BR112012023660A2 - novos métodos para direcionar células-tronco cancerosas - Google Patents

novos métodos para direcionar células-tronco cancerosas

Info

Publication number
BR112012023660A2
BR112012023660A2 BR112012023660A BR112012023660A BR112012023660A2 BR 112012023660 A2 BR112012023660 A2 BR 112012023660A2 BR 112012023660 A BR112012023660 A BR 112012023660A BR 112012023660 A BR112012023660 A BR 112012023660A BR 112012023660 A2 BR112012023660 A2 BR 112012023660A2
Authority
BR
Brazil
Prior art keywords
compounds
stem cells
cancer stem
naphthofuran
new methods
Prior art date
Application number
BR112012023660A
Other languages
English (en)
Other versions
BR112012023660B8 (pt
BR112012023660B1 (pt
Inventor
Chiang Jia Li
David Leggett
Wei Li
Youzhi Li
Original Assignee
Boston Biomedical Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boston Biomedical Inc filed Critical Boston Biomedical Inc
Publication of BR112012023660A2 publication Critical patent/BR112012023660A2/pt
Publication of BR112012023660B1 publication Critical patent/BR112012023660B1/pt
Publication of BR112012023660B8 publication Critical patent/BR112012023660B8/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

Abstract

novos métodos para direcionar células-tronco cancerosas a invenção fornece compostos de naftofurano, polimorfos de compostos de naftogurano, compostos de naftofurano na forma de partículas, as composições purificadas que contêm um ou mais compostos de naftofurano, as composições purificadas que contêm um ou mais compostos de naftofurano em forma de partículas, os métodos de produção destes compostos, polimorfos, composições purificadas e/ou formas de partículas de naftofurano, e os métodos de uso destes compostos, polimorfos, composições purificadas e/ou formas de partículas de naftofurano para o tratamento de sujeitos com necessidade dos mesmos.
BR112012023660A 2010-03-19 2011-03-21 usos de uma quantidade terapeuticamente eficaz de um composto, ou de um sal, solvato, hidrato ou pró-fármaco farmaceuticamente aceitável do mesmo para o tratamento de câncer BR112012023660B8 (pt)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US31588610P 2010-03-19 2010-03-19
US31589010P 2010-03-19 2010-03-19
US61/315,890 2010-03-19
US61/315,886 2010-03-19
US32581410P 2010-04-19 2010-04-19
US61/325,814 2010-04-19
PCT/US2011/029283 WO2011116399A1 (en) 2010-03-19 2011-03-21 Novel methods for targeting cancer stem cells

Publications (3)

Publication Number Publication Date
BR112012023660A2 true BR112012023660A2 (pt) 2015-09-15
BR112012023660B1 BR112012023660B1 (pt) 2021-05-18
BR112012023660B8 BR112012023660B8 (pt) 2021-05-25

Family

ID=47678420

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112012023660A BR112012023660B8 (pt) 2010-03-19 2011-03-21 usos de uma quantidade terapeuticamente eficaz de um composto, ou de um sal, solvato, hidrato ou pró-fármaco farmaceuticamente aceitável do mesmo para o tratamento de câncer

Country Status (9)

