BR9915512A - Análogos antagonìsticos de gh-rh que inibem igf-i e -ii - Google Patents
Análogos antagonìsticos de gh-rh que inibem igf-i e -iiInfo
- Publication number
- BR9915512A BR9915512A BR9915512-5A BR9915512A BR9915512A BR 9915512 A BR9915512 A BR 9915512A BR 9915512 A BR9915512 A BR 9915512A BR 9915512 A BR9915512 A BR 9915512A
- Authority
- BR
- Brazil
- Prior art keywords
- analogs
- inhibit igf
- inhibit
- antagonistic
- antagonistic analogs
- Prior art date
Links
- 230000003042 antagnostic effect Effects 0.000 title abstract 2
- 102000018997 Growth Hormone Human genes 0.000 abstract 1
- 108010051696 Growth Hormone Proteins 0.000 abstract 1
- 102000004218 Insulin-Like Growth Factor I Human genes 0.000 abstract 1
- 108090000723 Insulin-Like Growth Factor I Proteins 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000000122 growth hormone Substances 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000036515 potency Effects 0.000 abstract 1
- 238000006467 substitution reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/60—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
- A61P5/04—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin for decreasing, blocking or antagonising the activity of the hypothalamic hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
- A61P5/08—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH for decreasing, blocking or antagonising the activity of the anterior pituitary hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Endocrinology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
"ANáLOGOS ANTAGONìSTICOS DE GH-RH QUE INIBEM IGF-I E -II" é proporcionada uma nova série de análogos sintéticos de hGH-RH (1-29)NH~ 2~. Estes análogos inibem a atividade de hGH-RH endógeno, e portanto impedem a liberação do hormónio do crescimento. As potências inibitórias mais fortes dos novos análogos, em comparação com as previamente descritas, resultam da substituição de diversos aminoácidos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/199,381 US6057422A (en) | 1998-11-25 | 1998-11-25 | Antagonistic analogs of GH-RH inhibiting IGF-I and -II |
PCT/US1999/027822 WO2000031136A1 (en) | 1998-11-25 | 1999-11-23 | Antagonistic analogs of gh-rh inhibiting igf-i and -ii |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9915512A true BR9915512A (pt) | 2001-08-07 |
Family
ID=22737273
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9915512-5A BR9915512A (pt) | 1998-11-25 | 1999-11-23 | Análogos antagonìsticos de gh-rh que inibem igf-i e -ii |
Country Status (29)
Country | Link |
---|---|
US (2) | US6057422A (pt) |
EP (1) | EP1133522B1 (pt) |
JP (1) | JP2002530432A (pt) |
KR (1) | KR100629013B1 (pt) |
CN (1) | CN100422211C (pt) |
AR (1) | AR022392A1 (pt) |
AT (1) | ATE332310T1 (pt) |
AU (1) | AU757222B2 (pt) |
BG (1) | BG65137B1 (pt) |
BR (1) | BR9915512A (pt) |
CA (1) | CA2351665C (pt) |
CO (1) | CO5180565A1 (pt) |
CZ (1) | CZ20011794A3 (pt) |
DE (1) | DE69932255T2 (pt) |
DK (1) | DK1133522T3 (pt) |
ES (1) | ES2264279T3 (pt) |
HK (1) | HK1036461A1 (pt) |
HU (1) | HUP0105094A3 (pt) |
IL (1) | IL142899A0 (pt) |
NO (1) | NO20012489L (pt) |
NZ (1) | NZ511307A (pt) |
PL (1) | PL197471B1 (pt) |
PT (1) | PT1133522E (pt) |
RU (1) | RU2235099C2 (pt) |
SK (1) | SK7252001A3 (pt) |
TR (1) | TR200101492T2 (pt) |
TW (1) | TW585873B (pt) |
UA (1) | UA68407C2 (pt) |
WO (1) | WO2000031136A1 (pt) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003006611A2 (en) * | 2001-07-12 | 2003-01-23 | Exelixis, Inc. | GPCs AS MODIFIERS OF THE IRRTK AND p21 PATHWAYS AND METHODS OF USE |
US20040121407A1 (en) * | 2002-09-06 | 2004-06-24 | Elixir Pharmaceuticals, Inc. | Regulation of the growth hormone/IGF-1 axis |
RU2005111253A (ru) * | 2002-09-18 | 2005-11-20 | Сантр Оспиталье Де Л` Юниверсите Де Монреаль (Схюм) (Ca) | Аналоги ghrh |
TW200517400A (en) * | 2003-08-05 | 2005-06-01 | Univ Tulane | Antagonistic analogs of GH-RH (2003) |
BRPI0910873A2 (pt) * | 2008-03-28 | 2015-10-06 | Us Of America Represented By The Dept Of Veterans Affairs | análogos antagonistas de gh-rh substituídos nos terminais n e c |
US8691942B2 (en) | 2008-03-28 | 2014-04-08 | University Of Miami | N- and C- terminal substituted antagonistic analogs of GH-RH |
