BRPI1013822A2 - Método para síntese de um trissacarídeo. - Google Patents

Método para síntese de um trissacarídeo.

Info

Publication number
BRPI1013822A2
BRPI1013822A2 BRPI1013822-6A BRPI1013822A BRPI1013822A2 BR PI1013822 A2 BRPI1013822 A2 BR PI1013822A2 BR PI1013822 A BRPI1013822 A BR PI1013822A BR PI1013822 A2 BRPI1013822 A2 BR PI1013822A2
Authority
BR
Brazil
Prior art keywords
trisaccharide
synthesis
Prior art date
Application number
BRPI1013822-6A
Other languages
English (en)
Inventor
Gyula Dékany
Istvan Bajza
Julien Boutet
Ignacio Figueroa Pérez
Markus Hederos
Ferenc Horvath
Piroska Kovács-Pénzes
Lars Kröger
Johan Olsson
Christoph Röhrig
Andreas Schroven
Ioannis Vrasidas
Original Assignee
Glycom As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glycom As filed Critical Glycom As
Publication of BRPI1013822A2 publication Critical patent/BRPI1013822A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
    • C07H3/06—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
BRPI1013822-6A 2009-04-07 2010-04-07 Método para síntese de um trissacarídeo. BRPI1013822A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA200900469 2009-04-07
PCT/EP2010/054608 WO2010115935A1 (en) 2009-04-07 2010-04-07 Synthesis of 2 ' -o-fucosyllactose

Publications (1)

Publication Number Publication Date
BRPI1013822A2 true BRPI1013822A2 (pt) 2015-08-25

Family

ID=42173049

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI1013822-6A BRPI1013822A2 (pt) 2009-04-07 2010-04-07 Método para síntese de um trissacarídeo.

Country Status (13)

Country Link
US (2) US8927698B2 (pt)
EP (2) EP2417144B1 (pt)
JP (1) JP2012522827A (pt)
KR (1) KR20120022875A (pt)
CN (2) CN102459294A (pt)
AU (1) AU2010233770A1 (pt)
BR (1) BRPI1013822A2 (pt)
CA (1) CA2758097A1 (pt)
IL (1) IL215270A0 (pt)
MX (1) MX2011010214A (pt)
RU (1) RU2011144838A (pt)
WO (2) WO2010115935A1 (pt)
ZA (1) ZA201107336B (pt)

Families Citing this family (76)

