BRPI0807318B8 - "microrna associado a exossomos como marcador diagnóstico" - Google Patents

"microrna associado a exossomos como marcador diagnóstico"

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Publication number
BRPI0807318B8
BRPI0807318B8 BRPI0807318A BRPI0807318A BRPI0807318B8 BR PI0807318 B8 BRPI0807318 B8 BR PI0807318B8 BR PI0807318 A BRPI0807318 A BR PI0807318A BR PI0807318 A BRPI0807318 A BR PI0807318A BR PI0807318 B8 BRPI0807318 B8 BR PI0807318B8
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BR
Brazil
Prior art keywords
exosomes
micron
diagnostic marker
individual
present
Prior art date
Application number
BRPI0807318A
Other languages
English (en)
Inventor
Cicek Gercel-Taylor
Douglas D Taylor
Original Assignee
Univ Louisville Res Found Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Louisville Res Found Inc filed Critical Univ Louisville Res Found Inc
Publication of BRPI0807318A2 publication Critical patent/BRPI0807318A2/pt
Publication of BRPI0807318B1 publication Critical patent/BRPI0807318B1/pt
Publication of BRPI0807318B8 publication Critical patent/BRPI0807318B8/pt

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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
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    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
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    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G01N33/57492—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds localized on the membrane of tumor or cancer cells
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    • G07—CHECKING-DEVICES
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    • G07F17/3244—Payment aspects of a gaming system, e.g. payment schemes, setting payout ratio, bonus or consolation prizes
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    • C12Q2600/00—Oligonucleotides characterized by their use
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/178—Oligonucleotides characterized by their use miRNA, siRNA or ncRNA
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
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    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
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    • Y10T436/143333—Saccharide [e.g., DNA, etc.]

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  • Health & Medical Sciences (AREA)
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  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
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Abstract

microrna associado a exossomos como marcador diagnóstico a matéria revelada na presente invenção provê métodos para o diagnóstico de câncer ou de resultados adversos de gestações em um indivíduo por meio da medição das quantidades de um ou mais micrornas presentes em exossomos derivados de câncer de uma amostra biológica de um indivíduo.
BRPI0807318A 2007-07-25 2008-07-25 "microrna associado a exossomos como marcador diagnóstico" BRPI0807318B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US95181207P 2007-07-25 2007-07-25
US5043808P 2008-05-05 2008-05-05
PCT/US2008/071235 WO2009015357A1 (en) 2007-07-25 2008-07-25 Exosome-associated microrna as a diagnostic marker

Publications (3)

Publication Number Publication Date
BRPI0807318A2 BRPI0807318A2 (pt) 2015-03-24
BRPI0807318B1 BRPI0807318B1 (pt) 2018-11-13
BRPI0807318B8 true BRPI0807318B8 (pt) 2021-07-27

Family

ID=40281854

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0807318A BRPI0807318B8 (pt) 2007-07-25 2008-07-25 "microrna associado a exossomos como marcador diagnóstico"

Country Status (11)

Country Link
US (5) US8216784B2 (pt)
EP (3) EP2613149B1 (pt)
JP (3) JP5156829B2 (pt)
CN (2) CN103276062A (pt)
AU (1) AU2008279016B2 (pt)
BR (1) BRPI0807318B8 (pt)
CA (1) CA2676113C (pt)
ES (1) ES2420973T3 (pt)
GB (1) GB2459228B (pt)
IL (3) IL200028A (pt)
WO (1) WO2009015357A1 (pt)

