CA1291293C - 7-oxomitosanes substitues - Google Patents

7-oxomitosanes substitues

Info

Publication number
CA1291293C
CA1291293C CA000489937A CA489937A CA1291293C CA 1291293 C CA1291293 C CA 1291293C CA 000489937 A CA000489937 A CA 000489937A CA 489937 A CA489937 A CA 489937A CA 1291293 C CA1291293 C CA 1291293C
Authority
CA
Canada
Prior art keywords
formula
carbon atoms
compound
substituted
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA000489937A
Other languages
English (en)
Inventor
Dolatrai Mohanlal Vyas
Terrence William Doyle
Richard A. Partyka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Co
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Priority to CA000572256A priority Critical patent/CA1254892A/fr
Application granted granted Critical
Publication of CA1291293C publication Critical patent/CA1291293C/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CA000489937A 1984-09-04 1985-09-03 7-oxomitosanes substitues Expired - Lifetime CA1291293C (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA000572256A CA1254892A (fr) 1984-09-04 1988-07-15 Derives de substitution de 7-oxomitosanes

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US64688884A 1984-09-04 1984-09-04
US646,888 1984-09-04
US74457085A 1985-06-17 1985-06-17
US744,570 1985-06-17

Publications (1)

Publication Number Publication Date
CA1291293C true CA1291293C (fr) 1991-10-22

Family

ID=27095036

Family Applications (2)

Application Number Title Priority Date Filing Date
CA000489937A Expired - Lifetime CA1291293C (fr) 1984-09-04 1985-09-03 7-oxomitosanes substitues
CA000572256A Expired CA1254892A (fr) 1984-09-04 1988-07-15 Derives de substitution de 7-oxomitosanes

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA000572256A Expired CA1254892A (fr) 1984-09-04 1988-07-15 Derives de substitution de 7-oxomitosanes

Country Status (24)

Country Link
JP (1) JPS61112078A (fr)
KR (2) KR900008570B1 (fr)
AT (1) AT394723B (fr)
AU (1) AU581673B2 (fr)
BE (1) BE903169A (fr)
CA (2) CA1291293C (fr)
CH (2) CH667094A5 (fr)
CY (2) CY1585A (fr)
DE (1) DE3531453C2 (fr)
DK (1) DK169478B1 (fr)
ES (3) ES8702408A1 (fr)
FI (1) FI80700C (fr)
FR (1) FR2569696B1 (fr)
GB (2) GB2164038B (fr)
GR (1) GR852118B (fr)
HK (2) HK22391A (fr)
HU (1) HU195658B (fr)
IE (1) IE58720B1 (fr)
IT (1) IT1209660B (fr)
LU (1) LU86062A1 (fr)
NL (1) NL8502383A (fr)
NO (1) NO169441C (fr)
PT (1) PT81083B (fr)
SE (2) SE465929B (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4803212A (en) * 1983-04-11 1989-02-07 Bristol-Myers Company Amino disulfides
US4888341A (en) * 1984-09-04 1989-12-19 University Patents, Inc. 6-substituted mitomycin analogs
IL86665A0 (en) * 1987-06-12 1988-11-30 Bristol Myers Co Mitomycin analogs
ZA886812B (en) * 1987-11-23 1989-07-26 Bristol Myers Co Anti-tumor prodrugs
US5023253A (en) * 1987-12-21 1991-06-11 University Patents, Inc. 6-substituted mitomycin analogs
US5075454A (en) * 1990-03-08 1991-12-24 Bristol-Myers Squibb Company 7-(diphenylmethyl)oxy-9a-methoxymitosane
US5175303A (en) * 1990-03-08 1992-12-29 Bristol-Myers Squibb Company Preparation of 7-(diphenylmethyl)oxy-9A-methoxymitosane

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3306821A (en) * 1962-09-04 1967-02-28 Upjohn Co Porfiromycin derivatives and method of making same
US4487769A (en) * 1982-06-04 1984-12-11 Bristol-Myers Company Amidines
JPS59175493A (ja) * 1983-03-25 1984-10-04 Kyowa Hakko Kogyo Co Ltd マイトマイシン誘導体
EP0116208B1 (fr) * 1982-12-07 1988-03-30 Kyowa Hakko Kogyo Co., Ltd. Analogues de mitomycine
US4803212A (en) * 1983-04-11 1989-02-07 Bristol-Myers Company Amino disulfides
KR840008362A (ko) * 1983-04-11 1984-12-14 사무엘 제이. 두보프 아미노 이황산염
US4888341A (en) * 1984-09-04 1989-12-19 University Patents, Inc. 6-substituted mitomycin analogs

Also Published As

Publication number Publication date
DE3531453A1 (de) 1986-03-13
FI853338A0 (fi) 1985-08-30
JPS61112078A (ja) 1986-05-30
IE58720B1 (en) 1993-11-03
JPH0560469B2 (fr) 1993-09-02
HK22491A (en) 1991-04-04
HK22391A (en) 1991-04-04
KR860002507A (ko) 1986-04-26
GB2164038B (en) 1988-11-09
FR2569696A1 (fr) 1986-03-07
GB2164038A (en) 1986-03-12
NO169441B (no) 1992-03-16
GB2196006B (en) 1988-11-09
GB8726516D0 (en) 1987-12-16
LU86062A1 (fr) 1986-03-03
FR2569696B1 (fr) 1991-12-20
ES553549A0 (es) 1987-06-16
CA1254892A (fr) 1989-05-30
IT8522059A0 (it) 1985-09-03
BE903169A (fr) 1986-03-03
ES546687A0 (es) 1986-12-16
KR900008570B1 (ko) 1990-11-24
ES8702408A1 (es) 1986-12-16
ES8706326A1 (es) 1987-06-16
PT81083A (en) 1985-10-01
FI80700B (fi) 1990-03-30
DK401385D0 (da) 1985-09-03
SE465929B (sv) 1991-11-18
CH667457A5 (de) 1988-10-14
SE9004157D0 (sv) 1990-12-27
AU581673B2 (en) 1989-03-02
PT81083B (pt) 1988-01-22
NL8502383A (nl) 1986-04-01
CY1586A (en) 1992-04-03
IT1209660B (it) 1989-08-30
GB8521816D0 (en) 1985-10-09
DK169478B1 (da) 1994-11-07
FI853338L (fi) 1986-03-05
HUT38942A (en) 1986-07-28
GB2196006A (en) 1988-04-20
DE3531453C2 (de) 1996-07-18
KR900008840B1 (ko) 1990-11-30
IE852174L (en) 1986-03-04
CH667094A5 (de) 1988-09-15
ES8706327A1 (es) 1987-06-16
SE9004157L (sv) 1992-06-28
ATA258985A (de) 1991-11-15
NO169441C (no) 1992-06-24
FI80700C (fi) 1990-07-10
HU195658B (en) 1988-06-28
DK401385A (da) 1986-03-05
ES553548A0 (es) 1987-06-16
AU4571685A (en) 1986-03-13
NO853435L (no) 1986-03-05
GR852118B (fr) 1986-01-07
AT394723B (de) 1992-06-10
SE8504093D0 (sv) 1985-09-03
SE8504093L (sv) 1986-03-05
CY1585A (en) 1992-04-03

Similar Documents

Publication Publication Date Title
US4866180A (en) Amino disulfide thiol exchange products
CA1285567C (fr) Derives bisulfures de pyrroloindole
CA1291293C (fr) 7-oxomitosanes substitues
NZ204352A (en) Mitomycin analogs carrying one or more guanidino substituents in the 7- and/or 10-positions
PL160044B1 (pl) Sposób wytwarzania pochodnych imidazopirydazyny PL PL PL
US4814445A (en) Process for preparing mitomycin analogs
US4642352A (en) Acylamino mitosanes
US4927943A (en) Substituted 7-oxomitosanes
KR880001284B1 (ko) 아지노 리파마이신 화합물의 제조방법
US4691023A (en) Amino disulfides
US4771068A (en) Mitomycin derivatives having anti-tumor and antibacterial utility
US4652644A (en) Process for preparation of N7 -amidino substituted mitomycin C derivatives
US5097036A (en) Substituted 7-oxomitosanes
US5099016A (en) Substituted 7-oxomitosanes
EP0294828B1 (fr) Analogues de la mytomicine, procédé pour leur préparation et compositions pharmaceutiques
US4567256A (en) Amidine process
AU595183B2 (en) Crystalline form of 7-(dimethylaminomethylene) amino-9a- methoxymitosane
JPH04211688A (ja) ７−（ジフェニルメチル）オキシ−９ａ−メトキシマイトサン並びにその製造及び使用
JPS59205382A (ja) アミノ２硫化物
US4590074A (en) Bis-amidines
US4579737A (en) Bis-amidines
HU201074B (en) Process for producing mitomycine-a-amalogues

Legal Events

Date Code Title Description
MKLA Lapsed