* Cited by examiner, † Cited by third party
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WO2011150939A1 (en) 2010-06-01 2011-12-08 Glycom A/S Polymorphs of 2'-o-fucosyllactose and producing thereof
US9102966B2 (en) * 2010-07-16 2015-08-11 Glycom A/S Synthesis of sialooligosaccharide derivatives
MY192208A (en) 2010-12-31 2022-08-08 Abbott Lab Nutritional formulations including human milk oligosaccharides and antioxidants and uses thereof
WO2012092154A1 (en) 2010-12-31 2012-07-05 Abbott Laboratories Methods of using human milk oligosaccharides for improving airway respiratory health
WO2012092153A1 (en) 2010-12-31 2012-07-05 Abbott Laboratories Nutritional compositions comprising human milk oligosaccharides and nucleotides and uses thereof for treating and/or preventing enteric viral infection
CA2822219C (en) 2010-12-31 2020-12-29 Abbott Laboratories Methods for decreasing the incidence of necrotizing enterocolitis in infants, toddlers, or children using human milk oligosaccharides
CN103402376A (zh) 2010-12-31 2013-11-20 雅培制药有限公司 促进有益细菌生长的中性人乳寡糖
CN103384525A (zh) 2010-12-31 2013-11-06 雅培制药有限公司 用于调节炎症的人乳寡糖
NZ612504A (en) 2010-12-31 2015-02-27 Abbott Lab Methods for reducing the incidence of oxidative stress using human milk oligosaccharides, vitamin c and anti-inflammatory agents
EP2678348A4 (en) * 2011-02-21 2014-09-10 Glycom As NEW GLYCOSYL PHOSPHITE
US20140228554A1 (en) 2011-03-18 2014-08-14 Glycom A/S Synthesis of new fucose-containing carbohydrate derivatives
US20140323705A1 (en) * 2011-05-13 2014-10-30 Markus Hederos Manufacture of lacto-n-tetraose
EP2522232A1 (en) * 2011-05-13 2012-11-14 Nestec S.A. Nutritional products comprising human milk oligosaccharides and methods for manufacture thereof
CA2846603A1 (en) 2011-08-29 2013-03-07 Abbott Laboratories Human milk oligosaccharides for preventing injury and/or promoting healing of the gastrointestinal tract
WO2013044928A1 (en) * 2011-09-30 2013-04-04 Glycom A/S Synthesis of hmo core structures
US20140271562A1 (en) * 2011-10-18 2014-09-18 Nestec S.A. Composition for use in brain growth and/or cognitive and/or psychomotor development
WO2013091660A1 (en) * 2011-12-23 2013-06-27 Glycom A/S A method for obtaining crystalline lacto-n-tetraose and lacto-n-neotetraose precursors and mixtures thereof
CN104428307A (zh) * 2012-06-14 2015-03-18 格礼卡姆股份公司 增强人乳寡糖或其前体或掺合物的稳定性和纯度以及增加其生物利用度
ITFI20120143A1 (it) 2012-07-12 2014-01-13 Inalco S A S Di Giovanni Cipollett I & C Polimorfi idrati e anidri del 2'-o-fucosillattosio e loro metodi di produzione.
DK2708145T3 (en) 2012-09-14 2016-07-18 Abbott Lab Nutritional Compositions for Use in Methods to Modulate Corticosterone Levels in Psychologically Stressed Individuals
ES2795665T3 (es) 2012-09-14 2020-11-24 Abbott Lab Procedimientos para aumentar la funcionalidad cerebral utilizando 2-fucosil-lactosa
WO2014075680A1 (en) * 2012-11-13 2014-05-22 Glycom A/S Crystalline 3-o-fucosyllactose
US20160113952A1 (en) 2013-05-22 2016-04-28 Glycom As Synthetic Mixture of Oligosaccharides for Treating a Microbiota of a Mammal
CN103408609B (zh) * 2013-09-02 2016-01-13 济南尚博生物科技有限公司 一种制备1-S-2,3,4-三-O-苄基-l-硫代吡喃岩藻糖苷的方法
US9902984B2 (en) 2013-09-06 2018-02-27 Glycom A/S Fermentative production of oligosaccharides
