DD133150A5 - Verfahren zur herstellung von mehrfach halogenierten steroiden - Google Patents

Verfahren zur herstellung von mehrfach halogenierten steroiden

Info

Publication number
DD133150A5
DD133150A5 DD7700201226A DD20122677A DD133150A5 DD 133150 A5 DD133150 A5 DD 133150A5 DD 7700201226 A DD7700201226 A DD 7700201226A DD 20122677 A DD20122677 A DD 20122677A DD 133150 A5 DD133150 A5 DD 133150A5
Authority
DD
German Democratic Republic
Prior art keywords
production
multiple halogenated
halogenated steroids
steroids
halogenated
Prior art date
Application number
DD7700201226A
Other languages
German (de)
English (en)
Inventor
Jaroslav Kalvoda
Georg Anner
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Publication of DD133150A5 publication Critical patent/DD133150A5/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/008—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21
    • C07J7/0085—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21 by an halogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0061—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16
    • C07J5/0069—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group
    • C07J5/0076—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group by an alkyl group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes
    • C07J71/0015—Oxiranes at position 9(11)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DD7700201226A 1976-09-29 1977-09-27 Verfahren zur herstellung von mehrfach halogenierten steroiden DD133150A5 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
LU75903A LU75903A1 (ko) 1976-09-29 1976-09-29

Publications (1)

Publication Number Publication Date
DD133150A5 true DD133150A5 (de) 1978-12-13

Family

ID=19728370

Family Applications (1)

Application Number Title Priority Date Filing Date
DD7700201226A DD133150A5 (de) 1976-09-29 1977-09-27 Verfahren zur herstellung von mehrfach halogenierten steroiden

Country Status (24)

Country Link
JP (1) JPS5356652A (ko)
AT (3) AT363197B (ko)
AU (1) AU514200B2 (ko)
BE (1) BE859120A (ko)
CA (1) CA1101410A (ko)
CH (9) CH624967A5 (ko)
CY (1) CY1178A (ko)
DD (1) DD133150A5 (ko)
DE (1) DE2743069C2 (ko)
DK (1) DK146017C (ko)
ES (1) ES462763A1 (ko)
FR (1) FR2366311A1 (ko)
GB (1) GB1563638A (ko)
HK (1) HK16683A (ko)
HU (1) HU175218B (ko)
IE (1) IE46047B1 (ko)
IL (1) IL53012A (ko)
KE (1) KE3258A (ko)
LU (1) LU75903A1 (ko)
MY (1) MY8400092A (ko)
NL (1) NL7710089A (ko)
SE (1) SE436751B (ko)
SG (1) SG3383G (ko)
ZA (1) ZA775800B (ko)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL187577C (nl) * 1978-04-05 1991-11-18 Sibla Srl 3-acetoxy-9beta,11beta-epoxy-pregna-1,3,5-trienen, werkwijze voor de bereiding daarvan en werkwijze voor de bereiding van 6alfa-halogeen-pregna-1,4-dieen-3-onen.
DE3227312A1 (de) * 1982-07-19 1984-01-19 Schering AG, 1000 Berlin und 4709 Bergkamen Neue 6,16-dimethylkortikoide, ihre herstellung und verwendung
AU7556291A (en) * 1990-03-27 1991-10-21 Schering Corporation Process for 9alpha-hydroxy steroid dehydration
US5972922A (en) * 1990-06-11 1999-10-26 Alcon Laboratories, Inc. Steroids which inhibit angiogenesis
CA2473471A1 (en) 2001-11-29 2003-06-12 Taro Pharmaceuticals U.S.A., Inc. Method for the preparation of 6-alpha-fluoro corticosteroids
US11957753B2 (en) 2010-11-22 2024-04-16 Bausch Health Ireland Limited Pharmaceutical formulations containing corticosteroids for topical administration
US8809307B2 (en) 2010-11-22 2014-08-19 Dow Pharmaceutical Sciences, Inc. Pharmaceutical formulations containing corticosteroids for topical administration
WO2016205001A1 (en) 2015-06-18 2016-12-22 Valeant Pharmaceuticals North America Topical compositions comprising a corticosteroid and a retinoid for treating psoriasis
US11311482B2 (en) 2017-05-12 2022-04-26 Bausch Health Us, Llc Topical compositions and methods for treating skin diseases

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB898292A (en) * 1959-03-18 1962-06-06 Upjohn Co Improvements in or relating to steroids and the manufacture thereof
US3644340A (en) * 1970-03-19 1972-02-22 Syntex Corp Preparation of 21-chloro steroids
US3992422A (en) * 1975-08-14 1976-11-16 Schering Corporation Process for the preparation of 21-halogeno-21-desoxy-17α-acyloxy-20-keto-pregnenes

Also Published As

Publication number Publication date
ES462763A1 (es) 1978-05-16
HK16683A (en) 1983-05-27
SG3383G (en) 1983-09-09
CH632279A5 (en) 1982-09-30
DK256977A (da) 1978-03-30
IL53012A (en) 1982-05-31
JPS6214557B2 (ko) 1987-04-02
FR2366311B1 (ko) 1982-12-03
CY1178A (en) 1983-06-10
ATA691077A (de) 1980-12-15
AT363197B (de) 1981-07-10
DE2743069C2 (de) 1987-03-05
MY8400092A (en) 1984-12-31
BE859120A (fr) 1978-03-28
NL7710089A (nl) 1978-03-31
AT363202B (de) 1981-07-27
DE2743069A1 (de) 1978-03-30
ZA775800B (en) 1978-08-30
CH632521A5 (en) 1982-10-15
KE3258A (en) 1983-03-04
SE436751B (sv) 1985-01-21
FR2366311A1 (fr) 1978-04-28
CH625808A5 (en) 1981-10-15
AT363203B (de) 1981-07-27
ATA151379A (de) 1980-12-15
LU75903A1 (ko) 1978-05-16
AU514200B2 (en) 1981-01-29
CH625809A5 (en) 1981-10-15
IE46047L (en) 1978-03-29
CH631999A5 (en) 1982-09-15
HU175218B (hu) 1980-06-28
ATA151279A (de) 1980-12-15
CH632000A5 (en) 1982-09-15
SE7706673L (sv) 1978-03-30
IE46047B1 (en) 1983-02-09
DK146017B (da) 1983-05-24
CH631998A5 (en) 1982-09-15
IL53012A0 (en) 1977-11-30
AU2914877A (en) 1979-04-05
CH625810A5 (en) 1981-10-15
CH624967A5 (en) 1981-08-31
CA1101410A (en) 1981-05-19
JPS5356652A (en) 1978-05-23
DK146017C (da) 1983-10-24
GB1563638A (en) 1980-03-26

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