BRPI0806665A2 - compostos moduladores de receptores de acetilcolina nicotìnicos, composição farmacêutica e uso dos mesmos - Google Patents
compostos moduladores de receptores de acetilcolina nicotìnicos, composição farmacêutica e uso dos mesmos Download PDFInfo
- Publication number
- BRPI0806665A2 BRPI0806665A2 BRPI0806665-5A BRPI0806665A BRPI0806665A2 BR PI0806665 A2 BRPI0806665 A2 BR PI0806665A2 BR PI0806665 A BRPI0806665 A BR PI0806665A BR PI0806665 A2 BRPI0806665 A2 BR PI0806665A2
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- BR
- Brazil
- Prior art keywords
- formula
- mmol
- pyrazol
- added
- phenyl
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/38—Nitrogen atoms
- C07D231/40—Acylated on said nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US88062907P | 2007-01-16 | 2007-01-16 | |
| US60/880,629 | 2007-01-16 | ||
| PCT/IB2008/000090 WO2008087529A1 (en) | 2007-01-16 | 2008-01-16 | Nicotinic acetylcholine receptor modulators |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0806665A2 true BRPI0806665A2 (pt) | 2011-09-06 |
Family
ID=39345157
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0806665-5A BRPI0806665A2 (pt) | 2007-01-16 | 2008-01-16 | compostos moduladores de receptores de acetilcolina nicotìnicos, composição farmacêutica e uso dos mesmos |
Country Status (25)
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CL2008000119A1 (es) | 2007-01-16 | 2008-05-16 | Wyeth Corp | Compuestos derivados de pirazol, antagonistas del receptor nicotinico de acetilcolina; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como demencia senil, alzheimer y esquizofrenia. |
| US20090181953A1 (en) * | 2008-01-14 | 2009-07-16 | Wyeth | Compound forms and uses thereof |
| US20090181952A1 (en) * | 2008-01-14 | 2009-07-16 | Wyeth | Compounds useful as alpha7 nicotinic acetylcholine receptor agonists |
| WO2009091832A1 (en) * | 2008-01-14 | 2009-07-23 | Wyeth | Synthesis of pyrazoles |
| TW201004941A (en) * | 2008-07-16 | 2010-02-01 | Wyeth Corp | Alpha7 nicotinic acetylcholine receptor inhibitors |
| DK2328619T3 (en) | 2008-08-22 | 2017-03-13 | Baxalta GmbH | POLYMER BENZYL CARBONATE DERIVATES |
| EP2406264A4 (en) * | 2009-03-09 | 2012-08-08 | Univ California | SUBSTITUTED HETEROCYCLES AND THEIR USE AS ALLOSTERIC MODULATORS OF NICOTINE AND GABAA RECEPTORS |
| CN102573842A (zh) * | 2009-07-23 | 2012-07-11 | 诺瓦提斯公司 | 氮杂双环烷基衍生物或吡咯烷-2-酮衍生物的用途 |
| JO3250B1 (ar) | 2009-09-22 | 2018-09-16 | Novartis Ag | إستعمال منشطات مستقبل نيكوتينيك أسيتيل كولين ألفا 7 |
| MX343905B (es) * | 2010-11-03 | 2016-11-28 | Dow Agrosciences Llc | Composiciones pesticidas y procesos relacionados a las mismas. |
| US20130231290A1 (en) * | 2010-11-18 | 2013-09-05 | Dignity Health | Methods of diagnosing and treating neurodegenerative diseases |
| WO2014054635A1 (ja) * | 2012-10-02 | 2014-04-10 | 大日本住友製薬株式会社 | イミダゾール誘導体 |
| CN105254564A (zh) * | 2015-10-31 | 2016-01-20 | 丁玉琴 | 一种2-甲基-3,4-二硝基-5-(甲氧苯基)吡唑的合成方法 |