Families Citing this family (176)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8021847B2 (en) 2004-06-02 2011-09-20 Proxy Life Science Holdings, Inc. Microvesicle-based compositions and methods
EP1766053A4 (en) * 2004-06-02 2007-12-12 Sourcepharm Inc MICROVESICLES CONTAINING RNA AND METHODS
EP2468899B1 (en) 2006-01-05 2015-03-11 The Ohio State University Research Foundation MicroRNA-based methods for the diagnosis of stomach cancers
ES2880460T3 (es) * 2006-03-09 2021-11-24 Aethlon Medical Inc Eliminación extracorpórea de partículas microvesiculares
AU2007227423B2 (en) 2006-03-20 2013-11-07 The Ohio State University Research Foundation MicroRNA fingerprints during human megakaryocytopoiesis
EP2610347B1 (en) * 2007-04-30 2015-04-15 The Ohio State University Research Foundation Methods of determining the prognosis of a subject with pancreatic cancer
EP2613149B1 (en) * 2007-07-25 2014-09-17 University Of Louisville Research Foundation, Inc. Exosome-associated microRNA as a diagnostic marker
CN103866008B (zh) 2007-08-03 2016-06-29 俄亥俄州立大学研究基金会 编码ncrna的超保守区域
US20100255514A1 (en) * 2007-08-16 2010-10-07 The Royal Institution For The Advancement Of Learning/Mcgill University Tumor cell-derived microvesicles
JP5769417B2 (ja) 2007-08-16 2015-08-26 ザ ロイヤル インスティチューション フォー ザ アドバンスメント オブ ラーニング／マギル ユニバーシティ 腫瘍細胞由来微小胞
EP2775001B1 (en) * 2007-09-06 2016-03-09 The Ohio State University Research Foundation MicroRNA signatures in human ovarian cancer
CA2699646A1 (en) * 2007-09-14 2009-03-19 The Ohio State University Research Foundation Mirna expression in human peripheral blood microvesicles and uses thereof
US20100285471A1 (en) * 2007-10-11 2010-11-11 The Ohio State University Research Foundation Methods and Compositions for the Diagnosis and Treatment of Esphageal Adenocarcinomas
CN101424640B (zh) * 2007-11-02 2012-07-25 江苏命码生物科技有限公司 血清中微小核糖核酸的检测方法和用于检测的试剂盒、生物芯片及其制作和应用方法
CA2708661A1 (en) * 2008-01-27 2009-07-30 Rosetta Genomics Ltd. Methods and compositions for diagnosing complications of pregnancy
CN102084000B (zh) * 2008-02-01 2016-03-16 总医院有限公司 微泡在医学疾病和病况的诊断、预后以及治疗中的用途
US20110034538A1 (en) * 2008-02-28 2011-02-10 The Ohio State University Research Foundation MicroRNA-Based Methods and Compositions for the Diagnosis, Prognosis and Treatment of Gastric Cancer
US20110177054A1 (en) * 2008-06-06 2011-07-21 Derrick Gibbings Use of endo-lysosomal system and secreted vesicles (exosome-like) in treatments and diagnostics based on small rna and experimental study of small rna
US9410956B1 (en) * 2008-08-01 2016-08-09 University Of South Florida Micro-RNA profiling in ovarian cancer
US9487837B2 (en) 2008-10-06 2016-11-08 Morehouse School Of Medicine Exosome-mediated diagnosis of hepatitis virus infections and diseases
CA2742324A1 (en) 2008-10-30 2010-06-03 Caris Life Sciences Luxembourg Holdings, S.A.R.L. Methods for assessing rna patterns
CN102301002A (zh) * 2008-11-12 2011-12-28 卡里斯生命科学卢森堡控股有限责任公司 使用外来体来确定表现型的方法和系统
CN101475984A (zh) * 2008-12-15 2009-07-08 江苏命码生物科技有限公司 一种非小细胞肺癌检测标记物及其检测方法、相关生物芯片和试剂盒
AU2010205493A1 (en) * 2009-01-19 2011-09-08 Sistemic Scotland Limited Methods employing non-coding RNA expression assays
US20120115139A1 (en) * 2009-04-21 2012-05-10 Tokyo Medical University Method for evaluating cancer
US20120077263A1 (en) * 2009-06-05 2012-03-29 Mayo Foundation For Medical Education And Research Methods and materials for isolating exosomes
JP5909444B2 (ja) * 2009-07-16 2016-04-26 ザ ジェネラル ホスピタル コーポレイション 核酸分析
CN101988062A (zh) * 2009-07-30 2011-03-23 江苏命码生物科技有限公司 宫颈癌检测标记物及其检测方法、试剂盒和生物芯片
US8735074B2 (en) * 2009-08-28 2014-05-27 Asuragen, Inc. MiRNA biomarkers of lung disease
WO2011031892A1 (en) 2009-09-09 2011-03-17 The General Hospital Corporation Use of microvesicles in analyzing kras mutations
