HUP0105094A3 - Antagonistic analogs of gh-rh inhibiting igf-i and ii and their use - Google Patents
Antagonistic analogs of gh-rh inhibiting igf-i and ii and their useInfo
- Publication number
- HUP0105094A3 HUP0105094A3 HU0105094A HUP0105094A HUP0105094A3 HU P0105094 A3 HUP0105094 A3 HU P0105094A3 HU 0105094 A HU0105094 A HU 0105094A HU P0105094 A HUP0105094 A HU P0105094A HU P0105094 A3 HUP0105094 A3 HU P0105094A3
- Authority
- HU
- Hungary
- Prior art keywords
- inhibiting igf
- antagonistic analogs
- antagonistic
- analogs
- igf
- Prior art date
Links
- 230000003042 antagnostic effect Effects 0.000 title 1
- 230000002401 inhibitory effect Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/60—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
- A61P5/04—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin for decreasing, blocking or antagonising the activity of the hypothalamic hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
- A61P5/08—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH for decreasing, blocking or antagonising the activity of the anterior pituitary hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Endocrinology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/199,381 US6057422A (en) | 1998-11-25 | 1998-11-25 | Antagonistic analogs of GH-RH inhibiting IGF-I and -II |
| PCT/US1999/027822 WO2000031136A1 (en) | 1998-11-25 | 1999-11-23 | Antagonistic analogs of gh-rh inhibiting igf-i and -ii |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0105094A2 HUP0105094A2 (hu) | 2002-04-29 |
| HUP0105094A3 true HUP0105094A3 (en) | 2002-05-28 |
Family
ID=22737273
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0105094A HUP0105094A3 (en) | 1998-11-25 | 1999-11-23 | Antagonistic analogs of gh-rh inhibiting igf-i and ii and their use |
Country Status (29)
| Country | Link |
|---|---|
| US (2) | US6057422A (hu) |
| EP (1) | EP1133522B1 (hu) |
| JP (1) | JP2002530432A (hu) |
| KR (1) | KR100629013B1 (hu) |
| CN (1) | CN100422211C (hu) |
| AR (1) | AR022392A1 (hu) |
| AT (1) | ATE332310T1 (hu) |
| AU (1) | AU757222B2 (hu) |
| BG (1) | BG65137B1 (hu) |
| BR (1) | BR9915512A (hu) |
| CA (1) | CA2351665C (hu) |
| CO (1) | CO5180565A1 (hu) |
| CZ (1) | CZ20011794A3 (hu) |
| DE (1) | DE69932255T2 (hu) |
| DK (1) | DK1133522T3 (hu) |
| ES (1) | ES2264279T3 (hu) |
| HK (1) | HK1036461A1 (hu) |
| HU (1) | HUP0105094A3 (hu) |
| IL (1) | IL142899A0 (hu) |
| NO (1) | NO20012489L (hu) |
| NZ (1) | NZ511307A (hu) |
| PL (1) | PL197471B1 (hu) |
| PT (1) | PT1133522E (hu) |
| RU (1) | RU2235099C2 (hu) |
| SK (1) | SK7252001A3 (hu) |
| TR (1) | TR200101492T2 (hu) |
| TW (1) | TW585873B (hu) |
| UA (1) | UA68407C2 (hu) |
| WO (1) | WO2000031136A1 (hu) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060121041A1 (en) * | 2001-07-12 | 2006-06-08 | Lori Friedman | Gpcs as modifiers of the irrtk p21 pathways and methods of use |
| US20040121407A1 (en) * | 2002-09-06 | 2004-06-24 | Elixir Pharmaceuticals, Inc. | Regulation of the growth hormone/IGF-1 axis |
| KR20050071498A (ko) * | 2002-09-18 | 2005-07-07 | 상트르 오스피딸리에 드 루니버시떼 드 몬트리알 | 성장 호르몬 방출 호르몬 유사체 |
| TW200517400A (en) * | 2003-08-05 | 2005-06-01 | Univ Tulane | Antagonistic analogs of GH-RH (2003) |
| CN101983068B (zh) * | 2008-03-28 | 2014-12-24 | 迈阿密大学 | N末端和c末端取代的人gh-rh拮抗类似物 |
| US8691942B2 (en) | 2008-03-28 | 2014-04-08 | University Of Miami | N- and C- terminal substituted antagonistic analogs of GH-RH |
| EP2719392B1 (en) | 2008-06-12 | 2019-07-24 | Ipsen Bioinnovation Limited | Fusion proteins for use in the treatment of acromegaly |
| JP5799397B2 (ja) | 2008-06-12 | 2015-10-28 | イプセン・バイオイノベーション・リミテッドＩｐｓｅｎ Ｂｉｏｉｎｎｏｖａｔｉｏｎ Ｌｉｍｉｔｅｄ | 癌の抑制 |
| GB0820970D0 (en) | 2008-11-17 | 2008-12-24 | Syntaxin Ltd | Suppression of cancer |
| US8227421B2 (en) * | 2009-09-17 | 2012-07-24 | University Of Miami | Fluorinated GHRH antagonists |
