CA2118239C - 1h-imidazo{4,5-c}quinolin-4-amines as vaccine adjuvants - Google Patents

1h-imidazo{4,5-c}quinolin-4-amines as vaccine adjuvants Download PDF

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Publication number
CA2118239C
CA2118239C CA002118239A CA2118239A CA2118239C CA 2118239 C CA2118239 C CA 2118239C CA 002118239 A CA002118239 A CA 002118239A CA 2118239 A CA2118239 A CA 2118239A CA 2118239 C CA2118239 C CA 2118239C
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Canada
Prior art keywords
carbon atoms
group
alkyl
phenyl
immunogen
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
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CA002118239A
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English (en)
French (fr)
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CA2118239A1 (en
Inventor
Richard L. Miller
David I. Bernstein
Christopher J. Harrison
Mark A. Tomai
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3M Co
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Minnesota Mining and Manufacturing Co
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Publication of CA2118239A1 publication Critical patent/CA2118239A1/en
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Publication of CA2118239C publication Critical patent/CA2118239C/en
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/39Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511Organic adjuvants

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CA002118239A 1992-04-16 1993-04-08 1h-imidazo{4,5-c}quinolin-4-amines as vaccine adjuvants Expired - Lifetime CA2118239C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US86938692A 1992-04-16 1992-04-16
US07/869386 1992-04-16
PCT/US1993/003295 WO1993020847A1 (en) 1992-04-16 1993-04-08 Vaccine adjuvant

Publications (2)

Publication Number Publication Date
CA2118239A1 CA2118239A1 (en) 1993-10-28
CA2118239C true CA2118239C (en) 2009-04-07

Family

ID=25353454

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002118239A Expired - Lifetime CA2118239C (en) 1992-04-16 1993-04-08 1h-imidazo{4,5-c}quinolin-4-amines as vaccine adjuvants

Country Status (17)

Country Link
US (1) US6083505A (enExample)
EP (1) EP0636031B1 (enExample)
JP (2) JP3732506B2 (enExample)
KR (1) KR100263804B1 (enExample)
AT (1) ATE142110T1 (enExample)
AU (1) AU674313B2 (enExample)
CA (1) CA2118239C (enExample)
DE (1) DE69304521T2 (enExample)
DK (1) DK0636031T3 (enExample)
ES (1) ES2092306T3 (enExample)
HU (2) HU217209B (enExample)
IL (1) IL105325A (enExample)
MX (1) MX9302199A (enExample)
NO (1) NO313864B1 (enExample)
NZ (2) NZ280098A (enExample)
WO (1) WO1993020847A1 (enExample)
ZA (1) ZA932627B (enExample)

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* Cited by examiner, † Cited by third party
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