PL328771A1 - Derivatives of 4-aminopyrimidine, therapeutic agents containing such compounds, their application and method of obtaining such compounds - Google Patents

Derivatives of 4-aminopyrimidine, therapeutic agents containing such compounds, their application and method of obtaining such compounds

Info

Publication number
PL328771A1
PL328771A1 PL97328771A PL32877197A PL328771A1 PL 328771 A1 PL328771 A1 PL 328771A1 PL 97328771 A PL97328771 A PL 97328771A PL 32877197 A PL32877197 A PL 32877197A PL 328771 A1 PL328771 A1 PL 328771A1
Authority
PL
Poland
Prior art keywords
compounds
aminopyrimidine
derivatives
obtaining
application
Prior art date
Application number
PL97328771A
Other languages
English (en)
Inventor
Frank Himmelsbach
Georg Dahmann
Rueden Thomas Von
Thomas Metz
Original Assignee
Thomae Gmbh Dr K
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE1996108631 external-priority patent/DE19608631A1/de
Application filed by Thomae Gmbh Dr K filed Critical Thomae Gmbh Dr K
Publication of PL328771A1 publication Critical patent/PL328771A1/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
PL97328771A 1996-03-06 1997-03-03 Derivatives of 4-aminopyrimidine, therapeutic agents containing such compounds, their application and method of obtaining such compounds PL328771A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE1996108631 DE19608631A1 (de) 1996-03-06 1996-03-06 4-Amino-pyrimidin-Derivate, diese Verbindungen enthaltende Arnzeimittel, deren Verwendung und Verfahren zu ihrer Herstellung
DE19629652A DE19629652A1 (de) 1996-03-06 1996-07-23 4-Amino-pyrimidin-Derivate, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung

Publications (1)

Publication Number Publication Date
PL328771A1 true PL328771A1 (en) 1999-02-15

Family

ID=26023531

Family Applications (1)

Application Number Title Priority Date Filing Date
PL97328771A PL328771A1 (en) 1996-03-06 1997-03-03 Derivatives of 4-aminopyrimidine, therapeutic agents containing such compounds, their application and method of obtaining such compounds

Country Status (19)

Country Link
EP (1) EP0885226A1 (fr)
JP (1) JP2000506847A (fr)
KR (1) KR19990087550A (fr)
CN (1) CN1212695A (fr)
AU (1) AU710274B2 (fr)
BG (1) BG102708A (fr)
BR (1) BR9708312A (fr)
CA (1) CA2243994A1 (fr)
CZ (1) CZ281798A3 (fr)
DE (1) DE19629652A1 (fr)
EE (1) EE9800277A (fr)
HU (1) HUP9901820A3 (fr)
IL (1) IL125404A0 (fr)
NO (1) NO984084D0 (fr)
NZ (1) NZ331546A (fr)
PL (1) PL328771A1 (fr)
SK (1) SK120598A3 (fr)
TR (1) TR199801749T2 (fr)
WO (1) WO1997032881A1 (fr)

