BRPI0414030A - método para detectar desordens neoplásicas em uma amostra corporal solubilizada - Google Patents

método para detectar desordens neoplásicas em uma amostra corporal solubilizada

Info

Publication number
BRPI0414030A
BRPI0414030A BRPI0414030-3A BRPI0414030A BRPI0414030A BR PI0414030 A BRPI0414030 A BR PI0414030A BR PI0414030 A BRPI0414030 A BR PI0414030A BR PI0414030 A BRPI0414030 A BR PI0414030A
Authority
BR
Brazil
Prior art keywords
cervical
body sample
solubilized
carcinomas
sample
Prior art date
Application number
BRPI0414030-3A
Other languages
English (en)
Inventor
Ruediger Ridder
Anja Reichert
Magnus Von Knebel Doeberitz
Matthias Herkert
Alexander Duwe
Rainer Hipfel
Peter Martin
Original Assignee
Mtm Lab Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mtm Lab Ag filed Critical Mtm Lab Ag
Publication of BRPI0414030A publication Critical patent/BRPI0414030A/pt
Publication of BRPI0414030B1 publication Critical patent/BRPI0414030B1/pt
Publication of BRPI0414030B8 publication Critical patent/BRPI0414030B8/pt

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57411—Specifically defined cancers of cervix
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Oncology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Peptides Or Proteins (AREA)

Abstract

"MéTODO PARA DETECTAR DESORDEM NEOPLáSICAS EM UMA AMOSTRA CORPORAL SOLUBILIZADA". A presente invenção se refere a um método para diagnóstico precoce de desordens neoplásicas tais como cânceres, bem como seus estágios precursores, particularmente cânceres do trato respiratório, sistema urinário, trato reprodutivo, câncer associado com infecção por HPV ou câncer do trato anogenital, a partir de amostras solubilizadas. A invenção está também direcionada para kits de teste úteis para essa finalidade, bem como dispositivos de diagnóstico in vitro. O desenvolvimento desses kits e dispositivos de diagnóstico in vitro para a finalidade acima também é um aspecto da presente invenção.
BRPI0414030A 2003-08-25 2004-08-20 método para detectar desordens neoplásicas, dispositivos de diagnóstico in vitro, dispositivo híbrido de captura, uso de uma fase sólida, métodos para desenvolver kits e métodos para avaliação de diagnóstico de desordens neoplásicas BRPI0414030B8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03103218A EP1507148B1 (en) 2003-08-25 2003-08-25 Method for detecting carcinomas in a solubilized cervical body sample
PCT/EP2004/051872 WO2005088311A1 (en) 2003-08-25 2004-08-20 Method for detecting neoplastic disorders in a solubilized body sample

Publications (3)

Publication Number Publication Date
BRPI0414030A true BRPI0414030A (pt) 2007-01-23
BRPI0414030B1 BRPI0414030B1 (pt) 2017-04-04
BRPI0414030B8 BRPI0414030B8 (pt) 2021-07-27

Family

ID=33560881

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0414030A BRPI0414030B8 (pt) 2003-08-25 2004-08-20 método para detectar desordens neoplásicas, dispositivos de diagnóstico in vitro, dispositivo híbrido de captura, uso de uma fase sólida, métodos para desenvolver kits e métodos para avaliação de diagnóstico de desordens neoplásicas

Country Status (14)

