CA2113568A1 - 2-(4-hydroxypiperidino)-1-alkanol derivatives as antiischemic agents - Google Patents
2-(4-hydroxypiperidino)-1-alkanol derivatives as antiischemic agentsInfo
- Publication number
- CA2113568A1 CA2113568A1 CA002113568A CA2113568A CA2113568A1 CA 2113568 A1 CA2113568 A1 CA 2113568A1 CA 002113568 A CA002113568 A CA 002113568A CA 2113568 A CA2113568 A CA 2113568A CA 2113568 A1 CA2113568 A1 CA 2113568A1
- Authority
- CA
- Canada
- Prior art keywords
- carbons
- group
- alkyl
- hydrogen
- hydroxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- General Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US73157791A | 1991-07-17 | 1991-07-17 | |
US07/731,577 | 1991-07-17 |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2113568A1 true CA2113568A1 (en) | 1993-02-04 |
Family
ID=24940103
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002113568A Abandoned CA2113568A1 (en) | 1991-07-17 | 1992-06-19 | 2-(4-hydroxypiperidino)-1-alkanol derivatives as antiischemic agents |
Country Status (22)
Country | Link |
---|---|
EP (1) | EP0594729A1 (ko) |
JP (1) | JP2571904B2 (ko) |
KR (1) | KR0165003B1 (ko) |
CN (1) | CN1043759C (ko) |
AU (1) | AU655840B2 (ko) |
BR (1) | BR9206272A (ko) |
CA (1) | CA2113568A1 (ko) |
CZ (1) | CZ284133B6 (ko) |
EG (1) | EG20048A (ko) |
FI (2) | FI940192A0 (ko) |
HU (1) | HUT70528A (ko) |
IE (1) | IE922311A1 (ko) |
IL (1) | IL102473A (ko) |
MX (1) | MX9204190A (ko) |
NO (1) | NO180445C (ko) |
NZ (1) | NZ243580A (ko) |
PL (1) | PL169884B1 (ko) |
PT (1) | PT100689B (ko) |
RU (1) | RU2065859C1 (ko) |
TW (1) | TW201732B (ko) |
WO (1) | WO1993002052A1 (ko) |
ZA (1) | ZA925306B (ko) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5436255A (en) * | 1992-07-23 | 1995-07-25 | Pfizer Inc. | Method of treating diseases susceptable to treatment by blocking NMDA-receptors |
CA2146260C (en) * | 1992-10-30 | 1998-04-07 | Bertrand L. Chenard | Neuroprotective 3,4-dihydro-2(1h)-quinolone compounds |
US5498610A (en) * | 1992-11-06 | 1996-03-12 | Pfizer Inc. | Neuroprotective indolone and related derivatives |
ZA9610736B (en) | 1995-12-22 | 1997-06-27 | Warner Lambert Co | 2-Substituted piperidine analogs and their use as subtypeselective nmda receptor antagonists |
ZA9610741B (en) | 1995-12-22 | 1997-06-24 | Warner Lambert Co | 4-Substituted piperidine analogs and their use as subtype selective nmda receptor antagonists |
ZA9610745B (en) * | 1995-12-22 | 1997-06-24 | Warner Lambert Co | 4-Subsituted piperidine analogs and their use as subtype selective nmda receptor antagonists |
ZA9610738B (en) | 1995-12-22 | 1997-06-24 | Warner Lambert Co | Subtype selective nmda receptor ligands and the use thereof |
AU3676100A (en) * | 1999-04-09 | 2000-11-14 | Mochida Pharmaceutical Co., Ltd. | Remedies for neuropathic pain |
US6495561B2 (en) | 1999-10-29 | 2002-12-17 | Merck & Co., Inc. | 2-cyclohexyl imidazopyridine NMDA/NR2B antagonists |
US6489477B1 (en) | 1999-10-29 | 2002-12-03 | Merck & Co., Inc. | 2-aza-bicyclo[2.2.2]octane NMDA/NR2B antigonists |
US6380205B1 (en) | 1999-10-29 | 2002-04-30 | Merck & Co., Inc. | 2-cyclohexyl quinazoline NMDA/NR2B antagonists |
US6476041B1 (en) | 1999-10-29 | 2002-11-05 | Merck & Co., Inc. | 1,4 substituted piperidinyl NMDA/NR2B antagonists |
US6432976B1 (en) | 1999-10-29 | 2002-08-13 | Merck & Co., Inc. | 8-aza-bicyclo[3.2.1]octane NMDA/NR2B antagonists |
US6316474B1 (en) | 1999-10-29 | 2001-11-13 | Merck & Co., Inc. | 2-benzyl and 2-heteroaryl benzimidazole NMDA/NR2B antagonists |
EP1235572A2 (en) | 1999-10-29 | 2002-09-04 | MERCK SHARP & DOHME LTD. | Method to treat pain utilizing benzimidazole nmda/nr2b antagonists |
US6369076B1 (en) | 1999-10-29 | 2002-04-09 | Merck & Co. Inc. | 5-benzyl-octahydroindole and 6-benzyl-decahydroquinoline NMDA/NR2B antagonists |
US6291499B1 (en) | 1999-10-29 | 2001-09-18 | Merck & Co., Inc. | 2-cyclohexyl benzimidazole NMDA/NR2B antagonists |
UA75392C2 (en) | 2001-02-23 | 2006-04-17 | Merck & Co Inc | N-substituted non-aryl heterocyclic antagonists nmda/nr2b |
CA2443108A1 (en) | 2001-04-03 | 2002-10-17 | Merck & Co. Inc. | N-substituted nonaryl-heterocyclo amidyl nmda/nr2b antagonists |
