BRPI1013822A2 - Método para síntese de um trissacarídeo. - Google Patents

Método para síntese de um trissacarídeo.

Info

Publication number
BRPI1013822A2
BRPI1013822A2 BRPI1013822-6A BRPI1013822A BRPI1013822A2 BR PI1013822 A2 BRPI1013822 A2 BR PI1013822A2 BR PI1013822 A BRPI1013822 A BR PI1013822A BR PI1013822 A2 BRPI1013822 A2 BR PI1013822A2
Authority
BR
Brazil
Prior art keywords
trisaccharide
synthesis
Prior art date
Application number
BRPI1013822-6A
Other languages
English (en)
Inventor
Gyula Dékany
Istvan Bajza
Julien Boutet
Ignacio Figueroa Pérez
Markus Hederos
Ferenc Horvath
Piroska Kovács-Pénzes
Lars Kröger
Johan Olsson
Christoph Röhrig
Andreas Schroven
Ioannis Vrasidas
Original Assignee
Glycom As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glycom As filed Critical Glycom As
Publication of BRPI1013822A2 publication Critical patent/BRPI1013822A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
    • C07H3/06—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
BRPI1013822-6A 2009-04-07 2010-04-07 Método para síntese de um trissacarídeo. BRPI1013822A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA200900469 2009-04-07
PCT/EP2010/054608 WO2010115935A1 (en) 2009-04-07 2010-04-07 Synthesis of 2 ' -o-fucosyllactose

Publications (1)

Publication Number Publication Date
BRPI1013822A2 true BRPI1013822A2 (pt) 2015-08-25

Family

ID=42173049

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI1013822-6A BRPI1013822A2 (pt) 2009-04-07 2010-04-07 Método para síntese de um trissacarídeo.

Country Status (13)

Country Link
US (2) US9012625B2 (pt)
EP (2) EP2417144B1 (pt)
JP (1) JP2012522827A (pt)
KR (1) KR20120022875A (pt)
CN (2) CN102459295A (pt)
AU (1) AU2010233770A1 (pt)
BR (1) BRPI1013822A2 (pt)
CA (1) CA2758097A1 (pt)
IL (1) IL215270A0 (pt)
MX (1) MX2011010214A (pt)
RU (1) RU2011144838A (pt)
WO (2) WO2010115934A1 (pt)
ZA (1) ZA201107336B (pt)

Families Citing this family (78)