Country Link
US (1) US7932047B2 (pt)
EP (2) EP1507148B1 (pt)
JP (2) JP5619336B2 (pt)
CN (1) CN1836166B (pt)
AT (2) ATE289685T1 (pt)
AU (1) AU2004317284B2 (pt)
BR (1) BRPI0414030B8 (pt)
CA (1) CA2528490C (pt)
DE (2) DE60300339T2 (pt)
ES (1) ES2342535T3 (pt)
HK (1) HK1092219A1 (pt)
MX (1) MXPA05013903A (pt)
RU (1) RU2405158C2 (pt)
WO (2) WO2005088311A1 (pt)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7601497B2 (en) 2000-06-15 2009-10-13 Qiagen Gaithersburg, Inc. Detection of nucleic acids by target-specific hybrid capture method
EP1510820B1 (en) * 2003-08-25 2010-03-17 MTM Laboratories AG Method for detecting medically relevant conditions in a solubilized LBC sample
US7972776B2 (en) * 2005-11-15 2011-07-05 Oncohealth Corporation Protein chips for HPV detection
WO2007134252A1 (en) 2006-05-11 2007-11-22 Becton, Dickinson And Company Method of protein extraction from cells
US8968995B2 (en) * 2008-11-12 2015-03-03 Oncohealth Corp. Detection, screening, and diagnosis of HPV-associated cancers
WO2010129821A1 (en) * 2009-05-07 2010-11-11 Oncohealth Corporation Identification of high grade or ≥cin2 for early stages and late stages detection, screening, and diagnosis of human papillomavirus (hpv) and hpv-associated cancers
US20100003704A1 (en) * 2008-06-13 2010-01-07 Shuling Cheng IN SITU detection of early stages and late stages HPV infection
US9207240B2 (en) 2007-11-14 2015-12-08 Arbor Vita Corporation Method of efficient extraction of protein from cells
ES2453161T3 (es) 2008-01-25 2014-04-04 Berg Llc Sistema de ensayo para la evaluación de la oncogenicidad, progresión tumoral y eficacia de un tratamiento
US20090204009A1 (en) * 2008-02-07 2009-08-13 Los Alamos National Security Medical device system and related methods for diagnosing abnormal medical conditions based on in-vivo optical properties of tissue
DK2356460T3 (en) 2008-09-04 2018-03-26 Ventana Med Syst Inc PROCEDURE FOR Predicting Tumor Progression Risk
TWI419974B (zh) * 2008-10-27 2013-12-21 Qiagen Gaithersburg Inc 於自動平台上之快速結果雜交捕捉法
CN101487845B (zh) * 2009-02-19 2013-01-02 苏州海路生物技术有限公司 大便标本自动检测仪
JP5738278B2 (ja) 2009-05-01 2015-06-24 キアジェン ゲイサーズバーグ インコーポレイテッド 試料中のｒｎａスプライシング形態を検出するための非標的増幅法
WO2011084598A1 (en) 2010-01-08 2011-07-14 Oncohealth Corporation High throughput cell-based hpv immunoassays for diagnosis and screening of hpv-associated cancers
BR112012018545A2 (pt) 2010-01-29 2016-05-03 Qiagen Gaithersburg Inc método de determinação e confirmação da presença de um hpv em uma amostra
AU2011210734B2 (en) 2010-01-29 2017-02-09 Qiagen Gaithersburg, Inc. Methods and compositions for sequence-specific purification and multiplex analysis of nucleic acids
WO2011146629A2 (en) 2010-05-19 2011-11-24 Qiagen Gaithersburg Inc. Methods and compositions for sequence-specific purification and multiplex analysis of nucleic acids
AU2011258501B2 (en) 2010-05-25 2016-07-07 Qiagen Gaithersburg, Inc. Fast results hybrid capture assay and associated strategically-truncated probes
JP5841941B2 (ja) * 2010-06-17 2016-01-13 国立大学法人 岡山大学 ｍｉｃｒｏＲＮＡ標的遺伝子検出用キット及びｍｉｃｒｏＲＮＡ標的遺伝子の検出方法
GB201014335D0 (en) * 2010-08-27 2010-10-13 Forensic Science Service Ltd Improvements in and relating to analysis
SG10201506959SA (en) 2010-09-03 2015-10-29 Stemcentrx Inc Novel modulators and methods of use
CN102033056B (zh) * 2010-10-14 2012-05-30 中国科学院化学研究所 抑制膜蛋白受体聚集的抗癌药物鉴定方法
US9885092B2 (en) 2011-02-24 2018-02-06 Qiagen Gaithersburg Inc. Materials and methods for detection of HPV nucleic acids
CA2855971C (en) * 2011-11-15 2022-01-04 Elizabeth Franzmann Methods for detecting human papillomavirus and providing prognosis for head and neck squamous cell carcinoma
RU2508542C1 (ru) * 2012-07-16 2014-02-27 Полина Михайловна Шварцбурд Экспресс-способ определения риска злокачественности клеток
RU2535071C1 (ru) * 2013-04-09 2014-12-10 Государственное бюджетное образовательное учреждение высшего профессионального образования "Ивановская государственная медицинская академия" Министерства здравоохранения Российской Федерации Способ диагностики недифференцированной дисплазии соединительной ткани у женщин с потерей беременности в анамнезе
MX2016001439A (es) * 2013-07-31 2016-07-05 Univ Miami Composiciones y metodos para identificar un riesgo de cancer en un sujeto.
WO2015147370A1 (en) * 2014-03-28 2015-10-01 Seegene, Inc. Detection of target nucleic acid sequences using different detection temperatures
RU2558987C1 (ru) * 2014-04-21 2015-08-10 Государственное бюджетное образовательное учреждение высшего профессионального образования "Самарский государственный медицинский университет" Министерства здравоохранения Российской Федерации Способ диагностики степени тяжести недифференцированной дисплазии соединительной ткани у женщин репродуктивного возраста
ES2911415T3 (es) 2015-06-08 2022-05-19 Arquer Diagnostics Ltd Métodos y kits
EP3304082B1 (en) 2015-06-08 2020-05-13 Arquer Diagnostics Limited Methods for analysing a urine sample
CN106610434A (zh) * 2016-02-26 2017-05-03 弗雷米德生物医药技术（天津）有限公司 一种hpv16型e7蛋白的elisa检测试剂盒
RU2680930C2 (ru) * 2017-03-24 2019-02-28 федеральное государственное бюджетное образовательное учреждение высшего образования "Северный государственный медицинский университет" Министерства здравоохранения Российской Федерации Способ забора материала для цитологического исследования при опухолевых заболеваниях поджелудочной железы, печени и желчевыводящих путей
CN107748265A (zh) * 2017-09-29 2018-03-02 中南大学湘雅医院 Cdc6和ki67在制备癌症放疗抵抗的诊断标记物中的应用
EP3732301A4 (en) * 2017-12-29 2022-02-09 Vertex Pharmaceuticals Incorporated CANCER TREATMENT METHODS USING AN ATR INHIBITOR
US11230729B2 (en) 2018-04-20 2022-01-25 Inanna Diagnostics, Inc Methods and devices for obtaining cellular and DNA material from human female reproductive system
CN109781977B (zh) * 2019-01-09 2022-03-29 首都医科大学附属北京安定医院 IL15Rα以及相关膜蛋白检测试剂盒及其应用
RU2707099C1 (ru) * 2019-04-24 2019-11-22 Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр онкологии имени Н.Н. Петрова" Министерства здравоохранения Российской Федерации Способ скрининга злокачественных опухолей органов грудной полости
MX2019005940A (es) * 2019-05-21 2019-10-11 Atso Corp Affairs S A De C V Biomarcadores relacionados a cancer.