| CN105646358B (zh) * | 2016-03-01 | 2018-03-09 | 苏州艾缇克药物化学有限公司 | 一种3‑氨基‑5‑(4‑甲氧苯基)吡唑的合成方法 |
| CN109748873B (zh) * | 2017-11-08 | 2021-02-02 | 北京嘉林药业股份有限公司 | 化合物及其治疗癌症的用途 |
| TWI805699B (zh) | 2018-03-01 | 2023-06-21 | 日商日本煙草產業股份有限公司 | 甲基內醯胺環化合物及其用途 |
| US10988462B2 (en) | 2018-04-04 | 2021-04-27 | Japan Tobacco Inc. | Pyrazole compounds substituted with heteroaryl and pharmaceutical use thereof |
| GB202006382D0 (en) | 2020-04-30 | 2020-06-17 | Spermatech As | Use |
| CN113925606B (zh) * | 2021-10-25 | 2023-07-07 | 四川大学华西医院 | 一种神经调控导航定位方法、装置和神经调控治疗系统 |
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- 2008-01-15 TW TW097101453A patent/TW200901974A/zh unknown
- 2008-01-16 MX MX2009007615A patent/MX2009007615A/es active IP Right Grant
- 2008-01-16 EA EA200900831A patent/EA016948B1/ru not_active IP Right Cessation
- 2008-01-16 CA CA002675676A patent/CA2675676A1/en not_active Abandoned
- 2008-01-16 US US12/523,189 patent/US8163729B2/en not_active Expired - Fee Related
- 2008-01-16 JP JP2009546013A patent/JP2010515770A/ja active Pending
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- 2008-01-16 BR BRPI0806665-5A patent/BRPI0806665A2/pt not_active IP Right Cessation
- 2008-01-16 KR KR1020097014828A patent/KR20090116707A/ko not_active Application Discontinuation
- 2008-01-16 SA SA08290018A patent/SA08290018B1/ar unknown
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- 2008-01-16 CN CN200880008464XA patent/CN101679287B/zh not_active Expired - Fee Related
- 2008-01-16 AU AU2008206759A patent/AU2008206759B2/en not_active Ceased
- 2008-01-16 UA UAA200907422A patent/UA98317C2/ru unknown
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- 2008-01-16 ZA ZA200904943A patent/ZA200904943B/xx unknown
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Also Published As
| Publication number | Publication date |
|---|---|
| EA016948B1 (ru) | 2012-08-30 |
| US8163729B2 (en) | 2012-04-24 |
| EA200900831A1 (ru) | 2010-02-26 |
| UA98317C2 (ru) | 2012-05-10 |
| JP2010515770A (ja) | 2010-05-13 |
| SA08290018B1 (ar) | 2013-01-17 |
| IL199889A0 (en) | 2010-04-15 |
| KR20090116707A (ko) | 2009-11-11 |
| WO2008087529A1 (en) | 2008-07-24 |
| CN101679287A (zh) | 2010-03-24 |
| EP2118067B1 (en) | 2013-05-08 |
| AU2008206759B2 (en) | 2013-09-05 |
| TW200901974A (en) | 2009-01-16 |
| AR064921A1 (es) | 2009-05-06 |
| HK1142335A1 (en) | 2010-12-03 |
| NZ578411A (en) | 2011-06-30 |
| CO6351782A2 (es) | 2011-12-20 |
| EP2118067A1 (en) | 2009-11-18 |
| US20100029606A1 (en) | 2010-02-04 |
| CN101679287B (zh) | 2013-03-27 |
| CL2008000119A1 (es) | 2008-05-16 |
| AU2008206759A1 (en) | 2008-07-24 |
| ZA200904943B (en) | 2010-09-29 |
| ECSP099490A (es) | 2009-09-29 |
| CR10930A (es) | 2013-02-12 |
| MX2009007615A (es) | 2009-07-27 |
| SV2009003334A (es) | 2010-08-09 |
| CA2675676A1 (en) | 2008-07-24 |
| PA8766201A1 (es) | 2008-11-19 |
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