HUP0105094A2 - IGF-I- és IGF-II-gátló növekedési hormont leadó hormon antagonista analógjai és alkalmazásuk - Google Patents
IGF-I- és IGF-II-gátló növekedési hormont leadó hormon antagonista analógjai és alkalmazásukInfo
- Publication number
- HUP0105094A2 HUP0105094A2 HU0105094A HUP0105094A HUP0105094A2 HU P0105094 A2 HUP0105094 A2 HU P0105094A2 HU 0105094 A HU0105094 A HU 0105094A HU P0105094 A HUP0105094 A HU P0105094A HU P0105094 A2 HUP0105094 A2 HU P0105094A2
- Authority
- HU
- Hungary
- Prior art keywords
- arg
- nle
- ala
- har
- leu
- Prior art date
Links
- 230000003042 antagnostic effect Effects 0.000 title 1
- 230000002401 inhibitory effect Effects 0.000 title 1
- ODKSFYDXXFIFQN-SCSAIBSYSA-N D-arginine Chemical compound OC(=O)[C@H](N)CCCNC(N)=N ODKSFYDXXFIFQN-SCSAIBSYSA-N 0.000 abstract 4
- CCUAQNUWXLYFRA-IMJSIDKUSA-N Ala-Asn Chemical group C[C@H]([NH3+])C(=O)N[C@H](C([O-])=O)CC(N)=O CCUAQNUWXLYFRA-IMJSIDKUSA-N 0.000 abstract 1
- DCXYFEDJOCDNAF-UWTATZPHSA-N D-Asparagine Chemical group OC(=O)[C@H](N)CC(N)=O DCXYFEDJOCDNAF-UWTATZPHSA-N 0.000 abstract 1
- AHLPHDHHMVZTML-SCSAIBSYSA-N D-Ornithine Chemical compound NCCC[C@@H](N)C(O)=O AHLPHDHHMVZTML-SCSAIBSYSA-N 0.000 abstract 1
- 125000002038 D-arginyl group Chemical group N[C@@H](C(=O)*)CCCNC(=N)N 0.000 abstract 1
- KDXKERNSBIXSRK-RXMQYKEDSA-N D-lysine Chemical compound NCCCC[C@@H](N)C(O)=O KDXKERNSBIXSRK-RXMQYKEDSA-N 0.000 abstract 1
- 125000000010 L-asparaginyl group Chemical group O=C([*])[C@](N([H])[H])([H])C([H])([H])C(=O)N([H])[H] 0.000 abstract 1
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical group OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/60—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
- A61P5/04—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin for decreasing, blocking or antagonising the activity of the hypothalamic hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
- A61P5/08—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH for decreasing, blocking or antagonising the activity of the anterior pituitary hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Endocrinology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
InterLn=1733;>(57) A tal lm ny szerinti peptidek X-R1-R2-Asp-Ala -R5-R6-Thr-R8- R9- R10-Arg-R12-R13- R14-R15-R16- Leu-R18-R19- Arg-R21-R22-Leu- Gln-Asp-lle-R27-R28-R29-NH2 ltal nos képletében X jelentése PhAc,IndAc vagy Nac, R1 jelentése Tyr vagy His, R2 jelentése D-Arg, R5jelentése lle vagy Val, R6 jelentése Phe, Nal vagy Phe(CI), R8jelentése Asn, Gln, Ala vagy D-Asn, R9 jelentése Arg, Har, Lys, Orn,D-Arg, D-Har, D-Lys, D-Orn., Cit, Nle, Tyr(Me), Ser, Ala vagy Aib, R10jelentése Tyr vagy Tyr(Me), R12 jelentése Lys, R13 jelentése Val vagyNle, R14 jelentése Leu vagy Nle, R15 jelentése Gly, Ala, Abu, Nle vagyGln, R16 jelentése Gln vagy Arg, R18 jelentése Ser vagy Nle, R19jelentése Ala, R12 jelentése Lys, R22 jelentése Leu, Ala vagy Aib, R27jelentése Met, Leu, Nle, Abu vagy D-Arg, R28 jelentése Arg, D-Arg vagySer, és R29 jelentése Arg, D-Arg, Har vagy D-Har, azzal a megk"téssel,hogy ha R9 és R28 jelentése Ser, akkor R29 jelentése Arg-tól és Har-tól eltérő. A tal lm ny t rgyk"réhez tartozik tov bb a fentivegyületek alkalmaz sa r kos beteg kezelésére szolg ló gyógy szatikészítmény elő llít s ra. Ó
