CA2072509A1 - Composition de cyclosporines en emulsion pour administration orale - Google Patents

Composition de cyclosporines en emulsion pour administration orale

Info

Publication number
CA2072509A1
CA2072509A1 CA2072509A CA2072509A CA2072509A1 CA 2072509 A1 CA2072509 A1 CA 2072509A1 CA 2072509 A CA2072509 A CA 2072509A CA 2072509 A CA2072509 A CA 2072509A CA 2072509 A1 CA2072509 A1 CA 2072509A1
Authority
CA
Canada
Prior art keywords
oral administration
cyclosporin
emulsion compositions
tri
dosage forms
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2072509A
Other languages
English (en)
Other versions
CA2072509C (fr
Inventor
Birgit Hauer
Armin Meinzer
Ulrich Posanski
Jacky Vonderscher
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10697415&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2072509(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Individual filed Critical Individual
Priority to CA002175842A priority Critical patent/CA2175842C/fr
Publication of CA2072509A1 publication Critical patent/CA2072509A1/fr
Application granted granted Critical
Publication of CA2072509C publication Critical patent/CA2072509C/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11C—FATTY ACIDS FROM FATS, OILS OR WAXES; CANDLES; FATS, OILS OR FATTY ACIDS BY CHEMICAL MODIFICATION OF FATS, OILS, OR FATTY ACIDS OBTAINED THEREFROM
    • C11C3/00—Fats, oils, or fatty acids by chemical modification of fats, oils, or fatty acids obtained therefrom
    • C11C3/04—Fats, oils, or fatty acids by chemical modification of fats, oils, or fatty acids obtained therefrom by esterification of fats or fatty oils
    • C11C3/06—Fats, oils, or fatty acids by chemical modification of fats, oils, or fatty acids obtained therefrom by esterification of fats or fatty oils with glycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
CA002072509A 1991-06-27 1992-06-26 Composition de cyclosporines en emulsion pour administration orale Expired - Lifetime CA2072509C (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA002175842A CA2175842C (fr) 1991-06-27 1992-06-26 Produits transesterifies a base d'huile de mais

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9113872 1991-06-27
GB919113872A GB9113872D0 (en) 1991-06-27 1991-06-27 Improvements in or relating to organic compounds

Publications (2)

Publication Number Publication Date
CA2072509A1 true CA2072509A1 (fr) 1992-12-28
CA2072509C CA2072509C (fr) 1996-07-30

Family

ID=10697415

Family Applications (2)

Application Number Title Priority Date Filing Date
CA002175842A Expired - Lifetime CA2175842C (fr) 1991-06-27 1992-06-26 Produits transesterifies a base d'huile de mais
CA002072509A Expired - Lifetime CA2072509C (fr) 1991-06-27 1992-06-26 Composition de cyclosporines en emulsion pour administration orale

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CA002175842A Expired - Lifetime CA2175842C (fr) 1991-06-27 1992-06-26 Produits transesterifies a base d'huile de mais

Country Status (38)

Country Link
EP (2) EP0953630B1 (fr)
JP (2) JP2653958B2 (fr)
KR (3) KR0131064B1 (fr)
CN (1) CN1077798C (fr)
AT (1) AT403436B (fr)
AU (1) AU659460B2 (fr)
CA (2) CA2175842C (fr)
CH (2) CH684163A5 (fr)
CY (1) CY1906A (fr)
CZ (1) CZ281790B6 (fr)
DE (3) DE4219526C2 (fr)
DK (2) DK0953630T3 (fr)
EE (1) EE03108B1 (fr)
ES (2) ES2142818T3 (fr)
FI (2) FI109454B (fr)
FR (2) FR2678169B1 (fr)
GB (2) GB9113872D0 (fr)
GR (1) GR3032366T3 (fr)
HK (2) HK57196A (fr)
HU (1) HU216792B (fr)
IE (1) IE73662B1 (fr)
IL (3) IL102310A (fr)
IT (1) IT1254401B (fr)
LU (1) LU88138A1 (fr)
MX (1) MX9203236A (fr)
MY (1) MY109512A (fr)
NO (2) NO303964B1 (fr)
NZ (1) NZ243309A (fr)
PH (1) PH30337A (fr)
PT (2) PT953630E (fr)
RO (2) RO111021B1 (fr)
RU (1) RU2143919C1 (fr)
SA (1) SA92130213B1 (fr)
SK (1) SK278759B6 (fr)
TW (1) TW267943B (fr)
UA (1) UA35559C2 (fr)
UY (1) UY23864A1 (fr)
ZA (1) ZA924719B (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6159933A (en) * 1997-04-29 2000-12-12 Sherman; Bernard Charles Emulsion preconcentrate comprising a cyclosporin, propylene carbonate, and glycerides
US6258783B1 (en) 1997-04-29 2001-07-10 Bernard Charles Sherman Emulsion preconcentrate comprising a cyclosporin and acetylated monoglyceride
US7070802B1 (en) 1996-01-22 2006-07-04 Pliva, Inc. Pharmaceutical compositions for lipophilic drugs

