CA1101410A - Polyhalogenated steroids - Google Patents

Polyhalogenated steroids

Info

Publication number
CA1101410A
CA1101410A CA287,560A CA287560A CA1101410A CA 1101410 A CA1101410 A CA 1101410A CA 287560 A CA287560 A CA 287560A CA 1101410 A CA1101410 A CA 1101410A
Authority
CA
Canada
Prior art keywords
alpha
formula
chlorine
beta
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA287,560A
Other languages
English (en)
French (fr)
Inventor
Jaroslav Kalvoda
Georg Anner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy Investments Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy Investments Ltd filed Critical Ciba Geigy Investments Ltd
Application granted granted Critical
Publication of CA1101410A publication Critical patent/CA1101410A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/008—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21
    • C07J7/0085—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21 by an halogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0061—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16
    • C07J5/0069—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group
    • C07J5/0076—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group by an alkyl group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes
    • C07J71/0015—Oxiranes at position 9(11)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CA287,560A 1976-09-29 1977-09-27 Polyhalogenated steroids Expired CA1101410A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
LU75903A LU75903A1 (ko) 1976-09-29 1976-09-29
LU75903 1976-09-29

Publications (1)

Publication Number Publication Date
CA1101410A true CA1101410A (en) 1981-05-19

Family

ID=19728370

Family Applications (1)

Application Number Title Priority Date Filing Date
CA287,560A Expired CA1101410A (en) 1976-09-29 1977-09-27 Polyhalogenated steroids

Country Status (24)

Country Link
JP (1) JPS5356652A (ko)
AT (3) AT363197B (ko)
AU (1) AU514200B2 (ko)
BE (1) BE859120A (ko)
CA (1) CA1101410A (ko)
CH (9) CH624967A5 (ko)
CY (1) CY1178A (ko)
DD (1) DD133150A5 (ko)
DE (1) DE2743069C2 (ko)
DK (1) DK146017C (ko)
ES (1) ES462763A1 (ko)
FR (1) FR2366311A1 (ko)
GB (1) GB1563638A (ko)
HK (1) HK16683A (ko)
HU (1) HU175218B (ko)
IE (1) IE46047B1 (ko)
IL (1) IL53012A (ko)
KE (1) KE3258A (ko)
LU (1) LU75903A1 (ko)
MY (1) MY8400092A (ko)
NL (1) NL7710089A (ko)
SE (1) SE436751B (ko)
SG (1) SG3383G (ko)
ZA (1) ZA775800B (ko)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL187577C (nl) * 1978-04-05 1991-11-18 Sibla Srl 3-acetoxy-9beta,11beta-epoxy-pregna-1,3,5-trienen, werkwijze voor de bereiding daarvan en werkwijze voor de bereiding van 6alfa-halogeen-pregna-1,4-dieen-3-onen.
DE3227312A1 (de) * 1982-07-19 1984-01-19 Schering AG, 1000 Berlin und 4709 Bergkamen Neue 6,16-dimethylkortikoide, ihre herstellung und verwendung
AU7556291A (en) * 1990-03-27 1991-10-21 Schering Corporation Process for 9alpha-hydroxy steroid dehydration
US5972922A (en) * 1990-06-11 1999-10-26 Alcon Laboratories, Inc. Steroids which inhibit angiogenesis
CA2473471A1 (en) 2001-11-29 2003-06-12 Taro Pharmaceuticals U.S.A., Inc. Method for the preparation of 6-alpha-fluoro corticosteroids
US11957753B2 (en) 2010-11-22 2024-04-16 Bausch Health Ireland Limited Pharmaceutical formulations containing corticosteroids for topical administration
US8809307B2 (en) 2010-11-22 2014-08-19 Dow Pharmaceutical Sciences, Inc. Pharmaceutical formulations containing corticosteroids for topical administration
WO2016205001A1 (en) 2015-06-18 2016-12-22 Valeant Pharmaceuticals North America Topical compositions comprising a corticosteroid and a retinoid for treating psoriasis
US11311482B2 (en) 2017-05-12 2022-04-26 Bausch Health Us, Llc Topical compositions and methods for treating skin diseases

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB898292A (en) * 1959-03-18 1962-06-06 Upjohn Co Improvements in or relating to steroids and the manufacture thereof
US3644340A (en) * 1970-03-19 1972-02-22 Syntex Corp Preparation of 21-chloro steroids
US3992422A (en) * 1975-08-14 1976-11-16 Schering Corporation Process for the preparation of 21-halogeno-21-desoxy-17α-acyloxy-20-keto-pregnenes