WO2011031877A1 (en) 2009-09-09 2011-03-17 The General Hospital Corporation Use of microvesicles in analyzing nucleic acid profiles
WO2011044541A2 (en) * 2009-10-09 2011-04-14 Baylor Research Institute Identification of micrornas (mirnas) in fecal samples as biomarkers for gastroenterological cancers
EP2316972A1 (en) * 2009-10-29 2011-05-04 Deutsches Krebsforschungszentrum Circulating miRNAs as non-invasive markers for diagnosis and staging in prostate cancer
WO2011057003A2 (en) 2009-11-04 2011-05-12 Samuil Umansky Methods of using small rna from bodily fluids for diagnosis and monitoring of neurodegenerative diseases
CN101798594A (zh) * 2009-11-13 2010-08-11 北京命码生科科技有限公司 检测牛乳质量的标志物、检测方法、生物芯片和试验盒
WO2011063324A2 (en) * 2009-11-20 2011-05-26 The General Hospital Corporation Microfluidic systems for isolating microvesicles
CN102803511A (zh) 2009-11-23 2012-11-28 俄亥俄州立大学 用于影响肿瘤细胞生长、迁移和侵袭的材料和方法
EP2341145A1 (en) 2009-12-30 2011-07-06 febit holding GmbH miRNA fingerprint in the diagnosis of diseases
JP5808349B2 (ja) * 2010-03-01 2015-11-10 カリス ライフ サイエンシズ スウィッツァーランド ホールディングスゲーエムベーハー セラノーシスのためのバイオマーカー
JP2013526852A (ja) * 2010-04-06 2013-06-27 カリス ライフ サイエンシズ ルクセンブルク ホールディングス 疾患に対する循環バイオマーカー
EP2559442B1 (en) * 2010-04-13 2017-12-06 Jiangsu Mingma Biotech Co., Ltd Method for regulating microrna content in organisms and uses thereof
US20130203081A1 (en) * 2010-04-13 2013-08-08 Janusz Rak Tumor cell-derived microvesicles
WO2011156763A1 (en) 2010-06-11 2011-12-15 Hitachi Chemical Co., Ltd. Methods for characterizing kidney function
WO2011156734A2 (en) * 2010-06-11 2011-12-15 Hitachi Chemical Co., Ltd. Method of characterizing vascular diseases
ES2624284T3 (es) * 2010-07-07 2017-07-13 Aethlon Medical Inc Métodos para cuantificar exosomas
US20140045915A1 (en) 2010-08-31 2014-02-13 The General Hospital Corporation Cancer-related biological materials in microvesicles
CN101921759B (zh) * 2010-09-08 2013-05-29 南京医科大学 一种与宫颈癌及其癌前病变相关的血清/血浆miRNA标志物及其应用
EP2446929A1 (en) * 2010-10-27 2012-05-02 Johann Wolfgang Goethe-Universität Frankfurt am Main Microvesicles derived from atheroprotective endothelial cells for the treatment and prevention of atherosclerotic diseases
US20120107825A1 (en) 2010-11-01 2012-05-03 Winger Edward E Methods and compositions for assessing patients with reproductive failure using immune cell-derived microrna
WO2012064993A1 (en) 2010-11-10 2012-05-18 Exosome Diagnosties, Inc. Method for isolation of nucleic acid containing particles and extraction of nucleic acids therefrom
AU2011326032B2 (en) 2010-11-12 2016-10-06 The Ohio State University Research Foundation Materials and methods related to microRNA-21, mismatch repair, and colorectal cancer
BR112013011942A2 (pt) 2010-11-15 2016-11-01 Univ Michigan formulação, forma de dosagem de droga para administração transmucosa oral, sistema transmucoso de fornecimento de droga, método de tratamento e profilaxia de uma doença ou distúrbio, método de tratamento, formulação, método para tratamento ou prevenção de carcinoma de célula escamosa de cabeça e pescoço (hnscc), método para quimioprevenção de um câncer oral ou condição pré-cancerosa, método para aumentar a concentração de uma composição de retinida, método de tratamento e profilaxia de uma doença ou condição, método de ratamento de um sujeito apresentando uma condição médica sintomática, método de tratamento de um câncer oral ou condição pré-cancerosa num paciente, método para fazer um sistema de fornecimento de droga bucal, método para aumentar a liberação e permeação de uma composição de retinida.
JP2012125215A (ja) * 2010-12-17 2012-07-05 Osaka City Univ 肝線維症の存在及び／又は肝線維症の重症度の判定方法、判定マーカー、判定用キット、肝線維症の治療の効果予測方法、効果予測マーカー、並びに効果予測用キット
EP2505663A1 (en) * 2011-03-30 2012-10-03 IFOM Fondazione Istituto Firc di Oncologia Molecolare A method to identify asymptomatic high-risk individuals with early stage lung cancer by means of detecting miRNAs in biologic fluids