Country Link
US (2) US9730909B2 (pt)
EP (1) EP2547205B1 (pt)
JP (1) JP2013522326A (pt)
CN (1) CN103025159A (pt)
AU (1) AU2011227023B2 (pt)
BR (1) BR112012023660B8 (pt)
CA (2) CA2946890A1 (pt)
RU (1) RU2591823C2 (pt)
WO (1) WO2011116399A1 (pt)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009036059A2 (en) 2007-09-10 2009-03-19 Boston Biomedical, Inc. Novel stat3 pathway inhibitors and cancer stem cell inhibitors
ES2689928T3 (es) * 2010-03-19 2018-11-16 1Globe Biomedical Co., Ltd. Compuestos y composiciones novedosas para direccionar hacia células madre del cáncer
BR112015025347A2 (pt) * 2013-04-09 2017-07-18 Boston Biomedical Inc 2-acetil-nafto [2-3-b] furan-4,9-diona para uso no tratamento do câncer
JP6695275B2 (ja) 2014-02-07 2020-05-20 ボストン バイオメディカル， インコーポレイテッド ３−置換カルボニル−ナフト［２，３−ｂ］フラン誘導体又はその薬学的に許容される塩
JP6549115B2 (ja) * 2014-06-09 2019-07-24 京都薬品工業株式会社 新規抗癌剤
EP3283071A1 (en) 2015-04-17 2018-02-21 Boston Biomedical, Inc. Methods for treating cancer
EA201792287A1 (ru) 2015-04-17 2018-03-30 Бостон Биомедикал, Инк. Способы лечения рака
TW201717935A (zh) 2015-06-03 2017-06-01 波士頓生醫公司 用於治療癌症的組成物和方法
WO2017013270A1 (en) 2015-07-23 2017-01-26 Universite De Strasbourg Use of leptin signaling inhibitor for protecting kidneys from patients having ciliopathy
JP2019506392A (ja) 2016-01-20 2019-03-07 ボストン バイオメディカル， インコーポレイテッド がんを処置するための方法
CA3029596A1 (en) 2016-06-28 2018-01-04 Boston Biomedical, Inc. Methods for treating cancer
WO2018098352A2 (en) 2016-11-22 2018-05-31 Jun Oishi Targeting kras induced immune checkpoint expression
CA3045306A1 (en) 2016-11-29 2018-06-07 Boston Biomedical, Inc. Naphthofuran derivatives, preparation, and methods of use thereof
JP2020520923A (ja) 2017-05-17 2020-07-16 ボストン バイオメディカル， インコーポレイテッド がんを処置するための方法
US10953369B2 (en) * 2018-03-08 2021-03-23 Georgia Tech Research Corporation Spirocentric compounds and polymers thereof
SG11202103707TA (en) 2018-10-12 2021-05-28 1Globe Biomedical Co Ltd New combination solution for treating chemotherapy refractory cancer
CN111825644B (zh) * 2019-04-18 2023-07-28 中国医学科学院药物研究所 2,3-二氢萘并[2,3-b]呋喃-4,9-二酮类化合物及其制备方法和用途