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/199,381 US6057422A (en) | 1998-11-25 | 1998-11-25 | Antagonistic analogs of GH-RH inhibiting IGF-I and -II |
| PCT/US1999/027822 WO2000031136A1 (en) | 1998-11-25 | 1999-11-23 | Antagonistic analogs of gh-rh inhibiting igf-i and -ii |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0105094A2 true HUP0105094A2 (hu) | 2002-04-29 |
| HUP0105094A3 HUP0105094A3 (en) | 2002-05-28 |
Family
ID=22737273
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0105094A HUP0105094A3 (en) | 1998-11-25 | 1999-11-23 | Antagonistic analogs of gh-rh inhibiting igf-i and ii and their use |
Country Status (29)
| Country | Link |
|---|---|
| US (2) | US6057422A (hu) |
| EP (1) | EP1133522B1 (hu) |
| JP (1) | JP2002530432A (hu) |
| KR (1) | KR100629013B1 (hu) |
| CN (1) | CN100422211C (hu) |
| AR (1) | AR022392A1 (hu) |
| AT (1) | ATE332310T1 (hu) |
| AU (1) | AU757222B2 (hu) |
| BG (1) | BG65137B1 (hu) |
| BR (1) | BR9915512A (hu) |
| CA (1) | CA2351665C (hu) |
| CO (1) | CO5180565A1 (hu) |
| CZ (1) | CZ20011794A3 (hu) |
| DE (1) | DE69932255T2 (hu) |
| DK (1) | DK1133522T3 (hu) |
| ES (1) | ES2264279T3 (hu) |
| HK (1) | HK1036461A1 (hu) |
| HU (1) | HUP0105094A3 (hu) |
| IL (1) | IL142899A0 (hu) |
| NO (1) | NO20012489L (hu) |
| NZ (1) | NZ511307A (hu) |
| PL (1) | PL197471B1 (hu) |
| PT (1) | PT1133522E (hu) |
| RU (1) | RU2235099C2 (hu) |
| SK (1) | SK7252001A3 (hu) |
| TR (1) | TR200101492T2 (hu) |
| TW (1) | TW585873B (hu) |
| UA (1) | UA68407C2 (hu) |
| WO (1) | WO2000031136A1 (hu) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060121041A1 (en) * | 2001-07-12 | 2006-06-08 | Lori Friedman | Gpcs as modifiers of the irrtk p21 pathways and methods of use |
| US20040121407A1 (en) * | 2002-09-06 | 2004-06-24 | Elixir Pharmaceuticals, Inc. | Regulation of the growth hormone/IGF-1 axis |
| KR20050071498A (ko) * | 2002-09-18 | 2005-07-07 | 상트르 오스피딸리에 드 루니버시떼 드 몬트리알 | 성장 호르몬 방출 호르몬 유사체 |
| TW200517400A (en) * | 2003-08-05 | 2005-06-01 | Univ Tulane | Antagonistic analogs of GH-RH (2003) |
| CN101983068B (zh) * | 2008-03-28 | 2014-12-24 | 迈阿密大学 | N末端和c末端取代的人gh-rh拮抗类似物 |
| US8691942B2 (en) | 2008-03-28 | 2014-04-08 | University Of Miami | N- and C- terminal substituted antagonistic analogs of GH-RH |
| EP2719392B1 (en) | 2008-06-12 | 2019-07-24 | Ipsen Bioinnovation Limited | Fusion proteins for use in the treatment of acromegaly |
| JP5799397B2 (ja) | 2008-06-12 | 2015-10-28 | イプセン・バイオイノベーション・リミテッドＩｐｓｅｎ Ｂｉｏｉｎｎｏｖａｔｉｏｎ Ｌｉｍｉｔｅｄ | 癌の抑制 |
| GB0820970D0 (en) | 2008-11-17 | 2008-12-24 | Syntaxin Ltd | Suppression of cancer |
| US8227421B2 (en) * | 2009-09-17 | 2012-07-24 | University Of Miami | Fluorinated GHRH antagonists |
| KR20140027284A (ko) | 2011-04-21 | 2014-03-06 | 쎄러테크놀로지스 인코포레이티드 | 성장 호르몬 방출 인자(grf) 유사체 및 이의 용도 |
| US9079974B2 (en) * | 2011-12-21 | 2015-07-14 | The University Of Miami | GH-RH analogs with potent agonistic effects |
| EP2934565B1 (en) | 2012-12-21 | 2019-03-13 | University of Miami | Ghrh agonists for the treatment of ischemic disorders |
| WO2014100816A2 (en) | 2012-12-21 | 2014-06-26 | University Of Miami | Ghrh agonists for islet cell transplantation and function and the treatment of diabetes |
