CA1260474A - Benzoxazol- and benzothiazolamine derivatives - Google Patents
Benzoxazol- and benzothiazolamine derivativesInfo
- Publication number
- CA1260474A CA1260474A CA000494185A CA494185A CA1260474A CA 1260474 A CA1260474 A CA 1260474A CA 000494185 A CA000494185 A CA 000494185A CA 494185 A CA494185 A CA 494185A CA 1260474 A CA1260474 A CA 1260474A
- Authority
- CA
- Canada
- Prior art keywords
- formula
- radical
- alkyl
- aryl
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Hospice & Palliative Care (AREA)
- Toxicology (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pyrrole Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Paints Or Removers (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US67741284A | 1984-12-03 | 1984-12-03 | |
| US677,412 | 1984-12-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1260474A true CA1260474A (en) | 1989-09-26 |
Family
ID=24718604
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA000494185A Expired CA1260474A (en) | 1984-12-03 | 1985-10-30 | Benzoxazol- and benzothiazolamine derivatives |
Country Status (27)
| Country | Link |
|---|---|
| EP (1) | EP0184257B1 (enExample) |
| JP (1) | JPH0759578B2 (enExample) |
| KR (1) | KR870001512B1 (enExample) |
| CN (1) | CN1014790B (enExample) |
| AT (1) | ATE54916T1 (enExample) |
| AU (1) | AU582601B2 (enExample) |
| BG (1) | BG60431B2 (enExample) |
| CA (1) | CA1260474A (enExample) |
| CY (1) | CY1690A (enExample) |
| DE (1) | DE3578885D1 (enExample) |
| DK (1) | DK165370C (enExample) |
| DZ (1) | DZ863A1 (enExample) |
| ES (1) | ES8606306A1 (enExample) |
| FI (1) | FI82046C (enExample) |
| GR (1) | GR852830B (enExample) |
| HK (1) | HK49593A (enExample) |
| HU (1) | HU196068B (enExample) |
| IE (1) | IE58807B1 (enExample) |
| IL (1) | IL77197A (enExample) |
| MA (1) | MA20582A1 (enExample) |
| NO (1) | NO160076C (enExample) |
| NZ (1) | NZ214320A (enExample) |
| PH (1) | PH26458A (enExample) |
| PT (1) | PT81586B (enExample) |
| SU (1) | SU1428203A3 (enExample) |
| ZA (1) | ZA859224B (enExample) |
| ZW (1) | ZW21685A1 (enExample) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8333514D0 (en) * | 1983-12-16 | 1984-01-25 | Erba Farmitalia | Tetrahydrothiazolo(5 4-c)pyridine derivatives |
| KR930005004B1 (ko) * | 1985-04-15 | 1993-06-11 | 쟈안센 파아마슈우티카 엔. 부이. | 치환된 n-[(4-피페리디닐)알킬]이환 축합 옥사졸아민 및 티아졸아민의 제조방법 |
| GB2225574B (en) * | 1987-12-24 | 1991-04-24 | Wyeth John & Brother Ltd | Heterocyclic compounds |
| IE62231B1 (en) * | 1987-12-24 | 1995-01-11 | Wyeth John & Brother Ltd | Heterocyclic compounds |
| JPH0393762A (ja) * | 1989-09-04 | 1991-04-18 | Wako Pure Chem Ind Ltd | ４‐ハロゲノ‐２‐アルコキシイミノ‐３‐オキソ脂肪酸の製造方法 |
| MX9100517A (es) * | 1990-08-06 | 1992-04-01 | Smith Kline French Lab | Compuestos |
| ZW1992A1 (en) * | 1991-02-25 | 1993-09-22 | Janssen Pharmaceutica Nv | 4-/(2-benzotiazolyl)methylamino/-b-/(3,4-difluorephenoxy)methyl/-1-piperidine ethanol |