| KR20140027284A (ko) | 2011-04-21 | 2014-03-06 | 쎄러테크놀로지스 인코포레이티드 | 성장 호르몬 방출 인자(grf) 유사체 및 이의 용도 |
| US9079974B2 (en) * | 2011-12-21 | 2015-07-14 | The University Of Miami | GH-RH analogs with potent agonistic effects |
| EP2934565B1 (en) | 2012-12-21 | 2019-03-13 | University of Miami | Ghrh agonists for the treatment of ischemic disorders |
| WO2014100816A2 (en) | 2012-12-21 | 2014-06-26 | University Of Miami | Ghrh agonists for islet cell transplantation and function and the treatment of diabetes |
| AU2015346277B2 (en) | 2014-11-12 | 2020-03-26 | Centre Hospitalier Universitaire De Liège | Treatment of hormonal disorders of growth |
| WO2020163833A2 (en) | 2019-02-08 | 2020-08-13 | United States Government As Represented By The Department Of Veterans Affairs | Growth hormone-releasing hormone antagonists and uses thereof |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4659693A (en) * | 1984-04-30 | 1987-04-21 | Syntex (U.S.A.) Inc. | N,N'-dialkyl substituted guanidino amino acyl residue substituted GRF-analog peptides |
| EP0527914A4 (en) * | 1990-05-04 | 1993-08-11 | The Administrators Of The Tulane University Educational Fund | Novel synthetic grf analogs |
| US5550212A (en) * | 1993-12-17 | 1996-08-27 | The Administrators Of The Tulane Educational Fund | Analogues of hGH-RH(1-29)NH2 having antagonistic activity |
| US5942489A (en) * | 1996-05-03 | 1999-08-24 | The Administrators Of The Tulane Educational Fund | HGH-RH(1-29)NH2 analogues having antagonistic activity |
-
1998
- 1998-11-25 US US09/199,381 patent/US6057422A/en not_active Expired - Fee Related
-
1999
- 1999-11-16 CO CO99072002A patent/CO5180565A1/es not_active Application Discontinuation
- 1999-11-23 DK DK99963962T patent/DK1133522T3/da active
- 1999-11-23 CA CA002351665A patent/CA2351665C/en not_active Expired - Fee Related
- 1999-11-23 DE DE69932255T patent/DE69932255T2/de not_active Expired - Fee Related
- 1999-11-23 UA UA2001064393A patent/UA68407C2/uk unknown
- 1999-11-23 BR BR9915512-5A patent/BR9915512A/pt not_active Application Discontinuation
- 1999-11-23 AU AU20291/00A patent/AU757222B2/en not_active Ceased
- 1999-11-23 TR TR2001/01492T patent/TR200101492T2/xx unknown
- 1999-11-23 CN CNB998137359A patent/CN100422211C/zh not_active Expired - Fee Related
- 1999-11-23 PT PT99963962T patent/PT1133522E/pt unknown
- 1999-11-23 AT AT99963962T patent/ATE332310T1/de not_active IP Right Cessation
- 1999-11-23 SK SK725-2001A patent/SK7252001A3/sk unknown
- 1999-11-23 JP JP2000583962A patent/JP2002530432A/ja not_active Ceased
- 1999-11-23 IL IL14289999A patent/IL142899A0/xx not_active IP Right Cessation
- 1999-11-23 WO PCT/US1999/027822 patent/WO2000031136A1/en active IP Right Grant
- 1999-11-23 NZ NZ511307A patent/NZ511307A/en unknown
- 1999-11-23 RU RU2001117218/04A patent/RU2235099C2/ru not_active IP Right Cessation
- 1999-11-23 HU HU0105094A patent/HUP0105094A3/hu unknown
- 1999-11-23 CZ CZ20011794A patent/CZ20011794A3/cs unknown
- 1999-11-23 ES ES99963962T patent/ES2264279T3/es not_active Expired - Lifetime
- 1999-11-23 KR KR1020017006568A patent/KR100629013B1/ko not_active IP Right Cessation
- 1999-11-23 PL PL349877A patent/PL197471B1/pl unknown
- 1999-11-23 EP EP99963962A patent/EP1133522B1/en not_active Expired - Lifetime
- 1999-11-24 AR ARP990105977A patent/AR022392A1/es active IP Right Grant
- 1999-11-24 TW TW088120503A patent/TW585873B/zh not_active IP Right Cessation
-
2000
- 2000-04-11 US US09/547,215 patent/US7026281B1/en not_active Expired - Fee Related
-
2001
- 2001-05-21 NO NO20012489A patent/NO20012489L/no not_active Application Discontinuation
- 2001-06-22 BG BG105638A patent/BG65137B1/bg unknown
- 2001-10-29 HK HK01107515A patent/HK1036461A1/xx not_active IP Right Cessation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD9A | Lapse of provisional protection due to non-payment of fees |