EP2857410A1 (en) * 2013-10-04 2015-04-08 Jennewein Biotechnologie GmbH Process for purification of 2´-fucosyllactose using simulated moving bed chromatography
EP2896628B1 (en) 2014-01-20 2018-09-19 Jennewein Biotechnologie GmbH Process for efficient purification of neutral human milk oligosaccharides (HMOs) from microbial fermentation
CN104098615A (zh) * 2014-06-09 2014-10-15 华中科技大学 一种以氢氧根离子型的碱为催化剂进行脱酰基化的方法
US11098075B2 (en) * 2014-09-12 2021-08-24 Basf Se Method for preparing 2′-O-fucosyllactose
EP3209673B2 (en) 2014-10-24 2023-07-26 Glycom A/S Mixtures of human milk oligosaccharides
PL3212198T3 (pl) 2014-10-29 2021-08-23 Glycom A/S Syntetyczna kompozycja i sposób promowania gojenia się błony śluzowej
US11040049B2 (en) 2014-10-29 2021-06-22 Glycom A/S Composition comprising HMSs/HMOs and use thereof
US11040050B2 (en) 2014-10-29 2021-06-22 Glycom A/S Composition comprising HMSs/HMOs and use thereof
WO2016066175A1 (en) 2014-10-29 2016-05-06 Glycom A/S Synthetic composition and method for treating irritable bowel syndrome
WO2016086947A1 (en) 2014-12-05 2016-06-09 Glycom A/S Crystalline difucosyllactose
US10835544B2 (en) 2014-12-08 2020-11-17 Glycom A/S Synthetic composition for regulating satiety
US10987368B2 (en) 2014-12-08 2021-04-27 Glycom A/S Synthetic composition for preventing or treating CVD
US10828313B2 (en) 2014-12-08 2020-11-10 Glycom A/S Synthetic composition for treating metabolic disorders
US10881674B2 (en) 2014-12-08 2021-01-05 Glycom A/S Synthetic composition for treating metabolic disorders
ES2960750T3 (es) 2015-03-05 2024-03-06 Glycom As Oligosacáridos de la leche humana para el tratamiento de infecciones agudas del aparato respiratorio
WO2016157108A1 (en) 2015-03-31 2016-10-06 Glycom A/S Mixtures of human milk oligosaccharides comprising 3 '-o-sialyllactose
CN107614511B (zh) 2015-06-09 2020-10-23 格礼卡姆股份公司 6’-SL、LNnT和LST c的三元混合物
RU2634707C2 (ru) * 2015-07-23 2017-11-03 Федеральное государственное унитарное предприятие "Государственный научно-исследовательский институт особо чистых биопрепаратов" Федерального медико-биологического агентства Способ избирательного удаления О-ацетильных защитных групп в присутствии О-бензоильных
DK3349763T3 (en) 2015-09-14 2021-11-15 Glycom As Composition for use in microbiota modulation
EP3368046B1 (en) 2015-10-28 2022-07-27 Glycom A/S Synthetic composition and method for modulating brain function and behaviour
ES2950489T3 (es) 2015-10-28 2023-10-10 Glycom As Composición sintética y método para modular los trastornos de la emoción y del ánimo
CN108348536B (zh) 2015-11-17 2021-09-24 格礼卡姆股份公司 治疗抗生素相关性并发症的合成组合物
US11957148B2 (en) 2015-12-15 2024-04-16 Societe Des Produits Nestle S.A. Mixture of human milk oligosaccharides(HMOs)
JP2019504091A (ja) * 2016-02-03 2019-02-14 ビーエーエスエフ ソシエタス・ヨーロピアＢａｓｆ Ｓｅ ２’−ｏ−フコシルラクトースの製造方法
EP3419630A4 (en) 2016-02-24 2019-11-06 Glycom A/S SYNTHETIC COMPOSITION OF MICROBIOTIC MODULATION
US20190100547A1 (en) 2016-03-09 2019-04-04 Basf Se Method for preparing 2'-o-fucosyllactose
KR101731263B1 (ko) 2016-04-25 2017-05-02 서울대학교 산학협력단 코리네박테리움 글루타미쿰을 이용한 2'-푸코실락토오스의 생산방법
ES2924137T3 (es) 2016-05-05 2022-10-04 Glycom As Composición que comprende HMOS para uso en el tratamiento de la hipersensibilidad y/o dolor visceral mediados por mastocitos