| TW282469B (enExample) * | 1993-06-11 | 1996-08-01 | Janssen Pharmaceutica Nv | |
| GB9318431D0 (en) * | 1993-09-06 | 1993-10-20 | Boots Co Plc | Therapeutic agents |
| FR2725989B1 (fr) * | 1994-10-20 | 1997-01-10 | Pf Medicament | Nouvelles 2-(1-(omega-phenoxyalcoylpiperidin-4-yl) aminomethylene)-2h-benzofuran-3-ones substituees, leur preparation et leur application en therapeutique |
| EP0794777A1 (en) * | 1994-11-24 | 1997-09-17 | Janssen Pharmaceutica N.V. | Lubeluzole intravenous solutions |
| FR2737207B1 (fr) * | 1995-07-26 | 1997-10-17 | Pf Medicament | Nouvelles n-heterocyclyl-1-aryloxyalcoyl-4-piperidinamines substituees, leur preparation et leur application en therapeutique |
| CA2228054A1 (en) * | 1995-10-25 | 1997-05-01 | Janssen Pharmaceutica N.V. | Lubeluzole n-oxide |
| US6211199B1 (en) | 1995-11-17 | 2001-04-03 | Aventis Pharmaceuticals Inc. | Substituted 4-(1H-benzimidazol-2-yl-amino)piperidines useful for the treatment of allergic diseases |
| US6423704B2 (en) | 1995-12-20 | 2002-07-23 | Aventis Pharmaceuticals Inc. | Substituted 4-(1H-benzimidazol-2-yl)[1,4]diazepanes useful for the treatment of allergic diseases |
| US6194406B1 (en) | 1995-12-20 | 2001-02-27 | Aventis Pharmaceuticals Inc. | Substituted 4-(1H-benzimidazol-2-yl)[1,4]diazepanes useful for the treatment of allergic disease |
| US5932571A (en) * | 1996-02-21 | 1999-08-03 | Hoechst Marion Roussel, Inc. | Substituted N-methyl-N-(4-(4-(1H-benzimidazol-2-yl) {1,4}diazepan-1-yl)-2-(aryl) butyl) benzamides useful for the treatment of allergic diseases |
| US5922737A (en) * | 1996-02-21 | 1999-07-13 | Hoechst Marion Roussel, Inc. | Substituted N-methyl-N-(4-(4-(1H-Benzimidazol-2-YL-amino) piperidin-1-YL)-2-(arlyl) butyl) benzamides useful for the treatment of allergic diseases |
| US5998439A (en) * | 1996-02-21 | 1999-12-07 | Hoescht Marion Roussel, Inc. | Substituted N-methyl-N-(4-(piperidin-1-yl)-2-(aryl)butyl)benzamides useful for the treatment of allergic diseases |
| FR2753970B1 (fr) * | 1996-10-01 | 1998-10-30 | Synthelabo | Derives de n-(benzothiazol-2-yl) piperidine-1-ethanamine, leur preparation et leur application en therapeutique |
| GB0315203D0 (en) * | 2003-06-28 | 2003-08-06 | Celltech R&D Ltd | Chemical compounds |
| EP1838706A1 (en) | 2004-12-24 | 2007-10-03 | Prosidion Limited | G-protein coupled receptor agonists |
| KR100925307B1 (ko) | 2005-03-09 | 2009-11-04 | 에프. 호프만-라 로슈 아게 | 항당뇨성 화합물로서 벤조티아졸, 티아졸로피리딘,벤조옥사졸 및 옥사졸로피리딘 유도체 |
| KR101047221B1 (ko) * | 2005-09-02 | 2011-07-06 | 에프. 호프만-라 로슈 아게 | 벤조옥사졸, 옥사졸로피리딘, 벤조싸이아졸 및싸이아졸로피리딘 유도체 |
| DK2151439T3 (en) | 2007-04-27 | 2014-03-10 | Daiichi Sankyo Co Ltd | Nitrogenated AROMATIC 6-membered RINGDERIVAT, AND THIS pharmaceutical composition comprising |
| FR3001151B1 (fr) | 2013-01-21 | 2016-04-08 | Pf Medicament | Association d'un bloqueur de courant sodique lent et d'un inhibiteur du courant if sinusal et les compositions pharmarceutiques la contenant |
