HK1036461A1 - Antagonistic analogs of gh-rh inhibiting igf-i and-ii - Google Patents

Antagonistic analogs of gh-rh inhibiting igf-i and-ii

Info

Publication number
HK1036461A1
HK1036461A1 HK01107515A HK01107515A HK1036461A1 HK 1036461 A1 HK1036461 A1 HK 1036461A1 HK 01107515 A HK01107515 A HK 01107515A HK 01107515 A HK01107515 A HK 01107515A HK 1036461 A1 HK1036461 A1 HK 1036461A1
Authority
HK
Hong Kong
Prior art keywords
inhibiting igf
antagonistic analogs
antagonistic
analogs
igf
Prior art date
Application number
HK01107515A
Other languages
English (en)
Inventor
Andrew V Schally
Jozsef Varga
Marta Zarandi
Original Assignee
Univ Tulane
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Tulane filed Critical Univ Tulane
Publication of HK1036461A1 publication Critical patent/HK1036461A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/60—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A61P5/04—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin for decreasing, blocking or antagonising the activity of the hypothalamic hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A61P5/08—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH for decreasing, blocking or antagonising the activity of the anterior pituitary hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Endocrinology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
HK01107515A 1998-11-25 2001-10-29 Antagonistic analogs of gh-rh inhibiting igf-i and-ii HK1036461A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/199,381 US6057422A (en) 1998-11-25 1998-11-25 Antagonistic analogs of GH-RH inhibiting IGF-I and -II
PCT/US1999/027822 WO2000031136A1 (en) 1998-11-25 1999-11-23 Antagonistic analogs of gh-rh inhibiting igf-i and -ii

Publications (1)

Publication Number Publication Date
HK1036461A1 true HK1036461A1 (en) 2002-01-04

Family

ID=22737273

Family Applications (1)

Application Number Title Priority Date Filing Date
HK01107515A HK1036461A1 (en) 1998-11-25 2001-10-29 Antagonistic analogs of gh-rh inhibiting igf-i and-ii

Country Status (29)