Families Citing this family (81)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0880508B1 (fr) 1996-02-13 2003-04-16 AstraZeneca AB Derives de la quinazoline utilises comme inhibiteurs du vegf
IL125954A (en) 1996-03-05 2003-06-24 Zeneca Ltd Quinazoline derivatives, processes for their preparation, pharmaceutical compositions containing them and use thereof in the manufacture of medicaments having an antiangiogenic and/or vascular permeability reducing effect
EP1396489A1 (fr) * 1999-01-27 2004-03-10 Pfizer Products Inc. Composés hétéroaromatiques bicycliques a activité anticancereuse
UA71945C2 (en) * 1999-01-27 2005-01-17 Pfizer Prod Inc Substituted bicyclic derivatives being used as anticancer agents
PT1244647E (pt) 1999-11-05 2006-10-31 Astrazeneca Ab Derivados de quinazolina como inibidores de vegf
CA2530023A1 (fr) 2003-06-24 2004-12-29 Neurosearch A/S Nouveaux derives de 8-aza-bicyclo[3.2.1]octane et utilisation en tant qu'inhibiteurs de la reabsorption des neurotransmetteurs monoamine
WO2006088836A2 (fr) * 2005-02-16 2006-08-24 Schering Corporation Piperazine-piperidines a activite antagoniste cxcr3
MX2011004824A (es) 2008-11-07 2012-01-12 Triact Therapeutics Inc Uso de derivados de butano catecólico en terapia contra el cáncer.
CN102216299B (zh) * 2008-12-01 2015-02-11 默克专利有限公司 作为自体毒素抑制剂的2,5-二氨基取代的吡啶并[4,3-d]嘧啶化合物
US20120189641A1 (en) 2009-02-25 2012-07-26 OSI Pharmaceuticals, LLC Combination anti-cancer therapy
US20110171124A1 (en) 2009-02-26 2011-07-14 Osi Pharmaceuticals, Inc. In situ methods for monitoring the EMT status of tumor cells in vivo
WO2010099138A2 (fr) 2009-02-27 2010-09-02 Osi Pharmaceuticals, Inc. Procédés pour l'identification d'agents qui inhibent les cellules tumorales de type mésenchymateuses ou leur formation
JP2012519282A (ja) 2009-02-27 2012-08-23 オーエスアイ・ファーマシューティカルズ,エルエルシー 間葉様腫瘍細胞またはその生成を阻害する薬剤を同定するための方法
US8642834B2 (en) 2009-02-27 2014-02-04 OSI Pharmaceuticals, LLC Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation
US20120064072A1 (en) 2009-03-18 2012-03-15 Maryland Franklin Combination Cancer Therapy Comprising Administration of an EGFR Inhibitor and an IGF-1R Inhibitor
CA2780875A1 (fr) 2009-11-13 2011-05-19 Pangaea Biotech, S.L. Biomarqueurs moleculaires pour predire une reponse a des inhibiteurs de tyrosine kinase dans le cancer du poumon
EP2468883A1 (fr) 2010-12-22 2012-06-27 Pangaea Biotech S.L. Biomarqueurs moléculaires pour la prédiction de la réponse aux inhibiteurs de la tyrosine kinase dans le cancer du poumon
US9134297B2 (en) 2011-01-11 2015-09-15 Icahn School Of Medicine At Mount Sinai Method and compositions for treating cancer and related methods
EP2492688A1 (fr) 2011-02-23 2012-08-29 Pangaea Biotech, S.A. Biomarqueurs moléculaires pour la prédiction de la réponse à un traitement antitumoral dans le cancer du poumon
WO2012129145A1 (fr) 2011-03-18 2012-09-27 OSI Pharmaceuticals, LLC Polythérapie du cancer du poumon non à petites cellules (nsclc)
US9896730B2 (en) 2011-04-25 2018-02-20 OSI Pharmaceuticals, LLC Use of EMT gene signatures in cancer drug discovery, diagnostics, and treatment
CA2845179A1 (fr) 2011-08-31 2013-03-07 Genentech, Inc. Marqueurs de diagnostic
