YU37978A - Process for obtaining d-1,5-methyl-tetrahydro-folic acid and salts thereof - Google Patents

Process for obtaining d-1,5-methyl-tetrahydro-folic acid and salts thereof

Info

Publication number
YU37978A
YU37978A YU00379/78A YU37978A YU37978A YU 37978 A YU37978 A YU 37978A YU 00379/78 A YU00379/78 A YU 00379/78A YU 37978 A YU37978 A YU 37978A YU 37978 A YU37978 A YU 37978A
Authority
YU
Yugoslavia
Prior art keywords
tetrahydro
salts
methyl
obtaining
folic acid
Prior art date
Application number
YU00379/78A
Other versions
YU40505B (en
Inventor
F Gennari
Original Assignee
Bioresearch Sa Del Dr Livio Ca
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bioresearch Sa Del Dr Livio Ca filed Critical Bioresearch Sa Del Dr Livio Ca
Publication of YU37978A publication Critical patent/YU37978A/en
Publication of YU40505B publication Critical patent/YU40505B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
    • C07D475/04—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
YU379/78A 1977-02-22 1978-02-20 Process for producing d,1-5methyl-tetrahydro-folic acid and salts thereof YU40505B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB7290/77A GB1572137A (en) 1977-02-22 1977-02-22 Stable compositions for therapeutic use based on d,1-5-methyltetrahydrofolic acid and its salts

Publications (2)

Publication Number Publication Date
YU37978A true YU37978A (en) 1983-01-21
YU40505B YU40505B (en) 1986-02-28

Family

ID=9830275

Family Applications (1)

Application Number Title Priority Date Filing Date
YU379/78A YU40505B (en) 1977-02-22 1978-02-20 Process for producing d,1-5methyl-tetrahydro-folic acid and salts thereof

Country Status (32)

Country Link
JP (1) JPS5831353B2 (en)
AR (1) AR215162A1 (en)
AT (1) AT380020B (en)
AU (1) AU520715B2 (en)
BE (1) BE863808A (en)
CA (1) CA1093554A (en)
CH (1) CH635344A5 (en)
CZ (1) CZ279815B6 (en)
DD (1) DD134099A5 (en)
DE (1) DE2807393A1 (en)
DK (1) DK144944C (en)
EG (1) EG13399A (en)
ES (1) ES467153A1 (en)
FI (1) FI67082C (en)
FR (2) FR2381047A1 (en)
GB (1) GB1572137A (en)
GR (1) GR71704B (en)
HU (1) HU179422B (en)
IE (1) IE46402B1 (en)
IL (1) IL54052A (en)
IN (1) IN149574B (en)
LU (1) LU79067A1 (en)
MX (1) MX5288E (en)
NL (1) NL190285C (en)
NO (1) NO147793C (en)
NZ (1) NZ186465A (en)
PL (1) PL118654B1 (en)
PT (1) PT67656B (en)
SE (1) SE437028B (en)
SU (1) SU747427A3 (en)
YU (1) YU40505B (en)
ZA (1) ZA78837B (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5838285A (en) * 1981-08-25 1983-03-05 Kanegafuchi Chem Ind Co Ltd Preparation of 5-methyl-(6rs)-5,6,7,8-tetrahydro-l-folic acid magnesium salt or its free acid
GB8621268D0 (en) * 1986-09-03 1986-10-08 Univ Strathclyde Separation of substances
IT1229517B (en) * 1989-01-31 1991-09-03 Bioresearch Spa USE OF 5-METHYLTETRAHYDROPHOLIC ACID, OF 5 FORMYLTHETRAHYDROPHOLIC ACID, AND OF THEIR PHARMACEUTICALLY ACCEPTABLE SALTS FOR THE PREPARATION OF PHARMACEUTICAL COMPOSITIONS IN THE FORM OF CONTROLLED RELEASE SUITABLE FOR BEING EMPLOYED IN THE TREATMENT OF DISORDERS IN THE TREATMENT OF DISORDERS.
IT1229203B (en) * 1989-03-22 1991-07-25 Bioresearch Spa USE OF 5 METHYLTHETRAHYDROPHOLIC ACID, 5 FORMYLTHETRAHYDROPHOLIC ACID AND THEIR PHARMACEUTICALLY ACCEPTABLE SALTS FOR THE PREPARATION OF PHARMACEUTICAL COMPOSITIONS IN THE FORM OF CONTROLLED RELEASE ACTIVE IN THE THERAPY OF MENTAL AND ORGANIC DISORDERS.
NL8901432A (en) * 1989-06-06 1991-01-02 Pharmachemie Bv STABLE AQUEOUS FOLINATE SOLUTION AT REFRIGERATOR TEMPERATURE, AND METHOD FOR PREPARING THAT.
CH680731A5 (en) * 1990-04-12 1992-10-30 Sapec Fine Chemicals
US5217974A (en) * 1991-03-29 1993-06-08 Eli Lilly And Company Method for treating gar-transformylase tumors in mammals and reducing mammalian toxicity
CH683261A5 (en) * 1991-10-10 1994-02-15 Applied Pharma Res A process for the preparation of Methyltetrahydrofolic in the form (6 (R, S) (-)) N-5 and separation of the active diastereoisomer (6 (S) (-)) N-5) in the form of salts.
CH682665A5 (en) * 1991-10-29 1993-10-29 Sapec Fine Chemicals Process for the purification of crude alkaline earth metal salts from N (5) -methyl-5,6,7,8-tetrahydrofolic acid.
US6162914A (en) * 1998-04-24 2000-12-19 Cerbios-Pharma S.A. Process for the reduction of pterins
CH693905A5 (en) * 1999-04-15 2004-04-15 Eprova Ag Stable crystalline salts of 5-methyl tetrahydrofolic acid.
CH698729B1 (en) * 2007-05-30 2009-10-15 Cerbios Pharma Sa Stable crystalline (6S) -N (5) -methyl-5, 6,7,8-tetrahydrofolic acid.
CN103214487A (en) * 2013-04-12 2013-07-24 张家港威胜生物医药有限公司 Synthesis of important medical chemical raw material (6S)-5-methyl tetrahydrofolate
WO2015193778A1 (en) 2014-06-16 2015-12-23 Mylan Laboratories Ltd. Crystalline form of levomefolate calcium
US20210324176A1 (en) 2018-08-28 2021-10-21 Pmc Organometallix, Inc. Low free 2-mercaptoethanol ester and uses thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL80276C (en) *
GB1293541A (en) * 1969-03-18 1972-10-18 John Alexander Blair Folic acid derivatives
US3856959A (en) * 1972-07-24 1974-12-24 Department Of Health Education Inhibition of leukemia utilizing 5-methyltetrahydrohomofolate
US4148999A (en) * 1977-08-22 1979-04-10 The Government Of The United States Of America Preparation and purification of citrovorum factor
CH649550A5 (en) * 1984-02-09 1985-05-31 Eprova Ag Process for the preparation of alkaline earth metal salts of 5-methyltetrahydrofolic acid

Also Published As

Publication number Publication date
FR2381047A1 (en) 1978-09-15
PT67656A (en) 1978-03-01
FI67082B (en) 1984-09-28
ES467153A1 (en) 1978-11-16
BE863808A (en) 1978-05-29
NL7801775A (en) 1978-08-24
AU3343078A (en) 1979-08-30
DK144944C (en) 1982-11-29
IN149574B (en) 1982-01-30
IE46402B1 (en) 1983-06-01
IL54052A0 (en) 1978-04-30
DE2807393C2 (en) 1990-06-13
MX5288E (en) 1983-06-06
DD134099A5 (en) 1979-02-07
PL204747A1 (en) 1979-03-12
SE437028B (en) 1985-02-04
IL54052A (en) 1981-07-31
CZ112978A3 (en) 1995-02-15
NL190285B (en) 1993-08-02
NO147793C (en) 1983-06-15
DE2807393A1 (en) 1978-09-07
SE7801973L (en) 1978-08-23
CA1093554A (en) 1981-01-13
FI67082C (en) 1985-01-10
FR2385397B1 (en) 1981-07-17
CH635344A5 (en) 1983-03-31
CZ279815B6 (en) 1995-07-12
DK144944B (en) 1982-07-12
NL190285C (en) 1994-01-03
JPS5831353B2 (en) 1983-07-05
NZ186465A (en) 1980-10-08
DK76578A (en) 1978-08-23
FI780565A (en) 1978-08-23
HU179422B (en) 1982-10-28
GR71704B (en) 1983-06-21
GB1572137A (en) 1980-07-23
ZA78837B (en) 1979-09-26
AT380020B (en) 1986-03-25
PT67656B (en) 1979-07-19
SU747427A3 (en) 1980-07-23
AU520715B2 (en) 1982-02-25
EG13399A (en) 1981-12-31
JPS53124297A (en) 1978-10-30
ATA90378A (en) 1985-08-15
NO147793B (en) 1983-03-07
PL118654B1 (en) 1981-10-31
FR2385397A1 (en) 1978-10-27
YU40505B (en) 1986-02-28
LU79067A1 (en) 1978-06-27
NO780594L (en) 1978-08-23
IE780285L (en) 1978-08-22
FR2381047B1 (en) 1981-07-24
AR215162A1 (en) 1979-09-14

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