* Cited by examiner, † Cited by third party
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WO2011150939A1 (en) 2010-06-01 2011-12-08 Glycom A/S Polymorphs of 2'-o-fucosyllactose and producing thereof
JP2013531049A (ja) * 2010-07-16 2013-08-01 グリコム アー／エス オリゴ糖の誘導体化
MX338174B (es) * 2010-12-31 2016-04-06 Abbott Lab Metodos para reducir la incidencia de la tension oxidativa al usar los oligosacaridos de leche humana, la vitamina c y los agentes antiinflamatorios.
NZ612472A (en) 2010-12-31 2015-02-27 Abbott Lab Nutritional compositions comprising human milk oligosaccharides and nucleotides and uses thereof for treating and/or preventing enteric viral infection
US9539269B2 (en) 2010-12-31 2017-01-10 Abbott Laboratories Methods for decreasing the incidence of necrotizing enterocolitis in infants, toddlers, or children using human milk oligosaccharides
NZ612455A (en) 2010-12-31 2015-02-27 Abbott Lab Human milk oligosaccharides to promote growth of beneficial bacteria
EP3338784B1 (en) 2010-12-31 2020-07-22 Abbott Laboratories Human milk oligosaccharides for modulating inflammation
MY166945A (en) 2010-12-31 2018-07-25 Abbott Lab Nutritional formulations including human milk oligosaccharides and long chain polyunsaturated polyunsaturated fatty acids and uses thereof
CN103391783A (zh) 2010-12-31 2013-11-13 雅培制药有限公司 使用人乳寡糖改善呼吸道健康的方法
EP2678347A4 (en) * 2011-02-21 2014-10-08 Glycom As CATALYTIC HYDROGENOLYSIS OF A COMPOSITION FROM A MIXTURE OF OLIGOSACCHARIDE PROBLEMS AND APPLICATIONS THEREOF
EP2686330A4 (en) * 2011-03-18 2014-11-12 Glycom As SYNTHESIS OF NEW FUCOSE-CONTAINING CARBOHYDRATE DERIVATIVES
WO2012155916A1 (en) * 2011-05-13 2012-11-22 Glycom A/S Manufacture of lacto-n-tetraose
EP2522232A1 (en) * 2011-05-13 2012-11-14 Nestec S.A. Nutritional products comprising human milk oligosaccharides and methods for manufacture thereof
SG2014013478A (en) 2011-08-29 2014-05-29 Abbott Lab Human milk oligosaccharides for preventing injury and/or promoting healing of the gastrointestinal tract
WO2013044928A1 (en) * 2011-09-30 2013-04-04 Glycom A/S Synthesis of hmo core structures
US20140271562A1 (en) 2011-10-18 2014-09-18 Nestec S.A. Composition for use in brain growth and/or cognitive and/or psychomotor development
WO2013091660A1 (en) * 2011-12-23 2013-06-27 Glycom A/S A method for obtaining crystalline lacto-n-tetraose and lacto-n-neotetraose precursors and mixtures thereof
DE202013012827U1 (de) * 2012-06-14 2020-02-13 Glycom A/S Verbesserung der Stabilität und Reinheit sowie Erhöhung der Bioverfügbarkeit von menschlichen Milch-Oligosacchariden oder Vorläufern oder Mischungen davon
ITFI20120143A1 (it) 2012-07-12 2014-01-13 Inalco S A S Di Giovanni Cipollett I & C Polimorfi idrati e anidri del 2'-o-fucosillattosio e loro metodi di produzione.
DK2708145T3 (en) 2012-09-14 2016-07-18 Abbott Lab Nutritional Compositions for Use in Methods to Modulate Corticosterone Levels in Psychologically Stressed Individuals
DK2708147T3 (da) * 2012-09-14 2020-05-18 Abbott Lab Fremgangsmåder til forøgelse af hjernefunktionalitet under anvendelse af 2-fucosyl-lactose
CN104812768B (zh) 2012-11-13 2019-06-21 格礼卡姆股份公司 晶体3-o-岩藻糖基乳糖
ES2891731T3 (es) 2013-05-22 2022-01-31 Glycom As Mezcla sintética de oligosacáridos para el tratamiento de la microbiota de un mamífero
CN103408609B (zh) * 2013-09-02 2016-01-13 济南尚博生物科技有限公司 一种制备1-S-2,3,4-三-O-苄基-l-硫代吡喃岩藻糖苷的方法
US9902984B2 (en) 2013-09-06 2018-02-27 Glycom A/S Fermentative production of oligosaccharides
EP2857410A1 (en) * 2013-10-04 2015-04-08 Jennewein Biotechnologie GmbH Process for purification of 2´-fucosyllactose using simulated moving bed chromatography
EP2896628B1 (en) 2014-01-20 2018-09-19 Jennewein Biotechnologie GmbH Process for efficient purification of neutral human milk oligosaccharides (HMOs) from microbial fermentation
CN104098615A (zh) * 2014-06-09 2014-10-15 华中科技大学 一种以氢氧根离子型的碱为催化剂进行脱酰基化的方法
CR20170134A (es) 2014-09-12 2017-06-13 Basf Se Método para preparar 2´-o-fucosil-lactosa
CN107108677B (zh) 2014-10-24 2020-08-07 格礼卡姆股份公司 Hmo的混合物
US20170258820A1 (en) 2014-10-29 2017-09-14 Glycom A/S Synthetic composition and method for promoting mucosal healing
US11040049B2 (en) 2014-10-29 2021-06-22 Glycom A/S Composition comprising HMSs/HMOs and use thereof
CN115364113A (zh) 2014-10-29 2022-11-22 格礼卡姆股份公司 合成组合物以及用于治疗肠易激综合症的方法
US11040050B2 (en) 2014-10-29 2021-06-22 Glycom A/S Composition comprising HMSs/HMOs and use thereof
US10500221B2 (en) 2014-12-05 2019-12-10 Glycom A/S Crystalline difucosyllactose
US10987368B2 (en) 2014-12-08 2021-04-27 Glycom A/S Synthetic composition for preventing or treating CVD
US10835544B2 (en) 2014-12-08 2020-11-17 Glycom A/S Synthetic composition for regulating satiety