AU2012321248A1 (en) 2011-09-30 2014-04-24 Genentech, Inc. Diagnostic methylation markers of epithelial or mesenchymal phenotype and response to EGFR kinase inhibitor in tumours or tumour cells
WO2013152252A1 (fr) 2012-04-06 2013-10-10 OSI Pharmaceuticals, LLC Polythérapie antinéoplasique
WO2013190089A1 (fr) 2012-06-21 2013-12-27 Pangaea Biotech, S.L. Biomarqueurs moléculaires permettant de prédire l'issue dans le cancer du poumon
CA2941010A1 (fr) 2013-02-26 2014-09-04 Triact Therapeutics, Inc. Cancerotherapie
EP2976085A1 (fr) 2013-03-21 2016-01-27 INSERM - Institut National de la Santé et de la Recherche Médicale Méthode et composition pharmaceutique pour l'utilisation dans le traitement de maladies hépatiques chroniques associées à une faible expression d'hepcidine
CA2923667A1 (fr) 2013-09-09 2015-03-12 Triact Therapeutics, Inc. Traitement du cancer
WO2015156674A2 (fr) 2014-04-10 2015-10-15 Stichting Het Nederlands Kanker Instituut Méthode de traitement du cancer
EP3237638B1 (fr) 2014-12-24 2020-01-15 F.Hoffmann-La Roche Ag Méthodes de traitement, de diagnostic et de pronostic du cancer de la vessie
MX2019007643A (es) 2016-12-22 2019-09-09 Amgen Inc Benzoisotiazol, isotiazolo[3,4-b]piridina, quinazolina, ftalazina, pirido[2,3-d]piridazina y derivados de pirido[2,3-d]pirimidina como inhibirores de kras g12c para tratar el cancer de pulmon, pancreatico o colorrectal.
JOP20190272A1 (ar) 2017-05-22 2019-11-21 Amgen Inc مثبطات kras g12c وطرق لاستخدامها
EP4403175A3 (fr) 2017-09-08 2024-10-02 Amgen Inc. Inhibiteurs de kras g12c et leurs procédés d'utilisation
AU2019262599B2 (en) 2018-05-04 2023-10-12 Amgen Inc. KRAS G12C inhibitors and methods of using the same
WO2019213516A1 (fr) 2018-05-04 2019-11-07 Amgen Inc. Inhibiteurs de kras g12c et leurs procédés d'utilisation
EP3790886B1 (fr) 2018-05-10 2024-06-26 Amgen Inc. Inhibiteurs du kras g12c pour le traitement du cancer
AU2019278998B2 (en) 2018-06-01 2023-11-09 Amgen Inc. KRAS G12C inhibitors and methods of using the same
CA3099799A1 (fr) 2018-06-11 2019-12-19 Amgen Inc. Inhibiteurs de kras g12c pour le traitement du cancer
US11285156B2 (en) 2018-06-12 2022-03-29 Amgen Inc. Substituted piperazines as KRAS G12C inhibitors
JP2022512584A (ja) 2018-10-04 2022-02-07 アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル 角皮症を処置するためのegfrインヒビター
JP7516029B2 (ja) 2018-11-16 2024-07-16 アムジエン・インコーポレーテツド Kras g12c阻害剤化合物の重要な中間体の改良合成法
US11053226B2 (en) 2018-11-19 2021-07-06 Amgen Inc. KRAS G12C inhibitors and methods of using the same
JP7377679B2 (ja) 2018-11-19 2023-11-10 アムジエン・インコーポレーテツド がん治療のためのkrasg12c阻害剤及び1種以上の薬学的に活性な追加の薬剤を含む併用療法
CA3123227A1 (fr) 2018-12-20 2020-06-25 Amgen Inc. Amides d'heteroaryle utiles en tant qu'inhibiteurs de kif18a
WO2020132651A1 (fr) 2018-12-20 2020-06-25 Amgen Inc. Inhibiteurs de kif18a
MA54543A (fr) 2018-12-20 2022-03-30 Amgen Inc Inhibiteurs de kif18a
MX2021007157A (es) 2018-12-20 2021-08-16 Amgen Inc Heteroarilamidas utiles como inhibidores de kif18a.
AU2020232616A1 (en) 2019-03-01 2021-09-09 Revolution Medicines, Inc. Bicyclic heterocyclyl compounds and uses thereof
CN113767100A (zh) 2019-03-01 2021-12-07 锐新医药公司 双环杂芳基化合物及其用途
EP3738593A1 (fr) 2019-05-14 2020-11-18 Amgen, Inc Dosage d'inhibiteur de kras pour le traitement de cancers
