BRPI1007404A2 - método para síntese de (1s,2r)-milnaciprano - Google Patents

método para síntese de (1s,2r)-milnaciprano

Info

Publication number
BRPI1007404A2
BRPI1007404A2 BRPI1007404A BRPI1007404A BRPI1007404A2 BR PI1007404 A2 BRPI1007404 A2 BR PI1007404A2 BR PI1007404 A BRPI1007404 A BR PI1007404A BR PI1007404 A BRPI1007404 A BR PI1007404A BR PI1007404 A2 BRPI1007404 A2 BR PI1007404A2
Authority
BR
Brazil
Prior art keywords
milnacipran
synthesis
Prior art date
Application number
BRPI1007404A
Other languages
English (en)
Inventor
Catherine Diard
Laurent Subra
Marc Nicolas
Paul Hellier
Original Assignee
Pf Medicament
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pf Medicament filed Critical Pf Medicament
Publication of BRPI1007404A2 publication Critical patent/BRPI1007404A2/pt
Publication of BRPI1007404B1 publication Critical patent/BRPI1007404B1/pt
Publication of BRPI1007404B8 publication Critical patent/BRPI1007404B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/16—Preparation of optical isomers
    • C07C231/18—Preparation of optical isomers by stereospecific synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/57—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C233/58—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Steroid Compounds (AREA)
BRPI1007404A 2009-01-29 2010-01-29 método para síntese de (1s,2r)-milnaciprano BRPI1007404B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR0950552 2009-01-29
FR0950552A FR2941454B1 (fr) 2009-01-29 2009-01-29 Proced de synthese du (1s,2r)-milnacipran
PCT/EP2010/051045 WO2010086394A1 (en) 2009-01-29 2010-01-29 Method for synthesis of (1s, 2r)-milnacipran

Publications (3)

Publication Number Publication Date
BRPI1007404A2 true BRPI1007404A2 (pt) 2016-02-16
BRPI1007404B1 BRPI1007404B1 (pt) 2020-10-13
BRPI1007404B8 BRPI1007404B8 (pt) 2021-05-25

Family

ID=40920574

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI1007404A BRPI1007404B8 (pt) 2009-01-29 2010-01-29 método para síntese de (1s,2r)-milnaciprano

Country Status (23)