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GB9113872D0 (en) * 1991-06-27 1991-08-14 Sandoz Ag Improvements in or relating to organic compounds
DK0589843T3 (da) * 1992-09-25 2002-04-02 Novartis Ag Cyclosporinholdige farmaceutiske præparater
NZ247516A (en) * 1993-04-28 1995-02-24 Bernard Charles Sherman Water dispersible pharmaceutical compositions comprising drug dissolved in solvent system comprising at least one alcohol and at least one surfactant
GB2278780B (en) * 1993-05-27 1998-10-14 Sandoz Ltd Macrolide formulations
AT408520B (de) * 1993-05-27 2001-12-27 Novartis Erfind Verwalt Gmbh Galenische formulierungen
CH686761A5 (de) * 1993-05-27 1996-06-28 Sandoz Ag Galenische Formulierungen.
ES2308955T5 (es) 1993-09-28 2012-04-03 R.P. Scherer Gmbh Fabricación de cápsulas de gelatina blanda
DE4340781C3 (de) * 1993-11-30 2000-01-27 Novartis Ag Cyclosporin enthaltende flüssige Zubereitungen und Verfahren zu ihrer Herstellung
EP0694308A4 (fr) * 1994-02-17 1997-09-10 Shiseido Co Ltd Composition d'emulsion a base de cyclosporine
US5891846A (en) * 1994-02-17 1999-04-06 Shiseido Company, Ltd. Cyclosporin-containing emulsion composition
NZ270145A (en) * 1994-03-01 1996-08-27 Lilly Co Eli Non-aqueous pharmaceutical formulation for oral administration comprising water-insoluble active agent, fatty acid solubilising agent, an oil and a surface active agent
GB9405304D0 (en) * 1994-03-16 1994-04-27 Scherer Ltd R P Delivery systems for hydrophobic drugs
DE69510404T2 (de) * 1994-03-31 2000-01-20 Loders Croklaan Bv Öle mit niedrigem Gehalt an gesättigter Fettsäure
GB2308545B (en) * 1994-10-26 1999-06-02 Novartis Ag Pharmaceutical microemulsion preconcentrates
MY129435A (en) * 1994-10-26 2007-04-30 Novartis Ag Pharmaceutical microemulsion preconcentrates
PT789580E (pt) 1994-11-03 2002-09-30 Novartis Ag Formulacoes de ciclosporina para administracao oral com composicao simples e alta biodisponibilidade e processo para a sua producao
HU215966B (hu) * 1994-11-21 1999-07-28 BIOGAL Gyógyszergyár Rt. Orálisan alkalmazható, ciklosporint tartalmazó, összetett emulzió-előkoncentrátum
US7048906B2 (en) 1995-05-17 2006-05-23 Cedars-Sinai Medical Center Methods of diagnosing and treating small intestinal bacterial overgrowth (SIBO) and SIBO-related conditions
US6861053B1 (en) 1999-08-11 2005-03-01 Cedars-Sinai Medical Center Methods of diagnosing or treating irritable bowel syndrome and other disorders caused by small intestinal bacterial overgrowth
CA2220451A1 (fr) * 1995-05-17 1996-11-21 Cedars-Sinai Medical Center Methodes et compositions pour ameliorer la digestion et l'absorption dans l'intestin grele
WO1996036330A2 (fr) * 1995-05-17 1996-11-21 Cedars-Sinai Medical Center Compositions contenant des acides gras pour ameliorer la digestion et l'absorption dans l'intestin grele
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US6696413B2 (en) * 1995-06-16 2004-02-24 Hexal Ag Pharmaceutical preparation with cyclosporin A
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US5958876A (en) * 1996-06-19 1999-09-28 Novartis Ag Cyclosporin-containing pharmaceutical compositions
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CA2306448A1 (fr) 1997-10-16 1999-04-22 Board Of Regents, The University Of Texas System Modeles et traitement de l'hypertrophie cardiaque en liaison avec la fonction nf-at3
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GB9903547D0 (en) 1999-02-16 1999-04-07 Novartis Ag Organic compounds
CN1167462C (zh) * 1999-03-09 2004-09-22 杭州华东医药集团生物工程研究所有限公司 一种含环孢素的药物组合物
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AU2127400A (en) * 1999-11-02 2001-05-14 Cipla Limited A pharmaceutical composition for the administration of water-insoluble pharmaceutically active substances and process for preparation thereof
US7732404B2 (en) 1999-12-30 2010-06-08 Dexcel Ltd Pro-nanodispersion for the delivery of cyclosporin
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JP4261355B2 (ja) 2001-10-19 2009-04-30 アイソテクニカ インコーポレイテッド シクロスポリン類似体の合成法
KR100441167B1 (ko) * 2001-12-27 2004-07-21 씨제이 주식회사 마이크로에멀젼 예비 농축액 조성물
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JP4889262B2 (ja) * 2005-08-19 2012-03-07 理研ビタミン株式会社 脂溶性薬剤組成物
MD3347G2 (ro) * 2006-12-26 2008-01-31 Институт Сельскохозяйственной Техники "Mecagro" Procedeu de obţinere a esterilor metilici din ulei de rapiţă
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JP2010523554A (ja) 2007-04-04 2010-07-15 シグモイド・ファーマ・リミテッド タクロリムスの医薬組成物
CN101199836B (zh) * 2007-11-07 2011-03-30 安徽省药物研究所 一种阶段释放型环孢素a固体微乳制剂及其微乳固化方法
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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7070802B1 (en) 1996-01-22 2006-07-04 Pliva, Inc. Pharmaceutical compositions for lipophilic drugs
US7988995B1 (en) 1996-01-22 2011-08-02 Watson Laboratories, Inc. Pharmaceutical compositions for lipophilic drugs
US8119157B2 (en) 1996-01-22 2012-02-21 Watson Laboratories, Inc. Pharmaceutical compositions for lipophilic drugs
US6159933A (en) * 1997-04-29 2000-12-12 Sherman; Bernard Charles Emulsion preconcentrate comprising a cyclosporin, propylene carbonate, and glycerides
US6258783B1 (en) 1997-04-29 2001-07-10 Bernard Charles Sherman Emulsion preconcentrate comprising a cyclosporin and acetylated monoglyceride