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4281061A (en) * 1979-07-27 1981-07-28 Syva Company Double antibody for enhanced sensitivity in immunoassay
EP0584264A1 (en) 1991-05-16 1994-03-02 Cold Spring Harbor Laboratory D-type cyclin and uses related thereto
US5889169A (en) * 1991-05-16 1999-03-30 Cold Spring Harbor Laboratory Cell cycle regulatory protein p16 gene
ATE184399T1 (de) * 1991-12-13 1999-09-15 Bion Diagnostic Sciences Inc Agglutierungsassays und kolloide farbstoffe verwendende testsätze
US6316208B1 (en) * 1994-01-07 2001-11-13 Memorial Sloan-Kettering Cancer Center Methods for determining isolated p27 protein levels and uses thereof
EP0702730A4 (en) * 1994-03-18 1997-05-07 Univ Utah Res Found COREWAY MUTTATIONS IN THE MTS GENE AND METHODS FOR DETECTING AN APPROXIMATION OF CANCER IN THE MTS GENE
US5989815A (en) * 1994-03-18 1999-11-23 University Of Utah Research Foundation Methods for detecting predisposition to cancer at the MTS gene
US6060301A (en) * 1994-03-18 2000-05-09 Myriad Genetics, Inc. Vector containing MTS1E1β gene
CA2164167A1 (en) 1994-12-20 1996-06-21 Izak Bahar Assay normalization method
US6033847A (en) * 1995-02-06 2000-03-07 St. Jude Children's Research Hospital InK4c-p18 and InK4d-p19, inhibitors of cyclin-dependent kinases CDK4 and CDK6, and uses thereof
US5843756A (en) * 1995-06-07 1998-12-01 Myriad Genetics, Inc. Mouse MTSI gene
US6403383B1 (en) * 1996-03-11 2002-06-11 American Bio Medica Corp. Diagnostic test kit for immunological assays of fluid samples
US5976799A (en) * 1996-03-21 1999-11-02 The Board Of Trustees Of The University Of Arkansas Early detection of ovarian carcinoma using P16 gene products
US5858683A (en) * 1996-08-30 1999-01-12 Matritech, Inc. Methods and compositions for the detection of cervical cancer
AU8403098A (en) 1997-07-15 1999-02-10 Deaconess Hospital Reagents and methods for diagnosis and prognosis of proliferative disor ders
US6090579A (en) * 1997-08-12 2000-07-18 Smithkline Beecham Corporation Human SDR2 cDNA clone
US6355424B1 (en) * 1997-12-12 2002-03-12 Digene Corporation Assessment of human papillomavirus-related disease
US20010051364A1 (en) * 1997-12-23 2001-12-13 Francis Michon Procedures for the extraction and isolation of bacterial capsular polysaccharides for use as vaccines or linked to proteins as conjugate vaccines
US7399589B2 (en) * 1998-02-06 2008-07-15 Digene Corporation Immunological detection of RNA:DNA hybrids on microarrays
US6686151B1 (en) 1998-02-06 2004-02-03 Digene Corporation Immunological detection of RNA:DNA hybrids on microarrays
US5994079A (en) * 1998-02-06 1999-11-30 Digene Corporation Direct detection of RNA mediated by reverse transcriptase lacking RNAse H function
US6576420B1 (en) * 1998-06-23 2003-06-10 Regents Of The University Of California Method for early diagnosis of, and determination of prognosis in, cancer
DE19829473C2 (de) * 1998-07-01 2000-08-10 Magnus Von Knebel Doeberitz Ch Verfahren zur frühen Diagnose von Carcinomen
US7306926B2 (en) * 1998-07-01 2007-12-11 Mtm Laboratories Ag Method for detecting carcinomas in a solubilized cervical body sample
US6593084B2 (en) * 1998-10-13 2003-07-15 Robert E. Bird Carcinogen assay
WO2000031538A1 (en) * 1998-11-23 2000-06-02 Praxsys Biosystems, Inc. Improved lateral flow assays
SE515668C2 (sv) * 1999-02-22 2001-09-17 Quantovir Ab Metod och kit för tidig förutsägelse av cancer
DE10014685B4 (de) * 2000-03-24 2004-07-01 Schubert, Walter, Dr. Verfahren zur Identifizierung von zellspezifischen Zielstrukturen
GB0018140D0 (en) 2000-07-24 2000-09-13 Medical Res Council Screening for abnormalities
DE10063179A1 (de) * 2000-12-18 2002-06-20 Bayer Ag Verfahren zur spezifischen Detektion von Tumorzellen und ihren Vorstufen in Gebärmutterhalsabstrichen durch simultane Messung von mindestens zwei verschiedenen molekularen Markern
ITRM20010363A1 (it) * 2001-06-25 2001-09-24 Franco Castelmani Gancio adattivo applicato ad un generatore di vivrazioni sinusoidali.
NZ533703A (en) * 2002-01-07 2006-05-26 Norchip As Method for detecting human papillomavirus mRNA
EP1333278B1 (en) * 2002-02-01 2004-03-10 MTM molecular tools in medicine Methods for monitoring and prognosis of disease course of gastrointestinal tumors
ATE261126T1 (de) 2002-08-01 2004-03-15 Mtm Lab Ag Verfahren für lösung-basierte diagnose
US7361460B2 (en) * 2003-04-11 2008-04-22 Digene Corporation Approach to molecular diagnosis of human papillomavirus-related diseases

