YU40505B - Process for producing d,1-5methyl-tetrahydro-folic acid and salts thereof - Google Patents
Process for producing d,1-5methyl-tetrahydro-folic acid and salts thereofInfo
- Publication number
- YU40505B YU40505B YU379/78A YU37978A YU40505B YU 40505 B YU40505 B YU 40505B YU 379/78 A YU379/78 A YU 379/78A YU 37978 A YU37978 A YU 37978A YU 40505 B YU40505 B YU 40505B
- Authority
- YU
- Yugoslavia
- Prior art keywords
- 5methyl
- tetrahydro
- salts
- producing
- folic acid
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
- C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
- C07D475/04—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB7290/77A GB1572137A (en) | 1977-02-22 | 1977-02-22 | Stable compositions for therapeutic use based on d,1-5-methyltetrahydrofolic acid and its salts |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| YU37978A YU37978A (en) | 1983-01-21 |
| YU40505B true YU40505B (en) | 1986-02-28 |
Family
ID=9830275
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| YU379/78A YU40505B (en) | 1977-02-22 | 1978-02-20 | Process for producing d,1-5methyl-tetrahydro-folic acid and salts thereof |
Country Status (32)
| Country | Link |
|---|---|
| JP (1) | JPS5831353B2 (en) |
| AR (1) | AR215162A1 (en) |
| AT (1) | AT380020B (en) |
| AU (1) | AU520715B2 (en) |
| BE (1) | BE863808A (en) |
| CA (1) | CA1093554A (en) |
| CH (1) | CH635344A5 (en) |
| CZ (1) | CZ279815B6 (en) |
| DD (1) | DD134099A5 (en) |
| DE (1) | DE2807393A1 (en) |
| DK (1) | DK144944C (en) |
| EG (1) | EG13399A (en) |
| ES (1) | ES467153A1 (en) |
| FI (1) | FI67082C (en) |
| FR (2) | FR2381047A1 (en) |
| GB (1) | GB1572137A (en) |
| GR (1) | GR71704B (en) |
| HU (1) | HU179422B (en) |
| IE (1) | IE46402B1 (en) |
| IL (1) | IL54052A (en) |
| IN (1) | IN149574B (en) |
| LU (1) | LU79067A1 (en) |
| MX (1) | MX5288E (en) |
| NL (1) | NL190285C (en) |
| NO (1) | NO147793C (en) |
| NZ (1) | NZ186465A (en) |
| PL (1) | PL118654B1 (en) |
| PT (1) | PT67656B (en) |
| SE (1) | SE437028B (en) |
| SU (1) | SU747427A3 (en) |
| YU (1) | YU40505B (en) |
| ZA (1) | ZA78837B (en) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5838285A (en) * | 1981-08-25 | 1983-03-05 | Kanegafuchi Chem Ind Co Ltd | Preparation of 5-methyl-(6rs)-5,6,7,8-tetrahydro-l-folic acid magnesium salt or its free acid |
| GB8621268D0 (en) * | 1986-09-03 | 1986-10-08 | Univ Strathclyde | Separation of substances |
| IT1229517B (en) * | 1989-01-31 | 1991-09-03 | Bioresearch Spa | USE OF 5-METHYLTETRAHYDROPHOLIC ACID, OF 5 FORMYLTHETRAHYDROPHOLIC ACID, AND OF THEIR PHARMACEUTICALLY ACCEPTABLE SALTS FOR THE PREPARATION OF PHARMACEUTICAL COMPOSITIONS IN THE FORM OF CONTROLLED RELEASE SUITABLE FOR BEING EMPLOYED IN THE TREATMENT OF DISORDERS IN THE TREATMENT OF DISORDERS. |
| IT1229203B (en) * | 1989-03-22 | 1991-07-25 | Bioresearch Spa | USE OF 5 METHYLTHETRAHYDROPHOLIC ACID, 5 FORMYLTHETRAHYDROPHOLIC ACID AND THEIR PHARMACEUTICALLY ACCEPTABLE SALTS FOR THE PREPARATION OF PHARMACEUTICAL COMPOSITIONS IN THE FORM OF CONTROLLED RELEASE ACTIVE IN THE THERAPY OF MENTAL AND ORGANIC DISORDERS. |
| NL8901432A (en) * | 1989-06-06 | 1991-01-02 | Pharmachemie Bv | STABLE AQUEOUS FOLINATE SOLUTION AT REFRIGERATOR TEMPERATURE, AND METHOD FOR PREPARING THAT. |
| CH680731A5 (en) * | 1990-04-12 | 1992-10-30 | Sapec Fine Chemicals | |
| US5217974A (en) * | 1991-03-29 | 1993-06-08 | Eli Lilly And Company | Method for treating gar-transformylase tumors in mammals and reducing mammalian toxicity |
| CH683261A5 (en) * | 1991-10-10 | 1994-02-15 | Applied Pharma Res | A process for the preparation of Methyltetrahydrofolic in the form (6 (R, S) (-)) N-5 and separation of the active diastereoisomer (6 (S) (-)) N-5) in the form of salts. |
