BRPI0717125B8 - Composto derivado de ftalazinona como forma cristalina a, métodos para obter o mesmo e usos terapêuticos do dito composto - Google Patents

Composto derivado de ftalazinona como forma cristalina a, métodos para obter o mesmo e usos terapêuticos do dito composto

Info

Publication number
BRPI0717125B8
BRPI0717125B8 BRPI0717125A BRPI0717125A BRPI0717125B8 BR PI0717125 B8 BRPI0717125 B8 BR PI0717125B8 BR PI0717125 A BRPI0717125 A BR PI0717125A BR PI0717125 A BRPI0717125 A BR PI0717125A BR PI0717125 B8 BRPI0717125 B8 BR PI0717125B8
Authority
BR
Brazil
Prior art keywords
compound
crystalline form
methods
same
therapeutic uses
Prior art date
Application number
BRPI0717125A
Other languages
English (en)
Portuguese (pt)
Inventor
Allan Menear Keith
Peter Ottridge Anthony
John Londesbrough Derek
Raymond Hallett Michael
Raymond Mullholland Keith
David Pittam John
Dermot Patrick Laffan David
Woodward Ashworth Ian
Francis Jones Martin
Helen Cherryman Janette
Original Assignee
Kudos Pharm Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38952365&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0717125(B8) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Kudos Pharm Ltd filed Critical Kudos Pharm Ltd
Publication of BRPI0717125A2 publication Critical patent/BRPI0717125A2/pt
Publication of BRPI0717125B1 publication Critical patent/BRPI0717125B1/pt
Publication of BRPI0717125B8 publication Critical patent/BRPI0717125B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
    • C07D237/30—Phthalazines
    • C07D237/32—Phthalazines with oxygen atoms directly attached to carbon atoms of the nitrogen-containing ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/502—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Virology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
BRPI0717125A 2006-10-17 2007-10-15 Composto derivado de ftalazinona como forma cristalina a, métodos para obter o mesmo e usos terapêuticos do dito composto BRPI0717125B8 (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US82969406P 2006-10-17 2006-10-17
US60/829,694 2006-10-17
US60/829.694 2006-10-17
PCT/GB2007/003888 WO2008047082A2 (en) 2006-10-17 2007-10-15 Polymorphic form of 4-[3-(4-cyclopropanecarbonyl-piperazine-1-carbonyl)-4-fluoro-benzyl]-2h-phthalazin-1-one

Publications (3)

Publication Number Publication Date
BRPI0717125A2 BRPI0717125A2 (pt) 2013-12-17
BRPI0717125B1 BRPI0717125B1 (pt) 2022-02-08
BRPI0717125B8 true BRPI0717125B8 (pt) 2023-01-10

Family

ID=38952365

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0717125A BRPI0717125B8 (pt) 2006-10-17 2007-10-15 Composto derivado de ftalazinona como forma cristalina a, métodos para obter o mesmo e usos terapêuticos do dito composto

Country Status (34)

Country Link
US (2) US7692006B2 (en10)
EP (3) EP2374800A3 (en10)
JP (3) JP5248513B2 (en10)
KR (2) KR101494910B1 (en10)
CN (3) CN102627611A (en10)
AR (1) AR063320A1 (en10)
AT (1) ATE528296T1 (en10)
AU (1) AU2007311766B2 (en10)
BR (1) BRPI0717125B8 (en10)
CA (2) CA2875147C (en10)
CL (1) CL2007002967A1 (en10)
CO (1) CO6210728A2 (en10)
CY (1) CY1112345T1 (en10)
DK (1) DK2064189T3 (en10)
ES (2) ES2372630T3 (en10)
HR (1) HRP20120007T1 (en10)
IL (2) IL197420A (en10)
ME (1) ME01987B (en10)
MX (1) MX2009004103A (en10)
MY (2) MY147389A (en10)
NO (2) NO341963B1 (en10)
NZ (1) NZ575627A (en10)
PE (1) PE20081175A1 (en10)
PL (1) PL2064189T3 (en10)
PT (1) PT2064189E (en10)
RS (1) RS52112B (en10)
RU (1) RU2465270C3 (en10)
SA (2) SA07280551B1 (en10)
SG (2) SG168523A1 (en10)
SI (1) SI2064189T1 (en10)
TW (1) TWI404716B (en10)
UA (1) UA97494C2 (en10)
UY (1) UY30639A1 (en10)
WO (1) WO2008047082A2 (en10)

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CN105985294B (zh) * 2015-02-11 2020-12-25 四川科伦药物研究院有限公司 一种奥拉帕尼的制备方法
WO2016165650A1 (zh) * 2015-04-17 2016-10-20 苏州晶云药物科技有限公司 奥拉帕尼与尿素的共晶及其制备方法
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