CN105861712B (zh) 2011-04-18 2021-05-14 迪阿米尔有限责任公司 使用来自体液的miRNA来早期检测和监控轻度认知障碍(MCI)和阿尔茨海默病(AD)的方法
EP2707381B1 (en) * 2011-05-11 2019-08-14 Exosome Diagnostics, Inc. Nucleic acid extraction from heterogeneous biological materials
EP2717989B1 (en) 2011-06-10 2018-05-30 Hitachi Chemical Co., Ltd. Vesicle capturing devices and methods for using same
US20140275211A1 (en) * 2011-06-21 2014-09-18 Alnylam Pharmaceuticals, Inc. Assays and methods for determining activity of a therapeutic agent in a subject
BR112013033488B8 (pt) * 2011-06-27 2022-11-22 Eisai R&D Man Co Ltd Métodos para facilitar o diagnóstico do comprometimento cognitivo devido a doença de alzheimer ou comprometimento cognitivo leve (mci)e kit
CA2846211A1 (en) * 2011-08-05 2013-02-14 University Of Louisville Research Foundation, Inc. Microrna biomarkers
EP2742154A4 (en) * 2011-08-08 2015-08-12 Caris Life Sciences Switzerland Holdings Gmbh BIOMARKER COMPOSITIONS AND METHODS
AU2012323924A1 (en) * 2011-10-14 2014-05-29 The Ohio State University Methods and materials related to ovarian cancer
EP2584040A1 (en) * 2011-10-17 2013-04-24 Pharmahungary 2000 Kft. Compounds for treatment of ischemic injury
WO2013066678A1 (en) * 2011-10-26 2013-05-10 Georgetown University Microrna expression profiling of thyroid cancer
WO2013063439A1 (en) * 2011-10-27 2013-05-02 University Of Louisville Research Foundation, Inc. Characterizing melanoma
WO2013070324A1 (en) 2011-11-07 2013-05-16 University Of Louisville Research Foundation, Inc. Edible plant-derived microvesicle compositions for diagnosis and treatment of disease
WO2013079701A2 (en) * 2011-11-30 2013-06-06 University Of Bremen Expression of mirnas in placental tissue
CN104619353A (zh) * 2011-12-13 2015-05-13 俄亥俄州国家创新基金会 与miR-21和miR-29a相关的方法和组合物、外切体抑制和癌症转移
US9447471B2 (en) 2011-12-29 2016-09-20 Quest Diagnostics Investments Incorporated Microrna profiling for diagnosis of dysplastic nevi and melanoma
AU2013209477B2 (en) 2012-01-20 2016-12-08 The Ohio State University Breast cancer biomarker signatures for invasiveness and prognosis
EP2818549A4 (en) 2012-02-23 2015-09-02 Sumitomo Bakelite Co METHOD FOR CLASSIFYING BODY FLUID SAMPLE OF TEST
US20130273549A1 (en) * 2012-04-16 2013-10-17 Board Of Regents, The University Of Texas System Detection of extracellular jcv micrornas
WO2013155633A1 (en) * 2012-04-19 2013-10-24 Leong Hon Sing Method for detecting or monitoring prostate cancer
CA2882248A1 (en) 2012-08-15 2014-02-20 The University Of Chicago Exosome-based therapeutics against neurodegenerative disorders
EP2886122B1 (en) * 2012-08-20 2019-02-27 National Cancer Center Agent for treating cancer
CN102864224A (zh) * 2012-09-11 2013-01-09 南京大学 一种血清microRNAs试剂盒及其应用
WO2014041087A1 (en) 2012-09-12 2014-03-20 INSERM (Institut National de la Santé et de la Recherche Médicale) Muscle secretome and uses thereof
US9255924B2 (en) 2012-10-12 2016-02-09 University Of Notre Dame Du Lac Exosomes and diagnostic biomarkers
US10942184B2 (en) 2012-10-23 2021-03-09 Caris Science, Inc. Aptamers and uses thereof
EP4170031A1 (en) * 2012-10-23 2023-04-26 Caris Science, Inc. Aptamers and uses thereof
EP2746406B1 (en) * 2012-12-18 2017-08-23 Samsung Electronics Co., Ltd. Composition and kit for diagnosing breast cancer including miRNAs within vesicle, and method of diagnosing breast cancer using the same
WO2014100434A1 (en) 2012-12-19 2014-06-26 Caris Science, Inc. Compositions and methods for aptamer screening
US9086412B2 (en) * 2012-12-31 2015-07-21 University Of Louisville Research Foundation, Inc. Extracellular vesicle-associated protein markers of cancer
WO2014160032A1 (en) * 2013-03-13 2014-10-02 University Of Louisville Research Foundation, Inc. Exosome-associated rna as a diagnostic marker