| CH682665A5 (en) * | 1991-10-29 | 1993-10-29 | Sapec Fine Chemicals | Process for the purification of crude alkaline earth metal salts from N (5) -methyl-5,6,7,8-tetrahydrofolic acid. |
| US6162914A (en) * | 1998-04-24 | 2000-12-19 | Cerbios-Pharma S.A. | Process for the reduction of pterins |
| CH693905A5 (en) | 1999-04-15 | 2004-04-15 | Eprova Ag | Stable crystalline salts of 5-methyl tetrahydrofolic acid. |
| CH698729B1 (en) * | 2007-05-30 | 2009-10-15 | Cerbios Pharma Sa | Stable crystalline (6S) -N (5) -methyl-5, 6,7,8-tetrahydrofolic acid. |
| CN103214487A (en) * | 2013-04-12 | 2013-07-24 | 张家港威胜生物医药有限公司 | Synthesis of important medical chemical raw material (6S)-5-methyl tetrahydrofolate |
| WO2015193778A1 (en) | 2014-06-16 | 2015-12-23 | Mylan Laboratories Ltd. | Crystalline form of levomefolate calcium |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL80276C (en) * | ||||
| GB1293541A (en) * | 1969-03-18 | 1972-10-18 | John Alexander Blair | Folic acid derivatives |
| US3856959A (en) * | 1972-07-24 | 1974-12-24 | Department Of Health Education | Inhibition of leukemia utilizing 5-methyltetrahydrohomofolate |
| US4148999A (en) * | 1977-08-22 | 1979-04-10 | The Government Of The United States Of America | Preparation and purification of citrovorum factor |
| CH649550A5 (en) * | 1984-02-09 | 1985-05-31 | Eprova Ag | Process for the preparation of alkaline earth metal salts of 5-methyltetrahydrofolic acid |
-
1977
- 1977-02-22 GB GB7290/77A patent/GB1572137A/en not_active Expired
-
1978
- 1978-02-09 AT AT0090378A patent/AT380020B/en not_active IP Right Cessation
- 1978-02-09 CA CA296,754A patent/CA1093554A/en not_active Expired
- 1978-02-09 BE BE185038A patent/BE863808A/en not_active IP Right Cessation
- 1978-02-09 IE IE285/78A patent/IE46402B1/en not_active IP Right Cessation
- 1978-02-13 NZ NZ186465A patent/NZ186465A/en unknown
- 1978-02-13 ZA ZA00780837A patent/ZA78837B/en unknown
- 1978-02-15 IN IN174/CAL/78A patent/IN149574B/en unknown
- 1978-02-15 PT PT67656A patent/PT67656B/en unknown
- 1978-02-15 LU LU79067A patent/LU79067A1/en unknown
- 1978-02-15 IL IL54052A patent/IL54052A/en unknown
- 1978-02-16 NL NLAANVRAGE7801775,A patent/NL190285C/en not_active IP Right Cessation
- 1978-02-18 PL PL1978204747A patent/PL118654B1/en unknown
- 1978-02-20 DD DD78203761A patent/DD134099A5/en unknown
- 1978-02-20 YU YU379/78A patent/YU40505B/en unknown
- 1978-02-20 GR GR55500A patent/GR71704B/el unknown
- 1978-02-20 AU AU33430/78A patent/AU520715B2/en not_active Expired
- 1978-02-21 EG EG103/78A patent/EG13399A/en active
- 1978-02-21 DK DK76578A patent/DK144944C/en not_active IP Right Cessation
- 1978-02-21 FI FI780565A patent/FI67082C/en not_active IP Right Cessation
- 1978-02-21 ES ES467153A patent/ES467153A1/en not_active Expired
- 1978-02-21 DE DE19782807393 patent/DE2807393A1/en active Granted
- 1978-02-21 FR FR7804847A patent/FR2381047A1/en active Granted
- 1978-02-21 SU SU782588551A patent/SU747427A3/en active
- 1978-02-21 MX MX786871U patent/MX5288E/en unknown
- 1978-02-21 SE SE7801973A patent/SE437028B/en not_active IP Right Cessation
- 1978-02-21 NO NO780594A patent/NO147793C/en unknown
- 1978-02-22 AR AR271183A patent/AR215162A1/en active
- 1978-02-22 CH CH193678A patent/CH635344A5/en not_active IP Right Cessation
- 1978-02-22 HU HU78BI562A patent/HU179422B/en unknown
- 1978-02-22 CZ CS781129A patent/CZ279815B6/en unknown
- 1978-02-22 JP JP53018637A patent/JPS5831353B2/en not_active Expired
- 1978-07-13 FR FR7820936A patent/FR2385397A1/en active Granted
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