PL2391599T3 - Sposób syntezy (1S,2R)-milnacipranu - Google Patents

Sposób syntezy (1S,2R)-milnacipranu

Info

Publication number
PL2391599T3
PL2391599T3 PL10701538T PL10701538T PL2391599T3 PL 2391599 T3 PL2391599 T3 PL 2391599T3 PL 10701538 T PL10701538 T PL 10701538T PL 10701538 T PL10701538 T PL 10701538T PL 2391599 T3 PL2391599 T3 PL 2391599T3
Authority
PL
Poland
Prior art keywords
milnacipran
synthesis
Prior art date
Application number
PL10701538T
Other languages
English (en)
Inventor
Marc Nicolas
Paul Hellier
Catherine Diard
Laurent Subra
Original Assignee
Pf Medicament
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pf Medicament filed Critical Pf Medicament
Publication of PL2391599T3 publication Critical patent/PL2391599T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/16—Preparation of optical isomers
    • C07C231/18—Preparation of optical isomers by stereospecific synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/57—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C233/58—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
PL10701538T 2009-01-29 2010-01-29 Sposób syntezy (1S,2R)-milnacipranu PL2391599T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR0950552A FR2941454B1 (fr) 2009-01-29 2009-01-29 Proced de synthese du (1s,2r)-milnacipran
EP10701538.0A EP2391599B1 (en) 2009-01-29 2010-01-29 Method for synthesis of (1s, 2r)-milnacipran
PCT/EP2010/051045 WO2010086394A1 (en) 2009-01-29 2010-01-29 Method for synthesis of (1s, 2r)-milnacipran

Publications (1)

Publication Number Publication Date
PL2391599T3 true PL2391599T3 (pl) 2014-09-30

Family

ID=40920574

Family Applications (1)

Application Number Title Priority Date Filing Date
PL10701538T PL2391599T3 (pl) 2009-01-29 2010-01-29 Sposób syntezy (1S,2R)-milnacipranu

Country Status (23)