JP6562897B2 (ja) 2013-03-13 2019-08-21 ユニバーシティー オブ マイアミＵｎｉｖｅｒｓｉｔｙ Ｏｆ Ｍｉａｍｉ 細胞培養上清および生体液からの微小胞の単離および精製のための方法
MX2015013141A (es) * 2013-03-15 2016-06-21 Univ Texas Biogénesis de miarn en exosomas para diagnóstico y terapia.
CA2907377A1 (en) * 2013-03-15 2014-09-18 Baylor Research Institute Tissue and blood-based mirna biomarkers for the diagnosis, prognosis and metastasis-predictive potential in colorectal cancer
DE102013103447A1 (de) * 2013-04-05 2014-10-09 Bodo C. Melnik Verfahren und Vorrichtung zur Herstellung kommerzieller Milch und Milch mit reduzierter biologischer Wirkung exosomaler Ribonukleinsäuren
JP6297676B2 (ja) 2013-05-06 2018-03-20 日立化成株式会社 標的分子を捕捉するためのデバイス及び方法
US9213029B2 (en) 2013-06-25 2015-12-15 Samsung Electronics Co., Ltd. Method for diagnosing breast cancer by detection of polymeric immunoglobulin receptor in vesicles isolated from patients
EP3030675B1 (en) * 2013-08-06 2018-10-03 Exosome Diagnostics Inc. Urine biomarker cohorts, gene expression signatures, and methods of use thereof
WO2015045666A1 (ja) 2013-09-25 2015-04-02 国立大学法人東京大学 流体デバイス、エキソソームの分析方法、生体分子分析方法及び生体分子検出方法
PL405648A1 (pl) 2013-10-15 2015-04-27 Warszawski Uniwersytet Medyczny Sposób diagnozowania raka watrobowokomórkowego, zastosowanie markera mikroRNA do diagnozowania zmiany chorobowej w obrębie wątroby, oceny stopnia zaawansowania choroby oraz oceny podatności pacjenta i/lub choroby na zaproponowane leczenie oraz zawierający takie markery zestaw diagnostyczny
KR20150043937A (ko) 2013-10-15 2015-04-23 삼성전자주식회사 개체의 간암 진단용 조성물, 개체의 간암 진단하는 방법 및 개체의 간암 진단에 필요한 정보를 얻는 방법
EP3058101A4 (en) * 2013-10-15 2017-05-17 The Board of Trustees of the University of Illionis Serum mirnas for the prognosis of prostate cancer
JP6547625B2 (ja) 2013-10-25 2019-07-24 凸版印刷株式会社 膜小胞回収デバイス、膜小胞回収方法、及び膜小胞分析方法
PL406033A1 (pl) 2013-11-14 2015-05-25 Warszawski Uniwersytet Medyczny Sposób diagnozowania raka brodawkowatego tarczycy, zastosowanie markera mikroRNA do diagnozowania nowotworu tarczycy, oceny stopnia zaawansowania choroby oraz oceny podatności pacjenta i/lub choroby na zaproponowane leczenie oraz zawierający takie markery zestaw diagnostyczny
CA2931082C (en) 2013-11-18 2024-01-23 Diamir, Llc Methods of using mirnas from bodily fluids for detection and monitoring of parkinson's disease (pd)
FR3014198B1 (fr) * 2013-12-03 2017-03-03 Biomerieux Sa Procede d'isolement d'exosomes
KR101535737B1 (ko) * 2014-01-09 2015-07-09 충남대학교산학협력단 miRNA를 포함하는 자간전증 진단 및 치료용 조성물
CN106574927A (zh) * 2014-01-14 2017-04-19 崔元哲 使用luterial的形态学特征筛选癌症预防剂或抗癌剂的方法
WO2015126886A1 (en) 2014-02-18 2015-08-27 Baylor Research Institute Mir-320e and colorectal cancer
CA2940823C (en) * 2014-02-27 2017-03-28 Board Of Regents, The University Of Texas System Methods and compositions for isolating exosomes
CN103937888B (zh) * 2014-04-14 2016-08-17 上海交通大学 鉴别胃癌的血浆microRNA标志物的筛选与应用
CN103954770B (zh) * 2014-04-25 2015-09-30 江南大学 EVs-TRPC5在检测乳腺癌耐药程度中的应用
CN103993015B (zh) * 2014-05-23 2016-04-27 山西医科大学 人类子痫前期发生相关的外周血白细胞miRNA标志物及其应用
CA2951016A1 (en) * 2014-06-12 2015-12-17 Toray Industries, Inc. Prostate cancer detection kit or device, and detection method
JP6597614B2 (ja) 2014-07-24 2019-10-30 凸版印刷株式会社 脂質膜構造体、脂質膜構造体固定化担体、及び胞体の融合方法
KR101784714B1 (ko) 2014-08-19 2017-10-12 주식회사 엠모니터 재발 난소암 진단 또는 난소암 재발 예측용 mirna 마커 및 그 용도
US20170298352A1 (en) 2014-09-30 2017-10-19 Research Institute at Nationwide Children's Hospit al Compositions and methods for treating hepatic fibrosis
WO2016057474A1 (en) * 2014-10-06 2016-04-14 Indiana University Research & Technology Corporation Systems and methods for localized surface plasmon resonance biosensing
RU2571507C1 (ru) * 2014-10-09 2015-12-20 Федеральное государственное бюджетное учреждение науки Институт химической биологии и фундаментальной медицины Сибирского отделения Российской академии наук (ИХБФМ СО РАН) Способ диагностики и мониторинга онкологических заболеваний с использованием экзосом крови
