BRPI0918476B8 - compostos dímeros de pirrolobenzodiazepina assimétricos e uso dos mesmos para tratar uma doença proliferativa - Google Patents
compostos dímeros de pirrolobenzodiazepina assimétricos e uso dos mesmos para tratar uma doença proliferativaInfo
- Publication number
- BRPI0918476B8 BRPI0918476B8 BRPI0918476A BRPI0918476A BRPI0918476B8 BR PI0918476 B8 BRPI0918476 B8 BR PI0918476B8 BR PI0918476 A BRPI0918476 A BR PI0918476A BR PI0918476 A BRPI0918476 A BR PI0918476A BR PI0918476 B8 BRPI0918476 B8 BR PI0918476B8
- Authority
- BR
- Brazil
- Prior art keywords
- asymmetric
- group
- treat
- formula
- proliferative disease
- Prior art date
Links
- 201000010099 disease Diseases 0.000 title abstract 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 3
- 230000002062 proliferating effect Effects 0.000 title abstract 3
- -1 pyrrolobenzodiazepine dimer compounds Chemical class 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- YUOCYTRGANSSRY-UHFFFAOYSA-N pyrrolo[2,3-i][1,2]benzodiazepine Chemical class C1=CN=NC2=C3C=CN=C3C=CC2=C1 YUOCYTRGANSSRY-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 1
- IBAHLNWTOIHLKE-UHFFFAOYSA-N cyano cyanate Chemical compound N#COC#N IBAHLNWTOIHLKE-UHFFFAOYSA-N 0.000 abstract 1
- 239000000539 dimer Substances 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
- A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
- C07D519/06—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00 containing at least one condensed beta-lactam ring system, provided for by groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00, e.g. a penem or a cepham system
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0819095.1A GB0819095D0 (en) | 2008-10-17 | 2008-10-17 | Pyrrolobenzodiazepines |
| GB0819095.1 | 2008-10-17 | ||
| PCT/GB2009/002498 WO2010043880A1 (en) | 2008-10-17 | 2009-10-16 | Unsymmetrical pyrrolobenzodiazepine-dimers for treatment of proliferative diseases |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| BRPI0918476A2 BRPI0918476A2 (pt) | 2015-12-01 |
| BRPI0918476B1 BRPI0918476B1 (pt) | 2021-04-06 |
| BRPI0918476B8 true BRPI0918476B8 (pt) | 2021-05-25 |
Family
ID=40097621
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0918476A BRPI0918476B8 (pt) | 2008-10-17 | 2009-10-16 | compostos dímeros de pirrolobenzodiazepina assimétricos e uso dos mesmos para tratar uma doença proliferativa |
Country Status (23)
| Country | Link |
|---|---|
| US (3) | US8592576B2 (enExample) |
| EP (1) | EP2350080B1 (enExample) |
| JP (2) | JP5995441B2 (enExample) |
| KR (1) | KR101755722B1 (enExample) |
| CN (3) | CN102186855A (enExample) |
| AU (1) | AU2009305190B2 (enExample) |
| BR (1) | BRPI0918476B8 (enExample) |
| CA (1) | CA2735477C (enExample) |
| CY (1) | CY1117106T1 (enExample) |
| DK (1) | DK2350080T3 (enExample) |
| ES (1) | ES2557283T3 (enExample) |
| GB (1) | GB0819095D0 (enExample) |
| HR (1) | HRP20160003T1 (enExample) |
| HU (1) | HUE025905T2 (enExample) |
| IL (1) | IL211985A (enExample) |
| MX (1) | MX2011003342A (enExample) |
| NZ (1) | NZ591425A (enExample) |
| PL (1) | PL2350080T3 (enExample) |
| PT (1) | PT2350080E (enExample) |
| SI (1) | SI2350080T1 (enExample) |
| SM (1) | SMT201600017B (enExample) |
| WO (1) | WO2010043880A1 (enExample) |
| ZA (1) | ZA201101425B (enExample) |
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| SG173152A1 (en) | 2009-02-05 | 2011-08-29 | Immunogen Inc | Novel benzodiazepine derivatives |
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| KR101772354B1 (ko) * | 2010-04-15 | 2017-08-28 | 시애틀 지네틱스, 인크. | 표적화된 피롤로벤조디아제핀 접합체 |
| KR20190089048A (ko) * | 2011-02-15 | 2019-07-29 | 이뮤노젠 아이엔씨 | 컨쥬게이트의 제조방법 |
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