ATE522502T1 (de) | 2002-11-25 | 2011-09-15 | Mochida Pharm Co Ltd | Therapeutisches mittel gegen atemwegserkrankungen,das ein 4-hydroxypiperidinderivat als wirkstoff enthält |
MXPA06003748A (es) * | 2003-10-08 | 2006-06-14 | Pfizer | Compuestos de lactama condensada. |
TWI409289B (zh) | 2010-09-02 | 2013-09-21 | Taiwan Union Technology Corp | 由氮氧雜環化合物所製得之聚合物之穩態溶液及其製法與用途 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PH17194A (en) * | 1980-03-06 | 1984-06-19 | Otsuka Pharma Co Ltd | Novel carbostyril derivatives,and pharmaceutical composition containing the same |
FR2546166B1 (fr) * | 1983-05-19 | 1985-10-25 | Synthelabo | Enantiomeres du erythro (benzyl-4 piperidino)-2 (hydroxy-4 ou benzyloxy-4 phenyl)-1 propanol, leur preparation et leur application en therapeutique |
FR2640266B2 (fr) * | 1988-07-12 | 1992-07-10 | Synthelabo | Derives de (hydroxy-1 piperidinyl-2 alkyl) indolones-2, quinoleinones-2, benzo(b)azepinones-2 et benzimidazolones-2, leur preparation et leur application en therapeutique |
ES2098248T3 (es) * | 1989-05-17 | 1997-05-01 | Pfizer | Derivados de 2-piperidino-1-alcanoles como agentes antiisquemicos. |
KR0163355B1 (ko) * | 1990-05-10 | 1998-12-01 | 알렌 제이. 스피겔 | 신경보호성 인돌론 및 관련 유도체 |
-
1992
- 1992-06-19 HU HU9400136A patent/HUT70528A/hu unknown
- 1992-06-19 CZ CS924008A patent/CZ284133B6/cs not_active IP Right Cessation
- 1992-06-19 CA CA002113568A patent/CA2113568A1/en not_active Abandoned
- 1992-06-19 RU RU9294012366A patent/RU2065859C1/ru active
- 1992-06-19 BR BR9206272A patent/BR9206272A/pt not_active Application Discontinuation
- 1992-06-19 JP JP5502784A patent/JP2571904B2/ja not_active Expired - Lifetime
- 1992-06-19 WO PCT/US1992/004973 patent/WO1993002052A1/en not_active Application Discontinuation
- 1992-06-19 PL PL92302290A patent/PL169884B1/pl unknown
- 1992-06-19 AU AU23225/92A patent/AU655840B2/en not_active Ceased
- 1992-06-19 EP EP92915510A patent/EP0594729A1/en not_active Ceased
- 1992-06-23 TW TW081104921A patent/TW201732B/zh active
- 1992-07-12 IL IL102473A patent/IL102473A/xx not_active IP Right Cessation
- 1992-07-15 PT PT100689A patent/PT100689B/pt not_active IP Right Cessation
- 1992-07-16 ZA ZA925306A patent/ZA925306B/xx unknown
- 1992-07-16 IE IE231192A patent/IE922311A1/en not_active Application Discontinuation
- 1992-07-16 EG EG39792A patent/EG20048A/xx active
- 1992-07-16 NZ NZ243580A patent/NZ243580A/en unknown
- 1992-07-16 MX MX9204190A patent/MX9204190A/es unknown
- 1992-07-16 CN CN92105921A patent/CN1043759C/zh not_active Expired - Fee Related
-
1994
- 1994-01-14 FI FI940192A patent/FI940192A0/fi unknown
- 1994-01-14 NO NO940144A patent/NO180445C/no not_active IP Right Cessation
- 1994-01-15 KR KR1019940700124A patent/KR0165003B1/ko not_active IP Right Cessation
-
1998
- 1998-09-11 FI FI981956A patent/FI981956A0/fi unknown
Also Published As
Publication number | Publication date |
---|---|
CN1068566A (zh) | 1993-02-03 |
BR9206272A (pt) | 1995-04-11 |
HUT70528A (en) | 1995-10-30 |
WO1993002052A1 (en) | 1993-02-04 |
NZ243580A (en) | 1994-10-26 |
FI981956A (fi) | 1998-09-11 |
CZ400892A3 (en) | 1994-03-16 |
FI940192A (fi) | 1994-01-14 |
NO180445B (no) | 1997-01-13 |
NO940144L (no) | 1994-01-14 |
EG20048A (en) | 1997-03-27 |
PL169884B1 (pl) | 1996-09-30 |
IL102473A (en) | 1997-07-13 |
CZ284133B6 (cs) | 1998-08-12 |
FI940192A0 (fi) | 1994-01-14 |
HU9400136D0 (en) | 1994-05-30 |
IE922311A1 (en) | 1993-01-27 |
JPH06504293A (ja) | 1994-05-19 |
AU655840B2 (en) | 1995-01-12 |
PT100689B (pt) | 1999-06-30 |
IL102473A0 (en) | 1993-01-14 |
JP2571904B2 (ja) | 1997-01-16 |
FI981956A0 (fi) | 1998-09-11 |
ZA925306B (en) | 1994-01-17 |
EP0594729A1 (en) | 1994-05-04 |
NO940144D0 (no) | 1994-01-14 |
TW201732B (ko) | 1993-03-11 |
KR0165003B1 (en) | 1999-01-15 |
RU2065859C1 (ru) | 1996-08-27 |
PT100689A (pt) | 1993-10-29 |
NO180445C (no) | 1997-04-23 |
MX9204190A (es) | 1993-01-01 |
AU2322592A (en) | 1993-02-23 |
CN1043759C (zh) | 1999-06-23 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
FZDE | Discontinued |