)
DE (1) DE69939839D1 (enExample)
DK (1) DK1137797T3 (enExample)
ES (1) ES2315026T3 (enExample)
HU (1) HU228489B1 (enExample)
IL (2) IL143353A0 (enExample)
NO (1) NO329544B1 (enExample)
NZ (1) NZ512234A (enExample)
PL (1) PL200676B1 (enExample)
PT (1) PT1137797E (enExample)
RO (1) RO121604B1 (enExample)
RU (1) RU2249041C2 (enExample)
SI (1) SI20644B (enExample)
SK (1) SK286945B6 (enExample)
TR (1) TR200101592T2 (enExample)
UA (1) UA77383C2 (enExample)
WO (1) WO2000034505A1 (enExample)

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US6180108B1 (en) * 1998-12-10 2001-01-30 Bayer Corporation Vectors having terminal repeat sequence of Epstein-Barr virus
US6358703B1 (en) * 1998-12-10 2002-03-19 Bayer Corporation Expression system for factor VIII
EP1460131A3 (en) * 2000-03-22 2005-06-01 Octagene GmbH Production of recombinant blood clotting factors in human cell lines
EP2110385A1 (en) 2001-06-14 2009-10-21 The Scripps Research Institute Stabilized factor VIII with engineered disulfide bonds
AU2004215912B2 (en) * 2003-02-26 2009-03-26 Nektar Therapeutics Polymer-factor VIII moiety conjugates
US7709224B2 (en) * 2003-06-03 2010-05-04 Biosante Pharmaceuticals, Inc. Compositions and methods for enhanced expression of recombinant polypeptides from a single vector using a peptide cleavage site
US7485291B2 (en) * 2003-06-03 2009-02-03 Cell Genesys, Inc. Compositions and methods for generating multiple polypeptides from a single vector using a virus derived peptide cleavage site, and uses thereof
JP2008518597A (ja) * 2004-10-29 2008-06-05 セントカー・インコーポレーテツド 化学的規定培地組成物
SI1824988T1 (sl) 2004-11-12 2017-11-30 Bayer Healthcare Llc Usmerjena modifikacija FVIII
TWI423986B (zh) 2005-12-20 2014-01-21 必治妥美雅史谷比公司 組合物及製造組合物之方法
AR058568A1 (es) 2005-12-20 2008-02-13 Bristol Myers Squibb Co Metodos para producir una composicion con moleculas ctla4-ig a partir de un medio de cultivo
PL2235197T3 (pl) 2007-12-27 2018-01-31 Baxalta GmbH Sposoby hodowli komórek
KR101005967B1 (ko) * 2008-04-12 2011-01-05 (주)셀트리온 우수한 재조합 단백질을 생산하기 위한 인간 숙주 세포
CA2728708A1 (en) * 2008-06-25 2009-12-30 Bayer Healthcare Llc Factor viii muteins with reduced immunogenicity
AU2009284113B2 (en) 2008-08-21 2015-05-14 Octapharma Ag Recombinantly produced human factor VIII and IX
KR101691443B1 (ko) * 2008-09-03 2016-12-30 옥타파마 아게 재조합에 의해 제조된 인자 ⅷ을 위한 신규한 보호 조성물
WO2010091122A1 (en) 2009-02-03 2010-08-12 Amunix, Inc. Extended recombinant polypeptides and compositions comprising same
CN102427823A (zh) * 2009-03-24 2012-04-25 拜耳医药保健有限公司 因子viii变体及使用方法
BR112012004094A2 (pt) 2009-08-24 2016-03-08 Amunix Operating Inc composições de fator vii de coagulação e métodos para fazer e usar as mesmas
US20110150843A1 (en) * 2009-10-30 2011-06-23 National Institute Of Immunology Method for the therapeutic correction of hemophilia a by transplanting bone marrow cells
US20130017997A1 (en) * 2010-08-19 2013-01-17 Amunix Operating Inc. Factor VIII Compositions and Methods of Making and Using Same
KR101980164B1 (ko) * 2011-05-13 2019-05-20 옥타파마 아게 재조합 ｆｖｉｉｉ의 생산에서 진핵 세포의 생산성을 증가시키는 방법
EA035323B1 (ru) 2012-01-12 2020-05-28 Биовератив Терапьютикс Инк. Полипептиды химерного фактора viii и их применение
LT2822577T (lt) 2012-02-15 2019-03-25 Bioverativ Therapeutics Inc. Rekombinantiniai faktoriaus viii baltymai
HRP20221531T1 (hr) * 2012-02-15 2023-02-17 Bioverativ Therapeutics Inc. Pripravci faktora viii i postupci dobivanja i korištenja istih
EP3033097B1 (en) 2013-08-14 2021-03-10 Bioverativ Therapeutics Inc. Factor viii-xten fusions and uses thereof
DK3091997T5 (da) 2014-01-10 2024-10-14 Bioverativ Therapeutics Inc Kimære faktor viii-proteiner og anvendelser deraf
MX2018001497A (es) 2015-08-03 2018-05-15 Bioverativ Therapeutics Inc Proteinas de fusion de factor ix y metodos para producirlas y usarlas.
SG11201808475XA (en) 2016-04-15 2018-10-30 Baxalta Inc Method and apparatus for providing a pharmacokinetic drug dosing regiment
WO2018017923A1 (en) 2016-07-22 2018-01-25 Nektar Therapeutics Conjugates of a factor viii moiety having an oxime-containing linkage
WO2018102743A1 (en) 2016-12-02 2018-06-07 Bioverativ Therapeutics Inc. Methods of treating hemophilic arthropathy using chimeric clotting factors
US10896749B2 (en) 2017-01-27 2021-01-19 Shire Human Genetic Therapies, Inc. Drug monitoring tool
WO2019055717A1 (en) * 2017-09-13 2019-03-21 Evolve Biosystems, Inc. OLIGOSACCHARIDE COMPOSITIONS AND THEIR USE DURING THE TRANSIENT PHASES OF INTESTINAL MICROBIOMA OF A MAMMALIAN
KR20190086269A (ko) * 2018-01-12 2019-07-22 재단법인 목암생명과학연구소 체내 지속형 재조합 당단백질 및 이의 제조방법
RS66972B1 (sr) 2018-05-18 2025-07-31 Bioverativ Therapeutics Inc Metode lečenja hemofilije a
CA3115535A1 (en) * 2018-10-23 2020-04-30 The Children's Hospital Of Philadelphia Compositions and methods for modulating factor viii function