US10266895B2 (en) 2014-11-05 2019-04-23 Hitachi Chemical Company Ltd. Exosomes and microvesicles in intestinal luminal fluids and stool and use of same for the assessment of inflammatory bowel disease
JP6631852B2 (ja) 2014-11-12 2020-01-15 日立化成株式会社 臓器障害を診断するための方法および装置
WO2016094722A1 (en) 2014-12-10 2016-06-16 Xpecting Diagnostics, Inc. Detection of analytes in bodily fluid to determine the initiation of parturition
EP3250706A4 (en) * 2015-01-30 2018-09-05 The Johns Hopkins University Extracellular vesicles for agent delivery
WO2016140388A1 (ko) * 2015-03-05 2016-09-09 경북대학교 산학협력단 엑소좀 또는 이의 단백질을 포함하는 장기 독성 진단용 바이오마커 조성물 및 이를 이용한 진단 방법
US10071133B2 (en) * 2015-03-12 2018-09-11 Mitsui Chemicals, Inc. Method for destroying exosomes, kit for destroying exosomes, and method for isolating exosomes derived from normal cells
GB201504772D0 (en) * 2015-03-20 2015-05-06 Univ Aston Preeclampsia
US20160320390A1 (en) * 2015-05-01 2016-11-03 Morehouse School Of Medicine Compositions and methods for capturing exosomes
JP6777629B2 (ja) * 2015-05-20 2020-10-28 Jsr株式会社 分離方法、検出方法、シグナル測定方法、疾患の判定方法、薬効評価方法、キット、液状組成物及び検体希釈液
US10345310B2 (en) 2015-06-09 2019-07-09 The Board Of Regents Of The University Of Texas System Diagnostic test for early stage cancer
AU2016276942B2 (en) 2015-06-10 2022-08-25 Children's National Medical Center Adipocyte-derived exosomes, and compositions, kits, and methods of using the same for detection and screening
EP3307890A1 (en) 2015-06-10 2018-04-18 Board of Regents, The University of Texas System Use of exosomes for the treatment of disease
CN106319031A (zh) * 2015-06-23 2017-01-11 上海市计划生育科学研究所 反复自然流产相关微小rna及其应用
AU2016287499B2 (en) 2015-06-29 2022-08-04 Caris Science, Inc. Therapeutic oligonucleotides
CA2993652A1 (en) 2015-07-28 2017-02-02 Caris Science, Inc. Targeted oligonucleotides
DE112016003948T5 (de) 2015-08-31 2018-05-09 City Of Sapporo Molekulare verfahren zum beurteilen einer urothelialen erkrankung
CN109477144B (zh) 2015-09-29 2022-12-09 国家儿童医院研究所 用于检测肝脏纤维化和对疗法的响应性的方法
KR101695347B1 (ko) * 2015-10-12 2017-01-11 이화여자대학교 산학협력단 유전자의 CpG 메틸화 변화를 이용한 조산 위험성 예측용 조성물 및 이의 이용
CN105368931A (zh) * 2015-10-15 2016-03-02 天津市泌尿外科研究所 尿液中exosome源性miRNAs生物标记物的检测方法
US10975436B2 (en) 2016-01-05 2021-04-13 Diamir, Llc Methods of using miRNA from bodily fluids for diagnosis and monitoring of neurodevelopmental disorders
WO2017124000A1 (en) 2016-01-14 2017-07-20 The Regents Of The University Of California 3d-exoquant method for the analysis of surface molecules and quantification of tissue-specific exosomes in biological fluids
US10731166B2 (en) 2016-03-18 2020-08-04 Caris Science, Inc. Oligonucleotide probes and uses thereof
US11149313B2 (en) 2016-03-21 2021-10-19 Diamir, Llc Methods of using miRNAs from bodily fluids for detection and differentiation of neurodegenerative diseases
CA3025486A1 (en) 2016-05-25 2017-11-30 Caris Science, Inc. Oligonucleotide probes and uses thereof
WO2017223116A2 (en) 2016-06-20 2017-12-28 Healthtell Inc. Methods for differential diagnosis of autoimmune diseases
CN109790203A (zh) 2016-06-20 2019-05-21 健康之语公司 自身免疫疾病的诊断和治疗方法
JP6980219B2 (ja) * 2016-08-22 2021-12-15 いであ株式会社 がんを検出、又はがんの進行期を判定する方法
CN106282360B (zh) * 2016-08-31 2019-11-08 武汉博杰生物医学科技有限公司 一种用于结肠癌预测转移的血浆miRNA组合、其探针组合物及应用
IL259023B (en) 2016-09-30 2022-09-01 Cellex Life Sciences Incorporated Preparations containing protein-charged exosomes, methods for their production and uses thereof
WO2018071806A1 (en) * 2016-10-13 2018-04-19 University Of Louisville Research Foundation, Inc. Exosomal biomarkers for diagnosis and prognosis of cancer and related methods
CN106282387A (zh) * 2016-10-17 2017-01-04 上海赛安生物医药科技有限公司 胃癌检测引物探针及其试剂盒
