CA2243994A1 - Derives de 4-amino-pyrimidine, medicaments contenant ces composes, leur utilisation et leur procede de production - Google Patents

Derives de 4-amino-pyrimidine, medicaments contenant ces composes, leur utilisation et leur procede de production Download PDF

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Publication number
CA2243994A1
CA2243994A1 CA002243994A CA2243994A CA2243994A1 CA 2243994 A1 CA2243994 A1 CA 2243994A1 CA 002243994 A CA002243994 A CA 002243994A CA 2243994 A CA2243994 A CA 2243994A CA 2243994 A1 CA2243994 A1 CA 2243994A1
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CA
Canada
Prior art keywords
group
amino
piperidinyl
denotes
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002243994A
Other languages
English (en)
Inventor
Frank Himmelsbach
Georg Dahmann
Thomas Von Ruden
Thomas Metz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE1996108631 external-priority patent/DE19608631A1/de
Application filed by Individual filed Critical Individual
Publication of CA2243994A1 publication Critical patent/CA2243994A1/fr
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La présente invention concerne des dérivés de 4-amino-pyrimidine de formule générale (I), dans laquelle R¿a?, R¿b?, A et B sont définis dans la revendication 1, leurs tautomères, leurs stéréo-isomères et leurs sels, notamment leurs sels physiologiquement acceptables avec des acides ou des bases inorganiques ou organiques, lesdits composés présentant des propriétés pharmacologiques intéressantes, notamment un effet inhibiteur sur la transduction de signal par les tyrosine kinases. L'invention concerne également leur utilisation pour le traitement de maladies, notamment les maladies tumorales, ainsi que la production desdits composés.
CA002243994A 1996-03-06 1997-03-03 Derives de 4-amino-pyrimidine, medicaments contenant ces composes, leur utilisation et leur procede de production Abandoned CA2243994A1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE1996108631 DE19608631A1 (de) 1996-03-06 1996-03-06 4-Amino-pyrimidin-Derivate, diese Verbindungen enthaltende Arnzeimittel, deren Verwendung und Verfahren zu ihrer Herstellung
DE19608631.0 1996-03-06
DE19629652.8 1996-07-23
DE19629652A DE19629652A1 (de) 1996-03-06 1996-07-23 4-Amino-pyrimidin-Derivate, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung

Publications (1)

Publication Number Publication Date
CA2243994A1 true CA2243994A1 (fr) 1997-09-12

Family

ID=26023531

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002243994A Abandoned CA2243994A1 (fr) 1996-03-06 1997-03-03 Derives de 4-amino-pyrimidine, medicaments contenant ces composes, leur utilisation et leur procede de production

Country Status (19)

Country Link
EP (1) EP0885226A1 (fr)
JP (1) JP2000506847A (fr)
KR (1) KR19990087550A (fr)
CN (1) CN1212695A (fr)
AU (1) AU710274B2 (fr)
BG (1) BG102708A (fr)
BR (1) BR9708312A (fr)
CA (1) CA2243994A1 (fr)
CZ (1) CZ281798A3 (fr)
DE (1) DE19629652A1 (fr)
EE (1) EE9800277A (fr)
HU (1) HUP9901820A3 (fr)
IL (1) IL125404A0 (fr)
NO (1) NO984084D0 (fr)
NZ (1) NZ331546A (fr)
PL (1) PL328771A1 (fr)
SK (1) SK120598A3 (fr)
TR (1) TR199801749T2 (fr)
WO (1) WO1997032881A1 (fr)

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Publication number Priority date Publication date Assignee Title
KR19990082463A (ko) 1996-02-13 1999-11-25 돈 리사 로얄 혈관 내피 성장 인자 억제제로서의 퀴나졸린유도체
CN1116286C (zh) 1996-03-05 2003-07-30 曾尼卡有限公司 4－苯胺基喹唑啉衍生物
EP1396489A1 (fr) * 1999-01-27 2004-03-10 Pfizer Products Inc. Composés hétéroaromatiques bicycliques a activité anticancereuse
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PT1244647E (pt) 1999-11-05 2006-10-31 Astrazeneca Ab Derivados de quinazolina como inibidores de vegf
UA82517C2 (uk) * 2003-06-24 2008-04-25 Ньюросерч А/С Нові похідні 8-аза-біцикло[3.2.1]октану та їх застосування як інгібіторів ресорбції моноамінових медіаторів
CA2598489A1 (fr) * 2005-02-16 2006-08-24 Schering Corporation Piperazine-piperidines a activite antagoniste cxcr3
WO2010054264A1 (fr) 2008-11-07 2010-05-14 Triact Therapeutics, Inc. Utilisation de dérivés de butane catécholique dans la thérapie du cancer
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DE4431867A1 (de) * 1994-09-07 1996-03-14 Thomae Gmbh Dr K Pyrimido[5,4-d]pyrimidine, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung

Also Published As

Publication number Publication date
WO1997032881A1 (fr) 1997-09-12
PL328771A1 (en) 1999-02-15
AU1925197A (en) 1997-09-22
EE9800277A (et) 1999-02-15
DE19629652A1 (de) 1998-01-29
KR19990087550A (ko) 1999-12-27
JP2000506847A (ja) 2000-06-06
EP0885226A1 (fr) 1998-12-23
NO984084L (no) 1998-09-04
NZ331546A (en) 2000-03-27
HUP9901820A2 (hu) 1999-09-28
AU710274B2 (en) 1999-09-16
CN1212695A (zh) 1999-03-31
HUP9901820A3 (en) 2001-10-29
BR9708312A (pt) 1999-08-03
TR199801749T2 (xx) 1998-12-21
SK120598A3 (en) 1999-06-11
NO984084D0 (no) 1998-09-04
BG102708A (en) 1999-09-30
CZ281798A3 (cs) 1999-02-17
IL125404A0 (en) 1999-03-12

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Legal Events

Date Code Title Description
FZDE Discontinued