Also Published As

Publication number Publication date
ES462763A1 (es) 1978-05-16
HK16683A (en) 1983-05-27
SG3383G (en) 1983-09-09
CH632279A5 (en) 1982-09-30
DD133150A5 (de) 1978-12-13
DK256977A (da) 1978-03-30
IL53012A (en) 1982-05-31
JPS6214557B2 (ko) 1987-04-02
FR2366311B1 (ko) 1982-12-03
CY1178A (en) 1983-06-10
ATA691077A (de) 1980-12-15
AT363197B (de) 1981-07-10
DE2743069C2 (de) 1987-03-05
MY8400092A (en) 1984-12-31
BE859120A (fr) 1978-03-28
NL7710089A (nl) 1978-03-31
AT363202B (de) 1981-07-27
DE2743069A1 (de) 1978-03-30
ZA775800B (en) 1978-08-30
CH632521A5 (en) 1982-10-15
KE3258A (en) 1983-03-04
SE436751B (sv) 1985-01-21
FR2366311A1 (fr) 1978-04-28
CH625808A5 (en) 1981-10-15
AT363203B (de) 1981-07-27
ATA151379A (de) 1980-12-15
LU75903A1 (ko) 1978-05-16
AU514200B2 (en) 1981-01-29
CH625809A5 (en) 1981-10-15
IE46047L (en) 1978-03-29
CH631999A5 (en) 1982-09-15
HU175218B (hu) 1980-06-28
ATA151279A (de) 1980-12-15
CH632000A5 (en) 1982-09-15
SE7706673L (sv) 1978-03-30
IE46047B1 (en) 1983-02-09
DK146017B (da) 1983-05-24
CH631998A5 (en) 1982-09-15
IL53012A0 (en) 1977-11-30
AU2914877A (en) 1979-04-05
CH625810A5 (en) 1981-10-15
CH624967A5 (en) 1981-08-31
JPS5356652A (en) 1978-05-23
DK146017C (da) 1983-10-24
GB1563638A (en) 1980-03-26

Similar Documents

Publication Publication Date Title
CA1056371A (en) Polyhalogeno-steroids and processes for their manufacture
US4124707A (en) 7α-Halogeno-3,20-dioxo-1,4-pregnadienes, methods for their manufacture, their use as anti-inflammatory agents, and pharmaceutical formulations useful therefor
US4076708A (en) Process for the preparation of 7α-halogeno-3-oxo-4-dehydro steroids and novel 7α-halogeno derivatives produced thereby
US4267173A (en) Use of 6β-fluoro-7α-halogenocorticoids as topical anti-inflammatories and pharmaceutical formulations useful therefor
FI80888C (fi) Foerfarande foer framstaellning av terapeutiskt verkande steroida karboxylsyraestrar.
IE45023B1 (en) Androstadiene-17-carboxylic acids and their esters
US4036831A (en) Trimethyl siloxane steroid intermediates
US4226862A (en) Steroids and process for preparing the same
US4284558A (en) Chemical process for fluorinating a tertiary carbon atom in the steroid nucleus
CA1101410A (en) Polyhalogenated steroids
US3984544A (en) Retinoic acid esters of steroids of the pregnane series, their use in the treatment of acne and pharmaceutical formulations useful therefor
IE50829B1 (en) 6alpha-fluoro-9alpha-chloro-prednisolone-17,21 diesters,pharmaceutical compositions containing them and intermediates
CA1278293C (en) Androstane-17 beta-carboxylic acid esters
EP0072200B1 (en) Steroidal esters and process for the preparation of steroidal esters
US4990612A (en) 16α-methylation process
GB2105724A (en) Corticoid 17-ester 21-thioesters
US3932388A (en) -Azido-4,6-pregnadieno(3,2-c)pyrazoles, processes for their preparation and intermediates useful therein
US4185101A (en) 1,3,5(10),6,8-19-Nor-pregnapentaenes, their use as anti-psoriatic agents, and pharmaceutical formulations useful therefor
EP0136586B1 (en) Novel corticoid derivatives and process for production thereof
US3980680A (en) Process for the preparation of 21-desoxy-17-acyloxy-4-pregnenes and of 21-iodo-21-desoxy-17-acyl oxy-4-pregnene intermediates useful therein
US3046285A (en) 6-cyano cortical hormones
US3931167A (en) Process for the manufacture of 3-keto-6-azido-4,6-bis-dehydro-steroids and intermediates useful therein
HU182775B (en) Process for preparing new 3-chloro-pregnane derivatives
CA1058161A (en) 3,20-DIKETOPREGNENES HAVING AN 11.beta.-ACETAL GROUP AND DERIVATIVES THEREOF
DE2756550C2 (de) Verfahren zur Herstellung von 3,20-Dioxo-7α-halogen-4-pregnenen und 1,4-Pregnadienen, 3,20-Dioxo-7α-chlor und Brom-1,4-pregnadiene und letztere enthaltende Arzneimittel

Legal Events

Date Code Title Description
MKEX Expiry