SMT201600017B - Dimeri di pirrolobenzodiazepine non-simmetrici per il trattamento di malattie proliferative - Google Patents
Dimeri di pirrolobenzodiazepine non-simmetrici per il trattamento di malattie proliferativeInfo
- Publication number
- SMT201600017B SMT201600017B SM201600017T SM201600017T SMT201600017B SM T201600017 B SMT201600017 B SM T201600017B SM 201600017 T SM201600017 T SM 201600017T SM 201600017 T SM201600017 T SM 201600017T SM T201600017 B SMT201600017 B SM T201600017B
- Authority
- SM
- San Marino
- Prior art keywords
- treatment
- proliferative diseases
- pyrrolobenzodiazepine dimers
- symmetrical
- symmetrical pyrrolobenzodiazepine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
- A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
- C07D519/06—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00 containing at least one condensed beta-lactam ring system, provided for by groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00, e.g. a penem or a cepham system
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0819095.1A GB0819095D0 (en) | 2008-10-17 | 2008-10-17 | Pyrrolobenzodiazepines |
| PCT/GB2009/002498 WO2010043880A1 (en) | 2008-10-17 | 2009-10-16 | Unsymmetrical pyrrolobenzodiazepine-dimers for treatment of proliferative diseases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SMT201600017B true SMT201600017B (it) | 2016-02-25 |
Family
ID=40097621
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SM201600017T SMT201600017B (it) | 2008-10-17 | 2016-01-15 | Dimeri di pirrolobenzodiazepine non-simmetrici per il trattamento di malattie proliferative |
Country Status (24)
| Country | Link |
|---|---|
| US (3) | US8592576B2 (it) |
| EP (1) | EP2350080B1 (it) |
| JP (2) | JP5995441B2 (it) |
| KR (1) | KR101755722B1 (it) |
| CN (3) | CN102186855A (it) |
| AU (1) | AU2009305190B2 (it) |
| BR (1) | BRPI0918476B8 (it) |
| CA (1) | CA2735477C (it) |
| CY (1) | CY1117106T1 (it) |
| DK (1) | DK2350080T3 (it) |
| ES (1) | ES2557283T3 (it) |
| GB (1) | GB0819095D0 (it) |
| HK (1) | HK1154575A1 (it) |
| HR (1) | HRP20160003T1 (it) |
| HU (1) | HUE025905T2 (it) |
| IL (1) | IL211985A (it) |
| MX (1) | MX2011003342A (it) |
| NZ (1) | NZ591425A (it) |
| PL (1) | PL2350080T3 (it) |
| PT (1) | PT2350080E (it) |
| SI (1) | SI2350080T1 (it) |
| SM (1) | SMT201600017B (it) |
| WO (1) | WO2010043880A1 (it) |
| ZA (1) | ZA201101425B (it) |
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| ATE427949T1 (de) * | 2005-10-05 | 2009-04-15 | Spirogen Ltd | 4-a4-(5-oxo-2,3,5,11a-tetrahydro-5h-pyrrolo a2, 1-cua1,4ubenzodiazepin-8-yloxy)-butyrylaminou-1 - pyrrol-2-carbonsaurealkylesterderivate und verwandte verbindung zur behandlung einer proliferativen erkrankung |
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| MX346635B (es) * | 2011-02-15 | 2017-03-27 | Immunogen Inc | Derivados citotoxicos de la benzodiazepina. |
| RS59253B1 (sr) | 2011-05-08 | 2019-10-31 | Legochem Biosciences Inc | Konjugati aktivnog agensa proteina i postupak za njihovo dobijanje |
| AU2012311505B2 (en) | 2011-09-20 | 2016-09-29 | Medimmune Limited | Pyrrolobenzodiazepines as unsymmetrical dimeric PBD compounds for inclusion in targeted conjugates |
| JP6117801B2 (ja) * | 2011-10-14 | 2017-04-19 | メドイミューン・リミテッドＭｅｄＩｍｍｕｎｅ Ｌｉｍｉｔｅｄ | ピロロベンゾジアゼピン |
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| EA036202B1 (ru) * | 2011-10-14 | 2020-10-14 | Сиэтл Дженетикс, Инк. | Пирролбензодиазепины и конъюгаты направленного действия |
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