CN115350200A (zh) 2014-12-08 2022-11-18 格礼卡姆股份公司 用于治疗代谢障碍的合成组合物
US10881674B2 (en) 2014-12-08 2021-01-05 Glycom A/S Synthetic composition for treating metabolic disorders
EP3265099B1 (en) 2015-03-05 2023-08-09 Glycom A/S Human milk oligosaccharides for treating acute respiratory tract infections
EP3277287B8 (en) 2015-03-31 2023-12-27 Glycom A/S Mixtures of human milk oligosaccharides comprising 3 '-o-sialyllactose
ES2870973T3 (es) 2015-06-09 2021-10-28 Glycom As Mezclas ternarias de 6'-SL, LNnT y LST c
RU2634707C2 (ru) * 2015-07-23 2017-11-03 Федеральное государственное унитарное предприятие "Государственный научно-исследовательский институт особо чистых биопрепаратов" Федерального медико-биологического агентства Способ избирательного удаления О-ацетильных защитных групп в присутствии О-бензоильных
PL3349763T3 (pl) 2015-09-14 2022-01-03 Glycom A/S Kompozycja do zastosowania w modulowaniu mikrobioty
EP3368046B1 (en) 2015-10-28 2022-07-27 Glycom A/S Synthetic composition and method for modulating brain function and behaviour
ES2950489T3 (es) 2015-10-28 2023-10-10 Glycom As Composición sintética y método para modular los trastornos de la emoción y del ánimo
WO2017084673A1 (en) 2015-11-17 2017-05-26 Glycom A/S Synthetic Composition for Treating Antibiotic Associated Complications
US11432578B2 (en) 2015-12-15 2022-09-06 Glycom A/S Mixture of HMOs
BR112018015833A2 (pt) * 2016-02-03 2018-12-26 Basf Se métodos para preparar 2?-o-fucosil-lactose e produtos alimentícios, composto, e, uso de um dos compostos
WO2017144062A1 (en) 2016-02-24 2017-08-31 Glycom A/S Synthetic composition for microbiota modulation
US20190100547A1 (en) * 2016-03-09 2019-04-04 Basf Se Method for preparing 2'-o-fucosyllactose
KR101731263B1 (ko) 2016-04-25 2017-05-02 서울대학교 산학협력단 코리네박테리움 글루타미쿰을 이용한 2'-푸코실락토오스의 생산방법
PL3452051T3 (pl) 2016-05-05 2022-11-14 Glycom A/S Kompozycja zawierająca hmos do zastosowania w leczeniu nadwrażliwości trzewnej i/lub bólu trzewnego mediowanych komórkami tucznymi
WO2017190754A1 (en) 2016-05-05 2017-11-09 Glycom A/S Composition comprising hmos for the treatment of non-infectious diarrhoea
CN105924480B (zh) * 2016-05-10 2018-09-25 浙江大学 含岩藻糖三糖硫酸酯及其制备方法和应用
US11224605B2 (en) 2016-05-19 2022-01-18 Glycom A/S Synthetic composition
CN109414447A (zh) 2016-06-24 2019-03-01 格礼卡姆股份公司 包括hmo的组合物、其制备和用于预防和/或治疗病毒和/或细菌感染的用途
WO2018157900A1 (en) 2017-03-01 2018-09-07 Glycom A/S Synthetic composition for microbiota modulation
EP3634429A4 (en) 2017-05-09 2020-11-04 Glycom A/S SYNTHETIC COMPOSITION FOR MICROBIOTE MODULATION
WO2018215961A1 (en) 2017-05-24 2018-11-29 Glycom A/S Synthetic composition comprising oligosaccharides and its use in medical treatment.
WO2018215960A1 (en) 2017-05-24 2018-11-29 Glycom A/S Synthetic composition comprising one or more human milk oligosaccharides (hmos)
EP3672600A4 (en) 2017-08-21 2021-05-19 Glycom A/S SYNTHETIC COMPOSITION TO REDUCE ALLERGY SYMPTOMS
EP3450443A1 (en) 2017-08-29 2019-03-06 Jennewein Biotechnologie GmbH Process for purifying sialylated oligosaccharides
WO2019071021A2 (en) 2017-10-04 2019-04-11 The Regents Of The University Of California IMMUNOMODULATORY OLIGOSACCHARIDES
CA3081496A1 (en) 2017-11-02 2019-05-09 Glycom A/S Mixture of hmos for reducing or preventing fatigue
CN111698994A (zh) 2017-11-30 2020-09-22 格礼卡姆股份公司 治疗小麦敏感性的hmo混合物
US11602545B2 (en) 2017-12-05 2023-03-14 Glycom A/S Human milk oligosaccharides for treating migraine
US11304966B2 (en) 2017-12-22 2022-04-19 Glycom A/S Composition comprising HMOs for preventing or reducing nociception
CN108084234A (zh) * 2018-01-23 2018-05-29 佛山科学技术学院 双重随机糖基化合成三糖的方法
US11554131B2 (en) 2018-05-31 2023-01-17 Glycom A/S Mixture of HMOs for treating autoimmune diseases
AU2019362595A1 (en) 2018-10-18 2021-04-29 Basf Se Crystalline form II of 2'-O-fucosyllactose, process for its preparation, nutritional, cosmetic or pharmaceutical formulation containing the same
CN113194960A (zh) 2018-12-19 2021-07-30 格礼卡姆股份公司 用于治疗使用低fodmap饮食的人的组合物和方法
EP3741770A1 (en) 2019-05-21 2020-11-25 Jennewein Biotechnologie GmbH Purification of oligosaccharides from a fermentation broth by using filtration
CN111588726A (zh) * 2020-04-28 2020-08-28 南开大学 2′-岩藻糖基乳糖调节宿主肠道菌群及增强肠屏障的应用
WO2022223430A1 (en) 2021-04-19 2022-10-27 Dsm Ip Assets B.V. A composition of enzymes and human milk oligosaccharides
WO2023099297A1 (en) * 2021-12-02 2023-06-08 Dsm Ip Assets B.V. Synthesis of hmo butyrate
WO2024013393A1 (en) 2022-07-15 2024-01-18 Dsm Ip Assets B.V. Combination of bifidobacterium and fucosylated hmo for use in increasing nmn or nad+
WO2024105051A1 (en) * 2022-11-15 2024-05-23 Ecole Polytechnique Federale De Lausanne (Epfl) Method for preparing an at least partially acetal-protected sugar