Country Link
US (1) US8604241B2 (pt)
EP (1) EP2391599B1 (pt)
JP (1) JP5646509B2 (pt)
KR (1) KR101719011B1 (pt)
CN (2) CN102300840A (pt)
AR (2) AR077526A1 (pt)
AU (1) AU2010209686B2 (pt)
BR (1) BRPI1007404B8 (pt)
CA (1) CA2750488C (pt)
ES (1) ES2472695T3 (pt)
FR (1) FR2941454B1 (pt)
GE (1) GEP20135903B (pt)
IL (1) IL214241A (pt)
MA (1) MA33025B1 (pt)
MX (1) MX2011007846A (pt)
NZ (1) NZ594291A (pt)
PL (1) PL2391599T3 (pt)
RU (1) RU2521342C2 (pt)
TN (1) TN2011000363A1 (pt)
TW (1) TWI455911B (pt)
UA (1) UA104884C2 (pt)
WO (1) WO2010086394A1 (pt)
ZA (1) ZA201105414B (pt)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2944011B1 (fr) * 2009-04-03 2011-05-20 Pf Medicament Derives d'aminocyclobutane ou d'aminocyclobutene, leur procede de preparation et leur utilisation a titre de medicaments.
WO2011158249A1 (en) * 2010-06-16 2011-12-22 Glenmark Generics Limited Process for preparation of milnacipran intermediate and its use in preparation of pure milnacipran
WO2012046247A2 (en) * 2010-10-06 2012-04-12 Msn Laboratories Limited Process for the preparation of (±m1r(s), 2srr)l-2-(aminomethyl)-n,n-diethyl-l-phenylcyclopropane carboxamide hydrochloride
ES2613709T3 (es) * 2011-01-24 2017-05-25 Bayer Intellectual Property Gmbh Procedimiento para la preparación de 2,2-difluoroetilamina a partir de 2,2-difluoro-1-cloroetano
US9416109B2 (en) * 2012-02-17 2016-08-16 Eisai R&D Management Co., Ltd. Methods and compounds useful in the synthesis of orexin-2 receptor antagonists
WO2014009767A1 (en) 2012-07-07 2014-01-16 Micro Labs Limited An improved process for the preparation of 1-aryl 2-aminomethyl cyclopropane carboxyamide (z) derivatives, their isomers and salts
EP2805936A1 (en) 2013-05-20 2014-11-26 Cosma S.p.A. Process for preparing levomilnacipran HCL
WO2014203277A2 (en) * 2013-06-19 2014-12-24 Msn Laboratories Private Limited Process for the preparation of (1s,2r)-2-(aminomethyl)-n,n-diethyl-1-phenylcyclopropanearboxamide hydrochloride
CN103694162B (zh) * 2014-01-03 2015-09-02 上海现代制药股份有限公司 (1s,2r)-1-苯基2-(酞酰亚胺)甲基-n,n-二乙基-环丙甲酰胺的制备方法
CN104058992A (zh) * 2014-06-13 2014-09-24 上海现代制药股份有限公司 左旋米那普仑盐酸盐的晶型
JP2017533892A (ja) * 2014-10-03 2017-11-16 ピュラック バイオケム ビー． ブイ． Ｎ，ｎ−ジアルキルラクトアミドの製造法
ES2746081T3 (es) 2014-11-04 2020-03-04 Quim Sintetica S A Procedimiento para la preparación de (1S,2R)-milnaciprán
CN106083638A (zh) * 2016-07-07 2016-11-09 佛山市隆信医药科技有限公司 一种盐酸左旋米那普仑的制备方法
CN111175387B (zh) * 2018-11-13 2022-06-07 成都康弘药业集团股份有限公司 一种米那普仑异构体的检测方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2508035A1 (fr) 1981-06-23 1982-12-24 Fabre Sa Pierre Derives d'aryl-1-aminomethyl-2 cyclopropanes carboxamides (z), leur preparation et leur application en tant que medicaments utiles dans le traitement des troubles du systeme nerveux central
FR2581059B1 (fr) 1985-04-25 1988-04-22 Pf Medicament Procede de preparation du chlorhydrate de phenyl-1 diethyl amino carbonyl-1 aminomethyl-2 cyclopropane (z)
FR2640972B1 (pt) * 1988-12-28 1991-04-19 Pf Medicament
JPH0834765A (ja) * 1994-02-22 1996-02-06 Asahi Chem Ind Co Ltd アミノアルキルシクロプロパン誘導体
WO1995022521A1 (fr) 1994-02-22 1995-08-24 Asahi Kasei Kogyo Kabushiki Kaisha Derive d'aminoalkylcyclopropane
WO2005118564A2 (en) 2004-06-01 2005-12-15 Collegium Pharmaceutical, Inc. Methods for the synthesis of milnacipran and congeners thereof
JP4712320B2 (ja) 2004-06-16 2011-06-29 住友化学株式会社 ２−オキソ−１−フェニル−３−オキサビシクロ［３．１．０］ヘキサンの製造方法
JP4418717B2 (ja) * 2004-06-24 2010-02-24 住友化学株式会社 （ｚ）−１−フェニル−１−ジエチルアミノカルボニル−２−アミノメチルシクロプロパン塩酸塩の製造方法
CN100579954C (zh) 2004-06-25 2010-01-13 住友化学株式会社 (z)-1-苯基-1-二乙氨基羰基-2-羟甲基环丙烷的制造方法
JP4828863B2 (ja) 2005-01-28 2011-11-30 住友化学株式会社 （ｚ）−１−フェニル−１−（ｎ，ｎ−ジエチルアミノカルボニル）−２−フタルイミドメチルシクロプロパンの製造方法
KR100772244B1 (ko) * 2005-07-20 2007-11-01 안국약품 주식회사 밀나시프란염산염의 제조방법
KR20140068261A (ko) 2009-12-04 2014-06-05 인터디지탈 패튼 홀딩스, 인크 하이브리드 네트워크에서 통합 게이트웨이에 대한 확장형 로컬 ｉｐ 액세스

Also Published As

Publication number Publication date
TWI455911B (zh) 2014-10-11
FR2941454B1 (fr) 2011-04-01
KR101719011B1 (ko) 2017-03-22
RU2521342C2 (ru) 2014-06-27
GEP20135903B (en) 2013-08-12
MA33025B1 (fr) 2012-02-01
JP2012516307A (ja) 2012-07-19
IL214241A0 (en) 2011-09-27
CN110204455A (zh) 2019-09-06
AR115475A2 (es) 2021-01-20
IL214241A (en) 2015-03-31
CN102300840A (zh) 2011-12-28
CA2750488C (en) 2016-12-13
PL2391599T3 (pl) 2014-09-30
BRPI1007404B8 (pt) 2021-05-25
AU2010209686B2 (en) 2014-06-05
MX2011007846A (es) 2011-12-14
TW201031623A (en) 2010-09-01
BRPI1007404B1 (pt) 2020-10-13
UA104884C2 (uk) 2014-03-25
EP2391599A1 (en) 2011-12-07
WO2010086394A1 (en) 2010-08-05
US8604241B2 (en) 2013-12-10
NZ594291A (en) 2012-11-30
AR077526A1 (es) 2011-09-07
CA2750488A1 (en) 2010-08-05
ES2472695T3 (es) 2014-07-02
JP5646509B2 (ja) 2014-12-24
AU2010209686A1 (en) 2011-08-18
KR20110108409A (ko) 2011-10-05
ZA201105414B (en) 2012-03-28
EP2391599B1 (en) 2014-04-09
TN2011000363A1 (en) 2013-03-27
US20110295036A1 (en) 2011-12-01
RU2011135326A (ru) 2013-03-10
FR2941454A1 (fr) 2010-07-30

Similar Documents

Publication Publication Date Title
BRPI1007404A2 (pt) método para síntese de (1s,2r)-milnaciprano
BRPI1013822A2 (pt) Método para síntese de um trissacarídeo.
BRPI1011015A2 (pt) método aperfeiçoado para sintetizar pirfenidona
BRPI0911024A2 (pt) "método para produzir macarrão instantâneo"
BR112012002746A2 (pt) método para produção de copolímero
BRPI1010624A2 (pt) método para a fabricação de gás de síntese
BR112013029511A2 (pt) método de tratamento de gás de síntese
BR112012000687A2 (pt) tesoura para um endoscópio
UY33094A (es) Procedimiento para la preparacion de dronedarona
BRPI1014035A2 (pt) método para contracepção.
BRPI1007459A2 (pt) método para produção de manômeros olefínicos
BRPI0920621A2 (pt) processos para síntese de composto macrolidos
BRPI1009919A2 (pt) combinações de pentamidina para tratamento de câncer.
BRPI0922490A2 (pt) Método para produção de beta-santaleno
BRPI1015360A2 (pt) método para dessulfurização do metal quente.
BRPI0924013A2 (pt) método para o exame de câncer
ES2636441T8 (es) Un procedimiento novedoso para la síntesis de polifenoles
BRPI1016245A2 (pt) Preparação de c-pirazina-metilaminas.
FR2961209B1 (fr) Procede de synthese de la ferroquine par amination reductrice convergente.
BRPI1007320A2 (pt) Método para preparar nitrotetrazolato de cobre
BRPI1010841A2 (pt) método para a fabricação de fluoroalquilnitrilas
BRPI0923370A2 (pt) Método para produção de titanossilicato
ITPD20090053U1 (it) Paradordi per banchine
BR112013010755A2 (pt) método de formação de um catalisador de fischer-tropsch, e, catalisador
BRPI1010740A2 (pt) novos derivados de ciclopentano

Legal Events

Date Code Title Description
B06T Formal requirements before examination [chapter 6.20 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 13/10/2020, OBSERVADAS AS CONDICOES LEGAIS.

B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 29/01/2010 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF