ZA925306B - 2-(4-hydroxypiperidino)-1-alkanol derivatives as antiischemic agents - Google Patents

2-(4-hydroxypiperidino)-1-alkanol derivatives as antiischemic agents

Info

Publication number
ZA925306B
ZA925306B ZA925306A ZA925306A ZA925306B ZA 925306 B ZA925306 B ZA 925306B ZA 925306 A ZA925306 A ZA 925306A ZA 925306 A ZA925306 A ZA 925306A ZA 925306 B ZA925306 B ZA 925306B
Authority
ZA
South Africa
Prior art keywords
hydroxypiperidino
alkanol derivatives
antiischemic agents
antiischemic
agents
Prior art date
Application number
ZA925306A
Other languages
English (en)
Inventor
Willard Mckowan Welch Jr
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of ZA925306B publication Critical patent/ZA925306B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
ZA925306A 1991-07-17 1992-07-16 2-(4-hydroxypiperidino)-1-alkanol derivatives as antiischemic agents ZA925306B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US73157791A 1991-07-17 1991-07-17

Publications (1)

Publication Number Publication Date
ZA925306B true ZA925306B (en) 1994-01-17

Family

ID=24940103

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA925306A ZA925306B (en) 1991-07-17 1992-07-16 2-(4-hydroxypiperidino)-1-alkanol derivatives as antiischemic agents

Country Status (22)

Country Link
EP (1) EP0594729A1 (ko)
JP (1) JP2571904B2 (ko)
KR (1) KR0165003B1 (ko)
CN (1) CN1043759C (ko)
AU (1) AU655840B2 (ko)
BR (1) BR9206272A (ko)
CA (1) CA2113568A1 (ko)
CZ (1) CZ284133B6 (ko)
EG (1) EG20048A (ko)
FI (2) FI940192A (ko)
HU (1) HUT70528A (ko)
IE (1) IE922311A1 (ko)
IL (1) IL102473A (ko)
MX (1) MX9204190A (ko)
NO (1) NO180445C (ko)
NZ (1) NZ243580A (ko)
PL (1) PL169884B1 (ko)
PT (1) PT100689B (ko)
RU (1) RU2065859C1 (ko)
TW (1) TW201732B (ko)
WO (1) WO1993002052A1 (ko)
ZA (1) ZA925306B (ko)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5436255A (en) * 1992-07-23 1995-07-25 Pfizer Inc. Method of treating diseases susceptable to treatment by blocking NMDA-receptors
KR950704298A (ko) * 1992-10-30 1995-11-17 알렌 제이.스피겔 신경보호성 3,4-디하이드로-2(1h)-퀴놀론 화합물(neuroprotective 3,4-dihydro-2(1h)-quinolone compounds)
US5498610A (en) * 1992-11-06 1996-03-12 Pfizer Inc. Neuroprotective indolone and related derivatives
ZA9610736B (en) * 1995-12-22 1997-06-27 Warner Lambert Co 2-Substituted piperidine analogs and their use as subtypeselective nmda receptor antagonists
ZA9610738B (en) 1995-12-22 1997-06-24 Warner Lambert Co Subtype selective nmda receptor ligands and the use thereof
ZA9610741B (en) 1995-12-22 1997-06-24 Warner Lambert Co 4-Substituted piperidine analogs and their use as subtype selective nmda receptor antagonists
ZA9610745B (en) * 1995-12-22 1997-06-24 Warner Lambert Co 4-Subsituted piperidine analogs and their use as subtype selective nmda receptor antagonists
AU3676100A (en) * 1999-04-09 2000-11-14 Mochida Pharmaceutical Co., Ltd. Remedies for neuropathic pain
US6495561B2 (en) 1999-10-29 2002-12-17 Merck & Co., Inc. 2-cyclohexyl imidazopyridine NMDA/NR2B antagonists
EP1235572A2 (en) 1999-10-29 2002-09-04 MERCK SHARP & DOHME LTD. Method to treat pain utilizing benzimidazole nmda/nr2b antagonists
US6291499B1 (en) 1999-10-29 2001-09-18 Merck & Co., Inc. 2-cyclohexyl benzimidazole NMDA/NR2B antagonists
US6476041B1 (en) 1999-10-29 2002-11-05 Merck & Co., Inc. 1,4 substituted piperidinyl NMDA/NR2B antagonists
US6316474B1 (en) 1999-10-29 2001-11-13 Merck & Co., Inc. 2-benzyl and 2-heteroaryl benzimidazole NMDA/NR2B antagonists
US6489477B1 (en) 1999-10-29 2002-12-03 Merck & Co., Inc. 2-aza-bicyclo[2.2.2]octane NMDA/NR2B antigonists
US6380205B1 (en) 1999-10-29 2002-04-30 Merck & Co., Inc. 2-cyclohexyl quinazoline NMDA/NR2B antagonists
US6432976B1 (en) 1999-10-29 2002-08-13 Merck & Co., Inc. 8-aza-bicyclo[3.2.1]octane NMDA/NR2B antagonists
US6369076B1 (en) 1999-10-29 2002-04-09 Merck & Co. Inc. 5-benzyl-octahydroindole and 6-benzyl-decahydroquinoline NMDA/NR2B antagonists
DK1379520T3 (da) 2001-02-23 2006-08-21 Merck & Co Inc N-substituerede ikke-aryl-heterocykliske NMDA/NR2B-antagonister
EP1390034A4 (en) 2001-04-03 2005-07-13 Merck & Co Inc NMDA / NR2B NONARYL-HETEROCYCLO AMIDYL N-SUBSTITUTE ANTAGONISTS
EP1568688B1 (en) 2002-11-25 2011-08-31 Mochida Pharmaceutical Co., Ltd. Therapeutic agent for respiratory disease containing 4-hydroxypiperidine derivative as active ingredient
EP1673367A1 (en) * 2003-10-08 2006-06-28 Pfizer, Inc. Fused lactam compounds
TWI409289B (zh) 2010-09-02 2013-09-21 Taiwan Union Technology Corp 由氮氧雜環化合物所製得之聚合物之穩態溶液及其製法與用途