Also Published As

Publication number Publication date
DE4219526A1 (de) 1993-03-18
RU2143919C1 (ru) 2000-01-10
EP0539319A2 (fr) 1993-04-28
FI961513A0 (fi) 1996-04-03
CZ281790B6 (cs) 1997-01-15
FR2685706B1 (fr) 1994-12-23
PT539319E (pt) 2000-05-31
NO922506D0 (no) 1992-06-25
HU216792B (hu) 1999-08-30
CY1906A (en) 1992-06-24
HUT62201A (en) 1993-04-28
NO964382D0 (no) 1996-10-15
JPH05186365A (ja) 1993-07-27
FR2678169B1 (fr) 1994-08-26
CN1077798C (zh) 2002-01-16
DE4244930C2 (de) 1999-11-11
IL118546A (en) 1998-09-24
LU88138A1 (fr) 1994-03-01
TW267943B (fr) 1996-01-11
GB2257359A (en) 1993-01-13
MX9203236A (es) 1992-12-01
SA92130213B1 (ar) 2004-07-24
RO111110B1 (ro) 1996-06-28
DE4244986B4 (de) 2008-07-24
NZ243309A (en) 1995-02-24
GR3032366T3 (en) 2000-04-27
SK197792A3 (en) 1994-03-09
AU659460B2 (en) 1995-05-18
GB2257359B (en) 1996-01-10
PT953630E (pt) 2004-11-30
FI109454B (fi) 2002-08-15
IE922082A1 (en) 1992-12-30
ITRM920476A0 (it) 1992-06-23
MY109512A (en) 1997-02-28
UA35559C2 (uk) 2001-04-16
ITRM920476A1 (it) 1993-12-23
CN1079907A (zh) 1993-12-29
NO325267B1 (no) 2008-03-17
EE03108B1 (et) 1998-08-17
ZA924719B (en) 1993-12-27
EP0539319A3 (en) 1993-06-09
IL102310A0 (en) 1993-01-14
GB9213393D0 (en) 1992-08-05
FI922958A0 (fi) 1992-06-25
HK157696A (en) 1996-08-30
FI961513A (fi) 1996-04-03
AT403436B (de) 1998-02-25
GB9113872D0 (en) 1991-08-14
HU9201975D0 (en) 1992-09-28
PH30337A (en) 1997-04-02
ES2142818T3 (es) 2000-05-01
KR930000113A (ko) 1993-01-15
FR2685706A1 (fr) 1993-07-02
EP0953630A1 (fr) 1999-11-03
ATA129892A (de) 1997-07-15
IL102310A (en) 1997-03-18
UY23864A1 (es) 1995-05-29
CA2175842C (fr) 2002-05-07
RO111021B1 (ro) 1996-06-28
KR0131064B1 (ko) 1998-04-17
FI922958A (fi) 1992-12-28
NO964382L (no) 1992-12-28
CA2175842A1 (fr) 1992-12-28
DK0953630T3 (da) 2004-11-01
ES2227921T3 (es) 2005-04-01
IL118546A0 (en) 1996-10-16
FR2678169A1 (fr) 1992-12-31
HK57196A (en) 1996-04-12
IT1254401B (it) 1995-09-14
NO303964B1 (no) 1998-10-05
CZ197792A3 (en) 1993-01-13
IE73662B1 (en) 1997-06-18
JP2653958B2 (ja) 1997-09-17
AU1852792A (en) 1993-03-11
DK0539319T3 (da) 2000-05-22
CH685764A5 (de) 1995-09-29
DE4219526C2 (de) 1999-04-22
SK278759B6 (sk) 1998-02-04
EP0539319B1 (fr) 1999-12-08
KR100231384B1 (en) 1999-11-15
CH684163A5 (de) 1994-07-29
FI116199B (fi) 2005-10-14
KR100231385B1 (en) 1999-11-15
JPH09118894A (ja) 1997-05-06
NO922506L (no) 1992-12-28
JP3420897B2 (ja) 2003-06-30
CA2072509C (fr) 1996-07-30
EP0953630B1 (fr) 2004-09-08

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