BRPI0411882A - partìculas de liberação prolongada de medicamentos e método para preparar as mesmas - Google Patents
partìculas de liberação prolongada de medicamentos e método para preparar as mesmasInfo
- Publication number
- BRPI0411882A BRPI0411882A BRPI0411882-0A BRPI0411882A BRPI0411882A BR PI0411882 A BRPI0411882 A BR PI0411882A BR PI0411882 A BRPI0411882 A BR PI0411882A BR PI0411882 A BRPI0411882 A BR PI0411882A
- Authority
- BR
- Brazil
- Prior art keywords
- theophylline
- preparing
- particles
- release
- drug release
- Prior art date
Links
- 239000002245 particle Substances 0.000 title abstract 4
- 239000003814 drug Substances 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 3
- 230000002035 prolonged effect Effects 0.000 title abstract 3
- 229940079593 drug Drugs 0.000 title abstract 2
- ZFXYFBGIUFBOJW-UHFFFAOYSA-N theophylline Chemical compound O=C1N(C)C(=O)N(C)C2=C1NC=N2 ZFXYFBGIUFBOJW-UHFFFAOYSA-N 0.000 abstract 6
- 239000007771 core particle Substances 0.000 abstract 3
- 229960000278 theophylline Drugs 0.000 abstract 3
- 239000000203 mixture Substances 0.000 abstract 2
- 239000001856 Ethyl cellulose Substances 0.000 abstract 1
- 239000011248 coating agent Substances 0.000 abstract 1
- 238000000576 coating method Methods 0.000 abstract 1
- 235000014113 dietary fatty acids Nutrition 0.000 abstract 1
- 238000004090 dissolution Methods 0.000 abstract 1
- 229920001249 ethyl cellulose Polymers 0.000 abstract 1
- 235000019325 ethyl cellulose Nutrition 0.000 abstract 1
- -1 ethyl cellulose fatty acid ester Chemical class 0.000 abstract 1
- 238000013265 extended release Methods 0.000 abstract 1
- 239000000194 fatty acid Substances 0.000 abstract 1
- 229930195729 fatty acid Natural products 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 239000011159 matrix material Substances 0.000 abstract 1
- 229940126601 medicinal product Drugs 0.000 abstract 1
- 229920000223 polyglycerol Polymers 0.000 abstract 1
- 239000000843 powder Substances 0.000 abstract 1
- 238000013268 sustained release Methods 0.000 abstract 1
- 239000012730 sustained-release form Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/501—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
- A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
- A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Inorganic Chemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pulmonology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2003184040 | 2003-06-27 | ||
| PCT/JP2004/008824 WO2005000312A1 (ja) | 2003-06-27 | 2004-06-17 | 薬物徐放性粒子及びその製法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0411882A true BRPI0411882A (pt) | 2006-08-29 |
Family
ID=33549598
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0411882-0A BRPI0411882A (pt) | 2003-06-27 | 2004-06-17 | partìculas de liberação prolongada de medicamentos e método para preparar as mesmas |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US8734843B2 (https=) |
| EP (1) | EP1640006A4 (https=) |
| JP (1) | JP4592590B2 (https=) |
| KR (1) | KR101096357B1 (https=) |
| CN (2) | CN1812793A (https=) |
| AR (1) | AR045893A1 (https=) |
| AU (1) | AU2004251541B2 (https=) |
| BR (1) | BRPI0411882A (https=) |
| CA (1) | CA2529475C (https=) |
| MX (1) | MXPA05014194A (https=) |
| MY (1) | MY145784A (https=) |
| TW (1) | TW200505485A (https=) |