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US5438124A (en) 1991-07-16 1995-08-01 Health Research, Inc. Glycosylating reagent for the synthesis of linear and other α-L-fucosyl oligosaccharides
CN1072677C (zh) * 1998-07-17 2001-10-10 中国科学院生态环境研究中心 二糖及三糖原酸酯及其合成方法
IT1392456B1 (it) * 2008-12-18 2012-03-09 Inalco Spa Processo per la sintesi di di- o oligosaccaridi l-fucosilati e loro nuovi intermedi 2,3,4-tribenzil-fucosil-derivati.

Also Published As

Publication number Publication date
WO2010115935A1 (en) 2010-10-14
CA2758097A1 (en) 2010-10-14
US9012625B2 (en) 2015-04-21
KR20120022875A (ko) 2012-03-12
CN102459295A (zh) 2012-05-16
AU2010233770A1 (en) 2011-10-27
US8927698B2 (en) 2015-01-06
US20120116065A1 (en) 2012-05-10
EP2417144A1 (en) 2012-02-15
MX2011010214A (es) 2012-01-20
EP2417144B1 (en) 2017-08-23
IL215270A0 (en) 2011-11-30
EP2417143B1 (en) 2016-12-21
ZA201107336B (en) 2014-03-26
EP2417143A1 (en) 2012-02-15
WO2010115934A1 (en) 2010-10-14
RU2011144838A (ru) 2013-05-20
CN102459294A (zh) 2012-05-16
US20130131334A1 (en) 2013-05-23
JP2012522827A (ja) 2012-09-27

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Legal Events

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B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 5A ANUIDADE

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.11 NA RPI 2333 DE 22/09/2015