CA1093554A - Process for producing d,1-5-methyltetrahy-drofolic acid and its salts - Google Patents

Process for producing d,1-5-methyltetrahy-drofolic acid and its salts

Info

Publication number
CA1093554A
CA1093554A CA296,754A CA296754A CA1093554A CA 1093554 A CA1093554 A CA 1093554A CA 296754 A CA296754 A CA 296754A CA 1093554 A CA1093554 A CA 1093554A
Authority
CA
Canada
Prior art keywords
acid
ratio
tetrahydrofolic acid
tetrahydrofolic
solution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA296,754A
Other languages
English (en)
French (fr)
Inventor
Federico Gennari
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bioresearch Sas Del Dr Livio Camozzi & C
Original Assignee
Bioresearch Sas Del Dr Livio Camozzi & C
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bioresearch Sas Del Dr Livio Camozzi & C filed Critical Bioresearch Sas Del Dr Livio Camozzi & C
Application granted granted Critical
Publication of CA1093554A publication Critical patent/CA1093554A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
    • C07D475/04—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA296,754A 1977-02-22 1978-02-09 Process for producing d,1-5-methyltetrahy-drofolic acid and its salts Expired CA1093554A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB7290/77 1977-02-22
GB7290/77A GB1572137A (en) 1977-02-22 1977-02-22 Stable compositions for therapeutic use based on d,1-5-methyltetrahydrofolic acid and its salts

Publications (1)

Publication Number Publication Date
CA1093554A true CA1093554A (en) 1981-01-13

Family

ID=9830275

Family Applications (1)

Application Number Title Priority Date Filing Date
CA296,754A Expired CA1093554A (en) 1977-02-22 1978-02-09 Process for producing d,1-5-methyltetrahy-drofolic acid and its salts

Country Status (32)

Country Link
JP (1) JPS5831353B2 (enrdf_load_stackoverflow)
AR (1) AR215162A1 (enrdf_load_stackoverflow)
AT (1) AT380020B (enrdf_load_stackoverflow)
AU (1) AU520715B2 (enrdf_load_stackoverflow)
BE (1) BE863808A (enrdf_load_stackoverflow)
CA (1) CA1093554A (enrdf_load_stackoverflow)
CH (1) CH635344A5 (enrdf_load_stackoverflow)
CZ (1) CZ279815B6 (enrdf_load_stackoverflow)
DD (1) DD134099A5 (enrdf_load_stackoverflow)
DE (1) DE2807393A1 (enrdf_load_stackoverflow)
DK (1) DK144944C (enrdf_load_stackoverflow)
EG (1) EG13399A (enrdf_load_stackoverflow)
ES (1) ES467153A1 (enrdf_load_stackoverflow)
FI (1) FI67082C (enrdf_load_stackoverflow)
FR (2) FR2381047A1 (enrdf_load_stackoverflow)
GB (1) GB1572137A (enrdf_load_stackoverflow)
GR (1) GR71704B (enrdf_load_stackoverflow)
HU (1) HU179422B (enrdf_load_stackoverflow)
IE (1) IE46402B1 (enrdf_load_stackoverflow)
IL (1) IL54052A (enrdf_load_stackoverflow)
IN (1) IN149574B (enrdf_load_stackoverflow)
LU (1) LU79067A1 (enrdf_load_stackoverflow)
MX (1) MX5288E (enrdf_load_stackoverflow)
NL (1) NL190285C (enrdf_load_stackoverflow)
NO (1) NO147793C (enrdf_load_stackoverflow)
NZ (1) NZ186465A (enrdf_load_stackoverflow)
PL (1) PL118654B1 (enrdf_load_stackoverflow)
PT (1) PT67656B (enrdf_load_stackoverflow)
SE (1) SE437028B (enrdf_load_stackoverflow)
SU (1) SU747427A3 (enrdf_load_stackoverflow)
YU (1) YU40505B (enrdf_load_stackoverflow)
ZA (1) ZA78837B (enrdf_load_stackoverflow)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5217974A (en) * 1991-03-29 1993-06-08 Eli Lilly And Company Method for treating gar-transformylase tumors in mammals and reducing mammalian toxicity