| WO (1) | WO2005000312A1 (https=) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040146553A1 (en) * | 2002-12-23 | 2004-07-29 | Aventis Pharma S.A. | Compositions for oral administration of active principles requiring masking of taste |
| WO2006059716A1 (ja) * | 2004-12-03 | 2006-06-08 | Takeda Pharmaceutical Company Limited | 固形製剤 |
| ZA200805793B (en) * | 2005-12-22 | 2009-11-25 | Otsuka Pharma Co Ltd | Method of producing drug-containing wax matrix particles, extruder to be used in the method and sustained-release preparation containing cilostazol |
| CA2634059C (en) * | 2005-12-22 | 2015-11-24 | Otsuka Pharmaceutical Co., Ltd. | Method of producing drug-containing wax matrix particles, extruder to be used in the method and sustained-release preparation containing cilostazol |
| CA2681802C (en) * | 2007-02-16 | 2015-12-08 | Elevance Renewable Sciences, Inc. | Wax compositions and methods of preparing wax compositions |
| US8142803B2 (en) | 2007-03-22 | 2012-03-27 | Magceutics, Inc. | Magnesium compositions and uses thereof for neurological disorders |
| EP2448413A4 (en) | 2009-07-01 | 2013-02-13 | Magceutics Inc | SLOW RELEASE MAGNESIUM COMPOSITION AND USES THEREOF |
| JP5870023B2 (ja) * | 2010-02-22 | 2016-02-24 | 第一三共株式会社 | 経口用徐放性固形製剤 |
| ES2706880T3 (es) | 2010-02-22 | 2019-04-01 | Daiichi Sankyo Co Ltd | Preparación sólida de liberación sostenida para uso oral |
| CA2883077C (en) | 2012-09-03 | 2017-03-07 | Daiichi Sankyo Company, Limited | Hydromorphone hydrochloride-containing oral sustained-release pharmaceutical composition |
| CN107050023A (zh) * | 2017-01-13 | 2017-08-18 | 北京顺慈医药科技有限公司 | 一种盐酸小檗碱的制剂及遮盖药物不良味道的制剂方法 |
| JP7293131B2 (ja) | 2017-12-28 | 2023-06-19 | 住友ファーマ株式会社 | 新規微粒子コーティング（薬物含有中空粒子及びその製法） |
| CN111566130B (zh) | 2018-01-05 | 2023-01-24 | 凸版印刷株式会社 | 复合颗粒、复合颗粒的制造方法、干燥粉体以及成型用树脂组合物 |
| EP3786231A4 (en) | 2018-04-27 | 2021-06-09 | Toppan Printing Co., Ltd. | DELAYED RELEASE COMPOSITE PARTICLES, METHOD FOR MANUFACTURING DELAYED RELEASE COMPOSITE PARTICLES, DRY POWDER AND WALLPAPER |
| CN108904451A (zh) * | 2018-07-27 | 2018-11-30 | 广州柏赛罗药业有限公司 | 缓释制剂 |
| JP6618595B1 (ja) * | 2018-10-16 | 2019-12-11 | 佐藤薬品工業株式会社 | カフェインおよびヒヨスチアミン含有医薬組成物およびその製造方法 |
| US20210361581A1 (en) * | 2018-10-22 | 2021-11-25 | Ioi Oleo Gmbh | Additive for a powder material intended for compaction into shaped bodies |
| CN114209887B (zh) * | 2021-08-24 | 2023-03-03 | 杭州协合医疗用品有限公司 | 一种含可控降解聚酯微球的注射用凝胶 |
| CN113877000B (zh) * | 2021-10-13 | 2023-01-24 | 科笛生物医药(无锡)有限公司 | 注射用微球组合物及其应用 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3264131A (en) * | 1964-05-11 | 1966-08-02 | Polymer Corp | Process for fusion coating and materials used therein |
| JPH0647531B2 (ja) * | 1986-02-06 | 1994-06-22 | 第一製薬株式会社 | 徐放性粒状物の製造法 |
| JP2893191B2 (ja) | 1988-11-08 | 1999-05-17 | 武田薬品工業株式会社 | 放出制御性マトリックス剤 |
| JPH03124063A (ja) * | 1989-10-06 | 1991-05-27 | Ricoh Co Ltd | イメージセンサ |
| JP3078859B2 (ja) | 1990-02-23 | 2000-08-21 | 武田薬品工業株式会社 | 安定な放出制御性製剤用コーティング剤 |
| IE65045B1 (en) * | 1990-04-28 | 1995-10-04 | Takeda Chemical Industries Ltd | Granulated preparations and method of producing the same |
| JP2915590B2 (ja) | 1991-02-15 | 1999-07-05 | 第一製薬株式会社 | マスクされた粒状物 |
| JP3130058B2 (ja) | 1991-02-15 | 2001-01-31 | 第一製薬株式会社 | マスクされた粒状物 |
| US5359170A (en) | 1992-02-18 | 1994-10-25 | At&T Global Information Solutions Company | Apparatus for bonding external leads of an integrated circuit |