EP2719392B1 (en) | 2008-06-12 | 2019-07-24 | Ipsen Bioinnovation Limited | Fusion proteins for use in the treatment of acromegaly |
US10240138B2 (en) | 2008-06-12 | 2019-03-26 | Ipsen Bioinnovation Limited | Polypeptides that bind to and inhibit secretion from growth hormone secreting cells |
GB0820970D0 (en) | 2008-11-17 | 2008-12-24 | Syntaxin Ltd | Suppression of cancer |
US8227421B2 (en) * | 2009-09-17 | 2012-07-24 | University Of Miami | Fluorinated GHRH antagonists |
CN103547591A (zh) | 2011-04-21 | 2014-01-29 | 瑟瑞技术公司 | 生长激素释放因子(grf)类似物及其用途 |
US9079974B2 (en) * | 2011-12-21 | 2015-07-14 | The University Of Miami | GH-RH analogs with potent agonistic effects |
EP2934565B1 (en) | 2012-12-21 | 2019-03-13 | University of Miami | Ghrh agonists for the treatment of ischemic disorders |
WO2014100816A2 (en) | 2012-12-21 | 2014-06-26 | University Of Miami | Ghrh agonists for islet cell transplantation and function and the treatment of diabetes |
EP3218395B1 (en) | 2014-11-12 | 2022-01-05 | The United States of America, as represented by The Secretary, Department of Health and Human Services | Treatment of hormonal disorders of growth |
CA3129405A1 (en) | 2019-02-08 | 2020-08-13 | United States Government As Represented By The Department Of Veterans Affairs | Growth hormone-releasing hormone antagonists and uses thereof |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4659693A (en) * | 1984-04-30 | 1987-04-21 | Syntex (U.S.A.) Inc. | N,N'-dialkyl substituted guanidino amino acyl residue substituted GRF-analog peptides |
CA2082059A1 (en) * | 1990-05-04 | 1991-11-05 | David H. Coy | Synthetic grf analogs |
US5550212A (en) * | 1993-12-17 | 1996-08-27 | The Administrators Of The Tulane Educational Fund | Analogues of hGH-RH(1-29)NH2 having antagonistic activity |
US5942489A (en) * | 1996-05-03 | 1999-08-24 | The Administrators Of The Tulane Educational Fund | HGH-RH(1-29)NH2 analogues having antagonistic activity |
-
1998
- 1998-11-25 US US09/199,381 patent/US6057422A/en not_active Expired - Fee Related
-
1999
- 1999-11-16 CO CO99072002A patent/CO5180565A1/es not_active Application Discontinuation
- 1999-11-23 KR KR1020017006568A patent/KR100629013B1/ko not_active IP Right Cessation
- 1999-11-23 AT AT99963962T patent/ATE332310T1/de not_active IP Right Cessation
- 1999-11-23 UA UA2001064393A patent/UA68407C2/uk unknown
- 1999-11-23 PT PT99963962T patent/PT1133522E/pt unknown
- 1999-11-23 CZ CZ20011794A patent/CZ20011794A3/cs unknown
- 1999-11-23 RU RU2001117218/04A patent/RU2235099C2/ru not_active IP Right Cessation
- 1999-11-23 NZ NZ511307A patent/NZ511307A/en unknown
- 1999-11-23 SK SK725-2001A patent/SK7252001A3/sk unknown
- 1999-11-23 WO PCT/US1999/027822 patent/WO2000031136A1/en active IP Right Grant
- 1999-11-23 CA CA002351665A patent/CA2351665C/en not_active Expired - Fee Related
- 1999-11-23 PL PL349877A patent/PL197471B1/pl unknown
- 1999-11-23 TR TR2001/01492T patent/TR200101492T2/xx unknown
- 1999-11-23 DE DE69932255T patent/DE69932255T2/de not_active Expired - Fee Related
- 1999-11-23 BR BR9915512-5A patent/BR9915512A/pt not_active Application Discontinuation
- 1999-11-23 HU HU0105094A patent/HUP0105094A3/hu unknown
- 1999-11-23 CN CNB998137359A patent/CN100422211C/zh not_active Expired - Fee Related
- 1999-11-23 IL IL14289999A patent/IL142899A0/xx not_active IP Right Cessation
- 1999-11-23 DK DK99963962T patent/DK1133522T3/da active
- 1999-11-23 EP EP99963962A patent/EP1133522B1/en not_active Expired - Lifetime
- 1999-11-23 AU AU20291/00A patent/AU757222B2/en not_active Ceased
- 1999-11-23 ES ES99963962T patent/ES2264279T3/es not_active Expired - Lifetime
- 1999-11-23 JP JP2000583962A patent/JP2002530432A/ja not_active Ceased
- 1999-11-24 TW TW088120503A patent/TW585873B/zh not_active IP Right Cessation
- 1999-11-24 AR ARP990105977A patent/AR022392A1/es active IP Right Grant
-
2000
- 2000-04-11 US US09/547,215 patent/US7026281B1/en not_active Expired - Fee Related
-
2001
- 2001-05-21 NO NO20012489A patent/NO20012489L/no not_active Application Discontinuation
- 2001-06-22 BG BG105638A patent/BG65137B1/bg unknown
- 2001-10-29 HK HK01107515A patent/HK1036461A1/xx not_active IP Right Cessation
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
B11B | Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements |