BRPI0310032B8 - derivados de benzoxazina, seus usos e seus processos de produção, e composição farmacêutica - Google Patents

derivados de benzoxazina, seus usos e seus processos de produção, e composição farmacêutica

Info

Publication number
BRPI0310032B8
BRPI0310032B8 BRPI0310032A BR0310032A BRPI0310032B8 BR PI0310032 B8 BRPI0310032 B8 BR PI0310032B8 BR PI0310032 A BRPI0310032 A BR PI0310032A BR 0310032 A BR0310032 A BR 0310032A BR PI0310032 B8 BRPI0310032 B8 BR PI0310032B8
Authority
BR
Brazil
Prior art keywords
pharmaceutical composition
production processes
benzoxazine derivatives
compound
formula
Prior art date
Application number
BRPI0310032A
Other languages
English (en)
Portuguese (pt)
Other versions
BR0310032A (pt
BRPI0310032B1 (pt
Inventor
Berger Jacob
Douglas Clark Robin
Zhao Shu-Hai
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of BR0310032A publication Critical patent/BR0310032A/pt
Publication of BRPI0310032B1 publication Critical patent/BRPI0310032B1/pt
Publication of BRPI0310032B8 publication Critical patent/BRPI0310032B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
    • C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D267/02—Seven-membered rings
    • C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D267/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D267/14—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
BRPI0310032A 2002-05-13 2003-05-05 derivados de benzoxazina, seus usos e seus processos de produção, e composição farmacêutica BRPI0310032B8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US37800302P 2002-05-13 2002-05-13
PCT/EP2003/004671 WO2003095434A1 (en) 2002-05-13 2003-05-05 Benzoxazine derivatives as 5-ht6 modulators and uses thereof

Publications (3)

Publication Number Publication Date
BR0310032A BR0310032A (pt) 2005-02-15
BRPI0310032B1 BRPI0310032B1 (pt) 2019-01-08
BRPI0310032B8 true BRPI0310032B8 (pt) 2021-05-25

Family

ID=29420358

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0310032A BRPI0310032B8 (pt) 2002-05-13 2003-05-05 derivados de benzoxazina, seus usos e seus processos de produção, e composição farmacêutica

Country Status (37)

Country Link
US (4) US6867204B2 (ru)
EP (1) EP1506179B1 (ru)
JP (1) JP4307377B2 (ru)
KR (1) KR100636475B1 (ru)
CN (1) CN100429206C (ru)
AR (1) AR039988A1 (ru)
AT (1) ATE316523T1 (ru)
AU (1) AU2003233231B2 (ru)
BR (1) BRPI0310032B8 (ru)
CA (1) CA2485136C (ru)
DE (1) DE60303376T2 (ru)
DK (1) DK1506179T3 (ru)
EA (1) EA009982B1 (ru)
EC (1) ECSP045420A (ru)
EG (1) EG25683A (ru)
ES (1) ES2256744T3 (ru)
GT (1) GT200300108A (ru)
HK (1) HK1080846A1 (ru)
HR (1) HRP20041030B1 (ru)
IL (1) IL164928A0 (ru)
JO (1) JO2413B1 (ru)
MA (1) MA27118A1 (ru)
MX (1) MXPA04011254A (ru)
MY (1) MY139612A (ru)
NO (1) NO329380B1 (ru)
NZ (1) NZ536230A (ru)
PA (1) PA8573501A1 (ru)
PE (1) PE20040757A1 (ru)
PL (1) PL211057B1 (ru)
PT (1) PT1506179E (ru)
RS (1) RS51042B (ru)
TN (1) TNSN04225A1 (ru)
TW (1) TWI258479B (ru)
UA (1) UA76877C2 (ru)
UY (1) UY27803A1 (ru)
WO (1) WO2003095434A1 (ru)
ZA (1) ZA200408783B (ru)