| ES2194863T3 (es) | 1992-11-30 | 2003-12-01 | Kv Pharm Co | Materiales farmaceuticos con enmascarado de sabor. |
| TW282403B (https=) * | 1993-08-26 | 1996-08-01 | Takeda Pharm Industry Co Ltd | |
| KR100417746B1 (ko) | 1995-07-21 | 2004-05-31 | 다이이찌 세이야꾸 가부시기가이샤 | 입상제제의제조방법 |
| EP0799616A1 (en) * | 1996-04-01 | 1997-10-08 | Takeda Chemical Industries, Ltd. | Oral composition comprising a fumagillol derivative |
| JP3611456B2 (ja) | 1997-09-30 | 2005-01-19 | 日研化学株式会社 | テオフィリン徐放性錠剤 |
| JP3372242B2 (ja) | 1999-08-04 | 2003-01-27 | 沢井製薬株式会社 | 徐放性微粒子製剤及びその製造方法 |
| JP2001055342A (ja) * | 1999-08-17 | 2001-02-27 | Sakamoto Yakuhin Kogyo Co Ltd | 錠剤、錠菓用滑沢剤 |
| AU781058B2 (en) * | 1999-08-31 | 2005-05-05 | Grunenthal Gmbh | Delayed-action form of administration containing tramadol saccharinate |
| US6537671B2 (en) * | 2000-12-05 | 2003-03-25 | Alpha Coating Technologies, Llc | Coating powders having enhanced electrostatic chargeability |
| JP2002179571A (ja) | 2000-12-11 | 2002-06-26 | Nikken Chem Co Ltd | 小型徐放性錠剤 |
| JP2002226304A (ja) | 2001-01-31 | 2002-08-14 | Mitsui Chemicals Inc | 徐放型微粒子の製造方法 |
| JP4310605B2 (ja) * | 2001-05-25 | 2009-08-12 | 大塚製薬株式会社 | 医薬用組成物 |
| KR100913281B1 (ko) * | 2002-02-21 | 2009-08-21 | 오츠카 세이야쿠 가부시키가이샤 | 서방 제제 및 그의 제조 방법 |
-
2004
- 2004-06-17 US US10/561,444 patent/US8734843B2/en not_active Expired - Fee Related
- 2004-06-17 WO PCT/JP2004/008824 patent/WO2005000312A1/ja not_active Ceased
- 2004-06-17 MX MXPA05014194A patent/MXPA05014194A/es active IP Right Grant
- 2004-06-17 EP EP04746293A patent/EP1640006A4/en not_active Withdrawn
- 2004-06-17 CN CNA2004800181177A patent/CN1812793A/zh active Pending
- 2004-06-17 CN CN2008100067985A patent/CN101219115B/zh not_active Expired - Fee Related
- 2004-06-17 KR KR1020057025130A patent/KR101096357B1/ko not_active Expired - Fee Related
- 2004-06-17 AU AU2004251541A patent/AU2004251541B2/en not_active Ceased
- 2004-06-17 BR BRPI0411882-0A patent/BRPI0411882A/pt not_active Application Discontinuation
- 2004-06-17 JP JP2005511026A patent/JP4592590B2/ja not_active Expired - Fee Related
- 2004-06-17 CA CA2529475A patent/CA2529475C/en not_active Expired - Fee Related
- 2004-06-23 TW TW093118070A patent/TW200505485A/zh not_active IP Right Cessation
- 2004-06-24 MY MYPI20042492A patent/MY145784A/en unknown
- 2004-06-25 AR ARP040102231A patent/AR045893A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR101096357B1 (ko) | 2011-12-20 |
| HK1118484A1 (en) | 2009-02-13 |
| MY145784A (en) | 2012-04-30 |
| CA2529475A1 (en) | 2005-01-06 |
| AR045893A1 (es) | 2005-11-16 |
| CA2529475C (en) | 2012-08-07 |
| TW200505485A (en) | 2005-02-16 |
| AU2004251541B2 (en) | 2010-03-04 |
| MXPA05014194A (es) | 2006-02-24 |
| EP1640006A4 (en) | 2012-04-04 |
| US20070098843A1 (en) | 2007-05-03 |
| AU2004251541A1 (en) | 2005-01-06 |
| WO2005000312A1 (ja) | 2005-01-06 |
| JPWO2005000312A1 (ja) | 2006-08-03 |
| WO2005000312A8 (ja) | 2005-02-24 |
| KR20060026071A (ko) | 2006-03-22 |
| US8734843B2 (en) | 2014-05-27 |
| CN101219115A (zh) | 2008-07-16 |
| TWI333858B (https=) | 2010-12-01 |
| CN101219115B (zh) | 2012-09-19 |
| JP4592590B2 (ja) | 2010-12-01 |
| EP1640006A1 (en) | 2006-03-29 |
| CN1812793A (zh) | 2006-08-02 |
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