| AU2015346277B2 (en) | 2014-11-12 | 2020-03-26 | Centre Hospitalier Universitaire De Liège | Treatment of hormonal disorders of growth |
| WO2020163833A2 (en) | 2019-02-08 | 2020-08-13 | United States Government As Represented By The Department Of Veterans Affairs | Growth hormone-releasing hormone antagonists and uses thereof |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4659693A (en) * | 1984-04-30 | 1987-04-21 | Syntex (U.S.A.) Inc. | N,N'-dialkyl substituted guanidino amino acyl residue substituted GRF-analog peptides |
| EP0527914A4 (en) * | 1990-05-04 | 1993-08-11 | The Administrators Of The Tulane University Educational Fund | Novel synthetic grf analogs |
| US5550212A (en) * | 1993-12-17 | 1996-08-27 | The Administrators Of The Tulane Educational Fund | Analogues of hGH-RH(1-29)NH2 having antagonistic activity |
| US5942489A (en) * | 1996-05-03 | 1999-08-24 | The Administrators Of The Tulane Educational Fund | HGH-RH(1-29)NH2 analogues having antagonistic activity |
-
1998
- 1998-11-25 US US09/199,381 patent/US6057422A/en not_active Expired - Fee Related
-
1999
- 1999-11-16 CO CO99072002A patent/CO5180565A1/es not_active Application Discontinuation
- 1999-11-23 DK DK99963962T patent/DK1133522T3/da active
- 1999-11-23 CA CA002351665A patent/CA2351665C/en not_active Expired - Fee Related
- 1999-11-23 DE DE69932255T patent/DE69932255T2/de not_active Expired - Fee Related
- 1999-11-23 UA UA2001064393A patent/UA68407C2/uk unknown
- 1999-11-23 BR BR9915512-5A patent/BR9915512A/pt not_active Application Discontinuation
- 1999-11-23 AU AU20291/00A patent/AU757222B2/en not_active Ceased
- 1999-11-23 TR TR2001/01492T patent/TR200101492T2/xx unknown
- 1999-11-23 CN CNB998137359A patent/CN100422211C/zh not_active Expired - Fee Related
- 1999-11-23 PT PT99963962T patent/PT1133522E/pt unknown
- 1999-11-23 AT AT99963962T patent/ATE332310T1/de not_active IP Right Cessation
- 1999-11-23 SK SK725-2001A patent/SK7252001A3/sk unknown
- 1999-11-23 JP JP2000583962A patent/JP2002530432A/ja not_active Ceased
- 1999-11-23 IL IL14289999A patent/IL142899A0/xx not_active IP Right Cessation
- 1999-11-23 WO PCT/US1999/027822 patent/WO2000031136A1/en active IP Right Grant
- 1999-11-23 NZ NZ511307A patent/NZ511307A/en unknown
- 1999-11-23 RU RU2001117218/04A patent/RU2235099C2/ru not_active IP Right Cessation
- 1999-11-23 HU HU0105094A patent/HUP0105094A3/hu unknown
- 1999-11-23 CZ CZ20011794A patent/CZ20011794A3/cs unknown
- 1999-11-23 ES ES99963962T patent/ES2264279T3/es not_active Expired - Lifetime
- 1999-11-23 KR KR1020017006568A patent/KR100629013B1/ko not_active IP Right Cessation
- 1999-11-23 PL PL349877A patent/PL197471B1/pl unknown
- 1999-11-23 EP EP99963962A patent/EP1133522B1/en not_active Expired - Lifetime
- 1999-11-24 AR ARP990105977A patent/AR022392A1/es active IP Right Grant
- 1999-11-24 TW TW088120503A patent/TW585873B/zh not_active IP Right Cessation
-
2000
- 2000-04-11 US US09/547,215 patent/US7026281B1/en not_active Expired - Fee Related
-
2001
- 2001-05-21 NO NO20012489A patent/NO20012489L/no not_active Application Discontinuation
- 2001-06-22 BG BG105638A patent/BG65137B1/bg unknown
- 2001-10-29 HK HK01107515A patent/HK1036461A1/xx not_active IP Right Cessation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD9A | Lapse of provisional protection due to non-payment of fees |