BRPI0606839B8 - Uso de uma composição farmacêutica compreendendo um inibidor irreversível de receptor de fator de crescimento epidérmico (egfr) - Google Patents

Uso de uma composição farmacêutica compreendendo um inibidor irreversível de receptor de fator de crescimento epidérmico (egfr)

Info

Publication number
BRPI0606839B8
BRPI0606839B8 BRPI0606839A BRPI0606839A BRPI0606839B8 BR PI0606839 B8 BRPI0606839 B8 BR PI0606839B8 BR PI0606839 A BRPI0606839 A BR PI0606839A BR PI0606839 A BRPI0606839 A BR PI0606839A BR PI0606839 B8 BRPI0606839 B8 BR PI0606839B8
Authority
BR
Brazil
Prior art keywords
egfr
inhibitor
pharmaceutical composition
growth factor
factor receptor
Prior art date
Application number
BRPI0606839A
Other languages
English (en)
Inventor
Daniel Haber
Winifred Bell Daphne
L Kwak Eunice
E Settleman Jeffrey
G Godin-Heymann Nadia
Rafaella Sordella
Krishna Rabindran Sridhar
Original Assignee
Massachusetts Gen Hospital
Wyeth Corp
Wyeth Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36777922&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0606839(B8) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Massachusetts Gen Hospital, Wyeth Corp, Wyeth Llc filed Critical Massachusetts Gen Hospital
Publication of BRPI0606839A2 publication Critical patent/BRPI0606839A2/pt
Publication of BRPI0606839B1 publication Critical patent/BRPI0606839B1/pt
Publication of BRPI0606839B8 publication Critical patent/BRPI0606839B8/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4706—4-Aminoquinolines; 8-Aminoquinolines, e.g. chloroquine, primaquine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

uso de uma composição farmacêutica compreendendo um inibidor irreversível de receptor de fator de crescimento epidérmico (egfr). a presente invenção é dirigida a métodos para o tratamento de câncer resistente a gefitinib e/ou erlotinib. um indivíduo com câncer é monitorado para a progressão do câncer após tratamento com gefitinib e/ou erlotinib. a progressão do câncer é indicativa de que o câncer é resistente a gefitinib e/ou erlotinib. uma vez que a progressão do câncer é notada, o indivíduo é administrado com uma composição farmacêutica compreendendo um inibidor irreversível de receptor de fator de crescimento epidérmico (egfr). em formas de realização preferidas, o inibidor irreversível de egfr é ekb-569, hki-272 e hki-357.
BRPI0606839A 2005-02-03 2006-02-02 Uso de uma composição farmacêutica compreendendo um inibidor irreversível de receptor de fator de crescimento epidérmico (egfr) BRPI0606839B8 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US64948305P 2005-02-03 2005-02-03
US60/649,483 2005-02-03
US67198905P 2005-04-15 2005-04-15
US60/671,989 2005-04-15
PCT/US2006/003717 WO2006084058A2 (en) 2005-02-03 2006-02-02 Method for treating gefitinib resistant cancer

Publications (3)

Publication Number Publication Date
BRPI0606839A2 BRPI0606839A2 (pt) 2010-03-09
BRPI0606839B1 BRPI0606839B1 (pt) 2021-11-30
BRPI0606839B8 true BRPI0606839B8 (pt) 2021-12-14

Family

ID=36777922

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0606839A BRPI0606839B8 (pt) 2005-02-03 2006-02-02 Uso de uma composição farmacêutica compreendendo um inibidor irreversível de receptor de fator de crescimento epidérmico (egfr)

Country Status (28)

Country Link
US (3) US10603314B2 (pt)
EP (1) EP1848414B1 (pt)
JP (1) JP2008528695A (pt)
KR (1) KR101313702B1 (pt)
CN (7) CN113952338A (pt)
AT (1) ATE504299T1 (pt)
AU (1) AU2006210572B2 (pt)
BR (1) BRPI0606839B8 (pt)
CA (1) CA2596714C (pt)
CY (2) CY1111676T1 (pt)
DE (1) DE602006021142D1 (pt)
DK (1) DK1848414T3 (pt)
ES (1) ES2364495T3 (pt)
FR (1) FR16C1004I1 (pt)
HK (1) HK1105285A1 (pt)
HU (1) HUS1600033I1 (pt)
IL (3) IL184791A (pt)
LU (1) LU93160I2 (pt)
MX (1) MX2007009317A (pt)
NI (1) NI200700185A (pt)
NO (1) NO20074366L (pt)
NZ (1) NZ556673A (pt)
PL (1) PL1848414T3 (pt)
PT (1) PT1848414E (pt)
RU (2) RU2405566C2 (pt)
SI (1) SI1848414T1 (pt)
WO (1) WO2006084058A2 (pt)
ZA (1) ZA200706804B (pt)

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