KR870001512B1 - 벤조옥사졸- 및 벤조티아졸아민 유도체의 제조방법 - Google Patents

벤조옥사졸- 및 벤조티아졸아민 유도체의 제조방법 Download PDF

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Publication number
KR870001512B1
KR870001512B1 KR1019850008142A KR850008142A KR870001512B1 KR 870001512 B1 KR870001512 B1 KR 870001512B1 KR 1019850008142 A KR1019850008142 A KR 1019850008142A KR 850008142 A KR850008142 A KR 850008142A KR 870001512 B1 KR870001512 B1 KR 870001512B1
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KR
South Korea
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parts
methyl
melting point
alkyl
group
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Expired
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KR1019850008142A
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English (en)
Korean (ko)
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KR860004894A (ko
Inventor
안토이네 스톡크브록스 레이몬드
게레베르너스 마리아 루익스 마아셀
에드아드 쟈안센스 프란스
Original Assignee
쟈안센 파아마슈우티카 엔. 부이.
폴 아드리안 잔 쟈안센
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Publication of KR860004894A publication Critical patent/KR860004894A/ko
Priority to KR1019870006490A priority Critical patent/KR870001511B1/ko
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Publication of KR870001512B1 publication Critical patent/KR870001512B1/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Toxicology (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pyrrole Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Paints Or Removers (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
KR1019850008142A 1984-12-03 1985-11-01 벤조옥사졸- 및 벤조티아졸아민 유도체의 제조방법 Expired KR870001512B1 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019870006490A KR870001511B1 (ko) 1984-12-03 1987-06-25 벤조옥사졸-및 벤조티아졸아민 유도체의 제조방법

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US67741284A 1984-12-03 1984-12-03
US677412 1984-12-03

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1019870006490A Division KR870001511B1 (ko) 1984-12-03 1987-06-25 벤조옥사졸-및 벤조티아졸아민 유도체의 제조방법

Publications (2)

Publication Number Publication Date
KR860004894A KR860004894A (ko) 1986-07-14
KR870001512B1 true KR870001512B1 (ko) 1987-08-20

Family

ID=24718604

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019850008142A Expired KR870001512B1 (ko) 1984-12-03 1985-11-01 벤조옥사졸- 및 벤조티아졸아민 유도체의 제조방법

Country Status (27)