US20190284629A1 (en) * 2016-11-11 2019-09-19 University Of Tennessee Research Foundation Biomarkers for early embryonic viability and methods thereof
US11371990B2 (en) 2016-11-11 2022-06-28 Cowper Sciences Inc. Methods for identifying candidate biomarkers
WO2018144070A1 (en) * 2017-02-06 2018-08-09 Goetzl Edward J Endothelial cell derived exosomes and uses thereof
WO2018165532A1 (en) 2017-03-10 2018-09-13 Baylor Research Institute Methods for diagnosing and treating gastric cancer using mirna expression
WO2018170624A1 (zh) * 2017-03-18 2018-09-27 深圳市博奥康生物科技有限公司 降低微小rna-185和微小rna-424表达的方法
WO2018199231A1 (ja) * 2017-04-28 2018-11-01 一丸ファルコス株式会社 プラセンタ抽出物
WO2018218090A1 (en) * 2017-05-24 2018-11-29 Nanosomix, Inc. Detection of biomarkers on vesicles for the diagnosis and prognosis of diseases and disorders
CN107243012B (zh) * 2017-05-25 2020-01-24 江苏大学 一种exosomes装载的miR-93-5p在治疗类风湿性关节炎中的应用
WO2019008414A1 (en) * 2017-07-05 2019-01-10 Datar Rajan GENE EXPRESSION ANALYSIS BASED ON EXOSOMES FOR THE CARE OF CANCER
EP3652315A4 (en) 2017-07-12 2021-09-01 Exosome Diagnostics, Inc. METHOD OF ISOLATION AND ENRICHMENT OF POPULATIONS OF EXTRACELLULAR VESICULES FROM A BIOFLUID AND METHOD OF USING THEREOF
US10781487B2 (en) 2017-07-24 2020-09-22 Diamir, Llc miRNA-based methods for detecting and monitoring aging
CN107365852B (zh) * 2017-08-14 2021-08-13 江苏为真生物医药技术股份有限公司 血清外泌体中肺癌相关microRNA分子标记的应用及其检测试剂盒
KR102109921B1 (ko) * 2017-09-27 2020-05-12 ㈜로제타엑소좀 크기 배제 크로마토그래피를 이용한 세포밖 소포체의 순도 분석 방법
US12000834B2 (en) 2017-11-10 2024-06-04 Mayo Foundation For Medical Education And Research Methods and materials for assessing and treating cancer
CN108753964A (zh) * 2018-06-04 2018-11-06 谢丽 一种用于非小细胞肺癌诊断及转移预警的试剂盒
KR102184911B1 (ko) * 2019-06-07 2020-12-01 한림대학교 산학협력단 miR-548을 함유하는 조산 예방 또는 치료제 조성물
US20220275455A1 (en) * 2019-07-08 2022-09-01 Preferred Networks, Inc. Data processing and classification for determining a likelihood score for breast disease
CN110747268B (zh) * 2019-10-23 2023-02-03 华南农业大学 一种血清外泌体ssc-miR-17-5p作为母猪早期妊娠诊断分子标志物的应用
CN110878341A (zh) * 2019-12-18 2020-03-13 苏州绘真医学检验有限公司 一种检测血液外泌体miRNA的引物组、试剂盒及方法
KR102242639B1 (ko) * 2020-01-28 2021-04-21 고려대학교 산학협력단 간 섬유화 진단용 바이오마커 miRNA4668-5p
US11211147B2 (en) 2020-02-18 2021-12-28 Tempus Labs, Inc. Estimation of circulating tumor fraction using off-target reads of targeted-panel sequencing
US11475981B2 (en) 2020-02-18 2022-10-18 Tempus Labs, Inc. Methods and systems for dynamic variant thresholding in a liquid biopsy assay
US11211144B2 (en) 2020-02-18 2021-12-28 Tempus Labs, Inc. Methods and systems for refining copy number variation in a liquid biopsy assay
RU2769927C2 (ru) * 2020-02-28 2022-04-08 Общество с ограниченной ответственностью "МедФлорина" Способ диагностики меланомы с помощью экзосомальных микроРНК
WO2021195154A1 (en) * 2020-03-23 2021-09-30 Avem Holdings, Llc Isolation and purification of exosomes for regenerative medicine
US20230332234A1 (en) * 2020-09-23 2023-10-19 Ewinger, Inc. Reagents, methods and kits for identifying pregnant human beings at risk for placental bed disorder(s)
CN112575088B (zh) * 2020-12-29 2022-07-05 浙江大学医学院附属妇产科医院 一种血浆外泌体miRNA生物标记物及其应用
WO2022204378A2 (en) * 2021-03-24 2022-09-29 City Of Hope Identification of rna biomarkers in colorectal cancer
WO2022216765A1 (en) * 2021-04-07 2022-10-13 Trustees Of Boston University Exosome-based cancer assays
CN113736877A (zh) * 2021-10-15 2021-12-03 青岛大学附属医院 基于微小RNA 27a的子痫前期诊断用途及组合物
WO2024050519A2 (en) * 2022-09-02 2024-03-07 Ohio State Innovation Foundation Methods and compositions for detecting cancer using exosomal proteins
CN117802235A (zh) * 2022-09-30 2024-04-02 上海思路迪生物医学科技有限公司 血液胞外囊泡miRNA在卵巢癌诊断中的应用
KR20240058548A (ko) * 2022-10-26 2024-05-07 연세대학교 산학협력단 유방암 진단 또는 재발 예측을 위한 세포외 소포체 유래 miRNA 유전자 바이오마커 및 이의 용도

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US5089181A (en) 1987-02-24 1992-02-18 Vestar, Inc. Method of dehydrating vesicle preparations for long term storage
US5449754A (en) 1991-08-07 1995-09-12 H & N Instruments, Inc. Generation of combinatorial libraries
US6015880A (en) 1994-03-16 2000-01-18 California Institute Of Technology Method and substrate for performing multiple sequential reactions on a matrix
US5807522A (en) 1994-06-17 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods for fabricating microarrays of biological samples
IL131978A0 (en) 1997-03-20 2001-03-19 Univ Washington Solvent for biopolymer synthesis solvent microdots and methods of use
US6242266B1 (en) 1999-04-30 2001-06-05 Agilent Technologies Inc. Preparation of biopolymer arrays
US6180351B1 (en) 1999-07-22 2001-01-30 Agilent Technologies Inc. Chemical array fabrication with identifier
US6232072B1 (en) 1999-10-15 2001-05-15 Agilent Technologies, Inc. Biopolymer array inspection
US6171797B1 (en) 1999-10-20 2001-01-09 Agilent Technologies Inc. Methods of making polymeric arrays
US6812023B1 (en) 2000-04-27 2004-11-02 Anosys, Inc. Methods of producing membrane vesicles
JP2002330055A (ja) * 2001-04-27 2002-11-15 Tdk Corp 表面弾性波フィルタ、表面弾性波フィルタ用パッケージ及び表面弾性波フィルタモジュール
US20030036077A1 (en) 2001-05-31 2003-02-20 Chronix Biomedical Methods for generating an mRNA expression profile from an ecellular mRNA containing blood sample and using the same to identify functional state markers
US20050158708A1 (en) 2001-06-06 2005-07-21 Iris Alroy Methods and compositions related to tagging of membrane surface proteins
CN1753993A (zh) * 2002-12-18 2006-03-29 第三次浪潮技术公司 小核酸的检测
WO2005114192A1 (en) 2004-05-13 2005-12-01 Centre National De La Recherche Scientifique A device for binding a target entity to a bait entity and detection methods using the same
US8021847B2 (en) 2004-06-02 2011-09-20 Proxy Life Science Holdings, Inc. Microvesicle-based compositions and methods
EP1766053A4 (en) * 2004-06-02 2007-12-12 Sourcepharm Inc MICROVESICLES CONTAINING RNA AND METHODS
CA2573164A1 (en) * 2004-07-09 2006-01-26 Chronix Biomedical Detection of nucleic acids to assess risk for bovine spongiform encephalopathy
WO2006102687A1 (en) 2005-03-22 2006-09-28 The Trustees Of Columbia University In The City Of New York A liposome-based microarray and methods of use thereof
AU2006242154B2 (en) * 2005-05-02 2011-11-03 Cold Spring Harbor Laboratory Composition and methods for cancer diagnosis utilizing the mir 17-92 cluster
WO2007084962A2 (en) 2006-01-18 2007-07-26 The Regents Of The University Of California A fluid membrane-based ligand display system for live cell assays and disease diagnosis applications
EP2117305A4 (en) 2007-01-26 2011-03-30 Univ Louisville Res Found MODIFICATION OF EXOXIC COMPONENTS USED AS VACCINE
ATE535805T1 (de) 2007-01-26 2011-12-15 Univ Louisville Res Found Verfahren zur erkennung von autoantikörpern zur diagnostizierung und charakterisierung von erkrankungen
EP2613149B1 (en) * 2007-07-25 2014-09-17 University Of Louisville Research Foundation, Inc. Exosome-associated microRNA as a diagnostic marker
CA2699646A1 (en) 2007-09-14 2009-03-19 The Ohio State University Research Foundation Mirna expression in human peripheral blood microvesicles and uses thereof
CN102301002A (zh) 2008-11-12 2011-12-28 卡里斯生命科学卢森堡控股有限责任公司 使用外来体来确定表现型的方法和系统
US20130288258A1 (en) * 2012-04-27 2013-10-31 University Of Louisville Research Foundation, Inc. METHODS AND COMPOSITIONS FOR DETECTING COLORECTAL CANCER USING MICRO RNAs

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EP2613149A1 (en) 2013-07-10
US8216784B2 (en) 2012-07-10
JP2013188212A (ja) 2013-09-26
AU2008279016A1 (en) 2009-01-29
US20190085410A1 (en) 2019-03-21
CN101755208A (zh) 2010-06-23
JP5383940B2 (ja) 2014-01-08
EP2181332A4 (en) 2011-02-23
CA2676113C (en) 2014-07-08
US20170137892A1 (en) 2017-05-18
ES2420973T3 (es) 2013-08-28
US20100298151A1 (en) 2010-11-25
EP2181332B1 (en) 2013-04-10
US20100151480A1 (en) 2010-06-17
BRPI0807318B1 (pt) 2018-11-13
JP2013102768A (ja) 2013-05-30
EP2181332A1 (en) 2010-05-05
IL200028A (en) 2015-11-30
CN103276062A (zh) 2013-09-04
JP5291241B2 (ja) 2013-09-18
GB2459228A (en) 2009-10-21
WO2009015357A1 (en) 2009-01-29
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IL200028A0 (en) 2010-04-15

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