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ES2307919T3 (es) 2002-03-27 2008-12-01 Glaxo Group Limited Derivados de quinolina y su uso como ligandos de 5-ht6.
WO2003095434A1 (en) * 2002-05-13 2003-11-20 F. Hoffmann-La Roche Ag Benzoxazine derivatives as 5-ht6 modulators and uses thereof
JP4401297B2 (ja) * 2002-11-08 2010-01-20 エフ．ホフマン−ラ ロシュ アーゲー 置換ベンゾオキサジノン及びその使用
DK1558582T3 (da) 2003-07-22 2006-05-08 Arena Pharm Inc Diaryl og arylheteroarylureaderivater som modulatorer af aktiviteten af 5-HT2A-serotoninreceptoren anvendelige til profylakse eller behandling af forstyrrelser relateret dertil
JP4527730B2 (ja) 2003-12-09 2010-08-18 エフ．ホフマン−ラ ロシュ アーゲー ベンゾオキサジン誘導体及びその使用
CN1909909B (zh) * 2004-01-16 2010-12-15 弗·哈夫曼-拉罗切有限公司 作为5-羟色胺受体(5-ht)调节剂用于治疗中枢神经系统疾病的1-苄基-5-哌嗪-1-基-3，4二氢-1h-喹唑啉-2-酮衍生物和各个1h-苯并(1，2，6)噻二嗪-2，2-二氧化物和1，4-二氢-苯并(d)(1，3)*嗪-2-酮衍生物
JP2007536302A (ja) * 2004-05-05 2007-12-13 エフ．ホフマン−ラ　ロシュ　アーゲー ５−ｈｔ６受容体、５−ｈｔ２ａ受容体、又はその両方の調節に有用なアリールスルホニルベンゾジオキサン類
US7713954B2 (en) * 2004-09-30 2010-05-11 Roche Palo Alto Llc Compositions and methods for treating cognitive disorders
ES2359725T3 (es) * 2004-09-30 2011-05-26 F. Hoffmann-La Roche Ag Composiciones y métodos para el tratamiento de trastornos cognitivos.
US7378415B2 (en) * 2004-09-30 2008-05-27 Roche Palo Alto Llc Benzoxazine and quinoxaline derivatives and uses thereof
ATE477248T1 (de) * 2004-09-30 2010-08-15 Hoffmann La Roche Benzoxazin- und chinoxalinderivate und anwendungen
WO2009074607A1 (en) 2007-12-12 2009-06-18 Glaxo Group Limited Combinations comprising 3-phenylsulfonyl-8-piperazinyl-1yl-quinoline
WO2009123714A2 (en) 2008-04-02 2009-10-08 Arena Pharmaceuticals, Inc. Processes for the preparation of pyrazole derivatives useful as modulators of the 5-ht2a serotonin receptor
US9126946B2 (en) 2008-10-28 2015-09-08 Arena Pharmaceuticals, Inc. Processes useful for the preparation of 1-[3-(4-bromo-2-methyl-2H-pyrazol-3-yl)-4-methoxy-phenyl]-3-(2,4-difluoro-phenyl)urea and crystalline forms related thereto
AR078770A1 (es) * 2009-10-27 2011-11-30 Elara Pharmaceuticals Gmbh Derivados de dihidrobenzo oxacinas y tiazinas, composiciones farmaceuticas que los contienen y uso de los mismos para el tratamiento de enfermedades inflamatorias e hiperproliferativas.
KR101293384B1 (ko) * 2010-10-13 2013-08-05 주식회사 대웅제약 신규 피리딜 벤조옥사진 유도체, 이를 포함하는 약학 조성물 및 이의 용도
US9403800B2 (en) * 2012-01-24 2016-08-02 Chemregen, Inc. Compounds for inhibition of cancer cell proliferation
US10087151B2 (en) 2014-01-09 2018-10-02 The J. David Gladstone Institutes, A Testimentary Trust Established Under The Will Of J. David Gladstone Substituted benzoxazine and related compounds
MX2017016413A (es) 2015-06-12 2018-08-01 Axovant Sciences Gmbh Derivados de diaril y arilheteroaril urea como moduladores del receptor 5ht2a de serotonina útiles para la profilaxis y el tratamineto de un trastorno conductual del sueño rem.
RU2018103338A (ru) 2015-07-15 2019-08-15 Аксовант Сайенсиз Гмбх Производные диарил- и арилгетероарилмочевины для профилактики и лечения галлюцинаций, ассоциированных с нейродегенеративным заболеванием

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Also Published As

Publication number Publication date
MXPA04011254A (es) 2005-01-25
HRP20041030A2 (en) 2005-06-30
IL164928A0 (en) 2005-12-18
DK1506179T3 (da) 2006-06-06
US20130123251A1 (en) 2013-05-16
EP1506179B1 (en) 2006-01-25
HK1080846A1 (en) 2006-05-04
NO329380B1 (no) 2010-10-04
TNSN04225A1 (fr) 2007-03-12
ES2256744T3 (es) 2006-07-16
MY139612A (en) 2009-10-30
NO20044665L (no) 2004-12-03
TW200400188A (en) 2004-01-01
EG25683A (en) 2012-05-16
AU2003233231A1 (en) 2003-11-11
CN100429206C (zh) 2008-10-29
GT200300108A (es) 2004-03-15
PA8573501A1 (es) 2003-12-10
AR039988A1 (es) 2005-03-09
US20090325950A1 (en) 2009-12-31
BR0310032A (pt) 2005-02-15
EA200401455A1 (ru) 2005-06-30
HRP20041030B1 (hr) 2013-03-31
NZ536230A (en) 2007-05-31
US8377931B2 (en) 2013-02-19
DE60303376D1 (de) 2006-04-13
PL374019A1 (en) 2005-09-19
PE20040757A1 (es) 2004-11-06
KR100636475B1 (ko) 2006-10-18
US20030232825A1 (en) 2003-12-18
UY27803A1 (es) 2003-11-28
CN1653054A (zh) 2005-08-10
BRPI0310032B1 (pt) 2019-01-08
EP1506179A1 (en) 2005-02-16
CA2485136A1 (en) 2003-11-20
AU2003233231B2 (en) 2009-02-26
ECSP045420A (es) 2005-01-03
US6867204B2 (en) 2005-03-15
ZA200408783B (en) 2005-12-28
JO2413B1 (en) 2007-11-11
EA009982B1 (ru) 2008-04-28
RS51042B (sr) 2010-10-31
JP2005530774A (ja) 2005-10-13
CA2485136C (en) 2011-12-20
PL211057B1 (pl) 2012-04-30
TWI258479B (en) 2006-07-21
UA76877C2 (ru) 2006-09-15
DE60303376T2 (de) 2006-11-16
PT1506179E (pt) 2006-06-30
KR20040106538A (ko) 2004-12-17
JP4307377B2 (ja) 2009-08-05
ATE316523T1 (de) 2006-02-15
MA27118A1 (fr) 2004-12-20
US20050130962A1 (en) 2005-06-16
WO2003095434A1 (en) 2003-11-20
RS97004A (en) 2006-10-27

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B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

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