BRPI1010768A8 - composto, e, composição farmacêutica. - Google Patents

composto, e, composição farmacêutica. Download PDF

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Publication number
BRPI1010768A8
BRPI1010768A8 BRPI1010768A BRPI1010768A BRPI1010768A8 BR PI1010768 A8 BRPI1010768 A8 BR PI1010768A8 BR PI1010768 A BRPI1010768 A BR PI1010768A BR PI1010768 A BRPI1010768 A BR PI1010768A BR PI1010768 A8 BRPI1010768 A8 BR PI1010768A8
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BR
Brazil
Prior art keywords
group
compound
alkyl
pharmaceutical composition
hydroxyl
Prior art date
Application number
BRPI1010768A
Other languages
English (en)
Inventor
Brock Carsten
Scherrer Didier
Mahuteau Florence
Gadea Gilles
Tazi Jamal
Cahuzac Nathalie
Roux Pierre
Najman Romain
Original Assignee
Abivax
Centre Nat Rech Scient
Inst Curie
Soc Splicos
Univ Montpellier
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP09162630A external-priority patent/EP2261214A1/en
Priority claimed from EP20090305540 external-priority patent/EP2266972A1/en
Application filed by Abivax, Centre Nat Rech Scient, Inst Curie, Soc Splicos, Univ Montpellier filed Critical Abivax
Priority to BR122019013686-6A priority Critical patent/BR122019013686B1/pt
Priority to BR122019013687A priority patent/BR122019013687B1/pt
Publication of BRPI1010768A2 publication Critical patent/BRPI1010768A2/pt
Publication of BRPI1010768A8 publication Critical patent/BRPI1010768A8/pt
Publication of BRPI1010768B1 publication Critical patent/BRPI1010768B1/pt
Publication of BRPI1010768B8 publication Critical patent/BRPI1010768B8/pt
Publication of BRPI1010768C8 publication Critical patent/BRPI1010768C8/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/42—Nitrogen atoms attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/42—Nitrogen atoms attached in position 4
    • C07D215/46—Nitrogen atoms attached in position 4 with hydrocarbon radicals, substituted by nitrogen atoms, attached to said nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/58—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems with hetero atoms directly attached to the ring nitrogen atom
    • C07D215/60—N-oxides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
    • C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
    • C07D241/40—Benzopyrazines
    • C07D241/44—Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

composto, e, composição farmacêutica a presente invenção diz respeito a composto (i) em que: significa um grupo piridazina, pirimidina ou pirazina, r independentemente representa um átomo de hidrogênio, um átomo de halogênio ou um grupo escolhido entre um grupo -cn, um grupo hidroxila, um grupo -coor1, um grupo fluoralquila (c1-c3), um grupo fluoralcóxi (c1-c3), um grupo -n02, um grupo -nr1r2, um grupo alcóxi (c1-c4), um grupo fenóxi e um grupo alquila (c1-c3), o dito alquila sendo opcionalmente mono-substituído por um grupo hidroxila, n é 1, 2 ou 3, n' é 1 ou 2, r' é um átomo de hidrogênio, um átomo de halogênio ou um grupo escolhido entre um grupo alquila (c1-c3), um grupo hidroxila, um grupo -coor1, um grupo -n02, um grupo -nr1r2, um morfolinila ou um grupo morfolino, um grupo n-metilpiperazinila, um grupo fluoralquila (c1-c3), um grupo alcóxi (c1-c4) e um grupo -cn, z é n ou c, y é n ou c, x é n ou c, w é n ou c, t é n ou c, u é n ou c, para uso como um agente para prevenir, inibir ou tratar câncer. alguns dos ditos compostos são inéditos e também formam parte da invenção.
BRPI1010768A 2009-06-12 2010-06-14 composto de fórmula (i) BRPI1010768C8 (pt)

Priority Applications (2)