KR20220011670A (ko) 2019-05-21 2022-01-28 암젠 인크 고체 상태 형태
AU2020326627A1 (en) 2019-08-02 2022-03-17 Amgen Inc. KIF18A inhibitors
US20220281843A1 (en) 2019-08-02 2022-09-08 Amgen Inc. Kif18a inhibitors
US20240254100A1 (en) 2019-08-02 2024-08-01 Amgen Inc. Kif18a inhibitors
US20220372018A1 (en) 2019-08-02 2022-11-24 Amgen Inc. Kif18a inhibitors
JP2022552873A (ja) 2019-10-24 2022-12-20 アムジエン・インコーポレーテツド がんの治療におけるkras g12c及びkras g12d阻害剤として有用なピリドピリミジン誘導体
US11739074B2 (en) 2019-11-04 2023-08-29 Revolution Medicines, Inc. Ras inhibitors
AU2020379734A1 (en) 2019-11-04 2022-05-05 Revolution Medicines, Inc. Ras inhibitors
TW202132314A (zh) 2019-11-04 2021-09-01 美商銳新醫藥公司 Ras抑制劑
JP2023500328A (ja) 2019-11-08 2023-01-05 レボリューション メディシンズ インコーポレイテッド 二環式ヘテロアリール化合物及びその使用
US20230192681A1 (en) 2019-11-14 2023-06-22 Amgen Inc. Improved synthesis of kras g12c inhibitor compound
AR120456A1 (es) 2019-11-14 2022-02-16 Amgen Inc Síntesis mejorada del compuesto inhibidor de g12c de kras
WO2021108683A1 (fr) 2019-11-27 2021-06-03 Revolution Medicines, Inc. Inhibiteurs de ras covalents et leurs utilisations
JP2023509701A (ja) 2020-01-07 2023-03-09 レヴォリューション・メディスンズ,インコーポレイテッド Shp2阻害剤投薬およびがんを処置する方法
CN115916194A (zh) 2020-06-18 2023-04-04 锐新医药公司 用于延迟、预防和治疗针对ras抑制剂的获得性抗性的方法
WO2022060583A1 (fr) 2020-09-03 2022-03-24 Revolution Medicines, Inc. Utilisation d'inhibiteurs de sos1 pour traiter des malignités à mutations de shp2
AU2021345111A1 (en) 2020-09-15 2023-04-06 Revolution Medicines, Inc. Indole derivatives as Ras inhibitors in the treatment of cancer
AU2021409816A1 (en) 2020-12-22 2023-07-06 Qilu Regor Therapeutics Inc. Sos1 inhibitors and uses thereof
PE20240327A1 (es) 2021-04-13 2024-02-22 Nuvalent Inc Heterociclos con sustitucion amino para tratar canceres con mutaciones de egfr
WO2022235864A1 (fr) 2021-05-05 2022-11-10 Revolution Medicines, Inc. Inhibiteurs de ras
CN117616031A (zh) 2021-05-05 2024-02-27 锐新医药公司 用于治疗癌症的ras抑制剂
WO2022235866A1 (fr) 2021-05-05 2022-11-10 Revolution Medicines, Inc. Inhibiteurs de ras covalents et leurs utilisations
AR127308A1 (es) 2021-10-08 2024-01-10 Revolution Medicines Inc Inhibidores ras
WO2023114954A1 (fr) 2021-12-17 2023-06-22 Genzyme Corporation Composés pyrazolopyrazine utilisés comme inhibiteurs de la shp2
EP4227307A1 (fr) 2022-02-11 2023-08-16 Genzyme Corporation Composés pyrazolopyrazine en tant qu'inhibiteurs de shp2
WO2023172940A1 (fr) 2022-03-08 2023-09-14 Revolution Medicines, Inc. Méthodes de traitement du cancer du poumon réfractaire immunitaire
WO2023240263A1 (fr) 2022-06-10 2023-12-14 Revolution Medicines, Inc. Inhibiteurs de ras macrocycliques
WO2024081916A1 (fr) 2022-10-14 2024-04-18 Black Diamond Therapeutics, Inc. Méthodes de traitement de cancers à l'aide de dérivés d'isoquinoline ou de 6-aza-quinoléine
WO2024206858A1 (fr) 2023-03-30 2024-10-03 Revolution Medicines, Inc. Compositions pour induire une hydrolyse de ras gtp et leurs utilisations
WO2024211663A1 (fr) 2023-04-07 2024-10-10 Revolution Medicines, Inc. Composés macrocycliques condensés en tant qu'inhibiteurs de ras
WO2024211712A1 (fr) 2023-04-07 2024-10-10 Revolution Medicines, Inc. Composés macrocycliques condensés en tant qu'inhibiteurs de ras