Country Link
EP (1) EP0184257B1 (enExample)
JP (1) JPH0759578B2 (enExample)
KR (1) KR870001512B1 (enExample)
CN (1) CN1014790B (enExample)
AT (1) ATE54916T1 (enExample)
AU (1) AU582601B2 (enExample)
BG (1) BG60431B2 (enExample)
CA (1) CA1260474A (enExample)
CY (1) CY1690A (enExample)
DE (1) DE3578885D1 (enExample)
DK (1) DK165370C (enExample)
DZ (1) DZ863A1 (enExample)
ES (1) ES8606306A1 (enExample)
FI (1) FI82046C (enExample)
GR (1) GR852830B (enExample)
HK (1) HK49593A (enExample)
HU (1) HU196068B (enExample)
IE (1) IE58807B1 (enExample)
IL (1) IL77197A (enExample)
MA (1) MA20582A1 (enExample)
NO (1) NO160076C (enExample)
NZ (1) NZ214320A (enExample)
PH (1) PH26458A (enExample)
PT (1) PT81586B (enExample)
SU (1) SU1428203A3 (enExample)
ZA (1) ZA859224B (enExample)
ZW (1) ZW21685A1 (enExample)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8333514D0 (en) * 1983-12-16 1984-01-25 Erba Farmitalia Tetrahydrothiazolo(5 4-c)pyridine derivatives
KR930005004B1 (ko) * 1985-04-15 1993-06-11 쟈안센 파아마슈우티카 엔. 부이. 치환된 n-[(4-피페리디닐)알킬]이환 축합 옥사졸아민 및 티아졸아민의 제조방법
GB2225574B (en) * 1987-12-24 1991-04-24 Wyeth John & Brother Ltd Heterocyclic compounds
IE62231B1 (en) * 1987-12-24 1995-01-11 Wyeth John & Brother Ltd Heterocyclic compounds
JPH0393762A (ja) * 1989-09-04 1991-04-18 Wako Pure Chem Ind Ltd ４‐ハロゲノ‐２‐アルコキシイミノ‐３‐オキソ脂肪酸の製造方法
MX9100517A (es) * 1990-08-06 1992-04-01 Smith Kline French Lab Compuestos
ZW1992A1 (en) * 1991-02-25 1993-09-22 Janssen Pharmaceutica Nv 4-/(2-benzotiazolyl)methylamino/-b-/(3,4-difluorephenoxy)methyl/-1-piperidine ethanol
TW282469B (enExample) * 1993-06-11 1996-08-01 Janssen Pharmaceutica Nv
GB9318431D0 (en) * 1993-09-06 1993-10-20 Boots Co Plc Therapeutic agents
FR2725989B1 (fr) * 1994-10-20 1997-01-10 Pf Medicament Nouvelles 2-(1-(omega-phenoxyalcoylpiperidin-4-yl) aminomethylene)-2h-benzofuran-3-ones substituees, leur preparation et leur application en therapeutique
EP0794777A1 (en) * 1994-11-24 1997-09-17 Janssen Pharmaceutica N.V. Lubeluzole intravenous solutions
FR2737207B1 (fr) * 1995-07-26 1997-10-17 Pf Medicament Nouvelles n-heterocyclyl-1-aryloxyalcoyl-4-piperidinamines substituees, leur preparation et leur application en therapeutique
CA2228054A1 (en) * 1995-10-25 1997-05-01 Janssen Pharmaceutica N.V. Lubeluzole n-oxide
US6211199B1 (en) 1995-11-17 2001-04-03 Aventis Pharmaceuticals Inc. Substituted 4-(1H-benzimidazol-2-yl-amino)piperidines useful for the treatment of allergic diseases
US6423704B2 (en) 1995-12-20 2002-07-23 Aventis Pharmaceuticals Inc. Substituted 4-(1H-benzimidazol-2-yl)[1,4]diazepanes useful for the treatment of allergic diseases
US6194406B1 (en) 1995-12-20 2001-02-27 Aventis Pharmaceuticals Inc. Substituted 4-(1H-benzimidazol-2-yl)[1,4]diazepanes useful for the treatment of allergic disease
US5932571A (en) * 1996-02-21 1999-08-03 Hoechst Marion Roussel, Inc. Substituted N-methyl-N-(4-(4-(1H-benzimidazol-2-yl) {1,4}diazepan-1-yl)-2-(aryl) butyl) benzamides useful for the treatment of allergic diseases
US5922737A (en) * 1996-02-21 1999-07-13 Hoechst Marion Roussel, Inc. Substituted N-methyl-N-(4-(4-(1H-Benzimidazol-2-YL-amino) piperidin-1-YL)-2-(arlyl) butyl) benzamides useful for the treatment of allergic diseases
US5998439A (en) * 1996-02-21 1999-12-07 Hoescht Marion Roussel, Inc. Substituted N-methyl-N-(4-(piperidin-1-yl)-2-(aryl)butyl)benzamides useful for the treatment of allergic diseases
FR2753970B1 (fr) * 1996-10-01 1998-10-30 Synthelabo Derives de n-(benzothiazol-2-yl) piperidine-1-ethanamine, leur preparation et leur application en therapeutique
GB0315203D0 (en) * 2003-06-28 2003-08-06 Celltech R&D Ltd Chemical compounds
EP1838706A1 (en) 2004-12-24 2007-10-03 Prosidion Limited G-protein coupled receptor agonists
KR100925307B1 (ko) 2005-03-09 2009-11-04 에프. 호프만-라 로슈 아게 항당뇨성 화합물로서 벤조티아졸, 티아졸로피리딘,벤조옥사졸 및 옥사졸로피리딘 유도체
KR101047221B1 (ko) * 2005-09-02 2011-07-06 에프. 호프만-라 로슈 아게 벤조옥사졸, 옥사졸로피리딘, 벤조싸이아졸 및싸이아졸로피리딘 유도체
DK2151439T3 (en) 2007-04-27 2014-03-10 Daiichi Sankyo Co Ltd Nitrogenated AROMATIC 6-membered RINGDERIVAT, AND THIS pharmaceutical composition comprising
FR3001151B1 (fr) 2013-01-21 2016-04-08 Pf Medicament Association d'un bloqueur de courant sodique lent et d'un inhibiteur du courant if sinusal et les compositions pharmarceutiques la contenant
CN107573301B (zh) * 2017-11-08 2020-08-11 江苏长青农化股份有限公司 一种三环唑中间体的制备方法
CN114349745B (zh) * 2022-01-14 2023-12-08 黑龙江中医药大学 一种用于治疗心肌缺血的药物及其制备方法
CN117229228B (zh) * 2023-09-15 2025-09-12 中国人民解放军军事科学院防化研究院 一种2-硫代苯并噻唑类化合物的合成方法