Country Link
US (1) US8604241B2 (pl)
EP (1) EP2391599B1 (pl)
JP (1) JP5646509B2 (pl)
KR (1) KR101719011B1 (pl)
CN (2) CN110204455A (pl)
AR (2) AR077526A1 (pl)
AU (1) AU2010209686B2 (pl)
BR (1) BRPI1007404B8 (pl)
CA (1) CA2750488C (pl)
ES (1) ES2472695T3 (pl)
FR (1) FR2941454B1 (pl)
GE (1) GEP20135903B (pl)
IL (1) IL214241A (pl)
MA (1) MA33025B1 (pl)
MX (1) MX2011007846A (pl)
NZ (1) NZ594291A (pl)
PL (1) PL2391599T3 (pl)
RU (1) RU2521342C2 (pl)
TN (1) TN2011000363A1 (pl)
TW (1) TWI455911B (pl)
UA (1) UA104884C2 (pl)
WO (1) WO2010086394A1 (pl)
ZA (1) ZA201105414B (pl)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2944011B1 (fr) * 2009-04-03 2011-05-20 Pf Medicament Derives d'aminocyclobutane ou d'aminocyclobutene, leur procede de preparation et leur utilisation a titre de medicaments.
WO2011158249A1 (en) * 2010-06-16 2011-12-22 Glenmark Generics Limited Process for preparation of milnacipran intermediate and its use in preparation of pure milnacipran
WO2012046247A2 (en) * 2010-10-06 2012-04-12 Msn Laboratories Limited Process for the preparation of (±m1r(s), 2srr)l-2-(aminomethyl)-n,n-diethyl-l-phenylcyclopropane carboxamide hydrochloride
KR20140005994A (ko) * 2011-01-24 2014-01-15 바이엘 인텔렉쳐 프로퍼티 게엠베하 2,2-디플루오로-1-클로로에탄으로부터 출발하는 2,2-디플루오로에틸아민의 제조 방법
RU2617696C2 (ru) 2012-02-17 2017-04-26 ЭЙСАЙ Ар ЭНД Ди МЕНЕДЖМЕНТ КО., ЛТД Способы и соединения, которые можно использовать для синтеза антагонистов рецепторов орексина-2
WO2014009767A1 (en) 2012-07-07 2014-01-16 Micro Labs Limited An improved process for the preparation of 1-aryl 2-aminomethyl cyclopropane carboxyamide (z) derivatives, their isomers and salts
EP2805936A1 (en) 2013-05-20 2014-11-26 Cosma S.p.A. Process for preparing levomilnacipran HCL
WO2014203277A2 (en) * 2013-06-19 2014-12-24 Msn Laboratories Private Limited Process for the preparation of (1s,2r)-2-(aminomethyl)-n,n-diethyl-1-phenylcyclopropanearboxamide hydrochloride
CN103694162B (zh) * 2014-01-03 2015-09-02 上海现代制药股份有限公司 (1s,2r)-1-苯基2-(酞酰亚胺)甲基-n,n-二乙基-环丙甲酰胺的制备方法
CN104058992A (zh) * 2014-06-13 2014-09-24 上海现代制药股份有限公司 左旋米那普仑盐酸盐的晶型
US10144702B2 (en) 2014-10-03 2018-12-04 Purac Biochem B.V. Method for the manufacture of N,N-dialkyllactamide
WO2016071303A1 (en) 2014-11-04 2016-05-12 Quimica Sintetica, S.A. Process for the preparation of (1s,2r)-milnacipran
CN106083638A (zh) * 2016-07-07 2016-11-09 佛山市隆信医药科技有限公司 一种盐酸左旋米那普仑的制备方法
CN111175387B (zh) * 2018-11-13 2022-06-07 成都康弘药业集团股份有限公司 一种米那普仑异构体的检测方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2508035A1 (fr) 1981-06-23 1982-12-24 Fabre Sa Pierre Derives d'aryl-1-aminomethyl-2 cyclopropanes carboxamides (z), leur preparation et leur application en tant que medicaments utiles dans le traitement des troubles du systeme nerveux central
FR2581059B1 (fr) 1985-04-25 1988-04-22 Pf Medicament Procede de preparation du chlorhydrate de phenyl-1 diethyl amino carbonyl-1 aminomethyl-2 cyclopropane (z)
FR2640972B1 (pl) * 1988-12-28 1991-04-19 Pf Medicament
US5621142A (en) 1994-02-22 1997-04-15 Asahi Kasei Kogyo Kabushiki Kaisha Aminoalkylcyclopropane derivatives
JPH0834765A (ja) * 1994-02-22 1996-02-06 Asahi Chem Ind Co Ltd アミノアルキルシクロプロパン誘導体
WO2005118564A2 (en) 2004-06-01 2005-12-15 Collegium Pharmaceutical, Inc. Methods for the synthesis of milnacipran and congeners thereof
JP4712320B2 (ja) 2004-06-16 2011-06-29 住友化学株式会社 ２−オキソ−１−フェニル−３−オキサビシクロ［３．１．０］ヘキサンの製造方法
JP4418717B2 (ja) * 2004-06-24 2010-02-24 住友化学株式会社 （ｚ）−１−フェニル−１−ジエチルアミノカルボニル−２−アミノメチルシクロプロパン塩酸塩の製造方法
KR101070721B1 (ko) 2004-06-25 2011-10-07 스미또모 가가꾸 가부시키가이샤 (ｚ)-1-페닐-1-디에틸아미노카르보닐-2-히드록시메틸시클로프로판의 제조 방법
JP4828863B2 (ja) 2005-01-28 2011-11-30 住友化学株式会社 （ｚ）−１−フェニル−１−（ｎ，ｎ−ジエチルアミノカルボニル）−２−フタルイミドメチルシクロプロパンの製造方法
KR100772244B1 (ko) * 2005-07-20 2007-11-01 안국약품 주식회사 밀나시프란염산염의 제조방법
KR20140068261A (ko) 2009-12-04 2014-06-05 인터디지탈 패튼 홀딩스, 인크 하이브리드 네트워크에서 통합 게이트웨이에 대한 확장형 로컬 ｉｐ 액세스

Also Published As

Publication number Publication date
RU2011135326A (ru) 2013-03-10
RU2521342C2 (ru) 2014-06-27
MA33025B1 (fr) 2012-02-01
KR20110108409A (ko) 2011-10-05
BRPI1007404B1 (pt) 2020-10-13
MX2011007846A (es) 2011-12-14
EP2391599A1 (en) 2011-12-07
FR2941454A1 (fr) 2010-07-30
KR101719011B1 (ko) 2017-03-22
FR2941454B1 (fr) 2011-04-01
BRPI1007404B8 (pt) 2021-05-25
ZA201105414B (en) 2012-03-28
AR077526A1 (es) 2011-09-07
GEP20135903B (en) 2013-08-12
TN2011000363A1 (en) 2013-03-27
NZ594291A (en) 2012-11-30
AR115475A2 (es) 2021-01-20
WO2010086394A1 (en) 2010-08-05
JP5646509B2 (ja) 2014-12-24
IL214241A (en) 2015-03-31
CA2750488A1 (en) 2010-08-05
EP2391599B1 (en) 2014-04-09
CN110204455A (zh) 2019-09-06
UA104884C2 (uk) 2014-03-25
IL214241A0 (en) 2011-09-27
US20110295036A1 (en) 2011-12-01
TWI455911B (zh) 2014-10-11
US8604241B2 (en) 2013-12-10
CA2750488C (en) 2016-12-13
ES2472695T3 (es) 2014-07-02
AU2010209686B2 (en) 2014-06-05
AU2010209686A1 (en) 2011-08-18
BRPI1007404A2 (pt) 2016-02-16
TW201031623A (en) 2010-09-01
JP2012516307A (ja) 2012-07-19
CN102300840A (zh) 2011-12-28

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