| CN107573301B (zh) * | 2017-11-08 | 2020-08-11 | 江苏长青农化股份有限公司 | 一种三环唑中间体的制备方法 |
| CN114349745B (zh) * | 2022-01-14 | 2023-12-08 | 黑龙江中医药大学 | 一种用于治疗心肌缺血的药物及其制备方法 |
| CN117229228B (zh) * | 2023-09-15 | 2025-09-12 | 中国人民解放军军事科学院防化研究院 | 一种2-硫代苯并噻唑类化合物的合成方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE831249C (de) * | 1948-02-09 | 1952-02-11 | Ciba A G | Verfahren zur Herstellung heterocyclisch substituierter Diaminochinazoline |
| GB1234058A (enExample) * | 1968-10-21 | 1971-06-03 | ||
| DE2545645C2 (de) * | 1975-10-11 | 1983-04-14 | Bayer Ag, 5090 Leverkusen | Thiazolinylamino-piperidin-Derivate |
| US4634704A (en) * | 1983-10-06 | 1987-01-06 | Janssen Pharmaceutica, N.V. | Anti-allergic five membered heterocyclic ring containing N-(bicyclic heterocycyl)-4-piperidinamines |
| EP0144101B1 (en) * | 1983-11-30 | 1991-02-06 | Janssen Pharmaceutica N.V. | Bicyclic heterocyclyl containing n-(bicyclic heterocyclyl)-4-piperidinamines |
| PH23995A (en) * | 1984-01-09 | 1990-02-09 | Janssen Pharmaceutica Nv | 4((bicycle heterocyclyl)-methyl and hetero)piperidines |
-
1985
- 1985-10-30 CA CA000494185A patent/CA1260474A/en not_active Expired
- 1985-11-01 KR KR1019850008142A patent/KR870001512B1/ko not_active Expired
- 1985-11-12 SU SU853982357A patent/SU1428203A3/ru active
- 1985-11-22 EP EP85201937A patent/EP0184257B1/en not_active Expired - Lifetime
- 1985-11-22 DE DE8585201937T patent/DE3578885D1/de not_active Expired - Fee Related
- 1985-11-22 AT AT85201937T patent/ATE54916T1/de not_active IP Right Cessation
- 1985-11-25 NZ NZ214320A patent/NZ214320A/en unknown
- 1985-11-25 GR GR852830A patent/GR852830B/el unknown
- 1985-12-01 DZ DZ850258A patent/DZ863A1/fr active
- 1985-12-02 PT PT81586A patent/PT81586B/pt not_active IP Right Cessation
- 1985-12-02 IL IL77197A patent/IL77197A/xx not_active IP Right Cessation
- 1985-12-02 NO NO854837A patent/NO160076C/no unknown
- 1985-12-02 DK DK558185A patent/DK165370C/da not_active IP Right Cessation
- 1985-12-02 HU HU854596A patent/HU196068B/hu not_active IP Right Cessation
- 1985-12-02 CN CN85108556A patent/CN1014790B/zh not_active Expired
- 1985-12-02 MA MA20807A patent/MA20582A1/fr unknown
- 1985-12-02 FI FI854768A patent/FI82046C/fi not_active IP Right Cessation
- 1985-12-02 AU AU50574/85A patent/AU582601B2/en not_active Ceased
- 1985-12-02 ZW ZW216/85A patent/ZW21685A1/xx unknown
- 1985-12-02 ZA ZA859224A patent/ZA859224B/xx unknown
- 1985-12-02 IE IE302385A patent/IE58807B1/en not_active IP Right Cessation
- 1985-12-03 JP JP60270848A patent/JPH0759578B2/ja not_active Expired - Fee Related
- 1985-12-03 ES ES549542A patent/ES8606306A1/es not_active Expired
- 1985-12-03 PH PH33124A patent/PH26458A/en unknown
-
1993
- 1993-05-20 HK HK495/93A patent/HK49593A/en not_active IP Right Cessation
- 1993-06-16 BG BG097875A patent/BG60431B2/bg unknown
-
1994
- 1994-01-14 CY CY169094A patent/CY1690A/xx unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MKEX | Expiry |