GB585362A - New heterocyclic compounds - Google Patents

New heterocyclic compounds

Info

Publication number
GB585362A
GB585362A GB1044044A GB1044044A GB585362A GB 585362 A GB585362 A GB 585362A GB 1044044 A GB1044044 A GB 1044044A GB 1044044 A GB1044044 A GB 1044044A GB 585362 A GB585362 A GB 585362A
Authority
GB
United Kingdom
Prior art keywords
acetic acid
dichloro
chloroaniline
naphthylamine
quinoline
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB1044044A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Imperial Chemical Industries Ltd
Original Assignee
Imperial Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Imperial Chemical Industries Ltd filed Critical Imperial Chemical Industries Ltd
Priority to GB1044044A priority Critical patent/GB585362A/en
Publication of GB585362A publication Critical patent/GB585362A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/10—Aza-phenanthrenes

Abstract

4-Halogenoquinolines carrying in the 2-position an arylamino group free from acidic substituents, are obtained by the interaction of an appropriate arylamine with a 2 : 4-dihalogenoquinoline, optionally in the presence of a solvent or diluent. Examples relate to the interaction of 2 : 4-dichloroquinoline with (1) p-chloroaniline in acetic acid, (2) p-chloroaniline in chlorobenzene, (3) aniline in acetic acid, (4) p-anisidine in acetic acid, (5) p-toluidine in acetic acid, and (6) b -naphthylamine in acetic acid; (7) of 2 : 4-dichloro-7 : 8-benzquinoline with p-chloraniline in b -ethoxyethanol in the presence of p-chloroaniline hydrochloride; of 2 : 4-dichloro-quinoline with (8) 6-bromo-2-naphthylamine in acetic acid, and (9) p-nitroaniline in acetic acid; and of p-chloroaniline in acetic acid with (10) 2 : 4-dichloro - 3 - methyl - quinoline and (11) 2 : 4 - dichloro - 3 - ethyl - quinoline. Specification 585,363 is referred to. 7 : 8 - Benzo-, 3 - methyl - and 3 - ethyl - 2 : 4 - dichloroquinolines are obtained by treating with phosphorus oxychloride the products of reaction of a -naphthylamine with diethyl malonate, aniline with diethyl methyl malonate and aniline with diethyl ethyl malonate respectively.
GB1044044A 1944-08-31 1944-08-31 New heterocyclic compounds Expired GB585362A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB1044044A GB585362A (en) 1944-08-31 1944-08-31 New heterocyclic compounds

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB1044044A GB585362A (en) 1944-08-31 1944-08-31 New heterocyclic compounds

Publications (1)

Publication Number Publication Date
GB585362A true GB585362A (en) 1947-02-05

Family

ID=9967905

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1044044A Expired GB585362A (en) 1944-08-31 1944-08-31 New heterocyclic compounds

Country Status (1)

Country Link
GB (1) GB585362A (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20150307478A1 (en) * 2009-06-12 2015-10-29 Abivax Compounds useful for treating aids
US9827237B2 (en) 2013-07-05 2017-11-28 Abivax Compounds useful for treating diseases caused by retroviruses
US10253020B2 (en) 2009-06-12 2019-04-09 Abivax Compounds for preventing, inhibiting, or treating cancer, AIDS and/or premature aging
US11441181B2 (en) 2013-01-17 2022-09-13 Abivax miRNA-124 as a biomarker
US11649211B2 (en) 2014-07-17 2023-05-16 Abivax Use of quinoline derivatives for the treatment of inflammatory diseases

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20150307478A1 (en) * 2009-06-12 2015-10-29 Abivax Compounds useful for treating aids
US9637475B2 (en) 2009-06-12 2017-05-02 Abivax Compounds for treating cancer
US9908869B2 (en) 2009-06-12 2018-03-06 Abivax Compounds useful for treating aids
US10017498B2 (en) * 2009-06-12 2018-07-10 Abivax Compounds useful for treating AIDS
US10253020B2 (en) 2009-06-12 2019-04-09 Abivax Compounds for preventing, inhibiting, or treating cancer, AIDS and/or premature aging
US10683284B2 (en) 2009-06-12 2020-06-16 Abivax Compounds for preventing, inhibiting, or treating cancer, aids and/or premature aging
US10975063B2 (en) 2009-06-12 2021-04-13 Abivax Compound, and production method thereof, and methods of treatment using the compound
US11014918B2 (en) 2009-06-12 2021-05-25 Abivax Compounds and pharmaceutical compositions containing at least one of the compounds
US11441181B2 (en) 2013-01-17 2022-09-13 Abivax miRNA-124 as a biomarker
US9827237B2 (en) 2013-07-05 2017-11-28 Abivax Compounds useful for treating diseases caused by retroviruses
US11649211B2 (en) 2014-07-17 2023-05-16 Abivax Use of quinoline derivatives for the treatment of inflammatory diseases
US11649210B2 (en) 2014-07-17 2023-05-16 Abivax Use of quinoline derivatives for the treatment of inflammatory diseases

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