ES2938355T3 (es) 2016-05-05 2023-04-10 Glycom As Composición que comprende HMOS para el tratamiento de la diarrea no infecciosa
CN105924480B (zh) * 2016-05-10 2018-09-25 浙江大学 含岩藻糖三糖硫酸酯及其制备方法和应用
EP3458073B1 (en) 2016-05-19 2023-10-25 Glycom A/S Use of human milk oligosaccharides for treating migraine in patients with inflammatory bowel syndrome
EP3474861A4 (en) 2016-06-24 2020-04-15 Glycom A/S COMPOUNDS COMPRISING HMOS FOR THE PREVENTION AND / OR TREATMENT OF VIRAL AND / OR BACTERIAL INFECTIONS.
EP3589139A4 (en) 2017-03-01 2020-12-23 Glycom A/S SYNTHETIC COMPOSITION FOR MICROBIOTE MODULATION
EP3634429A4 (en) 2017-05-09 2020-11-04 Glycom A/S SYNTHETIC COMPOSITION FOR MICROBIOTE MODULATION
WO2018215960A1 (en) 2017-05-24 2018-11-29 Glycom A/S Synthetic composition comprising one or more human milk oligosaccharides (hmos)
US11541068B2 (en) 2017-05-24 2023-01-03 Glycom A/S HMO compositions and methods for reducing autism spectrum disorder symptoms
EP3672600A4 (en) 2017-08-21 2021-05-19 Glycom A/S SYNTHETIC COMPOSITION TO REDUCE ALLERGY SYMPTOMS
EP3450443A1 (en) 2017-08-29 2019-03-06 Jennewein Biotechnologie GmbH Process for purifying sialylated oligosaccharides
WO2019087140A1 (en) 2017-11-02 2019-05-09 Glycom A/S One or more hmos for reducing or preventing fatigue and/or improving focus or concentration
JP7327724B2 (ja) 2017-11-30 2023-08-16 グリコム・アクティーゼルスカブ 小麦過敏症を処置するためのｈｍｏの混合物
US11602545B2 (en) 2017-12-05 2023-03-14 Glycom A/S Human milk oligosaccharides for treating migraine
EP3743078A4 (en) 2017-12-22 2022-01-19 Glycom A/S COMPOSITION WITH HMOs TO PREVENT OR REDUCE NOCICEPTION
CN108084234A (zh) * 2018-01-23 2018-05-29 佛山科学技术学院 双重随机糖基化合成三糖的方法
CN112165947A (zh) 2018-05-31 2021-01-01 格礼卡姆股份公司 用于治疗自身免疫性疾病的hmo混合物
WO2020079114A1 (en) 2018-10-18 2020-04-23 Basf Se Method for obtaining crystalline 2'-fucosyllactose
KR20210104773A (ko) 2018-12-19 2021-08-25 글리콤 에이/에스 저-포드맵 식단을 사용한 인간 치료를 위한 조성물 및 방법
EP3741770A1 (en) 2019-05-21 2020-11-25 Jennewein Biotechnologie GmbH Purification of oligosaccharides from a fermentation broth by using filtration
CN111588726A (zh) * 2020-04-28 2020-08-28 南开大学 2′-岩藻糖基乳糖调节宿主肠道菌群及增强肠屏障的应用
WO2022223430A1 (en) 2021-04-19 2022-10-27 Dsm Ip Assets B.V. A composition of enzymes and human milk oligosaccharides
WO2023099297A1 (en) * 2021-12-02 2023-06-08 Dsm Ip Assets B.V. Synthesis of hmo butyrate
WO2024013393A1 (en) 2022-07-15 2024-01-18 Dsm Ip Assets B.V. Combination of bifidobacterium and fucosylated hmo for use in increasing nmn or nad+

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Also Published As

Publication number Publication date
MX2011010214A (es) 2012-01-20
EP2417144A1 (en) 2012-02-15
US9012625B2 (en) 2015-04-21
KR20120022875A (ko) 2012-03-12
CA2758097A1 (en) 2010-10-14
JP2012522827A (ja) 2012-09-27
WO2010115934A1 (en) 2010-10-14
US20130131334A1 (en) 2013-05-23
US8927698B2 (en) 2015-01-06
ZA201107336B (en) 2014-03-26
EP2417144B1 (en) 2017-08-23
WO2010115935A1 (en) 2010-10-14
CN102459294A (zh) 2012-05-16
US20120116065A1 (en) 2012-05-10
IL215270A0 (en) 2011-11-30
AU2010233770A1 (en) 2011-10-27
CN102459295A (zh) 2012-05-16
RU2011144838A (ru) 2013-05-20
EP2417143A1 (en) 2012-02-15
EP2417143B1 (en) 2016-12-21

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 5A ANUIDADE

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.11 NA RPI 2333 DE 22/09/2015