Country Link
US (2) US6057422A (xx)
EP (1) EP1133522B1 (xx)
JP (1) JP2002530432A (xx)
KR (1) KR100629013B1 (xx)
CN (1) CN100422211C (xx)
AR (1) AR022392A1 (xx)
AT (1) ATE332310T1 (xx)
AU (1) AU757222B2 (xx)
BG (1) BG65137B1 (xx)
BR (1) BR9915512A (xx)
CA (1) CA2351665C (xx)
CO (1) CO5180565A1 (xx)
CZ (1) CZ20011794A3 (xx)
DE (1) DE69932255T2 (xx)
DK (1) DK1133522T3 (xx)
ES (1) ES2264279T3 (xx)
HK (1) HK1036461A1 (xx)
HU (1) HUP0105094A3 (xx)
IL (1) IL142899A0 (xx)
NO (1) NO20012489L (xx)
NZ (1) NZ511307A (xx)
PL (1) PL197471B1 (xx)
PT (1) PT1133522E (xx)
RU (1) RU2235099C2 (xx)
SK (1) SK7252001A3 (xx)
TR (1) TR200101492T2 (xx)
TW (1) TW585873B (xx)
UA (1) UA68407C2 (xx)
WO (1) WO2000031136A1 (xx)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060121041A1 (en) * 2001-07-12 2006-06-08 Lori Friedman Gpcs as modifiers of the irrtk p21 pathways and methods of use
US20040121407A1 (en) * 2002-09-06 2004-06-24 Elixir Pharmaceuticals, Inc. Regulation of the growth hormone/IGF-1 axis
KR20050071498A (ko) * 2002-09-18 2005-07-07 상트르 오스피딸리에 드 루니버시떼 드 몬트리알 성장 호르몬 방출 호르몬 유사체
TW200517400A (en) * 2003-08-05 2005-06-01 Univ Tulane Antagonistic analogs of GH-RH (2003)
CN101983068B (zh) * 2008-03-28 2014-12-24 迈阿密大学 N末端和c末端取代的人gh-rh拮抗类似物
US8691942B2 (en) 2008-03-28 2014-04-08 University Of Miami N- and C- terminal substituted antagonistic analogs of GH-RH
EP2719392B1 (en) 2008-06-12 2019-07-24 Ipsen Bioinnovation Limited Fusion proteins for use in the treatment of acromegaly
JP5799397B2 (ja) 2008-06-12 2015-10-28 イプセン・バイオイノベーション・リミテッドＩｐｓｅｎ Ｂｉｏｉｎｎｏｖａｔｉｏｎ Ｌｉｍｉｔｅｄ 癌の抑制
GB0820970D0 (en) 2008-11-17 2008-12-24 Syntaxin Ltd Suppression of cancer
US8227421B2 (en) * 2009-09-17 2012-07-24 University Of Miami Fluorinated GHRH antagonists
KR20140027284A (ko) 2011-04-21 2014-03-06 쎄러테크놀로지스 인코포레이티드 성장 호르몬 방출 인자(grf) 유사체 및 이의 용도
US9079974B2 (en) * 2011-12-21 2015-07-14 The University Of Miami GH-RH analogs with potent agonistic effects
EP2934565B1 (en) 2012-12-21 2019-03-13 University of Miami Ghrh agonists for the treatment of ischemic disorders
WO2014100816A2 (en) 2012-12-21 2014-06-26 University Of Miami Ghrh agonists for islet cell transplantation and function and the treatment of diabetes
AU2015346277B2 (en) 2014-11-12 2020-03-26 Centre Hospitalier Universitaire De Liège Treatment of hormonal disorders of growth
WO2020163833A2 (en) 2019-02-08 2020-08-13 United States Government As Represented By The Department Of Veterans Affairs Growth hormone-releasing hormone antagonists and uses thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4659693A (en) * 1984-04-30 1987-04-21 Syntex (U.S.A.) Inc. N,N'-dialkyl substituted guanidino amino acyl residue substituted GRF-analog peptides
EP0527914A4 (en) * 1990-05-04 1993-08-11 The Administrators Of The Tulane University Educational Fund Novel synthetic grf analogs
US5550212A (en) * 1993-12-17 1996-08-27 The Administrators Of The Tulane Educational Fund Analogues of hGH-RH(1-29)NH2 having antagonistic activity
US5942489A (en) * 1996-05-03 1999-08-24 The Administrators Of The Tulane Educational Fund HGH-RH(1-29)NH2 analogues having antagonistic activity

Also Published As

Publication number Publication date
US6057422A (en) 2000-05-02
US7026281B1 (en) 2006-04-11
CA2351665C (en) 2008-09-02
HUP0105094A2 (hu) 2002-04-29
IL142899A0 (en) 2002-04-21
CN100422211C (zh) 2008-10-01
BR9915512A (pt) 2001-08-07
CO5180565A1 (es) 2002-07-30
EP1133522A1 (en) 2001-09-19
EP1133522B1 (en) 2006-07-05
AU2029100A (en) 2000-06-13
DE69932255T2 (de) 2007-05-31
RU2235099C2 (ru) 2004-08-27
BG105638A (en) 2002-01-31
KR100629013B1 (ko) 2006-09-26
NZ511307A (en) 2005-01-28
ATE332310T1 (de) 2006-07-15
CN1328570A (zh) 2001-12-26
CA2351665A1 (en) 2000-06-02
TR200101492T2 (tr) 2001-11-21
ES2264279T3 (es) 2006-12-16
NO20012489L (no) 2001-07-04
UA68407C2 (en) 2004-08-16
PL349877A1 (en) 2002-09-23
HUP0105094A3 (en) 2002-05-28
BG65137B1 (bg) 2007-03-30
WO2000031136A1 (en) 2000-06-02
NO20012489D0 (no) 2001-05-21
TW585873B (en) 2004-05-01
KR20010101079A (ko) 2001-11-14
PL197471B1 (pl) 2008-04-30
SK7252001A3 (en) 2002-02-05
AR022392A1 (es) 2002-09-04
CZ20011794A3 (cs) 2002-02-13
AU757222B2 (en) 2003-02-06
WO2000031136A9 (en) 2001-07-19
JP2002530432A (ja) 2002-09-17
DE69932255D1 (de) 2006-08-17
DK1133522T3 (da) 2006-11-06
PT1133522E (pt) 2006-11-30

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20091123