BRPI1012549B8 - moduladores do regulador da condutância transmembrana na fibrose cística, composição farmacêutica e kit - Google Patents

moduladores do regulador da condutância transmembrana na fibrose cística, composição farmacêutica e kit

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Publication number
BRPI1012549B8
BRPI1012549B8 BRPI1012549A BRPI1012549A BRPI1012549B8 BR PI1012549 B8 BRPI1012549 B8 BR PI1012549B8 BR PI1012549 A BRPI1012549 A BR PI1012549A BR PI1012549 A BRPI1012549 A BR PI1012549A BR PI1012549 B8 BRPI1012549 B8 BR PI1012549B8
Authority
BR
Brazil
Prior art keywords
cystic fibrosis
kit
pharmaceutical composition
conductance regulator
transmembrane conductance
Prior art date
Application number
BRPI1012549A
Other languages
English (en)
Portuguese (pt)
Inventor
F Van Goor Fredrick
Zlokarnik Gregor
C Botfield Martyn
d j grootenhuis Peter
S Hadida Ruah Sara
Yang Xiaoqing
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharma filed Critical Vertex Pharma
Publication of BRPI1012549A2 publication Critical patent/BRPI1012549A2/pt
Publication of BRPI1012549A8 publication Critical patent/BRPI1012549A8/pt
Publication of BRPI1012549B1 publication Critical patent/BRPI1012549B1/pt
Publication of BRPI1012549B8 publication Critical patent/BRPI1012549B8/pt

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    • C07—ORGANIC CHEMISTRY
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    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/233—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
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    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
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    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
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BRPI1012549A 2009-03-20 2010-03-19 moduladores do regulador da condutância transmembrana na fibrose cística, composição farmacêutica e kit BRPI1012549B8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US16213009P 2009-03-20 2009-03-20
PCT/US2010/028062 WO2010108155A1 (en) 2009-03-20 2010-03-19 Modulators of cystic fibrosis transmembrane conductance regulator

Publications (4)

Publication Number Publication Date
BRPI1012549A2 BRPI1012549A2 (pt) 2016-03-22
BRPI1012549A8 BRPI1012549A8 (pt) 2016-10-04
BRPI1012549B1 BRPI1012549B1 (pt) 2020-04-07
BRPI1012549B8 true BRPI1012549B8 (pt) 2021-05-25

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