Family Cites Families (6)

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Publication number Priority date Publication date Assignee Title
DE831249C (de) * 1948-02-09 1952-02-11 Ciba A G Verfahren zur Herstellung heterocyclisch substituierter Diaminochinazoline
GB1234058A (enExample) * 1968-10-21 1971-06-03
DE2545645C2 (de) * 1975-10-11 1983-04-14 Bayer Ag, 5090 Leverkusen Thiazolinylamino-piperidin-Derivate
US4634704A (en) * 1983-10-06 1987-01-06 Janssen Pharmaceutica, N.V. Anti-allergic five membered heterocyclic ring containing N-(bicyclic heterocycyl)-4-piperidinamines
EP0144101B1 (en) * 1983-11-30 1991-02-06 Janssen Pharmaceutica N.V. Bicyclic heterocyclyl containing n-(bicyclic heterocyclyl)-4-piperidinamines
PH23995A (en) * 1984-01-09 1990-02-09 Janssen Pharmaceutica Nv 4((bicycle heterocyclyl)-methyl and hetero)piperidines

Also Published As

Publication number Publication date
DK558185D0 (da) 1985-12-02
PT81586A (en) 1986-01-01
AU5057485A (en) 1986-07-17
HU196068B (en) 1988-09-28
ZW21685A1 (en) 1987-06-17
NO854837L (no) 1986-06-04
DK165370B (da) 1992-11-16
DZ863A1 (fr) 2004-09-13
BG60431B2 (bg) 1995-03-31
CN1014790B (zh) 1991-11-20
NZ214320A (en) 1988-03-30
NO160076C (no) 1989-03-08
KR860004894A (ko) 1986-07-14
HK49593A (en) 1993-05-27
CA1260474A (en) 1989-09-26
IE853023L (en) 1986-06-03
CY1690A (en) 1994-01-14
IE58807B1 (en) 1993-11-17
ATE54916T1 (de) 1990-08-15
SU1428203A3 (ru) 1988-09-30
GR852830B (enExample) 1986-03-27
FI854768A7 (fi) 1986-06-04
PT81586B (pt) 1988-01-22
AU582601B2 (en) 1989-04-06
DK558185A (da) 1986-06-04
IL77197A (en) 1991-07-18
DK165370C (da) 1993-04-05
MA20582A1 (fr) 1986-07-01
JPS61137884A (ja) 1986-06-25
NO160076B (no) 1988-11-28
HUT40668A (en) 1987-01-28
ES549542A0 (es) 1986-04-16
ZA859224B (en) 1987-07-29
PH26458A (en) 1992-07-27
DE3578885D1 (de) 1990-08-30
FI82046C (fi) 1991-01-10
EP0184257A1 (en) 1986-06-11
JPH0759578B2 (ja) 1995-06-28
EP0184257B1 (en) 1990-07-25
ES8606306A1 (es) 1986-04-16
CN85108556A (zh) 1986-07-30
FI82046B (fi) 1990-09-28
FI854768A0 (fi) 1985-12-02

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PA0109 Patent application

St.27 status event code: A-0-1-A10-A12-nap-PA0109

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