JP5995441B2 - 増殖性疾患治療用非対称ピロロベンゾジアゼピン−二量体 - Google Patents

増殖性疾患治療用非対称ピロロベンゾジアゼピン−二量体 Download PDF

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JP5995441B2
JP5995441B2 JP2011531560A JP2011531560A JP5995441B2 JP 5995441 B2 JP5995441 B2 JP 5995441B2 JP 2011531560 A JP2011531560 A JP 2011531560A JP 2011531560 A JP2011531560 A JP 2011531560A JP 5995441 B2 JP5995441 B2 JP 5995441B2
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JP2012505871A5 (enExample
JP2012505871A (ja
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ハワード，フィリップ，ウィルソン
グレッグソン，スティーヴン，ジョン
マスターソン，ルーク
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MedImmune Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C07D519/06—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00 containing at least one condensed beta-lactam ring system, provided for by groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00, e.g. a penem or a cepham system

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
JP2011531560A 2008-10-17 2009-10-16 増殖性疾患治療用非対称ピロロベンゾジアゼピン−二量体 Active JP5995441B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0819095.1 2008-10-17
GBGB0819095.1A GB0819095D0 (en) 2008-10-17 2008-10-17 Pyrrolobenzodiazepines
PCT/GB2009/002498 WO2010043880A1 (en) 2008-10-17 2009-10-16 Unsymmetrical pyrrolobenzodiazepine-dimers for treatment of proliferative diseases

Related Child Applications (1)

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JP2015084175A Division JP2015166354A (ja) 2008-10-17 2015-04-16 増殖性疾患治療用非対称ピロロベンゾジアゼピン−二量体

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Publication Number Publication Date
JP2012505871A JP2012505871A (ja) 2012-03-08
JP2012505871A5 JP2012505871A5 (enExample) 2012-11-22
JP5995441B2 true JP5995441B2 (ja) 2016-09-21

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JP2011531560A Active JP5995441B2 (ja) 2008-10-17 2009-10-16 増殖性疾患治療用非対称ピロロベンゾジアゼピン−二量体
JP2015084175A Pending JP2015166354A (ja) 2008-10-17 2015-04-16 増殖性疾患治療用非対称ピロロベンゾジアゼピン−二量体

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US (3) US8592576B2 (enExample)
EP (1) EP2350080B1 (enExample)
JP (2) JP5995441B2 (enExample)
KR (1) KR101755722B1 (enExample)
CN (3) CN102186855A (enExample)
AU (1) AU2009305190B2 (enExample)
BR (1) BRPI0918476B8 (enExample)
CA (1) CA2735477C (enExample)
CY (1) CY1117106T1 (enExample)
DK (1) DK2350080T3 (enExample)
ES (1) ES2557283T3 (enExample)
GB (1) GB0819095D0 (enExample)
HR (1) HRP20160003T1 (enExample)
HU (1) HUE025905T2 (enExample)
IL (1) IL211985A (enExample)
MX (1) MX2011003342A (enExample)
NZ (1) NZ591425A (enExample)
PL (1) PL2350080T3 (enExample)
PT (1) PT2350080E (enExample)
SI (1) SI2350080T1 (enExample)
SM (1) SMT201600017B (enExample)
WO (1) WO2010043880A1 (enExample)
ZA (1) ZA201101425B (enExample)

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