Also Published As

Publication number Publication date
JP2012032412A (ja) 2012-02-16
RU2405158C2 (ru) 2010-11-27
EP1664788A1 (en) 2006-06-07
JP5677270B2 (ja) 2015-02-25
US7932047B2 (en) 2011-04-26
ATE289685T1 (de) 2005-03-15
EP1507148A1 (en) 2005-02-16
WO2005084103A2 (en) 2005-09-15
CA2528490A1 (en) 2005-09-22
BRPI0414030B8 (pt) 2021-07-27
CN1836166B (zh) 2010-05-26
DE60300339T2 (de) 2006-04-13
AU2004317284B2 (en) 2009-11-05
EP1507148B1 (en) 2005-02-23
US20070190529A1 (en) 2007-08-16
CN1836166A (zh) 2006-09-20
WO2005088311A1 (en) 2005-09-22
BRPI0414030B1 (pt) 2017-04-04
CA2528490C (en) 2015-11-03
MXPA05013903A (es) 2006-03-09
ATE461449T1 (de) 2010-04-15
AU2004317284A1 (en) 2005-09-22
JP2007503208A (ja) 2007-02-22
ES2342535T3 (es) 2010-07-08
DE60300339D1 (de) 2005-03-31
HK1092219A1 (en) 2007-02-02
DE602004026014D1 (de) 2010-04-29
JP5619336B2 (ja) 2014-11-05
RU2006101395A (ru) 2006-06-10

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