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5838285A (ja) * 1981-08-25 1983-03-05 Kanegafuchi Chem Ind Co Ltd ５−メチル−（６ｒｓ）−５，６，７，８−テトラヒドロ−ｌ−葉酸のマグネシウム塩またはその遊離酸の製法
GB8621268D0 (en) * 1986-09-03 1986-10-08 Univ Strathclyde Separation of substances
IT1229517B (it) * 1989-01-31 1991-09-03 Bioresearch Spa Impiego di acido 5-metiltetraidrofolico, di acido 5 formiltetraidrofolico, e dei loro sali farmaceuticamente accettabili per la preparazione di composizioni farmaceutiche in forma a rilascio controllato adatte ad essere impiegate nella terapia dei disordini depressivi e composizioni farmaceutiche relative.
IT1229203B (it) * 1989-03-22 1991-07-25 Bioresearch Spa Impiego di acido 5 metiltetraidrofolico, di acido 5 formiltetraidrofolico e dei loro sali farmaceuticamente accettabili per la preparazione di composizioni farmaceutiche in forma a rilascio controllato attive nella terapia dei disturbi mentali organici e composizioni farmaceutiche relative.
NL8901432A (nl) * 1989-06-06 1991-01-02 Pharmachemie Bv Bij koelkasttemperatuur stabiele waterige folinaatoplossing, alsmede werkwijze ter bereiding daarvan.
CH680731A5 (enrdf_load_stackoverflow) * 1990-04-12 1992-10-30 Sapec Fine Chemicals
CH683261A5 (it) * 1991-10-10 1994-02-15 Applied Pharma Res Procedimento per la preparazione dell'acido metiltetraidrofolico nella forma (6(R,S)(-))N-5 e separazione del diastereoisomero attivo (6(S)(-))N-5) sotto forma di sali.
CH682665A5 (de) * 1991-10-29 1993-10-29 Sapec Fine Chemicals Verfahren zur Reinigung von rohen Erdalkalimetallsalzen von N(5)-Methyl-5,6,7,8-tetrahydrofolsäure.
US6162914A (en) * 1998-04-24 2000-12-19 Cerbios-Pharma S.A. Process for the reduction of pterins
CH693905A5 (de) * 1999-04-15 2004-04-15 Eprova Ag Stabile kristalline Salze von 5-Methyltetrahydrofolsäure.
CH698729B1 (de) * 2007-05-30 2009-10-15 Cerbios Pharma Sa Stabile, kristalline (6S)-N(5)-Methyl-5, 6,7,8-tetrahydrofolsäure.
CN103214487A (zh) * 2013-04-12 2013-07-24 张家港威胜生物医药有限公司 一种重要医药化工原料(6s)-5-甲基四氢叶酸盐的合成
WO2015193778A1 (en) 2014-06-16 2015-12-23 Mylan Laboratories Ltd. Crystalline form of levomefolate calcium
EP3844145A4 (en) 2018-08-28 2022-05-11 PMC Organometallix, Inc. Low free 2-mercaptoethanol ester and uses thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL80276C (enrdf_load_stackoverflow) *
GB1293541A (en) * 1969-03-18 1972-10-18 John Alexander Blair Folic acid derivatives
US3856959A (en) * 1972-07-24 1974-12-24 Department Of Health Education Inhibition of leukemia utilizing 5-methyltetrahydrohomofolate
US4148999A (en) * 1977-08-22 1979-04-10 The Government Of The United States Of America Preparation and purification of citrovorum factor
CH649550A5 (en) * 1984-02-09 1985-05-31 Eprova Ag Process for the preparation of alkaline earth metal salts of 5-methyltetrahydrofolic acid

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5217974A (en) * 1991-03-29 1993-06-08 Eli Lilly And Company Method for treating gar-transformylase tumors in mammals and reducing mammalian toxicity

Also Published As

Publication number Publication date
AU520715B2 (en) 1982-02-25
ATA90378A (de) 1985-08-15
SE437028B (sv) 1985-02-04
PL118654B1 (en) 1981-10-31
YU37978A (en) 1983-01-21
IE46402B1 (en) 1983-06-01
NL190285C (nl) 1994-01-03
GR71704B (enrdf_load_stackoverflow) 1983-06-21
FR2381047A1 (fr) 1978-09-15
JPS53124297A (en) 1978-10-30
FR2385397A1 (fr) 1978-10-27
DK76578A (da) 1978-08-23
SE7801973L (sv) 1978-08-23
IN149574B (enrdf_load_stackoverflow) 1982-01-30
BE863808A (fr) 1978-05-29
DK144944C (da) 1982-11-29
NL190285B (nl) 1993-08-02
MX5288E (es) 1983-06-06
EG13399A (en) 1981-12-31
FI780565A7 (fi) 1978-08-23
NO780594L (no) 1978-08-23
AT380020B (de) 1986-03-25
GB1572137A (en) 1980-07-23
PT67656B (en) 1979-07-19
PL204747A1 (pl) 1979-03-12
PT67656A (en) 1978-03-01
IL54052A0 (en) 1978-04-30
DK144944B (da) 1982-07-12
AU3343078A (en) 1979-08-30
CH635344A5 (en) 1983-03-31
FR2385397B1 (enrdf_load_stackoverflow) 1981-07-17
CZ279815B6 (cs) 1995-07-12
ES467153A1 (es) 1978-11-16
DE2807393C2 (enrdf_load_stackoverflow) 1990-06-13
HU179422B (en) 1982-10-28
FR2381047B1 (enrdf_load_stackoverflow) 1981-07-24
ZA78837B (en) 1979-09-26
NO147793B (no) 1983-03-07
CZ112978A3 (en) 1995-02-15
DE2807393A1 (de) 1978-09-07
NZ186465A (en) 1980-10-08
DD134099A5 (de) 1979-02-07
FI67082B (fi) 1984-09-28
IL54052A (en) 1981-07-31
IE780285L (en) 1978-08-22
JPS5831353B2 (ja) 1983-07-05
YU40505B (en) 1986-02-28
LU79067A1 (fr) 1978-06-27
FI67082C (fi) 1985-01-10
AR215162A1 (es) 1979-09-14
SU747427A3 (ru) 1980-07-23
NO147793C (no) 1983-06-15
NL7801775A (nl) 1978-08-24

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Legal Events

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