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0402192A1 (fr) 1989-05-31 1990-12-12 BODET, Jean Augustin Article en carton ou matière analogue et procédé de fabrication
JPH04139177A (ja) 1989-12-28 1992-05-13 Dainippon Ink & Chem Inc フラルベンゾキノン誘導体及びその製造方法並びに制癌剤
JPH1121284A (ja) 1997-06-30 1999-01-26 Kotobuki:Kk フラノナフトキノン誘導体及びこれを含有する医薬
US6174913B1 (en) 1998-06-05 2001-01-16 The University Of North Carolina At Chapel Hill Naphtho- and dihydrobenzo-thiophene derivatives as cytotoxic antitumor agents
AU2736400A (en) 1999-01-27 2000-08-18 University Of South Florida Inhibition of stat3 signal transduction for human cancer therapy
US6482943B1 (en) 1999-04-30 2002-11-19 Slil Biomedical Corporation Quinones as disease therapies
KR100466730B1 (ko) 1999-08-02 2005-01-24 에프. 호프만-라 로슈 아게 신규한 선택적 레티노이드 작용물질
JP2001097860A (ja) 1999-09-29 2001-04-10 Japan Science & Technology Corp 抗薬剤耐性菌剤と抗クラミジア剤
UA75055C2 (uk) 1999-11-30 2006-03-15 Пфайзер Продактс Інк. Похідні бензоімідазолу, що використовуються як антипроліферативний засіб, фармацевтична композиція на їх основі
WO2002078617A2 (en) 2001-03-28 2002-10-10 University Of South Florida Materials and methods for treatment of cancer and identification of anti-cancer compounds
GB0117696D0 (en) * 2001-07-20 2001-09-12 Bradford Particle Design Plc Particle information
AU2002357012A1 (en) 2001-11-27 2003-06-10 Transform Pharmaceuticals, Inc. Oral pharmaceutical formulations comprising paclitaxel, derivatives and methods of administration thereof
WO2003045979A2 (en) 2001-11-29 2003-06-05 Therakos, Inc. Methods for pretreating a subject with extracorporeal photopheresis and/or apoptotic cells
US7462596B2 (en) 2002-03-15 2008-12-09 Natimmune A/S Pharmaceutical compositions comprising mannose binding lectin
US20060142271A1 (en) * 2002-09-17 2006-06-29 Klaus Muller Novel lapacho compounds and methods of use thereof
AR042052A1 (es) 2002-11-15 2005-06-08 Vertex Pharma Diaminotriazoles utiles como inhibidores de proteinquinasas
IS6633A (is) 2002-11-22 2004-05-23 Omega Farma Ehf. Samsetningar af fínasteríð töflum
EP1639090A4 (en) 2003-06-09 2008-04-16 Univ Michigan COMPOSITIONS AND METHODS FOR TREATING AND DIAGNOSING CANCER
US20050049207A1 (en) 2003-09-03 2005-03-03 Kaufmann Doug A. Method of treating and preventing cancer
WO2005033048A2 (en) 2003-09-29 2005-04-14 The Johns Hopkins University Wnt pathway antagonists
ES2385831T3 (es) 2003-12-11 2012-08-01 Board Of Regents, The University Of Texas System Compuestos para el tratamiento de enfermedades celulares proliferativas
EP1748772A2 (en) 2004-04-09 2007-02-07 University Of South Florida Combination therapies for cancer and proliferative angiopathies
JP2004224802A (ja) 2004-04-21 2004-08-12 Japan Science & Technology Agency 抗菌剤
AU2005309019A1 (en) 2004-11-24 2006-06-01 Novartis Ag Combinations of JAK inhibitors and at least one of Bcr-Abl, Flt-3, FAK or RAF kinase inhibitors
AU2006216510A1 (en) 2005-02-25 2006-08-31 The Regent Of The University Of Michigan Small molecule inhibitors of STAT3 and the uses thereof
JP2006248978A (ja) 2005-03-10 2006-09-21 Mebiopharm Co Ltd 新規なリポソーム製剤
JP2006290871A (ja) 2005-03-16 2006-10-26 Taheebo Japan Kk 抗癌性を示す化合物およびその中間体ならびにそれらの製造方法
CN101142202A (zh) * 2005-03-16 2008-03-12 太日保日本株式会社 抗癌化合物及其中间体和生产方法
US20060252073A1 (en) 2005-04-18 2006-11-09 Regents Of The University Of Michigan Compositions and methods for the treatment of cancer
US20070243192A1 (en) 2006-02-21 2007-10-18 Regents Of The University Of Michigan Growth hormone receptor antagonist cancer treatment
WO2007115269A2 (en) 2006-03-31 2007-10-11 The Board Of Regents Of The University Of Texas System Orally bioavailable caffeic acid related anticancer drugs
US20070238770A1 (en) 2006-04-05 2007-10-11 Bristol-Myers Squibb Company Process for preparing novel crystalline forms of peliglitazar, novel stable forms produced therein and formulations
US8828451B2 (en) 2006-10-04 2014-09-09 University Of South Florida Akt sensitization of cancer cells
JP4077863B1 (ja) 2007-05-31 2008-04-23 タヒボジャパン株式会社 抗癌活性を有する光学活性２−（１−ヒドロキシエチル）−５−ヒドロキシナフト［２，３−ｂ］フラン−４，９−ジオンの製法
WO2009036059A2 (en) * 2007-09-10 2009-03-19 Boston Biomedical, Inc. Novel stat3 pathway inhibitors and cancer stem cell inhibitors
US20100298402A1 (en) 2007-11-06 2010-11-25 Orchid Research Laboratories Limited Stilbene derivatives as pstat3/il-6 inhibitors
ES2689928T3 (es) * 2010-03-19 2018-11-16 1Globe Biomedical Co., Ltd. Compuestos y composiciones novedosas para direccionar hacia células madre del cáncer