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Also Published As

Publication number Publication date
NO329544B1 (no) 2010-11-08
EP1137797B1 (en) 2008-10-29
EP1137797A1 (en) 2001-10-04
AU2170100A (en) 2000-06-26
HUP0200558A3 (en) 2004-11-29
BG105567A (en) 2002-03-29
ES2315026T3 (es) 2009-03-16
CA2354845A1 (en) 2000-06-15
IL143353A (en) 2010-12-30
NO20012718D0 (no) 2001-06-01
HU228489B1 (en) 2013-03-28
RO121604B1 (ro) 2007-12-28
PT1137797E (pt) 2008-12-26
NO20012718L (no) 2001-06-01
US6358703B1 (en) 2002-03-19
US9650431B2 (en) 2017-05-16
SK286945B6 (sk) 2009-08-06
US9249209B2 (en) 2016-02-02
US20090036358A1 (en) 2009-02-05
JP4240818B2 (ja) 2009-03-18
IL143353A0 (en) 2002-04-21
US20030077752A1 (en) 2003-04-24
BR9916069A (pt) 2001-09-04
WO2000034505A1 (en) 2000-06-15
KR100616028B1 (ko) 2006-08-28
CZ20012024A3 (cs) 2001-10-17
CZ302330B6 (cs) 2011-03-16
DE69939839D1 (de) 2008-12-11
ATE412765T1 (de) 2008-11-15
US20020115152A1 (en) 2002-08-22
US20110144025A1 (en) 2011-06-16
UA77383C2 (uk) 2006-12-15
AU761801B2 (en) 2003-06-12
DK1137797T3 (da) 2009-02-23
HUP0200558A2 (en) 2002-06-28
BRPI9916069B1 (pt) 2016-08-02
SK7922001A3 (en) 2002-01-07
BRPI9916069B8 (pt) 2021-05-25
PL349284A1 (en) 2002-07-15
BG65431B1 (bg) 2008-07-31
US7459525B2 (en) 2008-12-02
US20130143818A1 (en) 2013-06-06
SI20644A (sl) 2002-02-28
US20170267745A1 (en) 2017-09-21
SI20644B (sl) 2009-04-30
JP2002531137A (ja) 2002-09-24
NZ512234A (en) 2002-12-20
US20160115219A1 (en) 2016-04-28
US8945869B2 (en) 2015-02-03
RU2249041C2 (ru) 2005-03-27
TR200101592T2 (tr) 2001-11-21
US8207117B2 (en) 2012-06-26
US20130267468A1 (en) 2013-10-10
US20020102730A1 (en) 2002-08-01
KR20020013481A (ko) 2002-02-20
PL200676B1 (pl) 2009-01-30
EP1137797A4 (en) 2005-06-22

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Effective date: 20191209