Application Number Priority Date Filing Date Title
BR122019013686-6A BR122019013686B1 (pt) 2009-06-12 2010-06-14 Composto de fórmula (i), composto de fórmula (iq) e composição farmacêutica
BR122019013687A BR122019013687B1 (pt) 2009-06-12 2010-06-14 composto de fórmula (i)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US18655209P 2009-06-12 2009-06-12
US18654409P 2009-06-12 2009-06-12
EP09162630A EP2261214A1 (en) 2009-06-12 2009-06-12 Compounds useful to treat premature aging and in particular progeria
EP20090305540 EP2266972A1 (en) 2009-06-12 2009-06-12 New chemical molecules that inhibit the splicing mechanism for treating diseases resulting from splicing anomalies
PCT/IB2010/052650 WO2010143168A2 (en) 2009-06-12 2010-06-14 Compounds useful for treating cancer

Publications (5)

Publication Number Publication Date
BRPI1010768A2 BRPI1010768A2 (pt) 2016-11-01
BRPI1010768A8 true BRPI1010768A8 (pt) 2019-07-30
BRPI1010768B1 BRPI1010768B1 (pt) 2019-10-22
BRPI1010768B8 BRPI1010768B8 (pt) 2020-03-10
BRPI1010768C8 BRPI1010768C8 (pt) 2020-04-07

Family

ID=43309298

Family Applications (5)

Application Number Title Priority Date Filing Date
BRPI1010768A BRPI1010768C8 (pt) 2009-06-12 2010-06-14 composto de fórmula (i)
BR122019013686-6A BR122019013686B1 (pt) 2009-06-12 2010-06-14 Composto de fórmula (i), composto de fórmula (iq) e composição farmacêutica
BRPI1012892A BRPI1012892B8 (pt) 2009-06-12 2010-06-14 compostos de fórmula (i), como tal, composição farmacêutica que os compreende e seu uso no tratamento de hgps, progeria, desordem de charcot-marie-tooth, síndrome de werner, diabetes, osteoporose e envelhecimento da pele
BR122019013687A BR122019013687B1 (pt) 2009-06-12 2010-06-14 composto de fórmula (i)
BRPI1010772A BRPI1010772B8 (pt) 2009-06-12 2010-06-14 compostos de quinolina, suas composições farmacêuticas e seus usos para tratar aids

Family Applications After (4)

Application Number Title Priority Date Filing Date
BR122019013686-6A BR122019013686B1 (pt) 2009-06-12 2010-06-14 Composto de fórmula (i), composto de fórmula (iq) e composição farmacêutica
BRPI1012892A BRPI1012892B8 (pt) 2009-06-12 2010-06-14 compostos de fórmula (i), como tal, composição farmacêutica que os compreende e seu uso no tratamento de hgps, progeria, desordem de charcot-marie-tooth, síndrome de werner, diabetes, osteoporose e envelhecimento da pele
BR122019013687A BR122019013687B1 (pt) 2009-06-12 2010-06-14 composto de fórmula (i)
BRPI1010772A BRPI1010772B8 (pt) 2009-06-12 2010-06-14 compostos de quinolina, suas composições farmacêuticas e seus usos para tratar aids

Country Status (24)

Country Link
US (7) US9145367B2 (pt)
EP (6) EP2440547B1 (pt)
JP (8) JP5905385B2 (pt)
KR (14) KR101982461B1 (pt)
CN (13) CN102596935B (pt)
AU (3) AU2010258294B2 (pt)
BR (5) BRPI1010768C8 (pt)
CA (5) CA2965791C (pt)
CU (4) CU24245B1 (pt)
DK (4) DK2440546T3 (pt)
ES (3) ES2736198T3 (pt)
FI (3) FI2440546T3 (pt)
HK (8) HK1173153A1 (pt)
HR (3) HRP20230143T1 (pt)
HU (2) HUE045548T2 (pt)
LT (1) LT2440547T (pt)
MX (9) MX338823B (pt)
PL (4) PL2440547T3 (pt)
PT (4) PT3517534T (pt)
RU (1) RU2567752C2 (pt)
SI (1) SI2440547T1 (pt)
TR (1) TR201910781T4 (pt)
WO (3) WO2010143168A2 (pt)
ZA (2) ZA201109032B (pt)

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