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL112249A (en) * 1994-01-25 2001-11-25 Warner Lambert Co Pharmaceutical compositions containing di and tricyclic pyrimidine derivatives for inhibiting tyrosine kinases of the epidermal growth factor receptor family and some new such compounds
DE4431867A1 (de) * 1994-09-07 1996-03-14 Thomae Gmbh Dr K Pyrimido[5,4-d]pyrimidine, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung

Also Published As

Publication number Publication date
NZ331546A (en) 2000-03-27
JP2000506847A (ja) 2000-06-06
AU710274B2 (en) 1999-09-16
HUP9901820A2 (hu) 1999-09-28
EE9800277A (et) 1999-02-15
CN1212695A (zh) 1999-03-31
CZ281798A3 (cs) 1999-02-17
BG102708A (en) 1999-09-30
CA2243994A1 (fr) 1997-09-12
KR19990087550A (ko) 1999-12-27
IL125404A0 (en) 1999-03-12
NO984084L (no) 1998-09-04
EP0885226A1 (fr) 1998-12-23
BR9708312A (pt) 1999-08-03
WO1997032881A1 (fr) 1997-09-12
NO984084D0 (no) 1998-09-04
AU1925197A (en) 1997-09-22
HUP9901820A3 (en) 2001-10-29
TR199801749T2 (xx) 1998-12-21
SK120598A3 (en) 1999-06-11
DE19629652A1 (de) 1998-01-29

Similar Documents

Publication Publication Date Title
PL328771A1 (en) Derivatives of 4-aminopyrimidine, therapeutic agents containing such compounds, their application and method of obtaining such compounds
PL330841A1 (en) Benzosulphonic derivatives, method of obtaining them and therapeutic agents containing such derivatives
PL317930A1 (en) Oxalydine compounds, method of obtaining them and therapeutic agents
PL329440A1 (en) Derivatives of d-proline, method of obtaining them and therapeutic agent containing such compounds
PL321201A1 (en) Derivatives of 4-hydroxypiepridine, method of obtaining them and therapeutic agents containing such derivatives
PL313433A1 (en) Derivatives of benzazepin-, benzoxazepin- and benzothiazepin-n-acetic acids, method of obtaining them and therapeutic agents containing such derivatives
PL318277A1 (en) Novel substituted axazolydinones, method of obtaining and drugs containing them
PL320952A1 (en) Cycloalkanon pyridines, method of obtaining and therapeutic agents containing them
PL311999A1 (en) Piperazine derivatives, therapeutic agents containing them and method of obtaining such derivatives
PL332432A1 (en) Oxadiazoles, method of obtaining them as well as their application as therapeutic agents
PL331863A1 (en) 7alpha-(xi-aminoalkyl)-estrathienes, method of obtaining them, pharmacautic preparations containing such compounds and their application in production of therapeutic agents
PL329274A1 (en) Novel derivatives of isoquinolin-3-carboxylamides, method of obtaining them, their application, pharmaceutic agent containing them and method of obtaining such pharmaceutic agent
PL316613A1 (en) Novel derivatives of piperazine, methods of obtaining them and agents containing such derivatives
PL324436A1 (en) Novel derivatives of oxazolydinone, method of obtaining them and therapeutic agents containing such compounds
PL321003A1 (en) Derivatives of piperasine, drugs containing them, their application and methods of obtaining them
PL307669A1 (en) Benzimidazoles, therapeutic agents containing them and method of obtaining such compounds
PL338143A1 (en) Derivatives acylpiperazinylpyrimidines, method of obtaining and drugs containing them
ZA971964B (en) Azolobenzazepine derivatives and compositions and method of use thereof.
PL325322A1 (en) Novel substituted amine compounds, method of obtaining them and therapeutic agent
PL323177A1 (en) Azacycloalcane derivatives, method of obtaining them and their application for therapeutic purposes
PL322802A1 (en) Derivatives of 10,13,15-trioxatricyclo[9.2.1.1]-pentadecanone, method of obtaining them and therapeutic agents containing such compounds
PL316486A1 (en) Novel sulphonamides, method of obtaining them and therapeutic agent containing them
PL337716A1 (en) Method of obtaining thiazafurin and other c-nucleosides
PL330257A1 (en) Novel heterocyclic derivatives of benzocycloalkene, method of obtaining them and therapeutic agent
AU7961498A (en) 9a-azalides, compositions containing such compounds and methods of treatment