Also Published As

Publication number Publication date
RU2591823C2 (ru) 2016-07-20
AU2011227023B2 (en) 2015-05-28
US20130028944A1 (en) 2013-01-31
CA2946890A1 (en) 2011-09-22
US20170319537A1 (en) 2017-11-09
BR112012023660B8 (pt) 2021-05-25
CN103025159A (zh) 2013-04-03
JP2013522326A (ja) 2013-06-13
CA2793527A1 (en) 2011-09-22
EP2547205A1 (en) 2013-01-23
BR112012023660B1 (pt) 2021-05-18
EP2547205A4 (en) 2013-08-14
US9730909B2 (en) 2017-08-15
EP2547205B1 (en) 2024-03-20
AU2011227023A1 (en) 2012-09-27
WO2011116399A1 (en) 2011-09-22
RU2012144420A (ru) 2014-04-27

Similar Documents

Publication Publication Date Title
BR112012023660A2 (pt) novos métodos para direcionar células-tronco cancerosas
ECSP12012318A (es) Inhibidores de pirazolil quinazolina cinasa
GT201400111A (es) Triazolopiridinas sustituidas
CL2010001637A1 (es) Compuestos derivados de isoindolonas; composición farmacéutica que los comprende; y su uso como inhibidores de la quinasa mek para tratar enfermedades hiperproliferativas y/o inflamatorias tales como cáncer, artritis reumatoidea entre otras.
BR112015009942A2 (pt) derivados de tiofeno fundidos tricíclicos como inibidores de jak
CL2013002517A1 (es) Compuestos derivados de fosforoamidato de 5-fluoro-2'-desoxiuridina; procedimiento de preparacion; composicion farmaceutica que los comprende; su uso en el tratamiento o profilaxis del cancer.
UY33735A (es) Compuestos antivirales
EA201591632A1 (ru) Цитотоксические и антимитотические соединения и способы их применения
CL2012002319A1 (es) Compuestos derivados de amino-tienopirimidinas que contienen un grupo alquilo sustituido, inhibidores de mnk| o mnk2; composición farmacéutica; y su uso para la profilaxis o la terapia de enfermedades metabólicas, trastornos hematopoyéticos, enfermedades neurodegenerativas, cáncer, entre otras.
JOP20180104A1 (ar) مركبات بنزين مستبدلة بأريل أو أريل غير متجانس
EA201890333A1 (ru) Противовирусные соединения
CL2012002189A1 (es) Compuestos derivados de pirrolidina-2-carboxamidas sustituidas; inhibidores de la interaccion mdm2-p53; composicion farmaceutica; y su uso para el tratamiento del cancer, en particular de tumores solidos.
MX370721B (es) Compuestos y composiciones novedosas para atacar las células madre del cáncer.
EA201591527A1 (ru) Новые производные пиридина
BR112015011760A2 (pt) composto, uso do composto, e uso de uma composição farmacêutica
BR112014010183B8 (pt) Composto, composição farmacêutica, produto, e, uso de um composto
ECSP13012519A (es) Compuestos sustituidos de benzamida
BR112015025347A2 (pt) 2-acetil-nafto [2-3-b] furan-4,9-diona para uso no tratamento do câncer
BR112012024822B8 (pt) Composto, uso de um composto e composição farmacêutica
EA201400771A1 (ru) Новые производные азетидина, фармацевтические композиции и их применение
CY1120204T1 (el) Αμορφη στερεα διασπορα για χρηση σε θεραπεια καρκινου του εγκεφαλο
EA201590887A1 (ru) Композиция
UY33766A (es) COMPUESTOS CON ESTRUCTURA DE PIRIMIDINONA PARA USO EN EL TRATAMIENTO DE ENFERMEDADES MEDIADAS POR Lp-PLA2
BR112014028991A2 (pt) triazóis como inibidores de kv3
CO7020867A2 (es) Formulaciones de anticuerpo y metodos

Legal Events

Date Code Title Description
B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B04C Request for examination: application reinstated [chapter 4.3 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B15K Others concerning applications: alteration of classification

Free format text: AS CLASSIFICACOES ANTERIORES ERAM: A01N 43/16 , A61K 31/35

Ipc: A61K 31/35 (2006.01), A61K 31/27 (2006.01), A61K 3

B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 21/03/2011, OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF

B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 21/03/2011 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF