MA33025B1 - Procede pour la synthese de (1s.2r)-milnacipran - Google Patents
Procede pour la synthese de (1s.2r)-milnacipranInfo
- Publication number
- MA33025B1 MA33025B1 MA34052A MA34052A MA33025B1 MA 33025 B1 MA33025 B1 MA 33025B1 MA 34052 A MA34052 A MA 34052A MA 34052 A MA34052 A MA 34052A MA 33025 B1 MA33025 B1 MA 33025B1
- Authority
- MA
- Morocco
- Prior art keywords
- milnacipran
- acid
- amide
- lactone
- reacting
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/16—Preparation of optical isomers
- C07C231/18—Preparation of optical isomers by stereospecific synthesis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/57—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C233/58—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Steroid Compounds (AREA)
Abstract
LA PRÉSENTE INVENTION PORTE SUR UN PROCÉDÉ POUR LA SYNTHÈSE D'UN SEL D'ADDITION D'ACIDE PHARMACEUTIQUEMENT ACCEPTABLE DE (1S,2R)-MILNACIPRAN COMPRENANT LES ÉTAPES SUCCESSIVES SUIVANTES : (A) LA RÉACTION DE PHÉNYLACÉTONITRILE ET DE (R)-ÉPICHLORHYDRINE EN PRÉSENCE D'UNE BASE CONTENANT UN MÉTAL ALCALIN, SUIVIE PAR UN TRAITEMENT BASIQUE PUIS PAR UN TRAITEMENT ACIDE AFIN D'OBTENIR UNE LACTONE; (B) LA RÉACTION DE LADITE LACTONE AVEC MNET2, OÙ M REPRÉSENTE UN MÉTAL ALCALIN, OU AVEC NHET2 EN PRÉSENCE D'UN COMPLEXE ACIDE DE LEWIS-AMINE, AFIN D'OBTENIR UN AMIDE-ALCOOL; (C) LA RÉACTION DUDIT AMIDE-ALCOOL AVEC DU CHLORURE DE THIONYLE AFIN D'OBTENIR UN AMIDE CHLORÉ; (D) LA RÉACTION DUDIT AMIDE CHLORÉ AVEC UN SEL DE PHTALIMIDE AFIN D'OBTENIR UN DÉRIVÉ DE PHTALIMIDE; (E) L'HYDROLYSE DU GROUPE PHTALIMIDE DUDIT DÉRIVÉ DE PHTALIMIDE AFIN D'OBTENIR DU (1S,2R)-MILNACIPRAN ET (F) LA SALIFICATION DU (1S,2R)-MILNACIPRAN DANS UN SYSTÈME SOLVANT APPROPRIÉ EN PRÉSENCE D'UN ACIDE PHARMACEUTIQUEMENT ACCEPTABLE.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0950552A FR2941454B1 (fr) | 2009-01-29 | 2009-01-29 | Proced de synthese du (1s,2r)-milnacipran |
PCT/EP2010/051045 WO2010086394A1 (fr) | 2009-01-29 | 2010-01-29 | Procédé pour la synthèse de (1s,2r)-milnacipran |
Publications (1)
Publication Number | Publication Date |
---|---|
MA33025B1 true MA33025B1 (fr) | 2012-02-01 |
Family
ID=40920574
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA34052A MA33025B1 (fr) | 2009-01-29 | 2010-01-29 | Procede pour la synthese de (1s.2r)-milnacipran |
Country Status (23)
Country | Link |
---|---|
US (1) | US8604241B2 (fr) |
EP (1) | EP2391599B1 (fr) |
JP (1) | JP5646509B2 (fr) |
KR (1) | KR101719011B1 (fr) |
CN (2) | CN102300840A (fr) |
AR (2) | AR077526A1 (fr) |
AU (1) | AU2010209686B2 (fr) |
BR (1) | BRPI1007404B8 (fr) |
CA (1) | CA2750488C (fr) |
ES (1) | ES2472695T3 (fr) |
FR (1) | FR2941454B1 (fr) |
GE (1) | GEP20135903B (fr) |
IL (1) | IL214241A (fr) |
MA (1) | MA33025B1 (fr) |
MX (1) | MX2011007846A (fr) |
NZ (1) | NZ594291A (fr) |
PL (1) | PL2391599T3 (fr) |
RU (1) | RU2521342C2 (fr) |
TN (1) | TN2011000363A1 (fr) |
TW (1) | TWI455911B (fr) |
UA (1) | UA104884C2 (fr) |
WO (1) | WO2010086394A1 (fr) |
ZA (1) | ZA201105414B (fr) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2944011B1 (fr) * | 2009-04-03 | 2011-05-20 | Pf Medicament | Derives d'aminocyclobutane ou d'aminocyclobutene, leur procede de preparation et leur utilisation a titre de medicaments. |
WO2011158249A1 (fr) * | 2010-06-16 | 2011-12-22 | Glenmark Generics Limited | Méthode de préparation d'un intermédiaire de milnacipran et son utilisation dans la préparation de milnacipran pur |
WO2012046247A2 (fr) * | 2010-10-06 | 2012-04-12 | Msn Laboratories Limited | Procédé de préparation de chlorhydrate de (±m1r(s), 2srr)l-2-(aminométhyl)-n,n-diéthyl-l-phénylcyclopropane carboxamide |
JP5952305B2 (ja) * | 2011-01-24 | 2016-07-13 | バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングBayer Intellectual Property GmbH | 2,2−ジフルオロ−1−クロロエタンから出発して2,2−ジフルオロエチルアミンを製造する方法 |
EP2814798B1 (fr) * | 2012-02-17 | 2019-04-03 | Eisai R&D Management Co., Ltd. | Procédés et composés utiles dans la synthèse d'antagonistes du récepteur 2 de l'orexine |
WO2014009767A1 (fr) | 2012-07-07 | 2014-01-16 | Micro Labs Limited | Procédé perfectionné pour la préparation de dérivés de 1-aryl-2-aminométhylcyclopropanecarboxamide (z), de leurs isomères et de leurs sels |
EP2805936A1 (fr) | 2013-05-20 | 2014-11-26 | Cosma S.p.A. | Procédé de préparation de levomilnacipran HCL |
WO2014203277A2 (fr) * | 2013-06-19 | 2014-12-24 | Msn Laboratories Private Limited | Procédé de préparation de chlorhydrate de (1s-2r)-2-(aminométhyl)-n-n'-diéthyl-1-phénylcyclopropanecarboxamide |
CN103694162B (zh) * | 2014-01-03 | 2015-09-02 | 上海现代制药股份有限公司 | (1s,2r)-1-苯基2-(酞酰亚胺)甲基-n,n-二乙基-环丙甲酰胺的制备方法 |
CN104058992A (zh) * | 2014-06-13 | 2014-09-24 | 上海现代制药股份有限公司 | 左旋米那普仑盐酸盐的晶型 |
CN106795097A (zh) | 2014-10-03 | 2017-05-31 | 普拉克生化公司 | N,n‑二烷基乳酰胺的生产方法 |
CA2966437A1 (fr) | 2014-11-04 | 2016-05-12 | Quimica Sintetica, S.A. | Procede pour la preparation de (1s,2r)-milnacipran |
CN106083638A (zh) * | 2016-07-07 | 2016-11-09 | 佛山市隆信医药科技有限公司 | 一种盐酸左旋米那普仑的制备方法 |
CN111175387B (zh) * | 2018-11-13 | 2022-06-07 | 成都康弘药业集团股份有限公司 | 一种米那普仑异构体的检测方法 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2508035A1 (fr) | 1981-06-23 | 1982-12-24 | Fabre Sa Pierre | Derives d'aryl-1-aminomethyl-2 cyclopropanes carboxamides (z), leur preparation et leur application en tant que medicaments utiles dans le traitement des troubles du systeme nerveux central |
FR2581059B1 (fr) | 1985-04-25 | 1988-04-22 | Pf Medicament | Procede de preparation du chlorhydrate de phenyl-1 diethyl amino carbonyl-1 aminomethyl-2 cyclopropane (z) |
FR2640972B1 (fr) | 1988-12-28 | 1991-04-19 | Pf Medicament | |
JPH0834765A (ja) * | 1994-02-22 | 1996-02-06 | Asahi Chem Ind Co Ltd | アミノアルキルシクロプロパン誘導体 |
US5621142A (en) | 1994-02-22 | 1997-04-15 | Asahi Kasei Kogyo Kabushiki Kaisha | Aminoalkylcyclopropane derivatives |
WO2005118564A2 (fr) | 2004-06-01 | 2005-12-15 | Collegium Pharmaceutical, Inc. | Methodes de synthese du milnacipran et de ses homologues |
JP4712320B2 (ja) * | 2004-06-16 | 2011-06-29 | 住友化学株式会社 | 2−オキソ−1−フェニル−3−オキサビシクロ[3.1.0]ヘキサンの製造方法 |
JP4418717B2 (ja) * | 2004-06-24 | 2010-02-24 | 住友化学株式会社 | (z)−1−フェニル−1−ジエチルアミノカルボニル−2−アミノメチルシクロプロパン塩酸塩の製造方法 |
ZA200700599B (en) | 2004-06-25 | 2008-09-25 | Sumitomo Chemical Co | Method for producing (Z)-1-phenyl-1-diethylamino-carbonyl-2-hydroxymethyl cyclopropane |
JP4828863B2 (ja) | 2005-01-28 | 2011-11-30 | 住友化学株式会社 | (z)−1−フェニル−1−(n,n−ジエチルアミノカルボニル)−2−フタルイミドメチルシクロプロパンの製造方法 |
KR100772244B1 (ko) * | 2005-07-20 | 2007-11-01 | 안국약품 주식회사 | 밀나시프란염산염의 제조방법 |
KR20140068261A (ko) | 2009-12-04 | 2014-06-05 | 인터디지탈 패튼 홀딩스, 인크 | 하이브리드 네트워크에서 통합 게이트웨이에 대한 확장형 로컬 ip 액세스 |
-
2009
- 2009-01-29 FR FR0950552A patent/FR2941454B1/fr active Active
-
2010
- 2010-01-25 TW TW099101933A patent/TWI455911B/zh active
- 2010-01-29 KR KR1020117019602A patent/KR101719011B1/ko active IP Right Grant
- 2010-01-29 GE GEAP201012350A patent/GEP20135903B/en unknown
- 2010-01-29 AU AU2010209686A patent/AU2010209686B2/en active Active
- 2010-01-29 WO PCT/EP2010/051045 patent/WO2010086394A1/fr active Application Filing
- 2010-01-29 CN CN2010800057211A patent/CN102300840A/zh active Pending
- 2010-01-29 RU RU2011135326/04A patent/RU2521342C2/ru active
- 2010-01-29 EP EP10701538.0A patent/EP2391599B1/fr active Active
- 2010-01-29 CN CN201910530393.XA patent/CN110204455A/zh active Pending
- 2010-01-29 UA UAA201110404A patent/UA104884C2/uk unknown
- 2010-01-29 MX MX2011007846A patent/MX2011007846A/es active IP Right Grant
- 2010-01-29 BR BRPI1007404A patent/BRPI1007404B8/pt active IP Right Grant
- 2010-01-29 ES ES10701538.0T patent/ES2472695T3/es active Active
- 2010-01-29 US US13/146,361 patent/US8604241B2/en active Active
- 2010-01-29 NZ NZ594291A patent/NZ594291A/xx unknown
- 2010-01-29 AR ARP100100245A patent/AR077526A1/es not_active Application Discontinuation
- 2010-01-29 MA MA34052A patent/MA33025B1/fr unknown
- 2010-01-29 CA CA2750488A patent/CA2750488C/fr active Active
- 2010-01-29 JP JP2011546850A patent/JP5646509B2/ja active Active
- 2010-01-29 PL PL10701538T patent/PL2391599T3/pl unknown
-
2011
- 2011-07-21 IL IL214241A patent/IL214241A/en active IP Right Grant
- 2011-07-22 ZA ZA2011/05414A patent/ZA201105414B/en unknown
- 2011-07-22 TN TN2011000363A patent/TN2011000363A1/fr unknown
-
2019
- 2019-06-04 AR ARP190101513A patent/AR115475A2/es unknown
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