CA2037099C - Crystalline salt of 4-(di-n-propyl) amino-6-aminocarbonyl-1,3,4,5-tetrahydrobenz ¢cd! indole - Google Patents

Crystalline salt of 4-(di-n-propyl) amino-6-aminocarbonyl-1,3,4,5-tetrahydrobenz ¢cd! indole Download PDF

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Publication number
CA2037099C
CA2037099C CA002037099A CA2037099A CA2037099C CA 2037099 C CA2037099 C CA 2037099C CA 002037099 A CA002037099 A CA 002037099A CA 2037099 A CA2037099 A CA 2037099A CA 2037099 C CA2037099 C CA 2037099C
Authority
CA
Canada
Prior art keywords
hippurate
amino
indole
propyl
tetrahydrobenz
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA002037099A
Other languages
English (en)
French (fr)
Other versions
CA2037099A1 (en
Inventor
Thomas J. Kress
David L. Varie
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of CA2037099A1 publication Critical patent/CA2037099A1/en
Application granted granted Critical
Publication of CA2037099C publication Critical patent/CA2037099C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/90—Benzo [c, d] indoles; Hydrogenated benzo [c, d] indoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Child & Adolescent Psychology (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA002037099A 1990-02-26 1991-02-26 Crystalline salt of 4-(di-n-propyl) amino-6-aminocarbonyl-1,3,4,5-tetrahydrobenz ¢cd! indole Expired - Fee Related CA2037099C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US48518590A 1990-02-26 1990-02-26
US485,185 1990-02-26

Publications (2)

Publication Number Publication Date
CA2037099A1 CA2037099A1 (en) 1991-08-27
CA2037099C true CA2037099C (en) 2001-09-11

Family

ID=23927224

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002037099A Expired - Fee Related CA2037099C (en) 1990-02-26 1991-02-26 Crystalline salt of 4-(di-n-propyl) amino-6-aminocarbonyl-1,3,4,5-tetrahydrobenz ¢cd! indole

Country Status (28)

Country Link
US (1) US5397799A (en, 2012)
EP (1) EP0444852B1 (en, 2012)
JP (1) JP3157007B2 (en, 2012)
KR (1) KR100208114B1 (en, 2012)
CN (1) CN1027503C (en, 2012)
AT (1) ATE126506T1 (en, 2012)
AU (1) AU629453B2 (en, 2012)
BR (1) BR9100767A (en, 2012)
CA (1) CA2037099C (en, 2012)
CY (1) CY1887A (en, 2012)
DE (1) DE69112099T2 (en, 2012)
DK (1) DK0444852T3 (en, 2012)
ES (1) ES2077796T3 (en, 2012)
FI (1) FI95464C (en, 2012)
GR (1) GR3017940T3 (en, 2012)
HK (1) HK175495A (en, 2012)
HU (1) HU217118B (en, 2012)
IE (1) IE67801B1 (en, 2012)
IL (1) IL97306A (en, 2012)
LV (1) LV10251B (en, 2012)
NO (1) NO174149C (en, 2012)
NZ (1) NZ237181A (en, 2012)
PT (1) PT96852B (en, 2012)
RU (2) RU2034837C1 (en, 2012)
SG (1) SG69975A1 (en, 2012)
TW (1) TW219933B (en, 2012)
YU (1) YU47594B (en, 2012)
ZA (1) ZA911258B (en, 2012)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL97309A (en) * 1990-02-26 1996-11-14 Lilly Co Eli Intermediates for hexahydrobenz Úcd¾ indoles and process for the preparation of pure enantiomers thereof
IL97308A (en) * 1990-02-26 1996-10-31 Lilly Co Eli 6-Substituted-hexahydrobenz (cd) indoles process for their preparation and pharmaceutical compositions containing them
US5302612A (en) * 1990-02-26 1994-04-12 Eli Lilly And Company 6-substituted-hexahydrobenz[cd]indoles
US5643910A (en) * 1991-03-28 1997-07-01 Eli Lilly And Company 6-heterocyclic-4-amino-1,2,2A,3,4,5-hexahydrobenz[CD]indoles
US5364856A (en) * 1991-03-28 1994-11-15 Eli Lilly And Company 6-heterocyclic-4-amino-1,3,4,5-tetrahydrobenz[CD]indoles
TW248556B (en, 2012) * 1993-01-18 1995-06-01 Takeda Pharm Industry Co
UA53205C2 (en) * 2002-04-03 2006-06-15 Pharmatech Close Joint Stock C Antidepressant formulation and method for its manufacture
US7588924B2 (en) 2006-03-07 2009-09-15 Procter & Gamble Company Crystal of hypoxia inducible factor 1 alpha prolyl hydroxylase
PT2044005E (pt) 2006-06-26 2010-12-17 Warner Chilcott Co Llc Inibidores da prolil hidroxilase e métodos de utilização
MX2012005274A (es) 2009-11-06 2012-06-19 Aerpio Therapeutics Inc Inhibidores de prolil hidroxilasa.
NO2686520T3 (en, 2012) 2011-06-06 2018-03-17
CA2837560C (en) 2011-06-06 2017-02-14 Akebia Therapeutics Inc. Compounds and compositions for stabilizing hypoxia inducible factor-2 alpha as a method for treating cancer
KR102660040B1 (ko) 2013-06-13 2024-04-24 아케비아 테라퓨틱스 인코포레이티드 빈혈 치료용 조성물 및 치료방법
CR20160222U (es) 2013-11-15 2016-08-26 Akebia Therapeutics Inc Formas solidas de acido { [ -(3- clorofenil) -3- hidroxipiridin -2-carbonil] amino} acetico, composiciones, y usos de las mismas
EP3247355A4 (en) 2015-01-23 2018-06-13 Akebia Therapeutics, Inc. Solid forms of 2-(5-(3-fluorophenyl)-3-hydroxypicolinamido)acetic acid, compositions, and uses thereof
DK3277270T3 (da) 2015-04-01 2021-12-06 Akebia Therapeutics Inc Sammensætninger og fremgangsmåder til behandling af anæmi
CA3097219A1 (en) 2018-05-09 2019-11-14 Akebia Therapeutics, Inc. Process for preparing 2-[[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino]acetic acid
US11524939B2 (en) 2019-11-13 2022-12-13 Akebia Therapeutics, Inc. Solid forms of {[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino} acetic acid

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4110339A (en) * 1977-11-25 1978-08-29 Eli Lilly And Company 4-(Di-n-propyl)amino-1,3,4,5-tetrahydrobenz[cd]indole
US4576959A (en) * 1984-02-06 1986-03-18 Eli Lilly And Company 6-Substituted-4-dialkylaminotetrahydrobenz[c,d]indoles
US4745126A (en) * 1987-03-12 1988-05-17 Eli Lilly And Company Method of treating anxiety with tetrahydrobenz[c,d]indole-6-carboxamides
DE3809155A1 (de) * 1988-03-18 1989-09-28 Bayer Ag 1,3,4,5-tetrahydrobenz-(c,d)-indole
US5204340A (en) * 1989-04-11 1993-04-20 Eli Lilly And Company Tetrahydrobenz(c,d)indole serotonin agonists
US5229409A (en) * 1990-08-15 1993-07-20 Eli Lilly And Company 6-substituted-tetrahydrobenz[cd]indoles

Also Published As

Publication number Publication date
RU2083561C1 (ru) 1997-07-10
IL97306A0 (en) 1992-05-25
TW219933B (en, 2012) 1994-02-01
BR9100767A (pt) 1991-10-29
RU2034837C1 (ru) 1995-05-10
DE69112099T2 (de) 1996-02-08
FI910895L (fi) 1991-08-27
AU629453B2 (en) 1992-10-01
YU32791A (sh) 1994-01-20
NO910735L (no) 1991-08-27
IL97306A (en) 1996-10-16
LV10251A (lv) 1994-10-20
NO910735D0 (no) 1991-02-25
EP0444852B1 (en) 1995-08-16
EP0444852A3 (en) 1992-02-19
FI95464C (fi) 1996-02-12
HK175495A (en) 1995-11-24
CA2037099A1 (en) 1991-08-27
DE69112099D1 (de) 1995-09-21
JPH04217662A (ja) 1992-08-07
PT96852A (pt) 1991-10-31
NO174149B (no) 1993-12-13
DK0444852T3 (da) 1995-12-11
IE67801B1 (en) 1996-05-01
NZ237181A (en) 1992-06-25
HU217118B (hu) 1999-11-29
CY1887A (en) 1996-04-05
AU7197191A (en) 1991-08-29
ES2077796T3 (es) 1995-12-01
KR100208114B1 (ko) 1999-07-15
EP0444852A2 (en) 1991-09-04
HUT56542A (en) 1991-09-30
ZA911258B (en) 1992-10-28
NO174149C (no) 1994-03-23
ATE126506T1 (de) 1995-09-15
YU47594B (sh) 1995-10-24
IE910625A1 (en) 1991-08-28
CN1054589A (zh) 1991-09-18
JP3157007B2 (ja) 2001-04-16
FI95464B (fi) 1995-10-31
GR3017940T3 (en) 1996-02-29
LV10251B (en) 1995-04-20
FI910895A0 (fi) 1991-02-25
CN1027503C (zh) 1995-01-25
PT96852B (pt) 1998-07-31
KR910021375A (ko) 1991-12-20
SG69975A1 (en) 2000-01-25
US5397799A (en) 1995-03-14

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