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH17194A (en) * 1980-03-06 1984-06-19 Otsuka Pharma Co Ltd Novel carbostyril derivatives,and pharmaceutical composition containing the same
FR2546166B1 (fr) * 1983-05-19 1985-10-25 Synthelabo Enantiomeres du erythro (benzyl-4 piperidino)-2 (hydroxy-4 ou benzyloxy-4 phenyl)-1 propanol, leur preparation et leur application en therapeutique
FR2640266B2 (fr) * 1988-07-12 1992-07-10 Synthelabo Derives de (hydroxy-1 piperidinyl-2 alkyl) indolones-2, quinoleinones-2, benzo(b)azepinones-2 et benzimidazolones-2, leur preparation et leur application en therapeutique
EP0398578B1 (en) * 1989-05-17 1997-03-12 Pfizer Inc. 2-piperidino-1-alkanol derivatives as antiischemic agents
ATE192149T1 (de) * 1990-05-10 2000-05-15 Pfizer Neuroprotective indolone und verwandte derivate

Also Published As

Publication number Publication date
BR9206272A (pt) 1995-04-11
WO1993002052A1 (en) 1993-02-04
PL169884B1 (pl) 1996-09-30
RU2065859C1 (ru) 1996-08-27
MX9204190A (es) 1993-01-01
FI981956A (fi) 1998-09-11
FI940192A0 (fi) 1994-01-14
IL102473A0 (en) 1993-01-14
NO180445B (no) 1997-01-13
NZ243580A (en) 1994-10-26
HU9400136D0 (en) 1994-05-30
IL102473A (en) 1997-07-13
TW201732B (ko) 1993-03-11
AU2322592A (en) 1993-02-23
AU655840B2 (en) 1995-01-12
IE922311A1 (en) 1993-01-27
PT100689A (pt) 1993-10-29
CN1068566A (zh) 1993-02-03
JPH06504293A (ja) 1994-05-19
EP0594729A1 (en) 1994-05-04
FI981956A0 (fi) 1998-09-11
NO940144L (no) 1994-01-14
CA2113568A1 (en) 1993-02-04
FI940192A (fi) 1994-01-14
HUT70528A (en) 1995-10-30
CN1043759C (zh) 1999-06-23
PT100689B (pt) 1999-06-30
JP2571904B2 (ja) 1997-01-16
NO940144D0 (no) 1994-01-14
KR0165003B1 (en) 1999-01-15
EG20048A (en) 1997-03-27
CZ400892A3 (en) 1994-03-16
NO180445C (no) 1997-04-23
CZ284133B6 (cs) 1998-08-12

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